ES細胞、組織幹細胞の増殖・分化機構の解明とその臨床応用に関する研究

• Project/Area Number: 13GS0009
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Kyoto University
• Principal Investigator: 中畑 龍俊 京都大学, 医学研究科, 教授 (20110744)
• Co-Investigator(Kenkyū-buntansha): 平家 俊男 京都大学, 医学研究科, 助教授 (90190173) ; 依藤 亨 京都大学, 医学研究科, 講師 (60220779) ; 足立 壮一 京都大学, 医学研究科, 講師 (10273450) ; 西小森 隆太 京都大学, 医学研究科, 助手 (70359800) ; 片村 憲司 京都大学, 医学研究科, 講師 (40185806)
• Project Period (FY): 2001 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥342,550,000 (Direct Cost: ¥283,900,000、Indirect Cost: ¥58,650,000); Fiscal Year 2005: ¥82,550,000 (Direct Cost: ¥63,500,000、Indirect Cost: ¥19,050,000); Fiscal Year 2004: ¥83,200,000 (Direct Cost: ¥64,000,000、Indirect Cost: ¥19,200,000); Fiscal Year 2003: ¥88,400,000 (Direct Cost: ¥68,000,000、Indirect Cost: ¥20,400,000); Fiscal Year 2002: ¥88,400,000 (Direct Cost: ¥88,400,000)
• Keywords: 組織幹細胞 / ES細胞 / 自己複製 / 分化 / 倫理 / 再生 / 移植 / ヒト / 体性幹細胞 / 造血幹細胞 / 発生 / hemangioblast / 再生医学 / 遺伝子クローニング / ノックアウトマウス / 自己複製因子 / 可塑性 / ex vivo増幅

Research Abstract

われわれの臓器には、自己複製能と分化能を持った組織固有な幹細胞(組織幹細胞)が存在する。近年、種々の組織幹細胞をex vivoで増幅しそれを用いた新しい医療、所謂再生医療を目指した研究が盛んに行われているが、組織幹細胞の分離法、自己複製や増殖分化に関与する分子が同定されていないこともあってほとんど成功していない。最近樹立されたヒトES細胞は社会的、倫理的な問題を抱えているが、一方、この細胞を利用して慢性的に不足している移植用の細胞や臓器を産生できるのではないかという期待も膨らんできている。ES細胞は培養条件下で全能性、多分化能を保持しながら自己複製することから、ES細胞から特定の組織幹細胞を分化させる培養系を確立することができれば、目的とする細胞や臓器を無限に作り出すことが可能になると考えられる。しかし、現在、マウスの系においてもES細胞から特定の組織幹細胞を誘導する方法は確立していない。
本研究ではマウス及びヒトの組織幹細胞の種類とその細胞生物学性状を明らかにし、それぞれの組織幹細胞の自己複製、増殖、分化、形質転換に関与する分子を同定し、造血幹細胞、肝幹細胞等の組織幹細胞を増幅するための基盤技術を開発した。また、マウスES細胞から神経幹細胞等の組織幹細胞への分化誘導に特異的に作用する分子を明らかにし、サルES細胞を使った造血発生のin vitro構築を試み、将来のヒトES細胞を用いた研究に備えた。さらに、ヒト骨髄や臍帯血中に存在する組織幹細胞のex vivo増幅法を確立することにより、増幅組織幹細胞を用いた造血幹細胞移植、肝細胞移植、心筋細胞移植、神経細胞移植などの新しい再生医療の開発や、ES細胞から特異的に産生した組織幹細胞を用いた再生医学、再生医療の基盤技術開発を行った。

Research Products

• [Journal Article] Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo. (2005)
  • Author(s): Yasumi T
  • Journal Title: J.Immunol 177 Pages: 1325-1331
• [Journal Article] Early-onset sarcoidosis and CARD15 mutations : common genetic etiology with Blau syndrome. (2005)
  • Author(s): Kanazawa N
  • Journal Title: Blood 105 Pages: 1195-1197
• [Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers. (2005)
  • Author(s): Nagoto M
  • Journal Title: J.Neurosci. Res. 80 Pages: 456-466
• [Journal Article] CD34+CD7+leukemoc Progenitor cells may be involved in maintenance and clonal evolution of chronic myeloid leukemia. (2005)
  • Author(s): Kosugi N
  • Journal Title: Clin. Cancer Res. 11 Pages: 505-511
• [Journal Article] Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. (2005)
  • Author(s): Kawamura T
  • Journal Title: J. Biol. Chem. 280 Pages: 19682-19688
• [Journal Article] Somatic mosaicism of CIASI in a patient with chronic infantile neurologic,cutaneous,articular syndrome. (2005)
  • Author(s): Saito M
  • Journal Title: Aethritis ＆ Rheumatism 52 Pages: 3579-3585
• [Journal Article] Stem cell plasticity in hematopoietic system (2005)
  • Author(s): Heike T
  • Journal Title: Inflamation and Regeneration 25 Pages: 90-90
  • NAID: 10011958317
• [Journal Article] Identification of cardiac stem cells withFLK1,CD31, and VE-cadherin expression during embryonic stem cell differentiation (2005)
  • Author(s): Iida M
  • Journal Title: FASEB J 19 Pages: 371-371
• [Journal Article] A novel NF-kB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. (2005)
  • Author(s): Tanaka A
  • Journal Title: Blood 105 Pages: 2324-2331
• [Journal Article] Stem cell factor has a suppressive activity to IgE-mediated chem. otaxis of mast cells. (2005)
  • Author(s): Sawada J
  • Journal Title: J.Immunol 174 Pages: 3626-3632
• [Journal Article] Inhibition of leukemiac cell growth by a novel anti-cancer drug(GUT-70) from calophylim brasiilense that acts by induction of apoptosiss. (2005)
  • Author(s): Kimura S
  • Journal Title: Int. J. Cancer 133 Pages: 158-165
• [Journal Article] CpG inhibits IgE clas switch recombination through suppression of NFkB activity, but not through Id2 or Bcl6. Biochem. (2005)
  • Author(s): Kusunoki T
  • Journal Title: Biophys. Res. Commun. 328 Pages: 499-506
• [Journal Article] Characterization of mouse hepatic stem/progenytor cells in a novel culture system. (2005)
  • Author(s): Tsuchiya A
  • Journal Title: Gastroenterology 128 Pages: 2089-2104
• [Journal Article] Two different role of purified Cd45+ hematopoietic stem cells after transplantation in muscles. (2005)
  • Author(s): Yoshimoto M
  • Journal Title: Stem Cells 23 Pages: 610-618
• [Journal Article] Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo. (2005)
  • Author(s): Yasumi T, Katamura K., Okafuji I., Yoshioka T., Meguro T., Nishikomori R., Kusunoki T., Heike T., Nakahata T.
