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生物新機能と創薬をめざす生体内分子科学

Research Project

Project/Area Number 13NP0401
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionGifu University

Principal Investigator

鈴木 正昭  岐阜大学, 大学院医学系研究科, 教授 (90093046)

Co-Investigator(Kenkyū-buntansha) 渡辺 恭良  大阪市立大学, 大学院医学研究科, 教授 (40144399)
松田 彰  北海道大学, 大学院薬学研究科, 教授 (90157313)
石川 智久  東京工業大学, 大学院生命理工学研究科, 教授 (60193281)
伊藤 誠二  関西医科大学, 医学部, 教授 (80201325)
萩原 正敏  東京医科歯科大学, 大学院疾患生命科学研究部, 教授 (10208423)
根岸 学  京都大学, 大学院・生命科学研究科, 教授 (60201696)
鈴木 和年  (独)放射線医学総合研究所, 重粒子医科学センター, 室長(研究職) (90162932)
影近 弘之  東京大学, 大学院・薬学系研究科, 助教授 (20177348)
米倉 義晴  福井医科大学, 高エネルギー医学研究センター, 教授 (60135572)
森 望  国立長寿医療研究センター, 分子遺伝学研究部, 部長(研究職) (00130394)
袖岡 幹子  東北大学, 多元物質科学研究所, 教授 (60192142)
橋本 祐一  東京大学, 分子細胞生物学研究所, 教授 (90164798)
長野 哲雄  東京大学, 大学院・薬学系研究科, 教授 (20111552)
Project Period (FY) 2001 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥975,000,000 (Direct Cost: ¥816,000,000、Indirect Cost: ¥159,000,000)
Fiscal Year 2005: ¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000)
Fiscal Year 2004: ¥234,000,000 (Direct Cost: ¥180,000,000、Indirect Cost: ¥54,000,000)
Fiscal Year 2003: ¥260,000,000 (Direct Cost: ¥200,000,000、Indirect Cost: ¥60,000,000)
Fiscal Year 2002: ¥286,000,000 (Direct Cost: ¥286,000,000)
KeywordsPET / 高速メチル化 / 蛍光プローブ / 人工核酸 / キナーゼ / 阻害剤 / 神経因性疼痛 / シグナル解析 / 3成分連結PG合成法 / non-RI光親和性標識法 / ABCトランスポーター / Socius / 神経性疼痛 / プラナーポジトロンイメージング / MicroPET / 光親和性標識法 / レチノイド / キナーゼ阻害剤 / 34mCl / プロスグランジン / RXRアンタゴニスト / 可視化プローブ / 4'-チオリボヌクレオシド / ダントロレン誘導体 / Cu-ATSM / サリドマイド / リピドA / 15R-TIC / リアノジン受容体 / PGE_2 / アロディニア / DNAチップ
Research Abstract

PET法において,^<11>Cラベル化に活用できるアルケンsp2炭素の高速メチル化反応を開発した。本反応と既に開発している芳香環およびアルキンのメチル化との使い分けにより,ほとんどの有機化合物の^<11>Cラベル化が可能となった。実際のPET装置による反応でも放射化学収率85%が達成された。ダントロレン類縁体の二官能性non-RI光親和性標識プローブを合成し,骨格筋標本に対する光ラベル化反応を行って結合タンパク質を同定した。4'-チオリボヌクレオシドの立体選択的合成法を確立し,ヌクレアーゼ耐性のオリゴヌクレオチドおよび4'-チオDNAを創製した。人工核酸BNAを用いたアンチジーンブロック法により遺伝子発現の制御に成功した。ネクローシス選択的な細胞死抑制剤IM-54の開発に成功した。[^3H]ETB-TBOAを合成し,グルタミン酸トランスポーターサブタイプに対する結合特恒を解析した。サリドマイド類縁体を基盤とする各種創薬候補化合物を創製した。高感度アルカリホスファターゼ蛍光プローブTG-Phosの開発に成功した。各種ペプチドグリカンフラグメントを合成し,生物活性を明らかにした。細胞分化誘導能を示すカルボランを導入したビタミンD誘導体を合成した。マンガン誘発アポトーシス抑制化合物の創製に成功した。アロディニア誘発にかかわる新規グルタミン酸受容体アゴニストの創製に成功した。三量体Gタンパク質Ga12ファミリーを活性化する新分子Sociusを発見した。LPAによるアストログリアの活 化がRho-kinase依存性のMLC_<20>リン酸化亢進により起こることを実証した。脊髄における一酸化窒素の産生が神経因性疼痛の維持にかかわることを実証し,NOが痛みのバイオマーカーになる可能性を見いだした。CLK依存的選択的スプライスング制御剤を基にした画期的抗ウイルス剤の創製に成功した。遺伝子多型と薬物相互作用を解析する高速スクリーニングシステムとQSAR解析アルゴリズムを開発した。癌細胞の代謝物を解析し,酢酸を大量に排出していることを見いだした。神経特異的遺伝子の転写因子NRSF/RESTと制御因子との結合様式を解明した。MicroPET装置を用いたバイオラジオグラフィー法を確立した。グルタミン酸および受容体リガンドの^<11>Cラベル体を作製し,マウスやサルでのPET画像を検定した。^<11>CH_4を利用するシングルパス^<11>CH_3I変換装置を開発した。サルを用いたPETによる評価系を確立し,パーキンソン病,統合失調症,脳虚血モデルなどでの解析を行った。

Report

(5 results)
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (294 results)

All 2006 2005 2004 Other

All Journal Article (76 results) Publications (218 results)

  • [Journal Article] Rapid methylation on carbon frameworks useful for the synthesis of ^<11>CH_3-incorporated PET tracers : Pd(0)-mediated rapid coupling of metyl iodide with an alkenyl tributylstannaneleading to 1-metyhllalkene2006

    • Author(s)
      T.Hosoya
    • Journal Title

      Org. Biomol. Chem. 4

      Pages: 410-415

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis of peptidoglycan fragments and evaluation of their biological activity.2006

    • Author(s)
      S.Inamura
    • Journal Title

      Org. Biomol. Chem. 4・2

      Pages: 232-242

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of NRSF/REST in the molecular mechanisms regulating neural-spacific expression of trkC/neurotrophin-3 receptor gene.2006

    • Author(s)
      T.Nakatani
    • Journal Title

      Brain Res Mol Brain Res. 135

      Pages: 249-259

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Design of dantrolene-derived probes for radioisotope-free photoahhinity labeling of proteins in the psysiological Ca^<2+> release from sarcoplasmic reticulum of skeletal muscle.2005

    • Author(s)
      T.Hosoya
    • Journal Title

      Bioorg. Med. Chem. Lett. 15

      Pages: 1289-1294

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New NTP analogs : The synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX.2005

    • Author(s)
      Y.Kato
    • Journal Title

      Nucleic Acids Res. 33

      Pages: 2942-2951

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of a novel glutamate transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoil amino]benzyloxy}asparate (TFB-TBOA), on activities of hippocampal neurons.2005

    • Author(s)
      S.Tsukada
    • Journal Title

      Neuropharmacol 48

      Pages: 479-491

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of Hydrogen Peroxide-Induced Necrotic Cell Death with 3-Amino-2-Indolylmaleimide Derivatives.2005

    • Author(s)
      K.Dodo
    • Journal Title

      Bioorg. Med. Chem. Lett. 15

      Pages: 3114-3118

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005

    • Author(s)
      Y.Hashimoto
    • Journal Title

      Bioorg. Med. Chem. 13・17

      Pages: 5080-5093

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evolution of Fluorescein as a Platform for Finely Tunable Fluorescence Probes2005

    • Author(s)
      Y.Urano
    • Journal Title

      J. Am. Chem. Soc. 127

      Pages: 4888-4894

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Socius, anovel binding partner of Gα12/13, promotes the Gα12-induced RhoA activation.2005

    • Author(s)
      K.Tateiwa
    • Journal Title

      Biochem. Biophys. Res Commun. 337

      Pages: 615-620

    • Related Report
      2005 Annual Research Report
  • [Journal Article] microglia-specific expression of microsomal prostaglandin E_2 synthase-1 contributes to lipopoly-sacharide-induced prostaglandin E_2 production.2005

