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Elucidation and conquest of S. aureus antibiotic resistance based on the whole genome sequence information

Research Project

Project/Area Number 14021113
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research Institutionuntendo University

Principal Investigator

HIRAMATSU Keiichi  Juntendo University, School of Medicine, Professor, 医学部, 教授 (10173262)

Co-Investigator(Kenkyū-buntansha) 黒田 誠  順天堂大学, 医学部, 助手 (80317411)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥65,000,000 (Direct Cost: ¥65,000,000)
Fiscal Year 2005: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2004: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2003: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2002: ¥19,000,000 (Direct Cost: ¥19,000,000)
KeywordsMRSA / Vancomycin resistance / SCC / oriC environ / clogging of peptidoglycan / Staphylococcus aureus / Staphylococcus haemolvticus / Whole eenome seauencine / トランスクリプトーム / 耐性菌 / SCCmec / 肺炎 / 敗血症
Research Abstract

1) Novel mechanism of glycopeptide resistance of Vancomycin-Intermediate S.aureus (VISA)
We used experimental and mathematical approach to prove Clogging mechanim of vancomycin resistance.
2) Indentification of novel genes which are responsible for glycopeptide resistance of Staphylococcus aureus. Two component systems vraSR and graSR are involved in the mechanism.
3) Identification of a novel chromosomal region " oriC environ" where alien genes are accumulated presumably by SCC (Staphylcoccal cassette chromosome)-mediated horizontal gene transfer. We proposed that the region is directly involved in the evolution and speciation of Staphylococcus species.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (70 results)

All 2006 2005 2004 Other

All Journal Article (49 results) Publications (21 results)

  • [Journal Article] Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.2006

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother. 50.3

      Pages: 1079-1082

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus.2006

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother. 50.2

      Pages: 428-438

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cross-resistance of vancomycin-intermediate Staphylococcus aureus to daptomycin and vancomycin.2006

    • Author(s)
      Cui L, Tominaga E, Neoh Hui-min, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother 50

      Pages: 1079-1082

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel Mechanism of Antibiotic Resistance Originating in Vancomycin-Intermediate Staphylococcus aureus2006

    • Author(s)
      Cui L, Iwamoto A, Lian J-Q, Neoh Hui-min, Maruyama T, Horikawa Y, Hiramatsu K.
    • Journal Title

      AAC 50

      Pages: 428-438

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus2006

    • Author(s)
      Cui L
    • Journal Title

      Antimicrob Agents Chemother 50(3)

      Pages: 1079-1082

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus.2005

    • Author(s)
      Watanabe S, et al.
    • Journal Title

      J Bacteriol. 187.11

      Pages: 3698-3707

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay.2005

    • Author(s)
      Ma XX, et al.
    • Journal Title

      Emerg Infect Dis. 11.6

      Pages: 973-976

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children.2005

    • Author(s)
      Hisata K, et al.
    • Journal Title

      J Clin Microbiol. 43.7

      Pages: 3364-3372

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant staphylococcus aureus in a Turkish university hospital : brief report of a surveillance study2005

    • Author(s)
      Torun MM, et al.
    • Journal Title

      International Journal of Antimicrobial Agents 26.6

      Pages: 508-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic Differentiation of Methicillin-Resistant Staphylococcus aureus Strains from Korea and Japan2005

    • Author(s)
      Kwan Soo Ko, et al.
    • Journal Title

      Microbial Drug Resistance 11.3

      Pages: 279-286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DNA micro array-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.2005

    • Author(s)
      Cui L, et al.
    • Journal Title

      Antimicrob Agents Chemother 49.8

      Pages: 3404-3413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antibacterial Activity of Dipropofol and Related Compounds2005

    • Author(s)
      Ogata M, et al.
    • Journal Title

      Biological & Pharmaceutical Bulletin 28.6

      Pages: 1120-1122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacΑ/Βand smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 19992005

    • Author(s)
      Noguchi N, et al.
    • Journal Title

      J Med Microbiol 54

      Pages: 557-565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.2005

    • Author(s)
      Takeuchi F.
    • Journal Title

      J Bacteriol. 187.21

      Pages: 7292-7308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 臨床分離株に対するdoripenenの抗菌力2005

    • Author(s)
      桑原京子 他
    • Journal Title

      日本化学療法誌 53.S-1

      Pages: 17-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital : brief report of a surveillance study.2005

    • Author(s)
      Torun MM, Bahar H, Demirci M, Altas K, Bagdatli Y, Kocazeybek B, Kapi M, Hiramatsu K.
    • Journal Title

      Int J Antimicrob Agents. 26

      Pages: 508-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heterogeneous vancomy cin-resistant Staphylococcus aureus (hetero-VISA) in Singapore.2005