  • Journal Title: J.Immunol. 177 Pages: 1325-1331
• [Journal Article] Early-onset sarcoidosis and CARD15 mutations : common genetic etiology with Blau syndrome. (2005)
  • Author(s): Kanazawa N., Nishikomori R., Kambe N., Nakata-Hizume M., Okafuji I., Nagai S., Fuji A., Yuasa T., Utani A., Manki A., Sakurai Y., Nakajima M., Kobayashi H., Nishigori C., Heike T., Nakahata T., Miyachi Y.
  • Journal Title: Blood 105 Pages: 1195-1197
• [Journal Article] A novel NF-kB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. (2005)
  • Author(s): Tanaka A., Konno M., Muto S., Kambe N., Morii E., Nakahata T., Itai A., Matsuda H.
  • Journal Title: Blood 105 Pages: 2324-2331
• [Journal Article] Stem cell factor has a suppressive activity to IgE-mediated chemotaxis of mast cells. (2005)
  • Author(s): Sawada J., Shimizu S., Tamatani T., Kanagasaki S., Saito H., Tanaka A., Kambe N., Nakahata T., Matsuda H.
  • Journal Title: J.Immunol. 174 Pages: 3626-3632
• [Journal Article] Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophylim brasiilense that acts by induction of apoptosis. (2005)
  • Author(s): Kimura S., Ito C., Jyoko N., Segawa H., Kuroda J., Okada M., Adachi S., Nakahata T., Yuasa T., Filho VC., Furukawa H., Maekawa T.
  • Journal Title: Int.J.Cancer 133 Pages: 158-165
• [Journal Article] CpG inhibits IgE class switch recombination through suppression of NFkB activity, but not through Id2 or Bcl6. (2005)
  • Author(s): Kusunoki, T., Sugai M., Gonda H., Nambu Y., Nagata-Nakajima N., Katakai T., Kusunoki M., Sakamoto A., Tokuhisa T., Nakahata T., Yokota Y., Shimizu A.
  • Journal Title: Biochem.Biophys.Res.Commun. 328 Pages: 499-506
• [Journal Article] SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis. (2005)
  • Author(s): Kusunoki, T., Okafuji I., Yoshioka T., Saito M., Nishikomori R., Heike T., Shimizu A., Nakahata T.
  • Journal Title: J.Allergy Clin.Immunol 115 Pages: 636-638
• [Journal Article] 造血系幹細胞 (2005)
  • Author(s): 中畑龍俊
  • Journal Title: ティッシュエンジニアリング2005 1(2) Pages: 11-17
• [Journal Article] Development of primitive and definitive hemayopoiesis from nonhuman primate embryonic stem cells in vitro. (2004)
  • Author(s): Umeda K., Heike T., Yoshimoto M., Shiota M., Suemori H., Luo H.Y., Chui D.H.K., Shibuya M., Nakatsuji N., Nakahata T.
  • Journal Title: Development 131 Pages: 1869-1879
• [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. (2004)
  • Author(s): Kambe N., Hiramatsu H., Shimonaka M., Fujino H., Nishikomori R., Heike T., Ito M., Kobayashi K., Ueyama Y., Matsuyoshi N., Miyachi Y., Nakahata T.
  • Journal Title: Blood 103 Pages: 860-867
• [Journal Article] Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy. (2004)
  • Author(s): Matsubara H, Watanabe K, Sakai H, Chang H, Fujino H, Higashi Y, Kobayashi M, Adachi S, Seto S, Nakahata T
  • Journal Title: Spine 29
• [Journal Article] Apoptosis induced by molecular targeting therapy in hematological malignancies. (2004)
  • Author(s): Adachi S., Leoni M., Carson DA, Nakahata T.
  • Journal Title: Acta Haematol 111 Pages: 107-123
• [Journal Article] Differential Requirement of the Cd40-CD154 costimulatory pathway during Th cell priming by CD8a+ and CD8a- murine dendritic cell subsets. (2004)
  • Author(s): Yagasaki H., Oda T., Adachi D., Nakajima T., Nakahata T., Asano S., Yamashita T.
  • Journal Title: J.Immunol 172 Pages: 4826-4833
• [Journal Article] Earlier initiation of GH therapy does not influence adult height but earlier start of pubertal induction in children with multiple pituitary hormone deficiency. (2004)
  • Author(s): Kawai N., Momoi T., Mamada M., Yorifuji T., Nakahata T.
  • Journal Title: Clin.Endocrinology 60 Pages: 608-612
• [Journal Article] A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL positive human leukemic cells - caspase-independent, necrosis-like programmed cell death mediated by serine protease activity. (2004)
  • Author(s): Okada M, Adachi S, Imai T, Watanabe K, Toyokuni S, Ueno M, Zervos AS, Kroemer G, Nakahata T.
  • Journal Title: Blood 103 Pages: 2299-2397
• [Journal Article] Neonatal diabetes mellitus and neonatal polycystic, dysplastic kidneys : phenotypically discordant recurrence of a mutation in the hepatocyte nuclear factor 1b gene due to germ-line mosaicism. (2004)
  • Author(s): Yorifuji T., Kurokawa K., Mamada M., Imai T., Kawai M., Nishi Y., Shishido S., Hasegawa Y., Nakahata T.
