生物物理学的予後予測モデルに基づく循環型放射線治療計画法の開発

• Project/Area Number: 13J02944
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: 放射線科学
• Research Institution: The University of Tokyo
• Principal Investigator: 馬込 大貴 東京大学, 医学部附属病院, 特別研究員(PD)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,960,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: MVCT / Iterative reconstruction / Registration / 全骨髄照射 / TMI / 赤色骨髄照射 / DECT / 放射線治療 / 白血病 / 国際協力研究 / アメリカ / 予後予測 / パターン認識 / ニューラルネットワーク / 生存期間 / 脳腫瘍 / 臨床情報 / 線量情報

Outline of Annual Research Achievements

今年度は、ミネソタ大学と協力することで全骨髄照射（TMI: total marrow irradiation）症例における位置合わせ用高速Mega-voltage computed tomographyの再構成方法を開発した。
ミネソタ大学から提供された３体の献体を４種類の寝台速度で撮影した。撮影された投影データは、Iterative reconstruction （IR）algorithmに基づき三次元再構成され、従来法であるFiltered back projection （FBP）algorithmに基づき再構成された画像と比較した。定量評価（画像レジストレーションのずれ量）を行った結果、今回開発したIR法に基づく再構成方法を用いた方が、従来のFBP法に比べて、寝台速度が速い場合（3mm/sec, 4mm/sec）に有意に精度が向上した（P <0.05）。
本研究は、我々の知る限り、献体を画像再構成法の開発に用いた初めての研究であり、実際の患者での無用な被ばくを増やすことなく、新技術の開発に成功した。本研究で開発された手法は、現在、ミネソタ大学を中心とした国際臨床治験で実際に使用されている。
全骨髄照射は、従来の照射方法（全身照射）に比べて正常組織への不要な線量を減らすことができるため、治療成績の向上が期待されているが、治療時間が長い（１患者１日1.5-2時間）ため、日本でも数施設でしか実施されていない。本研究成果を用いることで、治療時間の短縮が予想されることから、全骨髄照射が広く国民に普及されることが期待される。
本年度に開発したMVCT画像を昨年度までに開発した治療計画方法と組み合わせることで、高精度な全骨髄照射を行うことが可能となる。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Minnesota/City of Hope Hospital(米国)
• [Int'l Joint Research] Universitair Ziekenhuis Brussel(Belgium)
• [Int'l Joint Research] Institute Curie/Paul Strauss/ICO, Nantes(France)
• [Int'l Joint Research] University of Genoa/San Raffaele(Italy)
• [Int'l Joint Research] Maria Sklodowska-Curie Memorial(Poland)
• [Int'l Joint Research]
• [Journal Article] Characterization of deformation and physical force in uniform low contrast anatomy and its impact on accuracy of deformable image registration (2016)
  • Author(s): Raj Varadhan, Taiki Magome, Susanta Hui
  • Journal Title: Medical Physics Volume: 43 Issue: 1 Pages: 52-61
  • DOI: 10.1118/1.4937935
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Patterns of Recurrence in Malignant Glioma Patients: Association with Subventricular Zone and Radiotherapy Dose (2015)
  • Author(s): Hiroshi Igaki, Taiki Magome, Madoka Sakuramachi, Akihiro Nomoto, Akira Sakumi, Mayuka Kitaguchi, Akihiro Haga, Jun Itami, Keiichi Nakagawa
  • Journal Title: Jacobs Journal of Radiation Oncology Volume: 2 Pages: 1-6
  • Peer Reviewed / Open Access
• [Journal Article] Computer-Assisted Delineation of Lung Tumor Regions in Treatment Planning CT Images with PET/CT Image Sets Based on an Optimum Contour Selection Method (2014)
  • Author(s): Ze Jin, Hidetaka Arimura, Yoshiyuki Shioyama, Katsumasa Nakamura, Jumpei Kuwazuru, Taiki Magome, Hidetake Yabuuchi, Hiroshi Honda, Hideki Hirata, Masayuki Sasaki
  • Journal Title: Journal of Radiation Research Volume: 55 Issue: 6 Pages: 1153-62
  • DOI: 10.1093/jrr/rru056
  • Peer Reviewed / Open Access
• [Journal Article] Reconstruction of the treatment area by use of sinogram in helical tomotherapy (2014)
  • Author(s): Akihiro Haga, Keiichi Nakagawa, Calvin Maurer, Ken Ruchala, Edward Chao, Dylan Casey, Satoshi Kida, Dousatsu Sakata, Masahiro Nakano, Taiki Magome, Yoshitaka Masutani
  • Journal Title: Radiation Oncology Volume: 9 Issue: 1 Pages: 252-252
  • DOI: 10.1186/s13014-014-0252-0
  • Peer Reviewed / Open Access
• [Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy (2014)
  • Author(s): Haga A, Magome T, et al.
  • Journal Title: Radiation Oncology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Similar-case-based optimization of beam arrangements in stereotactic body radiotherapy for assisting treatment planners (2013)
  • Author(s): Magome T, et al.
  • Journal Title: BioMed Research International Volume: 2013 Pages: 1-10
  • DOI: 10.1155/2013/309534
  • Peer Reviewed
• [Journal Article] Computer-aided beam arrangement based on similar cases in radiation treatment planning databases for stereotactic lung radiation therapy. (2013)
  • Author(s): Magome T, Arimura H, et al.
  • Journal Title: Journal of Radiation Research Volume: (In press) Issue: 3 Pages: 569-577
  • DOI: 10.1093/jrr/rrs123
  • Peer Reviewed
• [Presentation] 類似症例に基づく放射線治療計画支援システムの開発 (2016)
  • Author(s): 馬込大貴, 有村秀孝, 塩山善之, 中村和正, 芳賀昭弘, 中川恵一, 平田秀紀
  • Organizer: 第29回高精度放射線外部照射部会学術大会
  • Place of Presentation: 一橋講堂（東京）
  • Year and Date: 2016-02-27
• [Presentation] 「医療ビッグデータの将来像」 機械学習・パターン認識技術に基づく予後予測研究 (2016)
  • Author(s): 馬込大貴
  • Organizer: 第38回がんプロ合同セミナー
  • Place of Presentation: 東京大学（東京）
  • Year and Date: 2016-02-10
  • Invited
• [Presentation] Survival time prediction after radiotherapy for high-grade glioma patients based on machine learning technique (2015)
  • Author(s): Taiki Magome, Akihiro Haga, Hiroshi Igaki, Noriyasu Sekiya, Yoshitaka Masutani, Akira Sakumi, Akitake Mukasa, Keiichi Nakagawa
  • Organizer: YITP International Workshop: Biological & Medical Science based on Physics
  • Place of Presentation: 京都大学（京都）
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Marrow Response to Chemotherapy and Radiation in Gynecologic Malignancies As Assessed by Water-Fat MRI (2015)
  • Author(s): Christopher Wilke, Taiki Magome, Luke Arentsen, Rahel Ghebre, Levi Downs, Patrick Bolan, Kathryn Dusenbery, Clifford Rosen, Jerry Froelich, Douglas Yee, Susanta Hui
  • Organizer: ASTRO 2015
  • Place of Presentation: San Antonio, TX（USA）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Feasibility study for advanced total marrow irradiation (2015)
  • Author(s): Taiki Magome
  • Organizer: JSPS Core-to-Core Program Training Plan for Cancer Professionals Pre-AAPM Scientific Symposium
  • Place of Presentation: Anaheim, CA（USA）
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] Dose marrow recomposition (2015)
  • Author(s): Taiki Magome
  • Organizer: Total Marrow Irradiation Workshop
  • Place of Presentation: Paris（France）
  • Year and Date: 2015-05-22
  • Int'l Joint Research / Invited
• [Presentation] Patterns of Recurrence in Malignant Glioma Patients: Association With Neurogenic Niche and Radiation Therapy Dose (2014)
  • Author(s): Hiroshi Igaki, Taiki Magome, Madoka Sakuramachi, Akihiro Nomoto, Akira Sakumi, Mayuka Kitaguchi, Akihiro Haga, Jun Itami, Kiichi Nakagawa
  • Organizer: ASTRO 2014