    • Author(s)
      Sng LH, Koh TH, Wang GC, Hsu LY, Kapi M, Hiramatsu K.
    • Journal Title

      Int J Antimicrob Agents. 25

      Pages: 177-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan.2005

    • Author(s)
      Soo Ko K, Peck KR, Sup Oh W, Lee NY, Hiramatsu K, Song JH.
    • Journal Title

      Microb Drug Resist. 11

      Pages: 279-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.2005

    • Author(s)
      Cui L, Lian JQ, Neoh HM, Reyes E, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother. 49

      Pages: 3404-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children.2005

    • Author(s)
      Hisata K, Kuwahara-Arai K, Yamanoto M, Ito T, Nakatomi Y, Cui L, Baba T, Terasawa M, Sotozono C, Kinoshita S, Yamashiro Y, Hiramatsu K.
    • Journal Title

      J Clin Microbiol. 43

      Pages: 3364-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus,Uruguay.2005

    • Author(s)
      Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Lope L, Benaderet S, Buela F, Vincentino W, Albini M, Bertaux 0, Constenla I, Bagnulo H, Llosa L, Ito T, Hiramatsu K.
    • Journal Title

      Emerg Infect Dis.Erratum in : Emerg Infect Dis 1111

      Pages: 973-61329

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antibacterial activity of dipropofol and related compounds.2005

    • Author(s)
      Ogata M, Tutumimoto Sato K, Kunikane T, Oka K, Seki M, Urano S, Hiramatsu K, Endo T.
    • Journal Title

      Biol Pharm Bull. 28

      Pages: 1120-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus.2005

    • Author(s)
      Watanabe S, Ito T, Takeuchi F, Endo M, Okuno E, Hiramatsu K.
    • Journal Title

      J Bacteriol. 187

      Pages: 3698-707

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin- resistant Staphylococcus aureus isolated in Asia during 1998 and 1999.2005

    • Author(s)
      Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, Song JH.
    • Journal Title

      J Med Microbiol. 54

      Pages: 557-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.2005

    • Author(s)
      Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K.
    • Journal Title

      J Bacteriol. 187

      Pages: 7292-308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.2005

    • Author(s)
      Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M.
    • Journal Title

      Inflamm Res. 54

      Pages: 66-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus2005

    • Author(s)
      Watanabe S
    • Journal Title

      J Bacteriol 187(11)

      Pages: 3698-3707

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay2005

    • Author(s)
      Ma XX
    • Journal Title

      Emerg Infect Dis. 11(6)

      Pages: 973-976

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dissemination of methicillin-resistant staphylococci among healthy Japanese children2005

    • Author(s)
      Hisata K
    • Journal Title

      J Clin Microbiol 43(7)

      Pages: 3364-3372

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital : brief report of a surveillance study2005

    • Author(s)
      Torun MM
    • Journal Title

      Int J Antimicrob Agents 26(6)

      Pages: 508-510

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan2005

    • Author(s)
      Soo Ko K
    • Journal Title

      Microb Drug Resist 11(3)

      Pages: 279-286

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus2005

    • Author(s)
      Cui L
    • Journal Title

      Antimicrob Agents Chemother 49(8)

      Pages: 3404-3413

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antibacterial activity of dipropofol and related compounds2005

    • Author(s)
      Ogata M
    • Journal Title

      Biol Pharm Bull 28(6)

      Pages: 1120-1122

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 19992005

    • Author(s)
      Noguchi N
    • Journal Title

      J Med Microbiol 54(Pt 6)

      Pages: 557-565

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species2005

    • Author(s)
      Takeuchi F
    • Journal Title

      J Bacteriol 187(21)

      Pages: 7292-7308

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 臨床分離株に対するdoripenemの抗菌力2005

    • Author(s)
      桑原京子
    • Journal Title

      日本化学療法雑誌 53(S-1)

      Pages: 17-23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel Mechanism of Antibiotic Resistance Originating in Vancomycin-Intermediate Staphylococcus aureus2005

    • Author(s)
      Cui L
    • Journal Title

      Antimicrob Agents Chemother 50(2)

      Pages: 428-438

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Advance in Vancomycin Resistance : Research in Staphylococcus aureus2005

    • Author(s)
      Hiramatsu K. et al.
    • Journal Title

      Anti-infective Drug Discovery (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic characterization of methicillin-resistant Staphylococcus aureus.2004

    • Author(s)
      Hiramatsu K, Watanabe S, Takeuchi F, Ito T, Baba T.
    • Journal Title

      Vaccine. 22 Suppl

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asian Network for Surveillance of Resistant Pathogens Study Group. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin.2004

    • Author(s)
      Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, Kiem S, Kim YS, Oh WS, Peck KR, Lee NY
    • Journal Title

      Antimicrob Agents Chemother 48

      Pages: 4926-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Has vancomycin-resistant Staphylococcus aureus started going it alone?2004