  • Journal Title: J.Clin.Endo.Metab 89 Pages: 2905-2908
• [Journal Article] Living-related liver transplantation for propioric academia. (2004)
  • Author(s): Yorifuji T., Kawai M., Mamada M., Kurokawa K., Egawa H., Shigematsu Y., Kohno Y., Tanaka K., Nakahata T.
  • Journal Title: J.Inherit Metab.Dis. 27 Pages: 205-210
• [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival. (2004)
  • Author(s): Nishikomori R., Akutagawa H., Maruyama K., Nakata-Hizume M., Ohmori K., Mizuno K., Yachie A., Yasumi T., Kusunoki T., Heike T., Nakahata T.
  • Journal Title: Blood 103 Pages: 4565-4572
• [Journal Article] Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population. (2004)
  • Author(s): Yagasaki H., Hamanoue S., Oda T., Nakahata T., Asano S., Yamashita T.
  • Journal Title: Human Mutat 24 Pages: 481-490
• [Journal Article] Successful allogeneic bone marrow transplantation in apatient with acute myelogenous leukemia and cytomegalovirus retinitis. (2004)
  • Author(s): Matsubara H., Adachi S., Yano J., Kitamura N., Miyazaki M., Mizushima Y., Hiramatsu H., Kobayashi M., Nakahata T.
  • Journal Title: Int.J.Hematol. 80 Pages: 190-192
• [Journal Article] Second transplantation from HLA-2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation. (2004)
  • Author(s): Tanaka T., Matsubara H., Adachi S., Chang H., Fujino H., Yasumi T., Kobayashi M., Watanabe K., Takahashi M., Kobayashi Y., Maruya E., Saji H., Nakahata T
  • Journal Title: Int.J.Hematol. 80 Pages: 467-469
  • NAID: 10014089421
• [Journal Article] Viral infections in juvenile myelo-monocytic leukemia : Prevalence and clinical implications. (2004)
  • Author(s): Manabe A., Tsurusawa M., Manabe A., Hayashi Y., Akiyama Y., Kigasawa H., Inada H., Noguchi Y., Sawai N., Kobayashi R., Nagatoshi Y., Kawakami K., Nakahata T
  • Journal Title: J Pediatr Hematol Oncol 26 Pages: 636-641
• [Journal Article] Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice. (2004)
  • Author(s): Xu Y., Arai H., Zhuge X., Sano H., Murayama T., Yoshimoto M., Heike T., Nakahata T., Nishikawa S., Kita T., Yokode M.
  • Journal Title: Arterioscl.Throm.Vas. 24 Pages: 477-482
• [Journal Article] Identification of cardiac stem cells with FLK1 expression during embryonic stem cell differentiation. (2004)
  • Author(s): Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T.
  • Journal Title: FASEB J. 19 Pages: 371-378
• [Journal Article] Generation of multipotent stem cells from postnatal mouse testis. (2004)
  • Author(s): Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba T., Kazuki Y., Toyokuni S., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T.
  • Journal Title: Cell 119 Pages: 1001-1012
• [Journal Article] Specific recruitment of SPA1 to the immunological synapse : involvement of actin-bundling protein actinin. (2004)
  • Author(s): Harazaki M., Kawai Y., Su L., Hamazaki Y., Nakahata T., Minato N., Hattori M.
  • Journal Title: Immunol.Letter 92 Pages: 221-226
• [Journal Article] 造血幹細胞移植の最近の進歩 (2004)
  • Author(s): 中畑龍俊
  • Journal Title: 炎症と免疫 12(1) Pages: 1-2
• [Journal Article] 新しいヒト造血幹細胞の測定系 (2004)
  • Author(s): 平松英文, 中畑龍俊
  • Journal Title: 炎症と免疫 12(1) Pages: 11-17
• [Journal Article] 硬化性胆管炎から肝硬変に進行し生体肝移植を受けたランゲルハンス細胞組織球症の1例 (2004)
  • Author(s): 松原央, 渡邊健一郎, 小林道広, 足立壮一, 柴田実, 清益功浩, 橋本尚子, 秋山祐一, 中畑龍俊
  • Journal Title: 日本小児血液学会雑誌 18 Pages: 43-46
  • NAID: 10012655058
• [Journal Article] 再生医療の現状と問題点 (2004)
  • Author(s): 中畑龍俊
  • Journal Title: Inflammation and Regeneration 24(2) Pages: 84-91
  • NAID: 130000165334
• [Journal Article] 造血幹細胞移植と再生医療 (2004)
  • Author(s): 中畑龍俊
  • Journal Title: 再生医療 3(1) Pages: 33-41
• [Journal Article] 再生医療の新たな展開 (2004)
  • Author(s): 中畑龍俊
  • Journal Title: 分子リウマチ 1(3) Pages: 67-72
• [Journal Article] 臍帯血移植 (2004)
  • Author(s): 中畑龍俊
  • Journal Title: 治療学 38(10) Pages: 39-43
• [Journal Article] Cranial aneurysmal bone cystで発症したランゲルハンス細胞組織球症の女児例 (2004)
  • Author(s): 宮崎真紀, 平松英文, 國貞佳世, 徳舛麻友, 水嶋康浩, 松原央, 小林道弘, 足立壮一, 中畑龍俊
  • Journal Title: 小児科臨床 57(10) Pages: 2147-2152
• [Journal Article] 造血幹細胞移植医療とトランスレーショナルリサーチ (2004)
  • Author(s): 中畑龍俊
  • Journal Title: 血液フロンティア 14(11) Pages: 51-61
• [Journal Article] HOX decoy peptide enhances the ex vivo expansion of human umbilical cord blood HSCs.
  • Author(s): Tanaka H
  • Journal Title: Stem Cells. (in press)
• [Journal Article] RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells.
