• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

ラジカル含有ナノ粒子の経口投与法による潰瘍性大腸炎治療と大腸癌の予防

Research Project

Project/Area Number 13J00906
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Biomedical engineering/Biological material science
Research InstitutionUniversity of Tsukuba

Principal Investigator

VONG BINHLONG (2014)  筑波大学, 大学院数理物質科学研究科, 特別研究員(DC2)

VONG Binh Long (2013)  筑波大学, 大学院数理物質科学研究科, 特別研究員(DC2)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2014: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2013: ¥900,000 (Direct Cost: ¥900,000)
Keywordsoral nanotherapeutics / redox nanoparticle / reactive oxygen species / colon cancer / inflammation / side effect / ulcerative colitis / drug delivery system
Outline of Annual Research Achievements

Motivation and Objective: Ulcerative colitis (UC), an inflammatory and intractable disease in colon area, affects millions of patients worldwide. Moreover, UC increases the risk of the development of colitis-associated colon cancer.
Oral chemotherapy is the preferred treatment for colon cancer. However, this strategy faces many challenges, including instability in the gastrointestinal (GI) tract, insufficient bioavailability, low tumor targeting, and severe adverse effects. In this study, we designed a novel redox nanoparticle (RNP) that is an ideal oral therapeutics for colitis-associated colon cancer treatment.
Results: RNP possesses nitroxide radicals in the core, which act as reactive oxygen species (ROS) scavengers. Orally administered RNP highly accumulated in colonic mucosa, and specifically internalized in cancer tissues, but less in normal tissues. Despite of long-term oral administration of RNP, no noticeable toxicities were observed in major organs of mice. Because RNP effectively scavenged ROS, it significantly suppressed tumor growth after accumulation at tumor sites. Combination of RNP with the conventional chemotherapy, irinotecan, led to remarkably improved therapeutic efficacy and effectively suppressed its adverse effects on GI tract.
Conclusion: RNP is promising oral nanotherapeutics for UC and colon cancer treatment.

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (22 results)

All 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer2015

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 55 Pages: 54-63

    • DOI

      10.1016/j.biomaterials.2015.03.037

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recovery of Cognitive Dysfunction via Orally Administered Redox-polymer Nanotherapeutics in SAMP8 mice2015

    • Author(s)
      Pennapa Chonpathompikunlert, Toru Yoshitomi, Long Binh Vong, Natsuka Imaizumi, Yuki Ozaki, Yukio Nagasaki
    • Journal Title

      PLOS ONE

      Volume: ー Issue: 5 Pages: e0126013-e0126013

    • DOI

      10.1371/journal.pone.0126013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silica-installed redox nanoparticles for novel oral nanotherapeutics- Improvement in intestinal delivery with anti-inflammatory effects2014

    • Author(s)
      Md. Amran Hossain, Mayo Yamashita, Long Binh Vong, Yutaka Ikeda and Yukio Nagasaki
    • Journal Title

      Journal of Drug Targeting

      Volume: 22 Issue: 7 Pages: 638-647

    • DOI

      10.3109/1061186x.2014.928716

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of nitroxide radicals-containing polymer for scavenging ROS from cigarette smoke2014

    • Author(s)
      Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong, Yukio Nagasaki
    • Journal Title

      Science and Technology for Advanced Materials

      Volume: 15 Issue: 3 Pages: 035002-035002

    • DOI

      10.1088/1468-6996/15/3/035002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indomethacin-loaded redox nanoparticles improve oral bioavailability of indomethacin and suppress its small intestinal inflammation2014

    • Author(s)
      Toru Yoshitomi, Sha Sha, Long Binh Vong, Pennapa Chonp athompikunlert, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Therapeutic Delivery

      Volume: 5 Issue: 1 Pages: 29-38

    • DOI

      10.4155/tde.13.133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral nanotherapeutics : effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Kazuya Morikawa, Shinji Saito, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 5 Pages: 806-813

    • DOI

      10.1007/s00535-013-0836-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NSAID-induced Small Intestinal Inflammation by Orally Administered Redox Nanoparticles2013

    • Author(s)
      Sha Sha, Long Binh Vong, Pennapa Chonpathompikunlert, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 33 Pages: 8393-8400