    • Author(s)
      Y.Ikeda-Matsuo
    • Journal Title

      J. Neurochem. 94

      Pages: 1546-1558

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).2005

    • Author(s)
      S.Tatsumi
    • Journal Title

      Neuroscienc 131

      Pages: 491-498

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bio-object, a stochastic simulator for post-transcriptional regulation. Bioinformatics.2005

    • Author(s)
      N.Ohki
    • Journal Title

      Bioinformatics 21

      Pages: 2478-2487

    • Related Report
      2005 Annual Research Report
  • [Journal Article] high-speed screening of human ABC transporter function and genetic polymorphisms : New strategies in pharmacogenomics.2005

    • Author(s)
      T.Ishikawa
    • Journal Title

      Nethods in Enzymol. 400

      Pages: 485-510

    • Related Report
      2005 Annual Research Report
  • [Journal Article] MicroPET detection of enhanced ^<18>F-FDG utilization by PKA inhibitor in awake rat brain.2005

    • Author(s)
      R.Hosoi
    • Journal Title

      Brain Res. 1039

      Pages: 199-202

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sources of carbon which decrease the specific activity of [^<11>C]CH_3I sinthesized by the single pass I_2 method2005

    • Author(s)
      Z.Ming-Rong
    • Journal Title

      Applied Radiation and Isotopes 62

      Pages: 447-450

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors.2005

    • Author(s)
      S.Muramatsu
    • Journal Title

      Expert Opinion on Biological Therapy 5

      Pages: 667-671

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PET トレーサー合成基盤を刷新する高速メチル化反応 : プロスタグランジン受容体の可視化2005

    • Author(s)
      鈴木正昭
    • Journal Title

      科学と生物 43

      Pages: 804-808

    • NAID

      10016846717

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of Rho-kinase in through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS)2005

    • Author(s)
      S.Tatsumi
    • Journal Title

      Neuroscience 131・2

      Pages: 491-498

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Design of dantrolrne-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca^<2+> release from sarcoplasmic reticulum of skeletal muscle.2005

    • Author(s)
      T.Hosoya
    • Journal Title

      Bioorg.Med.Chem.Lett. 15・5

      Pages: 1289-1294

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel bifunctional probe for radioisotope-free photoaffinity labeling : compact structure comprised of photospecific ligand ligation and detectable tag anchoring units2004

    • Author(s)
      T.Hosoya
    • Journal Title

      Org.Biomol.Chem. 2・5

      Pages: 637-641

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Manipulation of alternative splicing by a newly developed inhibitor of Clks.2004

    • Author(s)
      M.Muraki
    • Journal Title

      J.Biol.Chem. 279・23

      Pages: 24246-24254

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies2004

    • Author(s)
      K.Furuta
    • Journal Title

      Tetrahedron Letters 45・20

      Pages: 3933-3936

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells2004

    • Author(s)
      Y.Hirata
    • Journal Title

      Brain Research 1021・2

      Pages: 241-247

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rapid methylation on carbon frameworks leading to the synthesis of a PET tracer capable of imaging a novel CNS-type prostacyclin receptor in living human brain2004

    • Author(s)
      M.Suzuki
    • Journal Title

      Trends in Analytical Chemistry 23・8

      Pages: 595-607

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synthesis of ^<11>C-labelled N, N'-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [^<11>C]isocyanatobenzene using phynyl azide and [^<11>C]carbon monoxide2004

    • Author(s)
      H.Doi
    • Journal Title

      Org.Biomol.Chem. 2・21

      Pages: 3063-3066

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ミニレビュー脳を探る分子プローブ設計:ヒト脳内IP_2受容体の分子イメージング2004

    • Author(s)
      鈴木正昭
    • Journal Title

      日本神経精神薬理学雑誌 24

      Pages: 221-229

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Positron Emission Tomography (PET)法による生体の分子イメージング研究と創薬・医療への応用2004

    • Author(s)
      鈴木正昭
    • Journal Title

      生物物理 44・6

      Pages: 265-270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Structure-based Design of a Selective Heparanase Inhibitor as an Antimetastatic Agent.2004

    • Author(s)
      K.Ishida
    • Journal Title

      Mol.Cancer Therapeutics 3・9

      Pages: 1069-1077

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Design, Synthesis, and Structure-Activity Relationship of New Isobenzofuranone Ligands of Protein Kinase C2004

    • Author(s)
      Y.Baba
    • Journal Title

      Bioorg.Med.Chem.Lett. 14・11

      Pages: 2963-2967

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of Series of Isobenzofuranone Dimers as PKCα Ligands : Implication for the Distance between the Two Ligand Binding Sites.2004

    • Author(s)
      Y.Baba
    • Journal Title

      Bioorg.Med.Chem.Lett. 14・11

      Pages: 2969-2972

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Amine-salt-controlled, Catalytic Asymmetric Conjugate Addition of Various Amines and Asymmetric Protonation.2004

    • Author(s)
      Y.Hamashima
    • Journal Title

      Org.Lett. 6・11

      Pages: 1861-1864

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe.2004

    • Author(s)
      Y.Gabe
    • Journal Title

      J.Am.Chem.Soc. 126・10

      Pages: 3357-3367

    • Related Report
      2004 Annual Research Report
  • [Journal Article] NMR conformational analysis of biosynthetic precursor-type lipid A : monomolecular state and supramolecular assembly2004

    • Author(s)
      M.Oikawa
    • Journal Title

      Org.Biomol.Chem. 2・24

      Pages: 3557-3565

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ligand-dependent Toll-like receptor 4(TLR4)-oligomerization is directly linked with TLR4-signaling.2004

    • Author(s)
      S.Saitoh
    • Journal Title

      J.Endotoxin Res. 10・4

      Pages: 257-260

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aggregates are the biologically active units of endotoxin2004

    • Author(s)
      M.Mueller
    • Journal Title

      J.Biol.Chem. 279・25

      Pages: 26307-26313

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses2004

    • Author(s)
      M.Triantafilou
    • Journal Title

      Biochem.J. 381・Pt2

      Pages: 527-536

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Lipid A antagonist, lipid 1Va, is distinct from lipid A in interaction with Toll-like receptor 4(TLR4)-MD-2 and ligand-induced TLR4 oligomerization2004

    • Author(s)
      S.Saitoh
    • Journal Title

      Int.Immun. 16・7

      Pages: 961-969

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enantioselective total synthesis of batzelladine A.2004

    • Author(s)
      J.Shimokawa
    • Journal Title

      Angew.Chem.Int.Ed. 43・12

      Pages: 1559-1562

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of novel chiral urea catalysts for the hetero Michael reaction2004

    • Author(s)
      Y.Sohtome
    • Journal Title

      Chem.Pharm.Bull. 52・4

      Pages: 477-480

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Thalidomide as a nitric oxide synthase inhibitor and its structural development.2004

    • Author(s)
      R.Shimazawa
    • Journal Title

      Chem.Pharm.Bull. 52・4

      Pages: 498-499

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synthesis of 1α,25-dihydroxyvitamin D_3-26,23-lactams (DLAMs), a novel series of 1α,25-dihydroxyvitamin D_3 antagonist.2004

    • Author(s)
      Y.Kato
    • Journal Title

      Bioorg.Med.Chem.Lett. 14・10

      Pages: 2579-2583

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel betaines from a Micronesian sponge Dysidea herbacea.2004

    • Author(s)
      R.Sakai
    • Journal Title

      J.Org.Chem. 69・4

      Pages: 1180-1185

    • Related Report
      2004 Annual Research Report
  • [Journal Article] L-Glutamate in the extracellular space regulates endogeneous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells.2004

    • Author(s)
      M.Adachi
    • Journal Title

      Arc.Biochem.Biophys. 424・1

      Pages: 89-96

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters.2004

    • Author(s)
      K.Shimamoto
    • Journal Title

      Mol.Pharmacol. 65・4

      Pages: 1008-1015

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synthesis of carbamate-type cages derivatives of a novel glutamate transporter blocker.2004