  • Author(s): Ohtsuka Y
  • Journal Title: Blood. (in press)
• [Journal Article] Identification and characterization of hemangioblasts during cynomolgus monkey embrionic stem cell differentiation.
  • Author(s): Umeda K
  • Journal Title: Stem Cells. (in press)
• [Journal Article] A neurosphere-derived factor(NDF),Cystatin C, supports differentiation of ES cells into neural stem cells.
  • Author(s): Kato T
  • Journal Title: Proc. Natl Acad. Sci. USA. (in press)
• [Journal Article] Characterization of mouse hepatic stem/progenytor cells in a novel culture system.
  • Author(s): Tsuchiya A., Heike T., Fujino H., Shiota M., Umeda K., Yoshimoto M., Matsuda Y., Ichida T., Aoyagi Y., Nakahata T.
  • Journal Title: Gastroenterology (in press)
• [Journal Article] Two different role of purified Cd45+ hematopoietic stem cells after transplantation in muscles.
  • Author(s): Yoshimoto M., Heike T., Shiota M., Kobayashi H., Umeda K., Nakahata T.
  • Journal Title: Stem Cells (in press)
• [Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers.
  • Author(s): Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H., Nakahata T.
  • Journal Title: J.Neurosci.Res. (in press)
• [Journal Article] Suplatast tosilate inhibits human mast cell development from cord blood progenitors.
  • Author(s): Kambe N., Nakahata T., Miyachi Y.
  • Journal Title: Allergology International. (in press)
  • NAID: 10015655875
• [Journal Article] Therapy-related myelodysplastic syndrome in childhood : A retrospective study of 36 patients in Japan.
  • Author(s): Tsurusawa M., Manabe A., Hayashi Y., Akiyama Y., Kigasawa H., Inada H., Noguchi Y., Sawai N., Kobayashi R., Nagatoshi Y., Kawakami K., Nakahata T.
  • Journal Title: Leukemia Res. (in press)
• [Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
  • Author(s): Hasegawa D., Manabe A., Kubota T., Kawasaki H., Hirose I., Ohtsuka Y., Tsuruta T., Ebihara Y., Goto Y., Yan Zhao X., Sakashita K., Koike K., Isomura M., Kojima S., Hoshika A., Tsuji K., Nakahata T
  • Journal Title: Brit.J.Haematol. (in press)
• [Journal Article] Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes.
  • Author(s): Kawamura T., Ono K., Morimoto T., Wada H., Hirai M., Hidaka K., Morisaki T., Heike T., Nakahata T., Kita T., Hasegawa K.
  • Journal Title: J.Biol.Chem. (in press)
• [Book] Chapter 13「IL-6」 サイトカイン・ケモカインのすべて-基礎から最新情報まで-(第三版 改訂新版) (2004)
  • Author(s): 吉崎和幸, 石橋敏幸, 中畑龍俊
  • Publisher: 日本医学館
• [Book] Chapter 57「造血構造とサイトカイン」 サイトカイン・ケモカインのすべて-基礎から最新情報まで-(第三版 改訂新版) (2004)
  • Author(s): 中畑龍俊
  • Publisher: 日本医学館
• [Publications] Mitsui T., Watanabe S., Nakahata T.et al.: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice."Blood. 101. 2990-2995 (2003)
• [Publications] Akizawa, Y., Nishiyama, C., Nakahata, T.et al.: "Regulation of human Fcepsilon RI beta chain gene expression by Oct-1."International Immunology. 15. 549-556 (2003)
• [Publications] Umeda K., Adachi S., Nakahata, T.et al.: "Successful T-cell-replete peripheral blood stem cell transplantation from HLA-haploidentical microchimeric mother to daughter with refractory acute lymphoblastic leukemia using reduced-intensity conditioning."Bone Marrow Transplant.. 31. 1061-1063 (2003)
• [Publications] Hiramatsu H., Nishikomori R, Nakahata, T.et al.: "Complete reconstitution of human lymphocytes from cord blood CD34+ cells using NOD/SCID/_<-c>^<null> mice model."Blood. 102. 873-880 (2003)
• [Publications] Yoshimoto M, Shinohara T., Heike T, Nakahata, T.et al.: "Direct visualization of transplanted hematopoietic cell reconstitution in intact mouse organs indicate the presence of a niche."Hematol.. 31. 733-740 (2003)
• [Publications] Ishida D, Kometani K., Yang H., Nakahata, T.et al.: "Myeloproliferative stem cell disorders by dysregulated Rap1 activation in SPA-1-deficient mice."Cancer Cell. 4. 55-65 (2003)
• [Publications] Lin YW, Watanabe K, Nakahata, T. et al.: "Serial Granulocyte transfusions as a treatment for sepsis due to multidrug-resistant pseudomonas aeruginosa in a neutropenic patient."J Clin Microbiol. 41. 4892-4893 (2003)
• [Publications] Imai T, Nishijo K, Nakahata, T. et al.: "FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells."Oncogene. 22. 9231-9242 (2003)
• [Publications] Heike T., Nakahata T.: "Stem cell plasticity in the hematopoietic system."Hematol.. 79. 7-14 (2003)
• [Publications] Matsubara H, Watanabe K, Nakahata, T. et al.: "Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy."Spine. 29. E4-E6 (2003)
• [Publications] Adachi S., Leoni M., Carson DA, Nakahata T.: "Apoptosis induced by molecular targeting therapy in hematological malignancies."Acta Haematol.. 111. 107-123 (2004)
• [Publications] Kambe N., Hiramatsu H, Nakahata, T.et al.: "Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body."Blood. 103. 860-867 (2004)
• [Publications] Umeda K., Yoshimoto M., Heike T., Nakahata T.: "Development of primitive and definitive hemayopoiesis from nonhuman primate embryonic stem cells in vitro."Development. (in press).