  • Place of Presentation: San Francisco CA, USA
  • Year and Date: 2014-09-01
• [Presentation] Prediction of survival time after radiotherapy based on artificial neural network, Dose reconstruction with daily MVCT in total marrow irradiation, Simulation of total hematopoietic marrow irradiation (2014)
  • Author(s): Taiki Magome
  • Organizer: University of Minnesota, The University of Tokyo, Osaka University Scientific symposium
  • Place of Presentation: Minneapolis MN, USA
  • Year and Date: 2014-07-25
• [Presentation] Comparison of Survival-Time Prediction Models After Radiotherapy for High-Grade Glioma Patients Based On Clinical and DVH Features (2014)
  • Author(s): Taiki Magome, Akihiro Haga, Hiroshi Igaki, Noriyasu Sekiya, Yoshitaka Masutani, Akira Sakumi, Akitake Mukasa, Keiichi Nakagawa
  • Organizer: 56th AAPM Annual Meeting
  • Place of Presentation: Austin TX, USA
  • Year and Date: 2014-07-24
• [Presentation] Reconstruction of the Treatment Area by Use of Sinogram in Helical Tomotherapy (2014)
  • Author(s): Akihiro Haga , Keiichi Nakagawa, Calvin Maurer, Ken Ruchala, Edward Chao, Dylan Casey, Satoshi Kida, Dousatsu Sakata, Taiki Magome, Masahiro Nakano, Yoshitaka Masutani
  • Organizer: 56th AAPM Annual Meeting
  • Place of Presentation: Austin TX, USA
  • Year and Date: 2014-07-20
• [Presentation] Photoelectric cross sections based on the Hartree-Fock calculation (2014)
  • Author(s): Akihiro Haga, Jun’ichi Kotoku, Yataro Horikawa, Dousatsu Sakata, Taiki Magome, and Keiichi Nakagawa
  • Organizer: 107回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜, 神奈川県
  • Year and Date: 2014-04-12
• [Presentation] Preliminary study for prediction of survival time after radiotherapy for high-grade glioma patients based on clinical and DVH features (2014)
  • Author(s): Taiki Magome, Akihiro Haga, Hiroshi Igaki, Noriyasu Sekiya, Yoshitaka Masutani, Akira Sakumi, Akitake Mukasa, and Keiichi Nakagawa
  • Organizer: 第107回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜, 神奈川県
  • Year and Date: 2014-04-10
• [Book] Computer-assisted treatment planning approaches for SBRT in Image‐Based Computer‐Assisted Radiation Therapy (2016)
  • Author(s): Taiki Magome
  • Publisher: Springer
• [Book] Computational Intelligent Image Analysis for Assisting Radiation Oncologists (2013)
  • Author(s): Arimura H, Magome T, et al.
  • Total Pages: 21
  • Publisher: Springer
• [Remarks] 東京大学医学部附属病院放射線科放射線治療部門ホームページ
  • URL: http://www.u-tokyo-rad.jp/
• [Remarks] ミネソタ大学Hui研究室ホームページ
  • URL: http://www.tc.umn.edu/~huixx019/index.html
• [Patent(Industrial Property Rights)] 画像処理装置及び画像処理方法 (2015)
  • Inventor(s): 芳賀昭弘，馬込大貴，中川恵一
  • Industrial Property Rights Holder: 芳賀昭弘，馬込大貴，中川恵一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-246604
  • Filing Date: 2015-12-17