    • Author(s)
      K.Takaoka
    • Journal Title

      Bioorg.Med.Chem. 12・13

      Pages: 3687-3694

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular pharmacology of glutamate transporters, EAATs and VGLUTs.2004

    • Author(s)
      Y.Shigeri
    • Journal Title

      Brain Res.Rev. 45・3

      Pages: 250-265

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line UF-1, carrying a patient-derived mutant PML-RARα chimetric gene.2004

    • Author(s)
      A.Sato
    • Journal Title

      Leukemia Res. 28・9

      Pages: 959-967

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Design and synthesis of cyclic urea compounds : a pharmacological study for retinoidal activity.2004

    • Author(s)
      M.Kurihara
    • Journal Title

      Bioorg.Med.Chem.Lett. 14・16

      Pages: 4131-4134

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Endocrine Disruptors Nonylphenol and Octylphenol Exert Direct Effects on T Cells to Suppress Th1 Development and Enhance Th2 Development.2004

    • Author(s)
      M.Iwata
    • Journal Title

      Immunol.Lett. 94・1-2

      Pages: 135-139

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Docosahexaenoic Acid Reduces Haloperidol-Induced Dyskinesias in Mice : Involvement of Nur77 and Retinoid Receptors.2004

    • Author(s)
      I.Ethier
    • Journal Title

      Biol.Psychiatry 56・7

      Pages: 522-526

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel Retinoid X Receptor (RXR) Antagonists Having a Dicarba-closo-dodecaborane as a Hydrophobic Moiety.2004

    • Author(s)
      K.Ohta
    • Journal Title

      Bioorg.Med.Chem.Lett. 14・23

      Pages: 5913-5918

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.2004

    • Author(s)
      S.Ishida
    • Journal Title

      Biochem.Pharmacol. 68・11

      Pages: 2177-2186

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Retinoic Acid Imprintis Gut-Homing Specificity on T Cells.2004

    • Author(s)
      M.Iwata
    • Journal Title

      Immunity 21・4

      Pages: 527-538

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.2004

    • Author(s)
      M.Yoshikawa
    • Journal Title

      J.Exp.Ther.Oncol. 4・1

      Pages: 25-35

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional evaluation of ABCB1 (P-Glycoprotein) polymorphisms : High-speed screening and Structure-activity relationship analyses.2004

    • Author(s)
      T.Ishikawa
    • Journal Title

      Drug Metabol.Pharmacokin. 19・1

      Pages: 1-14

    • NAID

      10012688427

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.2004

    • Author(s)
      M.Yoshikawa
    • Journal Title

      Int.J.Cancer 110・6

      Pages: 921-927

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pharmacogenomics of drug transporters : a new approach to functional analysis of the genetic polymorphisms of ABCB1(P-glycoprotein/MDR1)2004

    • Author(s)
      T.Ishikawa
    • Journal Title

      Biol.Pharm.Bull. 27・7

      Pages: 939-948

    • NAID

      110003608891

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The genetic polymorphism of drug transpoters : functional analysis approaches.2004

    • Author(s)
      T.Ishikawa
    • Journal Title

      Pharmacogenomics 5・1

      Pages: 67-99

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with N-WASP(neural Wiskott-Aldorich syndrome protein) and induces neurite branching.2004

    • Author(s)
      T.kakimoto
    • Journal Title

      J.Biol.Chem. 279・14

      Pages: 14104-14110

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts2004

    • Author(s)
      M.Takano
    • Journal Title

      J.Biol.Chem. 279・13

      Pages: 13265-13271

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abnormal angiogenesis in Foxol (FKHR)-deficient mice.2004

    • Author(s)
      T.Furuyama
    • Journal Title

      J Biol Chem. 279・33

      Pages: 34741-34749

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neural-specific member of the SCG10 family, by its N-terminal domain2004

    • Author(s)
      C.Nakao
    • Journal Title

      J.Biol.Chem. 279・22

      Pages: 23014-23021

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct interaction of NRSF with TBP : The chromatin-reorganization and the core promoter repression for neuron-specific gene transcription.2004

    • Author(s)
      K.Murai
    • Journal Title

      Nucl.Acid Res. 32・10

      Pages: 3180-3189

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 老化遺伝子2004

    • Author(s)
      森 望
    • Journal Title

      臨床整形外科 39・2

      Pages: 176-179

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ドッキング蛋白Shcの神経系における役割2004

    • Author(s)
      森 望
    • Journal Title

      生体の科学 55・2

      Pages: 103-110

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 脳の老化と寿命制御2004

    • Author(s)
      森 望
    • Journal Title

      日本老年医学会雑誌 41・3

      Pages: 266-270

    • NAID

      10014384723

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.2004

    • Author(s)
      T.Mabuchi
    • Journal Title

      J.Neurosci. 24・33

      Pages: 7283-7291

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid.2004

    • Author(s)
      T.Minami
    • Journal Title

      Br.J.Pharmacol. 142・4

      Pages: 679-688

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel peripheral benzodiazepine receptor ligand [^<11>C]DAA1106 for PET an imaging tool for glial cells in the brain.2004

    • Author(s)
      J.Maeda
    • Journal Title

      Synapse 52・4

      Pages: 283-291

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[^<18>F]fluoroethyl-5-methoxybenzyl) acetamide, for PET imaging of peripheral benzodiazepine receptor in primate brain.2004

    • Author(s)
      MR.Zhang
    • Journal Title

      J.Med.Chem. 47・9

      Pages: 2228-2235

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function : functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.2004

    • Author(s)
      H.Tsukada
    • Journal Title

      Synapse 52・1

      Pages: 1-10

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of [^<18>F]fluorinated sigma receptor ligands in the conscious monkey brain.2004

    • Author(s)
      P.H.Elsinga
    • Journal Title

      Synapse 52・1

      Pages: 29-37

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of in vivo selective binding of [^<11>C]doxepine to histamine H_1 receptors in five animal species.2004

    • Author(s)
      K.Ishikawa
    • Journal Title

      Nucl.Med.Biol. 31・4

      Pages: 493-502

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Catalytic Asymmetric Addition of β-Ketoesters to Various Imines Using Chiral Pd Complexes.

    • Author(s)
      Y.Hamashima
    • Journal Title

      Angew.Chem.Int.Ed. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.