• [Publications] Yagasaki H., Oda T, Nakahata T.et al.: "Two common founder mutations of the Fanconi anemia group G gene FANCG/XRCC in the Japanese popuration. Hum."Mutat.. 21. 555(DOI : 10.1002/humu.9142) (2003)
• [Publications] Yasumi T, Katamura K, Nakahata T. et al.: "Differential Requirement of the Cd40-CD154 costimulatory pathway during T helper cell priming by CD8_+ and CD8_- murine dendritic cell subsets."J.Immunol.. (In press).
• [Publications] Okada M., Imai T, Nakahata T.et al.: "A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL positive human leukemic cells-caspase-independent, necrosis-like programmed cell death mediated by serine protease activity."Blood. (in press). (2003)
• [Publications] Xu Y., Arai H., Zhuge X., Nakahata T.et al.: "Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice."Arterioscl.Throm.Vas.. (in press).
• [Publications] Nishikomori R., Akutagawa H., Nakahata T.et al.: "X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival."Blood. (in press).
• [Publications] Nishikomori R., Akutagawa H., Nakahata T.et al.: "X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival."Blood. (in press).
• [Publications] Harazaki M., Kawai Y., Su L., Hamazaki Y., Nakahata T et al.: "Specific recruitment of SPA1 to the immunological synapse : involvement of actin-bundling protein actinin."Immunol.Letter. (in press).
• [Publications] Hiroshi Yagasaki^1, Satoshi Hamanoue^<1, 2>, Nakahata T et al.: "Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population."Human Mutat.. (In press).
• [Publications] Yagasaki H., Hamanoue S., Nakahata T et al.: "Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population."Human Mutat.. (In press).
• [Publications] 中畑龍俊: "造血幹細胞を用いた再生医療"血液・免疫・腫瘍. 8(1). 27-32 (2003)
• [Publications] 中畑龍俊: "臍帯血利用 ex vivo増幅"最新医学. 58. 57-62 (2003)
• [Publications] 中畑龍俊: "幹細胞と再生医学"最新医学(2003年3月増刊号). 58. 527-536 (2003)
• [Publications] 中畑龍俊: "再生医療の現状と課題"シスメックスジャーナル. 25. 1-9 (2003)
• [Publications] 中畑龍俊: "再生医療の現状と課題"細胞工学. 22. 512-515 (2003)
• [Publications] 中畑龍俊: "造血幹細胞を用いた再生医療"細胞工学. 22. 516-520 (2003)
• [Publications] 平松英文, 平家俊男, 伊藤守, 中畑龍俊: "NOD/SCID/rs nullマウスを用いた新しいヒト造血幹細胞測定系の開発"臨床血液. 44. 193-197 (2003)
• [Publications] 平松英文, 中畑龍俊: "NOD/SCID/rs nullマウス"血液・腫瘍科. 47. 46-51 (2003)
• [Publications] 中畑龍俊: "造血幹細胞の体外増幅と臨床応用への可能性"内科. 92. 537-542 (2003)
• [Publications] 中畑龍俊: "再生医療のこれから"シスメックスジャーナル. 26. 59-68 (2003)
• [Publications] 中畑龍俊: "造血幹細胞移植の最近の進歩"炎症と免疫. 12. 1-2 (2004)
• [Publications] Manabe A., Nakahata T: "Myelodysplastic and myeloproliferatine disorders in children (eds. Lopes L.F. & Hasle M) Tecmedd"Experiences on MDS and JMML from Japan.. 317-324 (2003)
• [Publications] 中畑龍俊: "再生医学分子生物学イラストレイテッド(改訂第2版)"(株)羊土社. 358-360 (2003)
• [Publications] Ito M, Hiramatsu H, Kobayashi K, 他: "NOD/SCIDγ_C^<null> mouse : an excellent recipient mouse model for engraftment of human cells"Blood. 100(9). 3175-3182 (2002)
• [Publications] Umeda K, Adachi S, Watanabe K, 他: "Successful hematopoietic stem cell transplantation for aplastic following living-related liver transplantation"Bone Marrow Transplant. 30. 531-534 (2002)
• [Publications] Heike T, Nakahata T: "Ex vivo expansion of hematopoietic stem cells by cytokines"Biochim Biophys Acta.. 1592. 313-321 (2002)
• [Publications] Ebihara Y, Wada M, Ueda T, 他: "Reconstitution of human haematopoiesis is non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34^+Cd38-cells expressing Flk2/Fit3"Brit. J. Haematol.. 119. 525-534 (2002)
• [Publications] Kato T, Hattori H, Nagato M, 他: "Subclinical central pontine myelinolysis following liver transplantation"Brain & Development. 24. 179-182 (2002)
• [Publications] Uematsu A, Yorifuji T, Muroji J, 他: "Parental Origin of Normal X Chromosomes in Turner Syndrome Patients With Various Karyotypes : Implications for the Mechanism Leading to Generation of a 45, X Karyotype"American Journal of Medical Genetics. 111. 134-139 (2002)
• [Publications] Han H, Tanigaki K, Yamamoto N, 他: "Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision"Int. Immunol.. 14. 637-645 (2002)
• [Publications] Yorifuji T, Kawai M, Muroi J, 他: "Unexpectedly high prevalence of the mild form of propionic acidemia in Japan : presence of a common mutation and possible clinical implications"Hum Genet.. 111. 161-165 (2002)
• [Publications] Manabe A, Okamura J, Yumura-Yagi K, 他: "Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group"Leukemia.. 16. 645-649 (2002)
• [Publications] Hiramatsu H, Nishikomori R, Heike T, 他: "Establishment of functional human immune system in NOD/SCID γ_c^<null> mice after transplantation of cord blood CD34^+ cells"Blood. (In press).
• [Publications] Yoshimoto M, Heike T, Nakahata T.: "Direct visualization of reconstitution process of Transplanted hematopoietic cells in intact mouse organs : Indicative of the presence of a Niche"Exp. Hematol.. (In press).
• [Publications] Ishida D, Yang H, Hattori M, 他: "Dysregulated Rap1 cativation, T-cell anergy, and myeloproliferative disorders of late onset in SPA-1-deficient mice"Cancer Cell. (In press).