    • Author(s)
      Hiramatsu K, Cui L, Kuwahara-Arai K.
    • Journal Title

      Lancet. 364

      Pages: 565-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.2004

    • Author(s)
      Ito T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K.
    • Journal Title

      Antimicrob Agents Chemother 48

      Pages: 2637-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315.2004

    • Author(s)
      Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H.
    • Journal Title

      DNA Res. 29

      Pages: 51-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Emergence in Asian Countries of Staphylococcus aureus with Reduced Susceptibility to Vancomycin.2004

    • Author(s)
      Song JH. et al.
    • Journal Title

      Antimicrob Agents Chemother. 48(12)

      Pages: 4926-4928

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.2004

    • Author(s)
      Ito T.et al.
    • Journal Title

      Antimicrob Agents Chemother. 48(7)

      Pages: 2637-2651

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Has vancomycin-resistant Staphylococcus aureus started going it alone?2004

    • Author(s)
      Hiramatsu K. et al.
    • Journal Title

      Lancet 364(9434)

      Pages: 565-566

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiwan.2004

    • Author(s)
      Wang JL. et al.
    • Journal Title

      Emerg Infect Dis. 10(9)

      Pages: 1702-1704

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genome sequencing and annotation : an overview.2004

    • Author(s)
      Kuroda M. et al.
    • Journal Title

      Methods Mol Biol. 266

      Pages: 29-45

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic characterization of methicillin-resistant Staphylococcus aureus.2004

    • Author(s)
      Hiramatsu K. et al.
    • Journal Title

      Vaccine 22

    • Related Report
      2004 Annual Research Report
  • [Publications] Ito, T., et al.: "Insights on Antibiotic Resistance of Staphylococcus aureus from its Whole Genome : Genomic Island SCC"Drug Res.Updates. 6. 41-52 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Cui, L., et al.: "Cell Wall Thickening Is a Common Feature of Vancomycin Resistance in Staphylococcus aureus"J.Clin.Microbiol.. 41. 5-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshida, R., et al.: "Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance"J Antimicrob Chemother. 51. 247-255 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Katayama, Y., et al.: "Identification in a methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec (SCCmec) of methicillin-resistant Staphylococcus aureus."J.Bacteriol.. 185. 2711-2722 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Isnansetyo, A., et al.: "Antibacterial activity of 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus (VRSA)"Int J Antimicrob Agents. 22. 545-547 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuroda, M., et al.: "Two-component system VraSR positively modulates the regulation of cell wall biosynthesis pathway in Staphylococcus aureus"Molecular Microbiol. 49. 807-821 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Cui, L.et al.: "Vancomycin-resistant Staphylococcus aureus."Horizon Scientific Press. 340 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuroda, M. et al.: "Genomics, Proteomics and Clinical Bacteriology."Humana Press. 320 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Baba, T. et al.: "The Genome of Staphylococcus aureus."Eliis Harwood (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiramatsu, K.: "Elucidation of the mechanism of antibiotic resistance acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and determination of its whole genome nucleotide sequence"Jap Med Assoc J. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiramatsu, K., et al.: "The Staphylococcus aureus model"ASM Press (In Press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiramatsu, K.et al.: "Molecular Genetics of Methicillin-Resistant Staphylococcus aureus"Int J Med Microbiol. 292. 67-74 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yashida, R.et al.: "Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance"J Antimicrob Chemother. 51. 247-255 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Baba, T.et al.: "Genome and virulence determinants of high virulence community-acquired MRSA"Lancet.. 359. 1819-1827 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] van der Zwet W.C.et al.: "Nosocomial spread of a Staphylococcus capitis strain with hetero-resistance to vancmycin in a neonatal intensive care unit"J.Clin.Microbiol. 40. 2520-2525 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ma X X.et al.: "A novel type of staphylococcal cassette chromsome mec (SCCmec) identified in community-acquired methicillin-resistant Staphylococcus aureus strains"Antimicrob.Agents.Chemother. 46. 1147-1152 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okuma K.et al.: "Dissemination of New MRSA Clones in the Community"J.Clin.Microbiol. 40. 4289-4294 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Daum, R.S.et al.: "A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic"J Infect Dis.. 186. 1344-1347 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiramatsu, K.et al.: "New trends in Staphylococcus aureus infections : glycopeptide resistance in hospital and methicillin resistance in community"Current Opinion in Infections Diseases. 15. 407-413 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuroda, M.et al.: "Genome sequencing and annotation : an overview in Johnson, A.,and Woodford, N., et.,Genomics, Proteomics and Clinical Bacteriology"Humana Press.(in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiramatsu, K.et al.: "Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections : The Staphylococcus aureus model"ASM press(in press).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2018-03-28  

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