    • DOI

      10.1016/j.biomaterials.2013.06.032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ROS scavenging nanotherapeutics for prevention and treatment inflammation and cancer2015

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      第33 回Cytoprotection 研究会
    • Place of Presentation
      メルパルク京都、京都市
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combination therapy using ROS scavenging nanoparticles for effective treatment of colitis-associated colon cancer2015

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, and Yukio Nagasaki
    • Organizer
      MANA International Symposium on 2015
    • Place of Presentation
      Epochal Tsukuba, Tsukuba
    • Year and Date
      2015-03-11 – 2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral Nanotherapeutics of Polymeric Redox Nanoparticle for Treatment of Colitis-Associated Colon Cancer2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, and Yukio Nagasaki
    • Organizer
      10th SPSJ International Polymer Conference
    • Place of Presentation
      Epochal Tsukuba, Tsukuba
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral redox polymeric nanotherapeutics for treatment of colitis-associated colon cancer2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      2nd Functionality Organized Nanostructures、(FON'14)
    • Place of Presentation
      日本未来館、東京
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral delivery of redox nanoparticles for colitis-associated colon cancer therapy2014

    • Author(s)
      Long B. Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orally Administered Redox Polymeric Nanoparticle That Internalizes in Cancer Tissues and Inhibits the Colitis2014

    • Author(s)
      Long Binh Vong、Toru Yoshitomi、 Hirofumi Matsui、Yukio Nagasaki
    • Organizer
      63th Fall Meeting of Polymer Society, Japan
    • Place of Presentation
      Nagasaki University, Nagasaki
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral nanotherapeutics for inflammatory bowel disease: Mechanistic investigation of redox-active nanoparticle in colon mucosa2014

    • Author(s)
      Vong Binh Long、吉冨 徹、松井 裕史、長崎 幸夫
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶応大学芝共立キャンパス、東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral nanotherapeutics for inflammatory bowel disease: Mechanistic investigation of redox-active nanoparticle in colon mucosa2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      The 30th Annual Meeting of the Japan Society of Drug Delivery System
    • Place of Presentation
      Keio University, Tokyo
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oral nanotherapeutics of redox nanoparticles for treatment of colitis associated colon cancer2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      第63回高分子学会春季年会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Orally administered redox nanoparticles internalize in the inflamed tissue and prevent the colitis-associated colon cancer2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      MANA International Symposium
    • Place of Presentation
      Epochal, Tsukuba
    • Year and Date
      2014-03-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Oral nanotherapeutics : Redox nanoparticles accumulate in colonic mucosa and suppress the inflammation in colitis mice2014

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      つくば医工連携フォーラム
    • Place of Presentation
      つくば国際会議場、つくば
    • Year and Date
      2014-01-20
    • Related Report
      2013 Annual Research Report
  • [Presentation] 経口投与型レドックス反応性ナノ粒子による潰瘍性大腸炎治療とその腸内細菌へ及ぼす影響2013

    • Author(s)
      Vong Long Binh, 吉冨 徹, 森川 一也, 齋藤 慎二, 松井 裕史, 長崎 幸夫
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      ウィンクあいち、名古屋
    • Year and Date
      2013-06-14
    • Related Report
      2013 Annual Research Report
  • [Presentation] Orally Administered Redox Nanoparticle Prevents Colitis-Associated Colon Cancer by Suppressing the Inflammation2013

    • Author(s)
      Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
    • Organizer
      Tsukuba International Conference on Materials Science
    • Place of Presentation
      University of Tsukuba, Tsukuba
    • Related Report
      2013 Annual Research Report
  • [Book] Nanomedicine for treatment of oxidative stress injuries. Book chapter of Post-genomic Approaches in Cancer and Nano Medicine2015

    • Author(s)
      Yoshitomi Toru, Vong Long Binh, Nagasaki Yukio
    • Publisher
      River Publishers
    • Related Report
      2014 Annual Research Report
  • [Remarks] Nagasaki Laboratory

    • URL

      http://www.ims.tsukuba.ac.jp/~nagasaki_lab/index.htm

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-01-29   Modified: 2024-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi