小脳運動皮質遠心路の増強と小脳性運動障害の改善

• Project/Area Number: 13J05251
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: 小金丸 聡子 京都大学, 医学研究科, 特別研究員(PD)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,960,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 小脳性運動障害 / 経頭蓋直流電流刺激 / 非侵襲的脳刺激 / 小脳の運動学習 / 歩行 / リハビリテーション / 脳卒中 / 小脳失調 / 神経可塑性 / 経頭蓋磁気刺激装置 / 小脳皮質 / 運動学習 / 一次運動野

Outline of Annual Research Achievements

平成27年度は脳卒中後小脳失調症状のある患者において、小脳への歩行周期に合わせたリズム刺激を行った。その結果歩行機能の回復を得られることができた。小脳の歩行中枢への刺激が可能となったためと考えられる。本研究成果は論文にまとめ、国際雑誌へ投稿する予定である。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Neurophysiological measurements of affected and unaffected motor cortex from a cross-sectional, multi-center individual stroke patient data analysis study. (2016)
  • Author(s): Simis M, Di Lazzaro V, Kirton A, Pennisi G, Bella R, Kim YH, Takeuchi N, Khedr EM, Rogers LM, Harvey R, Koganemaru S, Turman B, Tarlac S, Gagliardi RJ, Fregni F.
  • Journal Title: Neurophysiol Clin. Volume: 46 Issue: 1 Pages: 53-61
  • DOI: 10.1016/j.neucli.2016.01.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two is More Than One: How to Combine Brain Stimulation Rehabilitative Training for Functional Recovery? (2016)
  • Author(s): Koganemaru S, Fukuyama H, Mima T.
  • Journal Title: Front Syst Neurosci. Volume: 9 Pages: 154-154
  • DOI: 10.3389/fnsys.2015.00154
  • NAID: 120005947022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Action observation with kinesthetic illusion can produce human motor plasticity. (2015)
  • Author(s): Nojima I, Koganemaru S, Kawamata T, Fukuyama H, Mima T.
  • Journal Title: Eur J Neurosci. Volume: 41 Issue: 12 Pages: 1614-23
  • DOI: 10.1111/ejn.12921
  • Peer Reviewed / Open Access
• [Journal Article] Static magnetic field can transiently alter the human intracortical inhibitory system. (2015)
  • Author(s): Nojima I, Koganemaru S, Fukuyama H, Mima T.
  • Journal Title: Clin Neurophysiol. Volume: 126 Issue: 12 Pages: 2314-9
  • DOI: 10.1016/j.clinph.2015.01.030
  • Peer Reviewed
• [Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke. (2015)
  • Author(s): Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
  • Journal Title: Neurosci Res. Volume: 92 Pages: 29-38
  • DOI: 10.1016/j.neures.2014.10.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 機能回復治療の最前線経頭蓋磁気刺激とUse-dependent plasticity (2013)
  • Author(s): 小金丸 聡子, 美馬 達哉, 福山 秀直, 道免 和久
  • Journal Title: The Japanese Journal of Rehabilitation Medicine Volume: 50 Pages: 264-270
  • Peer Reviewed
• [Journal Article] Transcranial direct current stimulation changes human endowment effect. (2013)
  • Author(s): Votinov M, Aso T, Koganemaru S, Fukuyama H, Mima T.
  • Journal Title: Neurosci Res. Volume: 76 Pages: 251-256
  • Peer Reviewed
• [Presentation] Human walking entrained by brain alternating current stimulation (2015)
  • Author(s): Koganemaru S.
  • Organizer: Society for neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] “Efficient strategy for combination of brain stimulation and rehabilitation for post-stroke recovery” (2015)
  • Author(s): 小金丸 聡子
  • Organizer: 第40回日本脳卒中学会
  • Place of Presentation: 広島市
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] “Effect of transcranial direct current stimulation (tDCS) over M1 pharyngeal area on swallowing phase in post-stroke dysphagia.” (2014)
  • Author(s): 小金丸 聡子
  • Organizer: Neuroscience 2014（北米神経科学会）
  • Place of Presentation: Washington、USA
  • Year and Date: 2014-11-18
• [Presentation] “周期性運動に連動した非侵襲的律動性脳刺激と脳活動変化” , (2014)
  • Author(s): 小金丸 聡子
  • Organizer: 第37回日本神経科学会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] 「経頭蓋的徐波律動刺激（tSOS）による歩行のニューロリハビリ」 (2014)
  • Author(s): 小金丸 聡子
  • Organizer: 2014年神経オシレーションカンファレンス
  • Place of Presentation: 岡崎市
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] ”Gait-specific plasticity in corticospinal excitability induced by rhythmic brain stimulation” (2014)
  • Author(s): 小金丸 聡子
  • Organizer: 第51回日本リハビリテーション医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-06-05
• [Presentation] Slow Oscillatory Stimulation simulating Gait Rhythm induces LTP-like effects on Corticospinal Excitability in Foot. (2014)
  • Author(s): 小金丸 聡子
  • Organizer: The 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin
  • Year and Date: 2014-03-21
• [Presentation] Case report : Seizure induction by single-pulse transcranial magnetic stimulation after anodal transcranial direct current stimulation in a stroke patient. (2014)
  • Author(s): 小金丸 聡子
  • Organizer: The 30th International Congress of Clinical Neuroph ysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin
  • Year and Date: 2014-03-21
• [Presentation] 両側病変による難治性嚥下障害に対してtDCSを施行した症例 (2014)
  • Author(s): 小金丸 聡子
  • Organizer: 第36回日本リハビリテーション学会近畿地方会
  • Place of Presentation: 京都市
  • Year and Date: 2014-03-08
• [Presentation] Task-Specific Brain Reorganization after 'Hybrid Rehab' in Stroke patients studied by fMRI. (2014)
  • Author(s): 小金丸 聡子
  • Organizer: Conference on Systems Neuroscience and Rehabilitation (SNR2014)
  • Place of Presentation: Tokorozawa
• [Presentation] シンポジウム7-脳卒中リハビリテーションのフロンティア6ヵ月の壁を越えて― 「脳刺激・プラス・エックスのリハビリ」 (2013)
  • Author(s): 小金丸 聡子
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知市
  • Year and Date: 2013-11-08
  • Invited
• [Presentation] 脳卒中後感覚失調患者におけるTMSを用いた運動出力路の増強と機能回復 (2013)
  • Author(s): 小金丸 聡子
  • Organizer: 第50回日本リハビリテーション医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-14
• [Presentation] UDP-related brain reorganization in post-stroke hemiparetic patients. (2013)
  • Author(s): 小金丸 聡子
  • Organizer: 第54回日本神経学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-29