• [Publications] Katamura K, Hattori H, Kunishima T, 他: "Non-progressive viral myelitis in X-linked aggammaglobulinemia"Brain Develop.. 24. 109-111 (2002)
• [Publications] Nakahata T, Toru H: "Cytokines Regulate Development of Human Mast Cells from Hematopoietic Progenitors"Int. J. Hematol.. 75(4). 350-356 (2002)
• [Publications] Iio J, Katamura K, Takeda H, 他: "Lipid A analogue, ONO-4007, inhibits IgE response and antigen-induced eosinophilic recruitment into airway in BALB/c mice"Int. Arch Allergy Immunol.. 127. 217-225 (2002)
• [Publications] Hamahata K, Kubota M, Usami I, 他: "Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation"Mutation Research. 517. 21-28 (2002)
• [Publications] Kusunoki T, Nakahata T, Miyanomae T, 他: "Possible dual effect of CD14 molecule on atopy"Am. J. Res. Crit. Care Med. 165. 551-552 (2002)
• [Publications] Suzuki N, Ohneda 0, Takahashi S.他: "Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality"Blood. 100(7). 2279-2288 (2002)
• [Publications] Yamasaki H, Oda T, Adachi D, 他: "Two common founder mutations of the Fanconi anemia group G gene FANCG/XRCC in the Japanese popuration"Human Mutat.. (In press).
• [Publications] Mitsui T, Watanabe S, Hanada S, 他: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice"Blood. (In press).
• [Publications] Kusunoki T, Miyamae T, Inoue Y, 他: "Lack of crrelation between serum levels of soluble CD14 and IgE in asthmatic children"J Allergy Clin Immunol. (In press).
• [Publications] Kusunoki T, Sugai M, Katakai T, 他: "Th2 dominance and defective development of CD8 + dendritic cell subset in Id2-deficient mice"J. Allergy Clin Immunol.. (In press).
• [Publications] 伊藤仁也, 中畑龍俊: "造血幹細胞のex vivo増幅"最新医学. 57(1). 23-30 (2002)
• [Publications] 吉本桃子, 中畑龍俊: "Aorta-Gonad-Mesonephros(AGM)領域における造血幹細胞の発生"炎症と免疫. 9(2). 77-82 (2001)
• [Publications] 吉本桃子, 中畑龍俊: "A orta-Gonad-Mesonephros(AGM)領域における造血幹細胞の発生"炎症と免疫. 9(2). 77-82 (2001)
• [Publications] 中畑龍俊: "胎児から小児期における造血"血液フロンティア. 12(2). 33-41 (2002)
• [Publications] 平家俊男, 中畑龍俊: "ヒトES細胞"血液・腫瘍科. 44(6). 413-420 (2002)
• [Publications] 中畑龍俊: "再生医療の現状と課題"Sysmex Journal Web. 3(1). (2002)
• [Publications] 中畑龍俊: "小児のMDSの治療戦略"血液フロンティア. 12(8). 131-138 (2002)
• [Publications] 平家俊男, 中畑龍俊: "発生・細胞分化におげるアセチル化"実験医学. 20(15). 2212-2218 (2002)
• [Publications] 中畑龍俊: "造血幹細胞の培養増幅とその応用"臨床病理レビュー. 122. 102-109 (2002)
• [Publications] 飯田みどり, 平家俊男, 吉本桃子, 他: "マウス胚性幹細胞を用いた心筋細胞分化機構解明の試み"炎症・再生. 22(2). 145-151 (2002)
• [Publications] 中畑龍俊(編 横田崇): "「再生医学がわかる」 造血幹細胞を用いた再生医療"羊土社. 10 (2002)
• [Publications] 平松英文, 中畑龍俊(編 高久史麿, 他): "「Annual Review 血液2002」NOD/SCID/rc-/-マウスを用いたヒト造血幹細胞の解析"中外医学社. 7 (2001)
• [Publications] 中畑龍俊(編 今西二郎, 他): "「別冊・医学のあゆみ 疾病疾患 state of arts Ver.2」 造血幹細胞移植"医歯薬出版. 5 (2002)
• [Publications] 中畑龍俊(編 小澤敬也): "「造血幹細胞-基礎から遺伝子治療・再生医療へ」 造血幹細胞の体外増幅-サイトカイン刺激によるアプローチ"中外医学社. 7 (2002)
• [Publications] 中畑龍俊(監 白木和夫他, 編 伊藤克己他): "「小児科学(第2版)」 慢性白血病.骨髄異形成症候群"医学書院. 7 (2002)
• [Publications] 中畑龍俊(編 室田誠逸): "「再生医学 再生医療(現代化学 増刊41)」 幹細胞の分化制御-オーバービュー"東京化学同人. 2 (2002)
• [Publications] Nakahata T: "Ex vivo expansion of human hematopoietic stem cells"Int.J.Hematol.. 73(1). 6-13 (2001)
• [Publications] Matsuoka S, Ebihara Y, Xu M-j, Ishii T, Sugiyama D, Yoshino H, Ueda T, Manabe A, Tanaka R, Ikeda Y, Nakahata T, Tsuji K: "CD34 expression on long-termduring repopulating hematopoietic stem cells changes during developmental stages"Blood. 97. 419-425 (2001)
• [Publications] Xu M-j, Matsuoka S.Yang F-C, Ebihara Y, Manabe A, Tanaka R, Eguchi M, Asano S, Nakahata T, Tsuji K: "Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac"Blood. 97. 2016-2022 (2001)
• [Publications] Yoshimasu T, Tanaka R, Suenobu S, Yagasaki H, Yoshino H, Ueda T, Hisakawa H, Ishii T, Maekawa T, Nakahata T, Asano S. Tsuji K: "Prompt and durable hematopoietic reconstitution by unrelated cord blood transplantation in a child with Fanconi anemia"Bone Marrow Transplant. 27. 767-769 (2001)