    • Author(s)
      Y.Hashimoto
    • Journal Title

      Drugs Future (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Publications] T.Hosoya: "Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes : a general protocol potentially useful for the synthesis of short-lived ^<11>CH_3-labeled PET tracers with a 1-propynyl group."Org.Biomol.Chem.. 2・1. 24-27 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Satoh: "Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress."Eur.J.Neurosci.. 17・11. 2249-2255 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木正昭: "PET法による脳内中枢型プロスタサイクリン受容体の分子イメージング"現代化学. 387. 46-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kazuta: "A systematic study of the hydride reduction of cyclopropyl ketones with structurally simplified sbstrates. Highly stereoselective reductions of trans substituted cyclopropyl ketones via the bisected s-cis-conformation."J.Org.Chem.. 68・9. 3511-3521 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kazuta: "Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-Aminoethyl)-1-(1H, imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane strusture."J.Med.Chem.. 46・10. 1980-1988 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Shuto: "Convergent synthesis and unexpected Ca^<2+>-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca^<2+>-mobilizing second messenger cyclic ADP-ribose."J.Med.Chem.. 46・22. 4741-4749 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Minakawa: "New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four hydrogen bonds."J.Am.Chem.Soc.. 125・33. 9970-9982 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Minakawa: "A versatile modification of on-column oligodeoxynucleotides using a copper-catalyzed oxidative acetylenic coupling reaction."J.Am.Chem.Soc.. 125・38. 11545-11552 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] L.Gan: "The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase."Biochemistry. 42・4. 857-863 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Tamura: "Control of α/β-stereoselectivity in Lewis acid-prmoted C-glycosidation using a controlling anomeric effect based on the conformtional restriction strategy."Angew.Chem.Int.Ed.Engl.. 42・9. 1021-1023 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Minakawa: "An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol."Tetrahedron. 59・10. 1699-1702 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Sukeda: "The first radical method for the introduction of an ethynyl group using a silicon tether and its application to the synthesis of 2'-deoxy-2'-C-ethynylnucleosides."J.Org.Chem.. 68・9. 3465-3475 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Itoh: "Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine."Nucleic Acids Res.. 31・10. 2514-2523 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Morisaki: "Conversion of Ca^<2+> salt of an organic compound to its Li^+ salt to simplify the fast atom bombardment mass spectrum."Chem.Pharm.Bull.. 51・11. 1341-1344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Hamashima: "Immobilization and reuse of Pd complexes in ionic liquid : efficient catalytic asymmetric fluorination and Michael reactions with β-ketoesters."Org.Lett.. 5・18. 3225-3228 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Baba: "Structure-based design of a highly selective catalytic site-directed inhibitor of Ser/Thr protein phosphatase 2B (calcineurin)."J.Am.Chem.Soc.. 125・32. 9740-9749 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Shoda: "Development of selective, visible light-excitable, fluorescent magnesium ion probes with a novel fluorescence switching mechanism."Analyst.. 128・6. 719-723 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Hanaoka: "Selective Detection of Zinc Ions with Novel Luminescent Lanthanide Probes."Angew.Chem.Int.Ed.Engl.. 42・26. 2996-2999 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Miura: "Rational design principle for modulating fluorescence properties of fluorescein-based probes by photoinduced electron transfer."J.Am.Chem.Soc.. 125・28. 8666-8671 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Yamamoto: "Production of singlet oxygen on irradiation of a photodynamic therapy agent, zinc-coproporphyrin III, with low host toxicity."Biometals.. 16・4. 591-597 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Takakusa: "A novel design method of ratiometric fluorescent probes based on fluorescence resonance energy transfer switching by spectral overlap integral."Chemistry-A European Journal.. 9・7. 1479-1485 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Setsukinai: "Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species."J.Biol.Chem.. 278・5. 3170-3175 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 長野哲雄: "活性酸素イメージングプローブ"実験医学. 21・15. 2144-2146 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 浦野泰照: "光誘起電子移動理論に基づく蛍光プローブの精密設計"ぶんせき. 8. 426-432 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Inohara: "Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease."J.Biol.Chem.. 278・8. 5509-5512 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Chamaillard: "An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid."Nat.Immunol.. 4・7. 702-707 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Akashi: "Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2 : higher affinity than that with MD-2 or CD14."J.Exp.Med.. 198・7. 1035-1042 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Fukase: "Synthesis and Biological Activities of Lipid A Analogs Possessing β-Glycosidic Linkage at 1-Position"Bull.Chem.Soc.Jpn.. 76・3. 485-500 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Ogawa: "Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1."FEMS Immunol.Med.Microbiol.. 36・1-2. 1-7 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] R.Tami: "Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4."Immunology. 110・1. 66-72 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] R.Haase: "A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages."J.Immunol.. 171・8. 4294-4303 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Kakuta: "Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells."Bioorg.Med.Chem.Lett.. 13・1. 83-86 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 長澤和夫: "サリドマイドの構造展開と活性拡張"細胞工学. 22・2. 152-155 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] G.D.Bujacz: "Crystallization and preliminary crystallographic studies of mung bean cytokinin-specific binding protein."Acta.Cryst.. D59. 522-525 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本祐一: "サリドマイドの過去・現在・未来"ファルマシア. 39・4. 315-319 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Bukowska: "Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets."Biol.Chem.. 384・4. 657-665 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本祐一: "がんにきく?使用広がるサリドマイド"Medical Technology. 31・6. 571-572 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本祐一: "サリドマイドの薬理作用とその構造展開"血液フロンティア. 13・7. 883-893 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本祐一: "サリドマイドの新しい適応"現代医療. 35・7. 1615-1619 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Kato: "Novel heteroatom-containing vitamin D_3 analogs : Efficient synthesis of 1α,25-dihydroxyvitamin D_3-26,23-lactam."Molecules. 8・6. 488-499 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Ishioka: "Androgen antagonists with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor."Bioorg.Med.Chem.Lett.. 13・16. 2655-2658 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Hashimoto: "Structural development of synthetic retinoids and thalidomide-related molecules."Cancer Chemother.Pharmacol.. 52・1. S16-S23 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Georgieva: "Stereoselective synthesis of novel ptilomycalin A analogs via successive 1,3-dipolar cycloaddition reactions and their Ca^<2+>-ATPase inhibitory activity."Synthesis. 2003・9. 1427-1432 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Suizu: "Cyclooxygenase inhibitors derived from thalidomide."Chem.Pharm.Bull.. 51・9. 1098-1102 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Kakuta: "Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton."Chem.Pharm.Bull.. 51・11. 1273-1282 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nagasawa: "Synthesis and application as chemical/biological tools of marine guanidine alkaloids."Chemical Record. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Takaoka: "Synthesis and photoreactivity of caged blockers for glutamate transporters."Bioorg.Med.Chem.Lett.. 13・5. 965-970 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] R.Sakaki: "Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges."J.Nat.Prod.. 66・6. 784-787 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Ohfune: "Stereocontrolled synthesis of a potent agonist of group II metabotropic glutamate receptors, (+)-LY354740, and its related derivatives"Tetrahedron Lett.. 44・29. 5431-5434 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Muratani: "Functional characterization of prostaglandin F_<2α> receptor in the spinal cord for tactile pain (allodynia)."J.Neurochem.. 86・2. 374-382 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Shigeri: "興奮性神経伝達物質グルタミン酸トランスポーターの制御分子開発と機能解析[Excitatory amino acid transporters : development of regulatory molecules for their functional analysis]"生化学. 75・4. 288-292 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Shigeri: "グルタミン酸トランスポーターの薬理学[Pharmacology of excitatory amino acid transporters(EAATs and VGLUTs)]"日本薬理学雑誌. 122・3. 253-264 (2003)

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      2003 Annual Research Report
  • [Publications] N.Miyagawa: "Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease."Pharmacology. 67・1. 21-31 (2003)

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      2003 Annual Research Report
  • [Publications] S.Ishida: "Clinically potential subclasses of retinoid synergists revealed by gene expression profiling."Mol.Cancer Ther.. 2・1. 49-58 (2003)

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      2003 Annual Research Report
  • [Publications] M.Farooqui: "Effects of retinoid ligands on RIP140 : molecular interaction with retinoid receptors and biological activity."Biochemistry. 42・4. 971-979 (2003)

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      2003 Annual Research Report
  • [Publications] M.Iwata: "Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors."Int.Immunol.. 15・8. 1017-1025 (2003)

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      2003 Annual Research Report
  • [Publications] Y.Endo: "Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups."Bioorg.Med.Chem.Lett.. 13・22. 4089-4092 (2003)

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      2003 Annual Research Report
  • [Publications] Y.Hari: "Selective Recognition of CG Interruption by 2',4'-BNA Having 1-Isoquinolone as a Nucleobase in a Pyrimidine Motif Triplex Formation"Tetrahedron. 59・27. 5123-5128 (2003)

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      2003 Annual Research Report
  • [Publications] H.Shimizu: "Characterization of mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue to human ABCC12"Gene. 310. 17-28 (2003)

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      2003 Annual Research Report
  • [Publications] H.Mitomo: "A functional study on the polymorphism of ATP-binding cassette transporter ABCG2 : Critical role of Arg-482 in Methotrexate transport."Biochem.J.. 373・3. 767-774 (2003)

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      2003 Annual Research Report
  • [Publications] K.Sano: "Simple non-ion-paired high performance liquid chromatograhic method for simultaneous quantification of carboxylate and lactone forms of 14 new camptothecin derivatives."J.Chromatogr.B Analyt.Technol.Biomed.Life Sci.. 795・1. 25-34 (2003)

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      2003 Annual Research Report
  • [Publications] T.Ishikawa: "The Genetic Polymorphism of Drug transporters : Functional Analysis Approaches."Pharmacogenomics. 5・1. 67-99 (2003)

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      2003 Annual Research Report
  • [Publications] 石川智久: "ヒトABCトランスポーター:新規遺伝子の探索とSNP機能解析"Bioベンチャー. 3・. 96-99 (2003)

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      2003 Annual Research Report
  • [Publications] R.Inoue: "Ca^<2+>-releasing effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal muscle fibers."J.Pharmacol.Sci.. 93・3. 279-288 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Ishikawa: "A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons."J.Neuroscience. 23・35. 11065-11072 (2003)

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      2003 Annual Research Report
  • [Publications] H.Katoh: "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo."Nature. 424・6947. 461-464 (2003)

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      2003 Annual Research Report
  • [Publications] I.Oinuma: "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells."J.Biol.Chem.. 278・28. 25671-25677 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Yamaguchi: "N-terminal short sequences of α subunits of the G12 family determine selective coupling to receptors"J.Biol.Chem.. 278・17. 14936-14939 (2003)

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      2003 Annual Research Report
  • [Publications] N.Mori: "Roles of Shc signaling in oxidative stress response and aging."J.Clin.Biochem.Nutr.. (印刷中).

