Structural and functional study of translation apparatus from the viewpoint of molecular mimicry and prion transmission

• Project/Area Number: 14035207
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAMURA Yoshikazu The University of Tokyo, Institute of Medical Science, Professor (40114590)
• Project Period (FY): 2002 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥130,900,000 (Direct Cost: ¥130,900,000); Fiscal Year 2006: ¥30,200,000 (Direct Cost: ¥30,200,000); Fiscal Year 2005: ¥30,200,000 (Direct Cost: ¥30,200,000); Fiscal Year 2004: ¥23,500,000 (Direct Cost: ¥23,500,000); Fiscal Year 2003: ¥23,500,000 (Direct Cost: ¥23,500,000); Fiscal Year 2002: ¥23,500,000 (Direct Cost: ¥23,500,000)
• Keywords: molecular mimicry / translation termination / release factor / peptide anticodon / stop codon / ribosome recycling factor / yeast prion / ribosome / 解離因子 / 翻訳調節

Research Abstract

Recent molecular and structural studies including those from this laboratory have revealed that proteins called translation factors mimic the shape of tRNA. One of them, a polypeptide release factor (RF), encodes a tripeptide that serves as an ‘anticodon' to decipher stop codons in mRNA. These findings let us to propose the novel concept of macromolecular mimicry between protein and RNA. Moreover, The [PSI^+] element of budding yeast represents the prion conformation of translation release factor eRF3 that is propagated and transmitted in the cytoplasm. On many levels, yeast prions are analogous to mammalian prions and much interest lies in understanding how prions are able to generate variation in isogenic strains. We have investigated RFs and ribosome-recycling-factor (RRF) from the viewpoint of molecular mimicry and prion transmission, and uncovered the following aspects.
1) Crystal structure and functional domain annotation of S. Pombe eRF3.
2) Functional interplay of EF-G and RRF at their tRNA-mimicry domains.
3) The critical role of the universally conserved A2602 of 23S rRNA for the peptide-release activity.
4) Part of the prion domain of yeast eRF3 masks the eRF3-binding site in eRF1.
5) The role of ribosomal protein L11 domains for the cooperative interaction with RF1 and RF2, responsible for translation termination.
6) The role of nonprion-state N-terminal domain of yeast eRF3 for functionality and stability of eRF3.
7) RRF disassembles the posttermination ribosomal complex independent of the ribosomal translocase activity of EF-G.
8) Discovery of a novel [PSI^+] prion variant that is independent of Hsp104.
9) Conformational memory preserved in a weak-to-strong or strong-to-weak [PSI^+] conversion during transmission to Sup35 prion variants.
10) The N-terminal 41-residue domain of S. cerevisiae Sup35 is a species-barrier determinant for [PSI^+] prion transmission.
11) Genome-wide screening and genetic selection for factors, including Hsp104 and other novel components, responsible for the maintenance of yeast prions.

Research Products

• [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. (2008)
  • Author(s): Wang, J, Takeuchi H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T., Suzumura. A.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 105 Pages: 3915-3920
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Selection of a novel class of RNA-RNA interaction motifs based on the ligase ribozyme with defined modular architecture. (2008)
  • Author(s): Ohuchi, S. P., Ikawa, Y., Nakamura, Y.
  • Journal Title: Nucl. Acids. Res. (May 6[Epub ahead of print])
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G. (2008)
  • Author(s): Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
  • Journal Title: RNA (Apr 25[Epub ahead of print])
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A regulatory role of the Rnq1 non-prion domain for prion propagation and polyglutamine aggregates. (2008)
  • Author(s): Kurahashi, H., Ishiwata, M., Shibata, S., Nakamura, Y.
  • Journal Title: Mol. Cell. Biol. 28 Pages: 3313-3323
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Translation termination, the prion [psr」, and ribosome recycling. ln : Sonenberg N, Hershey JWB, Mathews MB, eds. (2007)
  • Author(s): Ehrenberg, M., Hautyliuk V., Crist C. G., Nakamura, Y.
