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狂犬病ウイルスの伝播ダイナミクス及びワクチン戦略研究

Research Project

Project/Area Number 13J01263
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Virology
Research InstitutionTohoku University

Principal Investigator

当广 謙太郎  東北大学, 医学系研究科, 特別研究員(DC1)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2015: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2014: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2013: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords狂犬病 / 感染症伝播ダイナミクス / 景観遺伝学 / 国際研究者交流(フィリピン) / 国際研究者交流(イギリス) / 狂犬病ウイルス / 遺伝子系統解析 / フィリピン / 空間疫学
Outline of Annual Research Achievements

本研究では、人獣共通感染症である狂犬病のコントロールを目的とし、その撲滅のための戦略について検討を行なうべく研究を行った。狂犬病蔓延国であるフィリピン共和国(フィリピン)を対象地域として狂犬病ウイルスの伝播動態解明を行った。
フィリピンのルソン島内における地理的伝播について、地形遺伝子学に詳しいUniversity of GlasgowのDr. Roman Biekの協力を得て研究を行った。景観遺伝学的手法を用い、ウイルスの地理的伝播に寄与する因子を、地形(標高勾配/河川・湖/植生)・ヒトコミュニティ(人口密度/道路密度)・狂犬病対策活動(地方自治体における年間支出額/小学校数)の3種類のデータから探索・評価した。解析には、ウイルス遺伝的距離と検体採取地間コスト距離を用いたマンテル検定(距離行列の相関解析)及び、ウイルス遺伝子系統クラスターと採取地のコスト空間クラスターを用いた関連指標検定(Association index test)を用いた。結果、標高勾配がウイルスの伝播に対して最も大きな障壁であると推測された。しかし、ウイルス感染鎖の空間分布を決定づけるほど大きな影響を持つ因子は認められず、地形・ヒトコミュニティ・狂犬病対策活動といった因子のウイルス伝播に対する影響はさほど大きくないことが示唆された。
以上より、フィリピンにおける狂犬病ウイルスの島内伝播動態が明らかとなった。現状の対策では狂犬病清浄化の実現可能性が低いことが予想される。狂犬病清浄化のためにはサーベイランスの強化やワクチン接種といった対策の継続が重要であり、地域内の感染鎖の広がりを断ち切るために、地方自治政府間の連携した狂犬病対策が必要であると考えられた。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (5 results)

  • [Int'l Joint Research] Research Institute for Tropical Medicine(フィリピン)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Glasgow(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Identification of Asian and ECSA genotypes of Chikungunya Virus during a Nationwide Outbreak in the Philippines, 2011-20132016

    • Author(s)
      Sy AK, Saito-Obata M, Medado IA, Tohma K, Dapat C, Mercado ES, Tandoc AO 3rd, Lupisan S, Oshitani H
    • Journal Title

      Emerging Infectious Diseases

      Volume: 22 Issue: 5 Pages: 887-890

    • DOI

      10.3201/eid2205.151268

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Temporal dynamics of norovirus through monitoring of municipal wastewater by pyrosequencing and virological surveillance of gastroenteritis2016

    • Author(s)
      Kazama S, Masago Y, Tohma K, Souma N, Imagawa T, Suzuki A, Liu X, Saito M, Oshitani H, Omura T.
    • Journal Title

      Water Research

      Volume: 92 Pages: 244-253

    • DOI

      10.1016/j.watres.2015.10.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and mathematical modeling analyses of inter-island transmission of rabies into a previously rabies-free island in the Philippines2015

    • Author(s)
      Tohma K, Saito M, Demetria CS, Manalo DL, Quiambao BP, Kamigaki T, Oshitani H.
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 38 Pages: 22-28

    • DOI

      10.1016/j.meegid.2015.12.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular Characterization of Human Respiratory Syncytial Virus in the Philippines, 2012-20132015

    • Author(s)
      Malasao R, Okamoto M, Chaimongkol N, Imamura T, Tohma K, Dapat I, Dapat C, Suzuki A, Saito M, Saito M, Tamaki R, Pedrera-Rico GA, Aniceto R, Quicho RF, Segubre-Mercado E, Lupisan S, Oshitani H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 11 Pages: e0142192-e0142192

    • DOI

      10.1371/journal.pone.0142192

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Incidence and Risk Factors of Childhood Pneumonia-Like Episodes in Biliran Island, Philippines―A Community-Based Study2015