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      2003 Annual Research Report
  • [Publications] 森 望: "長寿命遺伝子の新潮流"Medical.Practice. 20・10. 1796-1797 (2003)

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      2003 Annual Research Report
  • [Publications] T.Mabuchi: "Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production."Eur.J.Neurosci.. 17・7. 1384-1392 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Muratani: "Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp 120."Neuropharmacology. 45・1. 96-105 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Kitano: "Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity."Neurochem.Int.. 44・2. 83-90 (2004)

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      2003 Annual Research Report
  • [Publications] K.Suzuki: "Production of ^<34m>Cl.A new PET Radionuclide."J.Label Compd.Radiopharm.. 46・. S287 (2003)

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      2003 Annual Research Report
  • [Publications] G.Zubal: "Automated kinetic analysis of FDG uptake in living rat brain slices from dynamic positron autoradiography"Cancer Biother.Radiopharm.. 18・3. 405-411 (2003)

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      2003 Annual Research Report
  • [Publications] N.Omata: "Different mechanisms of hypoxic injury on white matter and gray matter as revealed by dynamic changes in glucose metabolism in rats."Neuroscience Letter. 353・2. 148-152 (2003)

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      2003 Annual Research Report
  • [Publications] M.Inoue: "Functional brain mapping of the macaque related to spatial working memory as revealed by PET"Cereb.Cortex. 14・1. 106-119 (2004)

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      2003 Annual Research Report
  • [Publications] A.Noda: "Determination of kinetic rate constants for FDG and partition coefficient of water in conscious macaque and alterations in aging or anesthesia examined on parametric images with an anatomic standardization technique"J.Cereb.Blood Flow Metab.. 23・12. 1441-1447 (2003)

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      2003 Annual Research Report
  • [Publications] Y.Sekine: "Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms,"Am.J.Psychiatry. 160・9. 1699-1701 (2003)

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      2003 Annual Research Report
  • [Publications] K.Yanamoto: "Intrastriatal microinjection of sodium nitroprusside induces cell death and reduces binding of dopaminergic receptors,"Synapse. 50・2. 137-143 (2003)

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      2003 Annual Research Report
  • [Publications] A.Noda: "Effect of FK960, an anti-dementia drug with a novel mechanism of action, on regional cerebral blood flow and glucose metabolism in aged rhesus macaques studies with positron emission tomography,"J.Pharmacol.Exper.Ther.. 306・1. 213-217 (2003)

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      2003 Annual Research Report
  • [Publications] K.Kawamura: "An increase in sigma 1 receptors in the aged monkey brain : a positron emission tomography study with [^<11>C]SA4503"Neurobiol.Age. 24・5. 745-752 (2003)

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      2003 Annual Research Report
  • [Publications] O.Inoue: "Sensitivity of benzodiazepine receptor binding and muscarinic acetylcholine receptor binding for the detection of neural cell death caused by sodium nitroprusside microinjection in rat brain"Synapse. 49・2. 134-141 (2003)

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      2003 Annual Research Report
  • [Publications] H.Engler: "Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease,"Eur.J.Nucl.Med.Mol.Imaging. 30・1. 85-95 (2003)

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      2003 Annual Research Report
  • [Publications] 塚田秀夫: "基底核神経伝達機能の解析:動物PET"BRAIN MEDICAL. 15・3. 42-48 (2003)

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      2003 Annual Research Report
  • [Publications] 塚田秀夫: "動物PETによるサル脳神経機能のイメージング"医学のあゆみ. 204・4. 243-246 (2003)

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      2003 Annual Research Report
  • [Publications] Y.Sasaki: "New aspects of neurotransmitter release and exocytosis : Rho-kinase-dependent myristoylated alanine-rich C-kinase substrate phosphorylation and regulation of neurofilament structure in neuronal cells."J.Pharmacol.Sci.. 93・1. 35-40 (2003)

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      2003 Annual Research Report
  • [Publications] T.Hosoya: "Novel bifunctional probe for radioisotope-free photoaffinity labeling : compact structure comprised of photospecific ligand ligation and detectable tag anchoring units."Org.Biomol.Chem.. (印刷中). (2004)

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      2003 Annual Research Report
  • [Publications] K.Furuta: "A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies."Tetrahedron Lett.. (印刷中). (2004)

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      2003 Annual Research Report
  • [Publications] 石川智久: "ゲノム創薬と未来産業"エルゼビア・ジャパン. 112 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Ikenoya: "Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor"J.Neurochem.. 81・1. 9-16 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Sasaki: "The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-{(4-methyl-5-insoquinoline)sulfonyl}-homopiperazine as a probing molecule for Rho-kinase-involved pathway"Pharmacology & Therapeutics. 93・. 225-232 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Hosoya: "[^<125>I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [^<125>I]-N-{[3-iodo-5-(3-trifuoromethyl-3H-diazirin-3-yl)]benzyl}dantrolene : Photoaffinity Probes Specific for the Physiological Ca^<2+> Release from Sarcoplasmic Reticulum of Skeletal Muscle"Bioorg.Med.Chem.Lett.. 12・22. 3263-3265 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Hosoya: "Dantrolene Analogues Revisited : General Synthesis and Specific Functions Capable of Discriminating Two Kinds of Ca^<2+> Release from Sarcoplasmic Reticulum of Mouse Skeletal Muscle"Bioorg.Med.Chem.Lett.. 11・5. 663-673 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木正昭: "学術創成研究「生物新機能と創薬をめざす生体内分子科学」-化学・生物学・医学融合型研究プロジェクト-"MEDCHEM NEWS (essay). 12・9. 9-12 (2002)

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      2002 Annual Research Report
  • [Publications] 萩原正敏: "序 新たなパラダイムを拓く分子プローブの創製:生物学と化学の融合 (特集 分子プローブで変わる生物学-生命機能の解明から創薬まで)"細胞工学. 22・2. 134-135 (2003)

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      2002 Annual Research Report
  • [Publications] 鈴木正昭: "設計PGプローブによるヒト脳内IP_2受容体の分子イメージング (特集 分子プローブで変わる生物学-生命機能の解明から創薬まで)"細胞工学. 22・2. 165-171 (2003)

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      2002 Annual Research Report
  • [Publications] T.Kodama: "A highly stereoselective samarium diiodide-promoted aldol reaction with 1'-phenylseleno-2'-keto nucleosides. Synthesis of l'α-branched uridine derivatives"J.Org.Chem.. 67・22. 7706-7715 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Komatsu: "In vitro selection of hairpin ribozymes activated with short oligonucleotides"Biochemistry. 41・29. 9090-9098 (2002)