  • Journal Title: Translational Control in Biology and Medicine. Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press. Pages: 173-196
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RNA aptamers targeting the C-terminal of KRAS oncoprotein generated by an improved SELEX with isothermal RNA amplification (2007)
  • Author(s): Tanaka, Y., Akagi, K., Nakamura, Y., Kozu, T.
  • Journal Title: Oligonucleotides 17 Pages: 12-21
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human and mouse protein non-coding snoRNA host genes with dissimilar nucleotide sequences show ehromosomal synteny. (2007)
  • Author(s): Tanaka-Fujita, R., Soeno, Y., Satoh, H., Nakamura, Y., Mori, S.
  • Journal Title: RNA 13 Pages: 811-816
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Reduced activity or expression of polypeptide release factors induces mRNA cleavage and tmRNA tagging at, stop codons in E. coli. (2007)
  • Author(s): Li, X., Yokota, T., Ito, K., Nakamura, Y., Aiba, H.
  • Journal Title: Mol. Micro. 63 Pages: 116-126
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Channel mutations in Hsp104 hexamer distinctively affect thermotolerance and prion-specific propagation. (2007)
  • Author(s): Kurahashi, H., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 63 Pages: 1669-1683
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae. (2007)
  • Author(s): Kodama, H., Ito, K., Nakamura, Y.
  • Journal Title: Genes Cells 12 Pages: 639-650
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A systematic evaluation of the function of the protein-remodeling fact or HsplO104n [PSI^+] prion propagation in S. cerevisiae by comprehensive chromosomal mutations. (2007)
  • Author(s): Takahashi, A., Hara, H., Kurahashi, H., Nakamura, Y.
  • Journal Title: Prion 1 Pages: 69-77
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Translation termination, the prion [PSI^+], and ribosome recycling. (2007)
  • Author(s): Ehrenberg, M., Hauryliuk V., Crist C. G., Nakamura, Y.
  • Journal Title: In : Sonenberg N, Hershey JWB, Mathews MB, eds. Translational Control in Biology and Medicine. Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press Pages: 173-196
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] RNA aptamers targeting the C-terminal of KRAS oncoprotein generated by an improved SELEX with isothermal RNA amplification. (2007)
  • Author(s): Tanaka, Y., Akagi, K., Nakamura, Y., Kozu, T.
  • Journal Title: Oligonucleotides 17 Pages: 12-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human and mouse protein non-coding snoRNA host genes with dissimilar nucleotide sequences show chromosomal synteny. (2007)
  • Author(s): Tanaka-Fujita, R., Soeno, Y., Satoh, H., Nakamura, Y., Mori, S.
  • Journal Title: RNA (In Press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reduced activity or expression of polypeptide release factors induces mRNA cleavage and tmRNA tagging at stop codons in E. coli. (2007)
  • Author(s): Li, X., Yokota, T., Ito, K., Nakamura, Y., Aiba, H.
  • Journal Title: Mol. Micro. 63 Pages: 116-126
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A systematic evaluation of the function of the protein-remodeling factor Hsp104 in [PSI^+] prion propagation in S. cerevisiae by comprehensive chromosomal mutations. (2007)
  • Author(s): Takahashi, A., Hara, H., Kurahashi, H., Nakamura, Y.
  • Journal Title: Prion 1 Pages: 69-77
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Systematic Evaluation of the Function. of the Protein-Remodeling Factor Hsp104 in [PSI+] Prion Propagation in S. cerevisiae by Comprehensive Chromosomal Mutations. (2007)
  • Author(s): Takahashi, A., Hara, H., Kurahashi, H., Nakamura, Y.
  • Journal Title: Prion (In Press)
• [Journal Article] Translation termination, the prion [PSI^+], and ribosome recycling. In : Sonenberg N, Hershey JWB, Mathews MB, eds. Translational Control in Biology and Medicine. (2007)
  • Author(s): Ehrenberg, M., Hauryliuk V., Crist C.G., Nakamura, Y.
  • Journal Title: Cold Spring Harbor pp. (New York : Cold Spring Harbor Laboratory Press) Pages: 173-196
• [Journal Article] Human and mouse protein non-coding snoRNA host genes with dissimilar nucleotide sequences show chromosomal synteny. (2007)
  • Author(s): Tanaka-Fujita, R., Soeno, Y., Satoh H., Nakamura, Y., Mori, S.