• [Publications] Takahashi T, Ebihara Y, Manabe A, Tsuji K, Nakamura T, Nakakahata T, Iwamoto A: "Surfactant protein D and KL-6 as serologic indicators of pneurnocystis carinii pneumonia in a child with acute lymphoblastic leukemia"J.Med.. 32. 41-51 (2001)
• [Publications] Imai T, Hattori H, Miyazaki M, Higuchi Y, Adachi S., Nakahata T: "Dandy-Walker variant in Coffin-Siris Syndrome"Am.J.Med.Genet.. 100. 152-155 (2001)
• [Publications] Sawano A, Iwai S, Sakurai Y, Ito Y, Shitara K, Nakahata T, Shibuya M: "Flt-1, vascular endothelial growth farcor receptor-1 is a novel cell surface marker for the lineage of monocyte-macrophages in humans"Blood. 97. 785-791 (2001)
• [Publications] Ma F, Wada M, Yoshino H, Ebihara Y, Ishii T, Manabe A, Tanaka R, Maekawa T, Itoh M, Mugishima H, Asano S, Nakahata T, Tsuji K: "Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81"Blood. 97. 3755-3762 (2001)
• [Publications] Ueda T, Yoshida M, Yoshino H, Kobayashi K, Kawahata M, Ebihara Y, Ito M, Asano S, Nakahata T, Tsuji K: "Hematopoietic capability of CD34+ cord blood cells : a comparison with CD34+ adult bone marrow cells"Int.J.Hamatol.. 73. 457-462 (2001)
• [Publications] Yamashita T, Nakahata T: "Current knowlege on the pathophysiology of fanconi anemia : from genes to phenotypes"Int.J.Hematol.. 74. 33-41 (2001)
• [Publications] Matsuoka S, Tsuji K, Hisakawa H, Xu M, Ebihara Y, Ishii T, Tanaka R, Ikeda Y, Asano S, Nakahata T: "Generation of definitive hematopoietic stema cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells"Blood. 98. 6-12 (2001)
• [Publications] Miyamoto K, Tsuji K, Maekawa T, Asano S, Nakahata T: "Inhibitory effect of interleukin 3 on the early development of human B-lymphopoiesis"Br.J.Haematol.. 114. 690-697 (2001)
• [Publications] Lin YW, Hamahata K, Watanabe K, Adachi S, Akiyama Y, Kubota M, Nakahata T: "Repetitious appearance and disapparance of different kinds of clonal cytogenetic abnomalities after allogeneic bone marrow transplantation"Int.J.Hematol.. 74. 86-89 (2001)
• [Publications] Yorifuji T, Muroi J, Mamada M, Uematsu A, Kawai M, Momoi T, Kaji M, Yamanaka C, Nakahata T: "Analysis of the SRY gene in Turner syndrome patients with Y chromosmal material"J.Med.Genet.. 38. e41 (2001)
• [Publications] Sasaki H, Manabe A, Kojima S, Tsuchida M, Hayashi Y, Ikuta K, Okamura J, Koike K, Ohara A, Ishii E, Kodama Y, Hibi S, Nakahata T: "Myelodysplastic syndrome in childhood : a retrospective study of 189 patients in Japan"Leukemia. 15. 1713-1720 (2001)
• [Publications] Kato T, Hattori H, Yorifuji T, Tashiro Y, Nakahata T: "Intranial aneurysms in Ehiers-Danlos Syndrome type IV in early childhood"Pediatric Neurology. 25(4). 336-339 (2001)
• [Publications] Yamanaka Y, Tamari M, Nakahata T, Nakamura Y: "Gene expression profiles of human small airway epithelial cells treated with low doses of 14-and 16-membered macrolides"Biochemical and Biophysical Research Communications. 287. 198-203 (2001)
• [Publications] Hisakawa H, Sugiyama D, Nishijima I, Xu M-j, Wu H, N, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin recentors"Blood. 98(13). 3618-3625 (2001)
• [Publications] Iio J, Katamura K, Takeda H, Ohmura K, Yasumi T, Meguro T, Ohshima Y, Nakahata T: "Lipid A analogue, ONO-4007, inhibit IgE response and antigen-induced eosinophilic recruitment into airway in BALB/c mice"Int.Arch Allergy Immunol.. (In press). (2002)
• [Publications] Iwai-Kanai E., Hasegawa K., Sawamura T., Toyokuni S., Adachi S., Kihara Y., Sasayama S.: "Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac eyocytes"Circulation. 104. 2948-2954 (2001)