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      2002 Annual Research Report
  • [Publications] H.A.Guse: "Novel hydrolysis-resistant analogues of cyclic ADP-ribose : modification of the "northern" ribose and calcium release activity"Biochemistry. 41・21. 6744-6751 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Shimamoto: "Cellular and Biochemical Mechanisms of the Resistance of Human Cancer Cells to a New Anticancer Ribo-nucleoside, TAS-106"Jpn.J.Cancer Res.. 93・4. 445-452 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Kazuta: "Synthesis of (1S,2R)-1-phenyl-2-[(S)-l-aminopropyl]-N, N-diethylcyclopropanecarboxamide (PPDC) derivatives modified at the carbamoyl moiety as a new class of NMDA receptor antagonists"Bioorg.Med.Chem.. 10・6. 1777-1791 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Kazuta: "Development of versatile cis-and trans-dicarbon -substituted chiral cyclopropane units : synthesis of (1S,2R)-and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropanes and their enantiomers as conformationally restricted analogues of histamine"J.Org.Chem.. 67・5. 1669-1677 (2002)

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      2002 Annual Research Report
  • [Publications] S.Shuto: "New neplanocin analogues. 12. Alternatives synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor"J.Med.Chem.. 45・3. 748-751 (2002)

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      2002 Annual Research Report
  • [Publications] M.Nomura: "Nucleosides and nucleotides. Part 212: Practical large-scale synthesis of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd), a potent antitumor nucleoside. Isobutyryloxy group as an efficient anomeric leaving group in the Vorbruggen glycosylation reaction"Tetrahedron. 58・7. 1279-1288 (2002)

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      2002 Annual Research Report
  • [Publications] H.Sumiyoshi: "Solution-Phase Parallel Synthesis of Carbamates Using Polymer-Bound N-Hydroxysuccinimide"Org.Lett.. 4・22. 3923-3926 (2002)

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      2002 Annual Research Report
  • [Publications] K.Hanaoka: "Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion"Chem.Biol.. 9・9. 1027-1032 (2002)

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      2002 Annual Research Report
  • [Publications] S.Maruyama: "A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion"J.Am.Chem.Soc.. 124・36. 10650-10651 (2002)

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      2002 Annual Research Report
  • [Publications] N.Suzuki: "Multiple active intermediate in oxidation reaction catalyzed by synthetic hemethiolate complex relevant to cytochrome p450"J.Am.Chem.Soc.. 124・32. 9622-9628 (2002)

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      2002 Annual Research Report
  • [Publications] S.Ueno: "Mossy fiber Zn^<2+> spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits"J.Cell Biol.. 158・2. 215-220 (2002)

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      2002 Annual Research Report
  • [Publications] T.Hirano: "Improvement and biological applications of fluorescent probes for zinc, ZnAFs"J.Am.Chem.Soc.. 124・23. 6555-6562 (2002)

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      2002 Annual Research Report
  • [Publications] S.Mizukami: "A fulorescent anion sensor that works in neutral aqueous solution for bioanalytical application"J.Am.Chem.Soc.. 124・15. 3920-3925 (2002)

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      2002 Annual Research Report
  • [Publications] T.Nagano: "Bioimaging of nitric oxide"Chem.Rev.. 102・4. 1235-1270 (2002)

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      2002 Annual Research Report
  • [Publications] H.Takakusa: "Design and synthesis of an enzyme-cleavable sensor molecule for phosphodiesterase activity based on fluorescence resonance energy transfer"J.Am.Chem.Soc.. 124・8. 1653-1657 (2002)

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      2002 Annual Research Report
  • [Publications] M.Nishida: "Activation mechanism of Gi and Go by reactive oxygen species"J.Biol.Chem.. 277・11. 9036-9042 (2002)

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      2002 Annual Research Report
  • [Publications] S-J.Ma: "A direct continuous spectrophotometric assay for glycosidases with 3-nitro-2-pyridylglycosides by tautomerization of 2-hydroxy-3-nitropyridine"Anal.Biochem.. 302・2. 291-297 (2002)

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      2002 Annual Research Report
  • [Publications] H.Akamatsu: "New efficient route for solid-phase synthesis of bensimidazole derivatives"J.Comb.Chem.. 4・5. 475-783 (2002)

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      2002 Annual Research Report
  • [Publications] M.Wakao: "Chemical synthesis of cyclodextrins by using intramolecular glycosylation"J.Org.Chem.. 67・23. 8182-8190 (2002)

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      2002 Annual Research Report
  • [Publications] M.Izumi: "Solid-phase synthesis of oligosaccharides using novel alkyne-type linkers : selection of reactive sites on the support by Sonogashira reaction"Synlett.. 9. 1409-1416 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Akamatsu: "Reactivity switching on solid support : solid-phase synthesis of teritary amines by reduction of tertiary amides with LiAlH_4"Tetrahedron Lett.. 43・49. 8867-8869 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Hashimoto: "Structural development of biological response modifiers based on thalidomide"Bioorg.Med.Chem.. 10・3. 461-479 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Ishioka: "Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety"Bioorg.Med.Chem.. 10・5. 1555-1566 (2002)

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      2002 Annual Research Report
  • [Publications] T.Noguchi: "Thalidomide and its analog as cyclooxygenase inhibitors"Bioorg.Med.Chem.Lett.. 12・7. 1043-1046 (2002)

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      2002 Annual Research Report
  • [Publications] 加藤優子: "新規窒素含有ビタミンD_3誘導体の合成"ビタミン. 76・3. 151-151 (2002)

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      2002 Annual Research Report
  • [Publications] 橋本祐一: "サリドマイドのマルチ創薬テンプレートとしての活用一ドラマタイプ創薬の1例"Bioベンチャー. 2・5. 43-49 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Hashimoto: "Structural development of biological response modifiers based on retinoids and thalidomide"Mini-Rev.Med.Chem.. 2・6. 543-552 (2002)

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      2002 Annual Research Report
  • [Publications] H.Kakuta: "Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells"Bioorg.Med.Chem.Lett.. 13・1. 83-86 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Hashimoto: "Structural development of synthetic retinoids and thalidomide-related molecules"Cancer Chemother. Pharmacol.. (印刷中).

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      2002 Annual Research Report
  • [Publications] K.Nagasawa: "Total synthesisn of crambescidin 359"Org.Lett.. 4・2. 177-180 (2002)

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      2002 Annual Research Report
  • [Publications] H.Takahashi: "Novel Mannich-type nucleophilic substitution reaction with tertiary aromatic amines"Tetrahedron Lett.. 43・16. 2935-2938 (2002)

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      2002 Annual Research Report
  • [Publications] N.Morisaki: "Coordination of sodium cation to an oxygen function and olefinic double bond to form molecular adduct ion in fast bombardment mass spectroscopy"Chem.Pharm.Bull.. 50・7. 935-940 (2002)

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      2002 Annual Research Report
  • [Publications] H.Takahashi: "Nucleophilic substitution on 4-hydroxymethylanilines under neutral conditions via aza quinone methide intermediate"Tetrahedron Lett.. 43・33. 5751-5753 (2002)

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      2002 Annual Research Report
  • [Publications] B.Takahashi: "Novel retinoid X receptor antagonists : Specific inhibitors of retinoid synergism in RXR-RAR heterodimer actions"J.Med.Chem.. 45・16. 3227-3330 (2002)

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      2002 Annual Research Report
  • [Publications] T.Kita: "C_2-Symmetric chiral pentacyclic guanidine : A phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate Schiff base"Angew.Chem.Int.Ed.. 41・15. 2832-2834 (2002)

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      2002 Annual Research Report
  • [Publications] T.Ishiwata: "Total synthesis of batazelladine D"Org.Lett.. 4・17. 2921-2924 (2002)

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      2002 Annual Research Report
  • [Publications] K.Nagasawa: "Stereoselective synthesis of trycyclic guanidine, the key component of the batzelladin alkaloids"Tetrahedron Lett.. 43・36. 6383-6385 (2002)

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      2002 Annual Research Report
  • [Publications] H.Kagechika: "Novel Synthetic Retinoids and Separation of the Pleiotropic Retinoidal Activities"Curr.Med.Chem.. 9・5. 591-608 (2002)

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      2002 Annual Research Report
  • [Publications] T.Imanishi: "BNAs : novel nucleic acid analogs with a bridged sugar moiety"Chem.Commun.(Camb).. 16. 1653-1659 (2002)