  • Journal Title: RNA (In Press)
• [Journal Article] Reduced action of polypeptide release factors induces mRNA cleavage and tmRNA tagging at stop codons in Escherichia coli. (2007)
  • Author(s): Li, X., Yokota, T., Ito, K., Nakamura, Y., Aiba, H.
  • Journal Title: Mol. Micro. 63 Pages: 116-126
• [Journal Article] The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae. (2007)
  • Author(s): Kodama, H., Ito, K., Nakamura, Y.
  • Journal Title: Genes Cells (In Press)
• [Journal Article] 翻訳研究のダイナミズム (2007)
  • Author(s): 中村義一
  • Journal Title: 翻訳制御(実験医学)(中村義一 監修) 25 Pages: 2-4
• [Journal Article] RNA aptamers to mammalian initiation factor 4G inhibit cap- dependent translation by blocking the formation of initiation factor complexes. (2006)
  • Author(s): Miyakawa, S., Oguro, A., Ohtsu, T., Imataka, H., Sonenberg, N., Nakamura, Y.
  • Journal Title: RNA 12 Pages: 1825-1834
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ribosomal protein L1 1 mutations in two functional domains equally affect release factor l and 2 activity. (2006)
  • Author(s): Sato, H., Ito, K., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 60 Pages: 108-120
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cross-talk between RNA and prions. (2006)
  • Author(s): Crist, C. G., Nakamura, Y.
  • Journal Title: J. Biochem. 140 Pages: 167-173
  • NAID: 10018842764
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Selection of RNA aptamers against recombinant transforming growth factor-beta type III receptor displayed on cell surface. (2006)
  • Author(s): Ohuchi, S. P., Ohtsu, T., Nakamura, Y.
  • Journal Title: Biochimie 88 Pages: 897-904
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Conformation preserved in a weak-to-strong or strong-to-weak[psr]conversion during transmission to Sup35'prion variants. (2006)
  • Author(s): Crist, C. G., Kurahashi, H., Nakayashiki, T., Nakamura, Y.
  • Journal Title: Biochimie 88 Pages: 485-496
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes. (2006)
  • Author(s): Miyakawa, S., Oguro, A., Ohtsu, T., Imataka, H., Sonenberg, N., Nakamura, Y.
  • Journal Title: RNA 12 Pages: 1825-1834
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Conformation preserved in a weak-to-strong or strong-to-weak [PSI^+] conversion during transmission to Sup35 prion variants. (2006)
  • Author(s): Crist, C.G., Kurahashi, H., Nakayashiki, T., Nakamura,Y.
  • Journal Title: Biochimie 88 Pages: 485-496
• [Journal Article] Ribosomal protein L11 mutations in two functional domains equally affect release factor 1 and 2 activity. (2006)
  • Author(s): Sato, H., Ito, K., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 60 Pages: 108-120
• [Journal Article] Selection of RNA aptamers against recombinant transforming growth factor-beta type III receptor displayed on cell surface. (2006)
  • Author(s): Ohuchi, S.P., Ohtsu, T., Nakamura, Y.
  • Journal Title: Biochimie 88 Pages: 897-904
• [Journal Article] Cross-talk between RNA and prions. (2006)
  • Author(s): Crist, G.C., Nakamura, Y.