• [Publications] Iwai-Kanai E., Hasegawa K., Fujita M., Araki M., Yanazume T., Adachi S., Sasayama S.: "Basic fibroblast growth factor protects cardiac myocytes fromiNOS-mediated apoptosis"J Cell Physiol. 190. 54-62 (2002)
• [Publications] Kusunoki T., Miyanomae T., Inoue Y., Nakahata T.: "Lack of correlation between serum levels of soluble CD14 and IgE in asthmatic children"J Allergy Clin Immunol. (In press). (2002)
• [Publications] Nakahata T, Toru H.: "Cytokines Regulate Development of Human Mast Cells from Hematopojetic Progenitors"Int.J.Hematol.. (In press). (2002)
• [Publications] Mitsui T., Watanabe S., Hanada S., Ebihara Y., Sato T., Nakahata T., Tsuji K.: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice"Blood. (In press). (2002)
• [Publications] Hamahata K., Kubota M., Usami I., Lin Y.W., Shimizu K., Morimito A., Nakahata T.: "Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation"Mutation Research. (In press). (2002)
• [Publications] 林英蔚, 渡邊健一郎, 濱畑啓吾, 足立壮一, 秋山祐一, 宇佐美郁哉, 久保田優, 筒井孟, 片岡昭浩, 若園吉裕, 中畑龍俊: "小児t(8;21)急性骨髄性白血病:臨床的特徴と予後因子における成人例との比較"臨床血液. 42(1). 8-14 (2001)
• [Publications] 中畑龍俊: "同種末梢血幹細胞移植のための健常人ドナーからの末梢血幹細胞の動員・採取に関するガイドライン"分子細胞治療. 2(1). 69-74 (2001)
• [Publications] 中畑龍俊: "NOD/SCIDマウス"分子細胞治療. 2(2). 106-108 (2001)
• [Publications] 服部春生, 加藤竹雄, 長門雅子, 岡野智恵, 鈴木元, 名和行文, 中畑龍俊: "沖縄旅行後に発症した広東住血線虫症による好酸球性髄膜炎の1例"日本小児科学会雑誌. 105(6). 719-721 (2001)
• [Publications] 中畑龍俊, 小島勢二, 土田昌宏, 生田孝一郎, 岡村純, 小池健一, 小原明, 秋山祐一, 林英蔚, 増永敦子: "第1回MDS委員会活動報告(2000.11.6)"日本小児血液学会雑誌. 15. 54-56 (2001)
• [Publications] 中畑龍俊: "造血幹細胞のex vivo増幅の現状と将来"臨床血液. 42(6). 441-446 (2001)
• [Publications] 谷口義弘, 中畑龍俊: "小児先天性好中球減少症"血液・免疫・腫瘍. 6(3). 83-85 (2001)
• [Publications] 河井昌彦, 金沢房子, 今井剛, 中畑龍俊: "未熟児貧血に対するエリスロポエチン治療中に出現した高CPK血症に関する検討"日本産婦人科・新生児血液学会誌. 11(1). 77-78
• [Publications] 藤田潤, 駿地眞由美, 小杉眞二, 依藤亨, 藤村聡, 富和清隆, 一山智, 中畑龍俊, 福井次矢: "京都大学医学部付属病院遺伝子診療部の紹介・心理職との連携"JIM. 11(6). 554-556 (2001)
• [Publications] 平家俊男, 中畑龍俊: "ES細胞を用いた再生医療の構築に向けて"Organ Biology. 8(3). 143-153 (2001)
• [Publications] 中畑龍俊: "同種末梢幹細胞移植のためのガイドライン"遺伝子医学. 5(3). 134-139 (2001)
• [Publications] 平家俊男, 中畑龍俊: "幹細胞と自己複製"癌と化学療法. 28. 1049-1056 (2001)
• [Publications] 中畑龍俊: "造血幹細胞の可塑性"内科. 88(3). 525-529 (2001)
• [Publications] 渡邊健一郎, 中川剛, 林英蔚, 梅田雄嗣, 足立壮一, 服部春夫, 中畑龍俊: "除脳硬直姿勢をとったIfosfamide脳症の1例"小児がん. 38(1). 52-55
• [Publications] 梅田雄嗣, 林英蔚, 渡邊健一郎, 足立壮一, 宇佐美郁哉, 秋山祐一, 久保田優, 中畑龍俊: "小児難治性急性リンパ性白血病に対するbusulfan, thiotepa, cyclophosphamideを前処置とした造血幹細胞移植の治療成績"臨床血液. 42(9). 685-690 (2001)
• [Publications] 中畑龍俊: "造血系幹細胞と血液疾患"治療学. 35(1). 25-28 (2001)
• [Publications] 平松英文, 中畑龍俊: "NOD/SCIDマウスにおけるヒト造血と免疫の再構築"分子細胞治療. 2(5). 9-15 (2001)
• [Publications] 久保田優, 濱畑啓悟, 渡邊健一郎, 林英蔚, 宇佐美郁哉, 中畑龍俊: "全身の色素沈着を伴ったビタミンB12欠乏巨赤芽球性貧血の1例"日本小児血液学会雑誌. 15(5). 401-404
• [Publications] 中畑龍俊: "再生医療の現状と展望-概説"小児科診療. 64(12). 2180-2183 (2001)
• [Publications] 中畑龍俊: "造血幹細胞移植"小児科診療. 64(12). 2184-2189 (2001)
• [Publications] 足立壮一, 中畑龍俊: "小児疾患への対応"日本臨床. 59(12). 2401-2406 (2001)
• [Publications] 伊藤仁也, 中畑龍俊: "造血幹細胞のex vivo増幅"最新医学. 57(1). 23-30 (2002)
• [Publications] 中畑龍俊: "胎児からの小児期における造血"血液フロンティア. 12(2). 33-41 (2002)
• [Publications] 中畑龍俊: "サイトカインによる造血幹細胞の増幅 FLk-2, Flt-3 リカンド FLk-2, Flt-3 リカンド(fetal liver kinase-2 ; Flk-2), (fms-like tyrosine kinase-3 ligannd ; FL)"「造血サイトカイン」メディカルレビュー社(編 元吉和夫). 85-99, 198-210, 444 (2001)
• [Publications] 中畑龍俊: "造血幹細胞研究の現状と期待"「造血幹細胞のいまと医療への展開」(羊土社)(編 中内啓光). 12-25 (2001)
• [Publications] 中畑龍俊: "造血幹細胞"「プラクティカル内科シリーズ 11-造血器腫瘍-白血病・悪性リンパ腫・多発性骨髄腫 治癒をめざした診断・治療の実践-」(南江堂)(編 上田龍三). 184-190 (2001)
• [Publications] 中畑龍俊: "In Vitroでの造血幹細胞の増幅"「コロニー刺激因子(SCF)の臨床-現状と将来-」(日本医学館)(編 元吉和夫、浦部晶夫). 93-101 (2001)
• [Publications] 融 葉乃, 中畑龍俊: "ヒト培養肥満細胞に及ぼすIL-4の効果"「肥満細胞の臨床」(先端医学社)(編 黒沢元博). 550-558 (2001)
• [Publications] 平松英文, 中畑龍俊: "NOD/SCID/rc/-マウスを用いた造血幹細胞の解析"「Annual Review血液2002」(中外医学社)(編 高久史麿). 7-13 (2001)