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      2002 Annual Research Report
  • [Publications] K.Morita: "2'-O, 4'-C-ethylene-bridged nucleic acids (ENA) : highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug"Bioorg.Med.Chem.Lett.. 12・1. 73-76 (2002)

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      2002 Annual Research Report
  • [Publications] T.Imanishi: "Down-regulation of a gene-expression by an antisense BNA oligonucleotide"Nippon Yakurigaku Zasshi. 120・2. 85-90 (2002)

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      2002 Annual Research Report
  • [Publications] S.Obika: "Synthesis and conformation of a novel bridged nucleoside with S-type sugar puckering, trans-3',4'-BNA monomer"Tetrahedron Lett.. 43・24. 4365-4368 (2002)

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      2002 Annual Research Report
  • [Publications] S.Obika: "Synthesis and conformation of 3',4'-BNA monomers, 3'-O, 4'-C methyleneribonucleosides"Tetrahedron. 58・15. 3093-3049 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Hari: "Effecttive synthesis of C-nucleosides with 2',4'-BNA modification"Tetrahedron. 58・15. 3051-3063 (2002)

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      2002 Annual Research Report
  • [Publications] M.Yoshikawa: "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4"Gene. 293・1-2. 67-75 (2002)

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      2002 Annual Research Report
  • [Publications] H.Yabuuchi: "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver"Biochem.Biophys.Res.Commun.. 299・3. 410-417 (2002)

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      2002 Annual Research Report
  • [Publications] H.Shimizu: "Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12"Gene. (印刷中).

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      2002 Annual Research Report
  • [Publications] Y.Hosaka: "α1-synthrophin-deficient skeletal muscle exhibits hypertrophy and aberrant formation of neuromuscular junctions during regeneration"J.Cell.Biol.. 158・6. 1097-1107 (2002)

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      2002 Annual Research Report
  • [Publications] M.Sakamoto: "Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgene"Biochem.Biophys.Res.Commun.. 293・4. 1265-1272 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Yamaguchi: "G12 and G13 interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity"Curr.Biol.. 12・15. 1353-1358 (2002)

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      2002 Annual Research Report
  • [Publications] M.Negishi: "Rho family GTPases as key regulators for neuronal network formation"J.Biochem.(Tokyo). 132・2. 157-166 (2002)

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      2002 Annual Research Report
  • [Publications] K.Nakamura: "The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area"J.Neurosci.. 22・11. 4600-4610 (2002)

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      2002 Annual Research Report
  • [Publications] H.Okada: "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response"Biochem.J.. 366・Pt2. 585-594 (2002)

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      2002 Annual Research Report
  • [Publications] A.Mouihate: "Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus"Am.J.Physiol.Regul.Integr.Comp.Physiol.. 283・3. R800-805 (2002)

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      2002 Annual Research Report
  • [Publications] H.Katoh: "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers"Mol.Cell.Biol.. 22・9. 2952-2964 (2002)

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      2002 Annual Research Report
  • [Publications] H.Tanaka: "Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2"Biochem.J.. 365・Pt2. 349-353 (2002)

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      2002 Annual Research Report
  • [Publications] N.Hatae: "Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner"Biochem.Biophys.Res.Commun.. 290・1. 162-168 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Hippo: "Global gene expression analysis of gastric cancer by oligonucleotide microarrays"Cancer Research. 62・1. 233-240 (2002)

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      2002 Annual Research Report
  • [Publications] A.Mukasa: "Distinction in gene expression profiles of oligodendrogliomas with and without alleic loss of 1p"Oncogene. 21・25. 3961-3968 (2002)

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      2002 Annual Research Report
  • [Publications] T.Ota: "Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells"J.Cell.Physiol.. 193・3. 299-318 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Fujiwara: "Influence of polyunsaturated fatty acid on gene expression in HepG2 cells"J.Anteroscler.Thromb.. 9・3. 157-162 (2002)

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      2002 Annual Research Report
  • [Publications] J.M.Chong: "Interleukin-1 beta Expression in Human Gastric Carcinoma with Epstein-Barr Virus Infection"J.Virol.. 76・13. 6825-6831 (2002)

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      2002 Annual Research Report
  • [Publications] A.Saiura: "Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gammma by means of DNA microarray 1"Transplantation. 73・9. 1480-1486 (2002)

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      2002 Annual Research Report
  • [Publications] Y.Midorikawa: "Identification of genes associated with de differentiation of hepatocellular carcinoma with expression profiling analysis"Jpn.J.Cancer Res.. 93・6. 636-643 (2002)

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      2002 Annual Research Report
  • [Publications] M.Takahashi: "Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production"Am.J.Physiol.Gastrointest Liver Physiol.. 282・2. G338-348 (2002)

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      2002 Annual Research Report
  • [Publications] T.Nakamura: "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules"Mol.Cell Biol.. 22・24. 8721-8734 (2002)

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      2002 Annual Research Report
  • [Publications] T.Nakazawa: "Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development : potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation"J.Neurosci.Res.. 68・6. 668-680 (2002)

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      2002 Annual Research Report
  • [Publications] T.Nakamura: "Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules"Oncogene. 21・1. 22-31 (2002)

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      2002 Annual Research Report
  • [Publications] T.Muratani: "Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide monohydrochloride"J.Pharamocol.Exp.ther.. 303・1. 424-430 (2002)

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      2002 Annual Research Report
  • [Publications] M-R.Zhang: "Development of an automated system for synthesizing ^<18>F-labeled compounds using [^<18>F]fluoroethyl bromide as a synthetic precursor"Appl.Radiat.Isot.. 57・3. 335-342 (2002)

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      2002 Annual Research Report
  • [Publications] M-R.Zhang: "Synthesis and preliminary evaluation of [^<18>F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo"Nucl.Med.Biol.. 29・4. 463-468 (2002)

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      2002 Annual Research Report
  • [Publications] H.Tsukada: "Comparative effects of methamphetamine and nicotine on the striatal [^<11>C]raclopride binding in unanesthetized monkeys"Synapse. 45・4. 207-212 (2002)

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      2002 Annual Research Report
  • [Publications] N.Harada: "Age-related changes in the striatal dopaminergic system in the living brain : a multiparametric PET study in conscious monkeys"Synapse. 45・1. 38-45 (2002)

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      2002 Annual Research Report
  • [Publications] N.Harada: "Age differences in phosphodiesterase type-IV and its functional response to dopamine D_1 receptor modulation in the living brain : a PET study in conscious monkeys"Synapse. 44・3. 139-145 (2002)

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      2002 Annual Research Report
  • [Publications] K.Sakurada: "Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC21 cells stimulated with bradykinin"J.Biol.Chem.. 277・47. 45473-45479 (2002)

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      2002 Annual Research Report
  • [Publications] T.Satoh: "Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins"J.Neurochem. 77・1. 50-62 (2001)

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      2001 Annual Research Report
  • [Publications] S.Fukushima: "Antitumor activity, optimum administration method and pharmacokinetics of 13,14-dihydro-15-deoxy-Δ^7-prostaglandin A_1 methyl ester (TEI-9826) integrated in lipid microspheres (Lipo TEI-9826)"Anticancer Drugs. 12・3. 221-234 (2001)

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      2001 Annual Research Report
  • [Publications] T.Ikemoto: "Effects of dantrolene and its derivatives on Ca^<2+> from the sarcoplasmic reticulum of mouse skeletal muscle fibres"Br.J.Pharmacol.. 134・4. 729-736 (2001)

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      2001 Annual Research Report
  • [Publications] Y.Sasaki: "NOVEL AND SPECIFIC Rho-KINASE INHBITOR, H1152P, DIRECTED AGAINST THE Rho-KINASE INVOLVED PATHWAY"CELL.MOL.BIOL.LETT.. 6・2B. 506 (2001)

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      2001 Annual Research Report
  • [Publications] 鈴木正昭: "陽電子放射断層画像撮影法(PET法)によるヒト脳機能分析のための高次プロスタグランジン(PG)プローブの創製"ファルマシア. 37・11. 994-998 (2001)