  • Journal Title: J. Biochem. (Tokyo) 140 Pages: 167-173
  • NAID: 10018842764
• [Journal Article] RNA科学概論 (2006)
  • Author(s): 中村義一
  • Journal Title: 遺伝子医学MOOK「RNAと創薬」(中村義一 監修)(メディカルドゥ) Pages: 23-30
• [Journal Article] RNA抗体としてのポテンシャル (2006)
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• [Journal Article] アプタマー工学 (2006)
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  • Journal Title: 遺伝子医学MOOK「RNAと創薬」(中村義一 監修)(メディカルドゥ) Pages: 32-38
• [Journal Article] リボザイム・テクノロジー (2006)
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• [Journal Article] 翻訳開始因子 (elF) の異常による癌化と創薬 (2006)
  • Author(s): 望月潔隆, 小黒明広, 中村義一
  • Journal Title: 遺伝子医学MOOK「RNAと創薬」(中村義一 監修)(メディカルドゥ) Pages: 195-201
• [Journal Article] 構造体として機能するRNA (2006)
  • Author(s): 大内将司
  • Journal Title: 実験医学 24 Pages: 800-804
• [Journal Article] RNAは擬態する (2006)
  • Author(s): 中村義一
  • Journal Title: 科学 76 Pages: 500-506
• [Journal Article] アプタマー医薬品 (2006)
  • Author(s): 藤原将寿, 宮川伸, 中村義一
  • Journal Title: BIO Clinica 21 Pages: 725-729
  • NAID: 130007884129
• [Journal Article] 核酸創薬 (2006)
  • Author(s): 藤原将寿, 宮川伸, 中村義一
  • Journal Title: バイオテクノロジージャーナル 6 Pages: 650-654
• [Journal Article] RNAルネッサンスー遺伝子新革命 (2006)
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  • Journal Title: 医薬経済社
• [Journal Article] アプタマー創薬 (2006)
  • Author(s): 藤原将寿, 宮川伸, 中村義一
  • Journal Title: ファルマシア 42 Pages: 1232-1236
  • NAID: 40015652174
• [Journal Article] 「RNAと疾患」監修序文 (2006)
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• [Journal Article] 酵母においてプリオン説は証明された (2006)
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• [Journal Article] 「RNAと生命」編集序文 (2006)
  • Author(s): 中村義一
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• [Journal Article] 桧舞台に躍り出たRNA (2006)
  • Author(s): 中村義一
  • Journal Title: 「RNAと生命」(蛋白質核酸酵素)(中村義一編集) 51 Pages: 2409-2412
• [Journal Article] アプタマー医薬 (2006)
  • Author(s): 宮川伸, 藤原将寿, 中村義一
  • Journal Title: 「RNAと生命」(蛋白質核酸酵素)(中村義一編集) 51 Pages: 2521-2527
• [Journal Article] 翻訳終結因子とプリオン (2006)
  • Author(s): 中村義一
  • Journal Title: 「RNAと生命」(蛋白質核酸酵素)(中村義一編集) 51 Pages: 2574-2582
• [Journal Article] Conformation preserved in a weak-to-strong or strong-to-weak [PSI^+] conversion during transmission to Sup35 prion variants. (2006)
  • Author(s): Crist C.G., Kurahashi, H., Nakayashiki, T., Nakamura, Y.
  • Journal Title: Biochimie (in press)
• [Journal Article] Ribosomal protein L11 mutations in two functional domains equally affect release factor 1 and 2 activity. (2006)
  • Author(s): Sato, H., Ito K., Nakamura, Y.
  • Journal Title: Mol.Microbiol. 60 Pages: 108-120
• [Journal Article] Selection of RNA aptamers against recombinant transforming growth factor-beta type III receptor displayed on cell surface. (2006)
  • Author(s): Ohuchi, S.P., Ohtsu, T., Nakamura, Y.
  • Journal Title: Biochimie (in press)
• [Journal Article] 翻訳開始因子(e1F)の異常による癌化と創薬 (2006)
  • Author(s): 望月潔隆, 小黒明広, 中村義一
  • Journal Title: 遺伝子医学MOOK「RNAと創薬」(中村義一 監修)(メディカルドゥ) Pages: 195-201
• [Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A. (2005)
  • Author(s): Sakamoto, T., Oguro, A., Kawai, G., Sonenberg, N., Ohtsu, T., Nakamura, Y.
  • Journal Title: Nucl. Acids Res. 33 Pages: 745-754
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. (2005)
  • Author(s): Mochizuki, K., Oguro, A., Ohtsu, T., Sonenberg, N., Nakamura, Y.
  • Journal Title: RNA 11 Pages: 77-89
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A. (2005)
  • Author(s): Sakamoto, T., Oguro, A., Kawai, G., Sonenberg, N., Ohtsu, T., Nakamura, Y.