    • Author(s)
      Kosai H, Tamaki R, Saito M, Tohma K, Alday PP, Tan AG, Inobaya MT, Suzuki A, Kamigaki T, Lupidan S, Tallo V, Oshitani H.
    • Journal Title

      PLoS One

      Volume: 10(5) Issue: 5 Pages: e0125009-e0125009

    • DOI

      10.1371/journal.pone.0125009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human G3P[4] rotavirus obtained in Japan, 2013, possibly emerged through a human-equine rotavirus reassortment event2015

    • Author(s)
      Malasao R, Saito M, Suzuki A, Imagawa T, Nukiwa-Soma N, Tohma K, Liu X, Okamoto M, Chaimongkol N, Dapat C, Kawamura K, Kayama Y, Masago Y, Omura T, and Oshitani H
    • Journal Title

      Virus Genes

      Volume: 50(1) Issue: 1 Pages: 129-133

    • DOI

      10.1007/s11262-014-1135-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Investigation of an Influenza A (H3N2) outbreak in evacuation centres following the Great East Japan earthquake, 20112014

    • Author(s)
      Kamigaki T, Seino J, Tohma K, Nukiwa S N, Otani K, and Oshitani H
    • Journal Title

      BMC Public Health

      Volume: 14:34 Issue: 1

    • DOI

      10.1186/1471-2458-14-34

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phylogeographic analysis of rabies viruses in the Philippines2014

    • Author(s)
      K. Tohma, M. Saito, T. Kamigaki, L. T. Tuason, C. S. Demetria, J. R. C. Orbina, D. L. Manalo, M. E. Miranda, A. Noguchi, S. Inoue, A. Suzuki, B. P. Quiambao, H. Oshitani
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 23 Pages: 86-94

    • DOI

      10.1016/j.meegid.2014.01.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Drivers and barriers for the spread of the rabies viruses in the Philippines2015

    • Author(s)
      当广 謙太郎
    • Organizer
      5th International Conference on Infectious Disease Dynamics
    • Place of Presentation
      フロリダ(アメリカ合衆国)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 狂犬病ウイルスの地理的伝播に影響を与える因子の探索と評価2015

    • Author(s)
      当广 謙太郎
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学(青森県十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Recently observed Island-to-island transmission of rabies in Romblon, the Philippines2015

    • Author(s)
      Tohma K, Saito M, Demetria CS, Manalo DL, Quiambao BP, Kamigaki T, and Oshitani H
    • Organizer
      82nd PVMA (Philippine Veterinary Medical Association) Annual Convention and Scientific Conference
    • Place of Presentation
      Cebu City, Philippines
    • Year and Date
      2015-02-18 – 2015-02-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Recently observed Island-to-island transmission of rabies in Romblon, the Philippines2014

    • Author(s)
      Tohma K, Saito M, Demetria CS, Manalo DL, Quiambao BP, Kamigaki T, and Oshitani H
    • Organizer
      12th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-12-11 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel protocol to detect recombinant noroviruses and its application to the next generation sequencing2014

    • Author(s)
      Tohma K, Masago Y, Gilman RH, Jahuria H, Omura T, Saito M, and Oshitani H
    • Organizer
      NIH-Japan-JSPS Symposium
    • Place of Presentation
      Bethesda, Maryland, U.S.A
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transmission Dynamics of Rabies Viruses in the Philippines2013

    • Author(s)
      Kentaro Tohma
    • Organizer
      18th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology
    • Place of Presentation
      University of Florida (Gainesville, Florida, U.S.A)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学大学院 医学系研究科 微生物学分野

    • URL

      http://www.virology.med.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学・RITM新興・再興感染症共同研究センター

    • URL

      http://www.virology.med.tohoku.ac.jp/project/jgrid/jgrid.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院 医学系研究科 微生物学分野

    • URL

      http://www.virology.med.tohoku.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学・RITM新興・再興感染症共同研究センター(フィリピン拠点)

    • URL

      http://www.eid.med.tohoku.ac.jp/index_j.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学医学系研究科微生物学分野ホームページ

    • URL

      http://www.virology.med.tohoku.ac.jp/biseibutugaku_j/publication.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2014-01-29   Modified: 2024-03-26  

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