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      2001 Annual Research Report
  • [Publications] T.Takamatsu: "Specific ligand for a central type prostacyclin receptor attenuates damage in a rat model of focal cerebral ischemia"Brain Research. 925・2. 176-182 (2002)

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      2001 Annual Research Report
  • [Publications] S.Shuto: "Total synthesis of cyclic ADP-carbocyclic-ribose, a stable mimic of Ca^<2+>-mobilizing second messenger cyclic ADP-ribose"J.Am.Chem.Soc.. 123・36. 8750-8759 (2001)

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      2001 Annual Research Report
  • [Publications] T.Usui: "Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase : implications for the molecular mechanism of the inhibition"Chem.& Biol.. 8・12. 1209-1220 (2001)

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      2001 Annual Research Report
  • [Publications] M.Sodeoka: "Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition"J.Med.Chem.. 44・20. 3216-3222 (2001)

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      2001 Annual Research Report
  • [Publications] M.Sodeoka: "Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography"Chem.Pharm.Bull.. 49・2. 206-212 (2001)

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      2001 Annual Research Report
  • [Publications] S.Motoori: "Overexpression of Mitochondrial Manganese Superoxide Dismutase Protects Againt Radiation-Induced Cell Death in Human Hepatocellular Carcinoma Cell Line, HLE"Cancer Research. 61・14. 5382-5388 (2001)

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      2001 Annual Research Report
  • [Publications] M.Wada: "Synthesis and Optical Properties of a New-Class of Pyrromethene-BF_2 complex Fused with Rigid Bicycle Rings and Benzo Derivatives"Tetrahedron Letters. 42・38. 6711-6713 (2001)

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      2001 Annual Research Report
  • [Publications] N.Suzuki: "Orthogonality of Calcium Concentration and Ability of 4, 5-Diaminofluorescein (DAF-2) to Detect NO"J.Biol.Chem.. 277・1. 47-49 (2002)

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      2001 Annual Research Report
  • [Publications] Ye Hashimoto: "Structural development of biological response modifiers based on thalidomide"Bioorg.Med.Chem.. 10・3. 461-479 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Sou: "α-Gluctural inhibitors with a 4, 5, 6, 7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecarborane group"Chem.Pharm.Bull.. 49・6. 791-793 (2001)

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      2001 Annual Research Report
  • [Publications] T.Kita: "Thymidine phosphorylase inhibitors with a homophthalimide skeleton"Biol.Pharm.Bull.. 24・7. 860-862 (2001)

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      2001 Annual Research Report
  • [Publications] H.Kakuta: "Aminopeptidase inhibitors : 3-(2, 6-diethylphenyl)-2,4(1H, 3H)-quinazolinedione and N-(2, 6-diethylphenyl)-2-amini-4H-3, 1-benzoxazin-3-one"Heterocycles. 55. 1433-1438 (2001)

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      2001 Annual Research Report
  • [Publications] S.Akashi: "Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition"Int Immunol.. 13・12. 1595-1599 (2001)

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      2001 Annual Research Report
  • [Publications] Y.Fukase: "New Efficient Route for Synthesis of Lipid A by using Affinity Separation"Synlett. 11. 1693-1698 (2001)

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      2001 Annual Research Report
  • [Publications] Y.Shigeri: "Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)"J.Neurochem. 79・2. 297-302 (2001)

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      2001 Annual Research Report
  • [Publications] M.Ebisawa: "Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure"Chem.Pharm.Bull.. 49・4. 501-503 (2001)

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      2001 Annual Research Report
  • [Publications] Y.Endo: "Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal acitivity and conformation of two aromatic nuclei"Bioorg.Med.Chem.Lett.. 11・10. 1307-1311 (2001)

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      2001 Annual Research Report
  • [Publications] T.Yamauchi: "Replenishment of the fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity"Nature Medicine. 7・8. 941-946 (2001)

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      2001 Annual Research Report
  • [Publications] T.Yamauchi: "Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes"J.Clin.Invest.. 108・7. 1001-1013 (2001)

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      2001 Annual Research Report
  • [Publications] H.Torigoe: "Promotion of triplex formation by 2'-O, 4'-C-methilene bridged nucleic acid (2', 4'-BNA) modification : thermodynamic and kinetic studies"Nucleosides Nucleotides Nucleic Acids.. 20・4-7. 1235-1238 (2001)

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  • [Publications] S.Obika: "2'-O, 4'-C-Methylene bridged nucleic acid (2', 4'-BNA ) : synthesis and tripllex-forming properties"Bioorg.Med.Chem.. 9・4. 1001-1011 (2001)

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  • [Publications] S.Obika: "A 2', 4'-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase : Efficient Recognition of a C・G Interruption by Triplex Formation with a Pyrimidine Motif"Angew.Chem.Int.Ed.Engi.. 40・11. 2079-2081 (2001)

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  • [Publications] 石川智久: "ゲノム創薬に何が必要か?"現代化学. 11月. 56-60 (2001)

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  • [Publications] T.Ikemoto: "Properties of Ca^<2+> release induced by clofibiric acid in the sarcoplasmic reticulum of mouse skeletal muscle fibres"Br.J.Pharmacol.. 134・4. 719-728 (2001)

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  • [Publications] K.Nakamura: "Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups : a double immunofluorescence study in the rat brain"Neuroscience. 103・3. 763-775 (2001)

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  • [Publications] S.Akiyoshi: "Targets of transcriptional regulation by transforming growth factor-beta : Expression profile analysis using oligonucleotide arrays"Jpn.J.Cancer Res.. 92・3. 257-268 (2001)

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  • [Publications] Y.Hippo: "Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes"Cancer Res.. 61・3. 889-895 (2001)

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  • [Publications] T.Kamimoto: "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1"J.Biol.Chem.. 276・40. 37520-37528 (2001)

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  • [Publications] T.Kojima: "Cloning of Human PRP4 Reveals Interaction with Clk1"J.Biol.Chem.. 276・34. 32247-32256 (2001)

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  • [Publications] M.Osada: "Regulatory Domain of Protein Stability of Human P51/TAP63, a P53 Homologue"Biochem.& Biophys.Res.Comm.. 283・5. 1135-1141 (2001)

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  • [Publications] S.Aritani: "Dual roles of RNA helicase A in CREB-dependent transcription"Mol.Cell Biol.. 21・14. 4460-4469 (2001)

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  • [Publications] H.R.Ueda: "Robust oscillations within the interlocked feedback model of drosophila circadian rhythm"J.Theo.Biol.. 210・4. 401-406 (2001)

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  • [Publications] S.Maekawa: "Localization of neuronal growth-associated, microtubule-destabilizing factor SCG1O in brain-derived raft membrane microdomains"J.Biochem.. 129・5. 691-697 (2001)

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  • [Publications] M.Chida: "[^<18>F] labeled diacylglycerol analogue as potential agent to trace myocardial phosphoinositide metabolism"Nucl.Med.Biology. 28・7. 815-819 (2001)

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  • [Publications] T.Valdes-Gonzalez: "Neuropeptides interact with glycolipid receptors : A surface plasmon resonance study"Peptides. 22・7. 1099-1106 (2001)

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  • [Publications] H.Tsukada: "Age differences in muscarinic cholinergic receptor assayed with (+)N-[(11)C]methyl-3-piperidyl benzilate in the brains of consious monkeys"Synapse. 41・3. 248-257 (2001)

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  • [Publications] T.Kakiuchi: "Age-related changes in muscarinic cholinergic receptors in the living brain : a PET study using N-[^<11>C]methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys"Brain Res.. 916・1-2. 22-31 (2001)

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  • [Publications] H.Tsukada: "Effects of aging on 5-HT(1A) receptors and their functional response to 5-HT(1a) agonist in the living brain : PET study with [carbonyl-(11)C]WAY-100635 in conscious monkeys"Synapse. 42・4. 242-251 (2001)

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  • [Publications] T.Kakiuchi: "Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain : PET study with"Synapse. 40・3. 170-179 (2001)

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Published: 2002-04-01   Modified: 2016-04-21  

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