  • Journal Title: Nucl.Acids Res. 33 Pages: 745-754
• [Journal Article] High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. (2005)
  • Author(s): Mochizuki K., Oguro A., Ohtsu, T., Sonenberg, N., Nakamura, Y.
  • Journal Title: RNA 11 Pages: 77-89
• [Journal Article] A novel method to generate aptamers against recombinant targets displayed on the cell surface. (2005)
  • Author(s): Ohuchi, S.P., Ohtsu, T., Nakamura, Y.
  • Journal Title: Nucl.Acids Symp.Series. 49 Pages: 351-352
• [Journal Article] 人工的な機能性核酸分子の創出 (2005)
  • Author(s): 大内将司, 中村義一
  • Journal Title: 臨床化学 34 Pages: 197-204
  • NAID: 10026892403
• [Journal Article] RNA入門 (2005)
  • Author(s): 中村義一
  • Journal Title: RNA工学の最前線(中村義一・大内将司 監修)(シーエムシー出版) Pages: 1-6
• [Journal Article] NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A. (2005)
  • Author(s): Sakamoto, T.
  • Journal Title: Nucl.Acids Res. 33 Pages: 745-754
• [Journal Article] High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. (2005)
  • Author(s): Mochizuki, K.
  • Journal Title: RNA 11 Pages: 77-89
• [Journal Article] Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. Pombe. (2004)
  • Author(s): Kong, C., Ito, K., Walsh, M., Wada, M., Liu, Y., Kumar, S., Barford, D., Nakamura, Y., Song, H.
  • Journal Title: Mol. Cell 14 Pages: 233-245
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ribosome recycling factor disassembles the posttermination ribosomal complex independent of the ribosomal translocase activity of elongation factor G. (2004)
  • Author(s): Fujiwara, T., Ito, K., Yamami, T., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 53 Pages: 517-28
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. Pombe. (2004)
  • Author(s): Kong, C, Ito, K., Walsh, M., Wada, M., Liu, Y., Kumar, S., Barford, D., Nakamura, Y., Song, H.
  • Journal Title: Mol. Cell 14 Pages: 233-245
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heterologous expression of Aquifex aeolicus ribosome recycling factor in Escherichia coli is dominant lethal by forming a complex that la cks functional coordination for ribosome disassembly. (2004)
  • Author(s): Yamami, T., Ito, K., Fujiwara, T., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 55 Pages: 150-161
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transient idling of posttermination ribosomes ready to reinitiate protein synthesis. (2004)
  • Author(s): Karamyshev, A. L., Karamysheva, Z. N., Ito, K., Nakamura, Y.
  • Journal Title: Biochimie 86 Pages: 933-938
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (2004)
  • Author(s): Kasashima, K., Nakamura, Y., Kozu, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 322 Pages: 403-410
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RNA aptamers selected against the receptor activator of NF-kappaB acquire general affinity to proteins of the tumor necrosis factor receptor family. (2004)
  • Author(s): Mori, T., Oguro, A., Ohtsu, T., Nakamura, Y.
  • Journal Title: Nucl. Acids Res. 32 Pages: 6120-6128
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. Pombe. (2004)
  • Author(s): Kong., C, Ito, K., Walsh, M., Wada, M., Liu, Y., Kumar, S., Barford, D., Nakamura, Y., Song, H.
  • Journal Title: Mol. Cell 14 Pages: 233-245
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heterologous expression of Aquifex aeolicus ribosome recycling factor in Escherichia coli is dominant lethal by forming a complex that lacks functional coordination for ribosome disassembly. (2004)
  • Author(s): Yamami, T., Ito, K., Fujiwara, T., Nakamura, Y.
  • Journal Title: Mol. Microbiol. 55 Pages: 150-161
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (2004)
  • Author(s): Kasashima, K., Nakamura, Y., Kozu, T.
  • Journal Title: Biochem. Biophys. Res. Commun 322 Pages: 403-410
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S.Pombe. (2004)
  • Author(s): Kong, C.
  • Journal Title: Mol.Cell 14 Pages: 233-245
• [Journal Article] Ribosome recycling factor disassembles s the posttermination ribosomal complex independent of the ribosomal translocase activity of elongation factor G. (2004)
  • Author(s): Fujiwara, T.
  • Journal Title: Mol.Microbiol. 53 Pages: 517-528
• [Journal Article] Heterologous expression of Aquifex aeolicus ribosome recycling factor in Escherichia coli is dominant lethal by forming a complex that lacks functional coordination for ribosome disassembly. (2004)
  • Author(s): Yamami, T.
  • Journal Title: Mol.Microbiol. 55 Pages: 150-161
• [Journal Article] Transient idling of posttermination ribosomes ready to reinitiate protein synthesis. (2004)
  • Author(s): Karamyshev, A.L.
  • Journal Title: Biochimie 86 Pages: 933-938
• [Journal Article] Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (2004)
  • Author(s): Kasashima, K.
  • Journal Title: Biochem.Biophys.Res.Commun. 322 Pages: 403-410
• [Journal Article] RNA aptamers selected against the receptor activator of NF-kappaB acquire general affinity to proteins of the tumor necrosis factor receptor family. (2004)
  • Author(s): Mori, T.
  • Journal Title: Nucl.Acids Res. 32 Pages: 6120-6128
• [Journal Article] RNAとゲノム・特集にあたって (2004)
  • Author(s): 中村義一
  • Journal Title: RNAとゲノム(中村義一編)、ゲノム医学 4 Pages: 360-361
• [Journal Article] RNAとゲノム・概論 (2004)
  • Author(s): 大内将司, 中村義一
  • Journal Title: RNAとゲノム(中村義一編)、ゲノム医学 4 Pages: 365-370
• [Journal Article] RNAルネッサンス (2004)
  • Author(s): 中村義一, 塩見春彦
  • Journal Title: 躍進するRNA研究(中村義一, 塩見春彦編)、実験医学 22 Pages: 2368-2377
• [Journal Article] RNAアプタマーの応用展開 (2004)
  • Author(s): 小黒明広, 中村義一
  • Journal Title: 躍進するRNA研究(中村義一, 塩見春彦編)、実験医学 22 Pages: 2529-2533
• [Journal Article] RNAとプリオン (2004)
  • Author(s): Colin G.Crist, 小玉裕之, 中村義一
  • Journal Title: 躍進するRNA研究(中村義一, 塩見春彦編)、実験医学 22 Pages: 2573-2581
• [Journal Article] 翻訳終結機構 (2004)
  • Author(s): 伊藤耕一
  • Journal Title: 躍進するRNA研究(中村義一, 塩見春彦編)、実験医学 22 Pages: 2408-2412
• [Journal Article] Prion domain interaction responsible for species discrimination in yeast[PSI^+]transmission. (2003)
  • Author(s): Hara, H., Nakayashiki, T., Crist, C. G., Nakamura, Y.
  • Journal Title: Genes Cells 8 Pages: 925-939
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antizyme frameshifting as a functional probe of eukaryotic translational termination. (2003)
  • Author(s): Karamysheva, Z. N., Karamyshev, A. L., Ito, K., Yokogawa, T., Nishikawa, K., Nakamura, Y., Matsufuji, s.
  • Journal Title: Nucl. Acids Res. 31 Pages: 5949-5956
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination. (2003)
  • Author(s): Polacek, N., Gomez, M., Ito, K., Xiong, L., Nakamura, Y., Mankin, A.
  • Journal Title: Mol. Cell 11 Pages: 103-112
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Making sense of mimic in translation termination. (2003)
  • Author(s): Nakamura, Y., Ito, K.
  • Journal Title: Trends Biochem. Sci. 28 Pages: 99-105
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] [PHI^+], a novel Sup35-prion variant propagated with non-Gln/Asn oligopeptide repeats in the absence of the chaperone protein Hsp1O4. (2003)
  • Author(s): Crist, C, Nakayashiki, T., Kurahashi, H., Nakamura, Y.
  • Journal Title: Genes Cells 8 Pages: 603-618
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis. (2003)
  • Author(s): Oguro, A., Ohtsu, T., Svitkin, Y., Sonenberg, N., Nakamura, Y.
  • Journal Title: RNA 9 Pages: 394-407
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of mutations in the GTP-binding domain of IF2 resulting in cold-sensitive growth of Escherichia coli. (2003)
  • Author(s): Laursen, B. S., Siwanowicz, I., Larigauderie, G., Hedegaard, J., Ito, K., Nakamura, Y., Kenney, J., Mortensen, K. K., Sperling-Petersen, H. U.
  • Journal Title: J. Mol. Bid. 326 Pages: 543-551
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prion domain interaction responsible for species discrimination in yeast [PSI^+] transmission. (2003)
  • Author(s): Hara, H., Nakayashiki, T., Crist, C. G., Nakamura, Y.
  • Journal Title: Genes Cells 8 Pages: 925-939
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antizyme frameshifting as a functional probe of eukaryotic translational termination. (2003)
  • Author(s): Karamysheva, Z. N., Karamyshev, A. L., Ito, K., Yokogawa, T., Nishikawa, K., Nakamura, Y., Matsufuji, S.
  • Journal Title: Nucl. Acids Res. 31 Pages: 5949-5956
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] [PHI^+], a novel Sup35-prion variant propagated with non-Gln/Asn oligopeptide repeats in the absence of the chaperone protein Hsp104. (2003)
  • Author(s): Crist, C., Nakayashiki, T., Kurahashi, H., Nakamura, Y.
  • Journal Title: Genes Cells 8 Pages: 603-618
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of mutations in the GTP-binding domain of IF2 resulting in cold-sensitive growth of Escherichia coli. J. Mol. Biol. (2003)
  • Author(s): Laursen, B. S., Siwanowicz, I., Larigauderie, G., Hedegaard, J., Ito, K., Nakamura, Y., Kenney, J., Mortensen, K. K., Sperling-Petersen, H. U.
  • Journal Title: J. Mol. Biol. 326 Pages: 543-551
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors. (2002)
  • Author(s): Uno, M., Ito, K., Nakamura, Y.
  • Journal Title: Proc. Natl. Acad. Sci. 99 Pages: 1819-1824
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protein tRNA mimicry in translation termination. Cold Spring Harbor Symp. Quant. Biol. (2002)
  • Author(s): Nakamura, Y., Uno, M., Toyoda, T., Fujiwara, T., Ito, K.
  • Journal Title: Cold Spring Harbor Symp. Quant. Biol. 66 Pages: 469-475
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Isolation and expression of two genes encoding eukaryotic release factor 1 (eRFl)from Paramedum tetraurelia. (2002)
  • Author(s): Kervestin, S., Gamier, O. A., Karamyshev, A. L., Ito, K., Nakamura, Y., Meyer, E., Jean-Jean, O.
  • Journal Title: J. Euk. Microbiol. 49 Pages: 374-382
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A tripeptide discriminator for stop codon recognition. (2002)
  • Author(s): Nakamura, Y., Ito, K.
  • Journal Title: FEBS Lett. 514 Pages: 30-33
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structure of ribosomal protein LI from Methanococcus thermolithotrophicus. Functionally important structural invariants on L1 surface. (2002)
  • Author(s): Nevskaya, N., Tishchenko, S., Paveliev, M., Smolinskaya, Y., Fedorov, R., Piendl, W., Nakamura, Y., Toyoda, T., Garber, M., Nikonov, s.
  • Journal Title: Acta Cryst. D58 Pages: 1023-1029
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Elongation factor G participates in ribosome disassembly by interacting with ribosome recycling factor at their tRNA-mimicry domains. (2002)
  • Author(s): Ito, K., Fujiwara, T., Toyoda, T., Nakamura, Y.
  • Journal Title: Mol. Cell 9 Pages: 1263-1272
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Omnipotent decoding potential resides in eukaryotic translation termination factor eRFl of variant-code organisms and is modulatedby the interactions of amino acid sequences within the domain 1. (2002)
  • Author(s): Ito, K., Frolova, L., Seit-Nebi, A., Karamyshev, A. L., Kisselev, L., Nakamura, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 99 Pages: 8494-8499
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Backbone ^1H, ^<13>C, and ^<15>N assignments of the ribosome recycling factor from Thermus thermophilus. (2002)
  • Author(s): Blake, B. K., Ito, K., Nakamura, Y., Alam, s.
  • Journal Title: J. Biomol. NMR 24 Pages: 81-82
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors. (2002)
  • Author(s): Uno, M., Ito, K., Nakamura, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA 99 Pages: 1819-1824
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein tRNA mimicry in translation termination. (2002)
  • Author(s): Nakamura, Y., Uno, M., Toyoda, T., Fujiwara, T., Ito, K.
  • Journal Title: Cold Spring Harbor Symp. Quant. Biol. 66 Pages: 469-475
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isolation and expression of two genes encoding eukaryotic release factor 1 (eRF1) from Paramecium tetraurelia. (2002)
  • Author(s): Kervestin, S., Garnier, O. A., Karamyshev, A. L., Ito, K., Nakamura, Y., Meyer, E., Jean-Jean, O. J. Euk. Microbiol.
  • Journal Title: J. Euk. Microbiol. 49 Pages: 374-382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on L1 surface. (2002)
  • Author(s): Nevskaya, N., Tishchenko, S., Paveliev, M., Smolinskaya, Y., Fedorov, R., Piendl, W., Nakamura, Y., Toyoda, T., Garber, M., Nikonov, S.
  • Journal Title: Acta Cryst. D58 Pages: 1023-1029
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within the domain 1. (2002)
  • Author(s): Ito, K., Frolova, L., Seit-Nebi, A., Karamyshev, A. L., Kisselev, L., Nakamura, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 99 Pages: 8494-8499
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Backbone ^1H, ^<13>C, and ^<15>N assignments of the ribosome recycling factor from Thermus thermophilus. (2002)
  • Author(s): Blake, B. K., Ito, K., Nakamura, Y., Alam, S.
  • Journal Title: J. Biomol. NMR 24 Pages: 81-82
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional mapping of the ribosome contact site in the ribosome recycling factor. (2001)
  • Author(s): Fujiwara, T., Ito, K., Nakamura, Y.
  • Journal Title: RNA 7 Pages: 64-70
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Yeast[PSI^+]prions that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state. (2001)
  • Author(s): Nakayashiki, T., Ebihara, K., Bannai, H., Nakamura, Y.
  • Journal Title: Mol. Cell 7 Pages: 1121-1130
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular mimicry between protein and tRNA. (2001)
  • Author(s): Nakamura, Y.
  • Journal Title: J. Mol. Evol. 53 Pages: 282-289
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The mechanism of tryptophan induction of tryptophanase operon expression : Tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA^<Pro>. (2001)
  • Author(s): Gong, F., Ito, K., Nakamura, Y., Yanofsky, c.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 98 Pages: 8997-9001
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Yeast [PSI^+] prions that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state. (2001)
  • Author(s): Nakayashiki, T., Ebihara, K., Bannai, H., Nakamura, Y.
  • Journal Title: Mol. Cell 7 Pages: 1121-1130
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The mechanism of tryptophan induction of tryptophanase operon expression : Tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA^<Pro>. (2001)
  • Author(s): Gong, F, Ito, K., Nakamura, Y., Yanofsky, C.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 98 Pages: 8997-9001
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] N-terminal prion domain of yeast release factor eRF3 : functionality and biogenesis. (2007)
  • Author(s): Nakamura, Y., Kurahashi, H., Kodama。H., Takahashi, A., Hara, H., Ito, K.
  • Organizer: International Symposium "Milestones in the Life of Proteins"
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aptamer as RNA-made super-antibody for therapeutics. (2007)
  • Author(s): Nakamura, Y.
  • Organizer: A-IMBN Delivery Symposium on Genomics
  • Place of Presentation: Kathmandu
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アプタマーRNA医薬の基礎、現状、将来。 (2007)
  • Author(s): 中村義一
  • Organizer: 第9回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗体医薬に代わる"次世代高分子医薬 (2006)
  • Author(s): 中村義一
  • Organizer: 第46回今堀フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2006-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Antibody equivalent RNA. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: 第11回慶応医学賞受賞記念シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2006-11-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aptamer as RNA-made super antibody for basic and therapeutic applications. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: Manchester Interdisciplinary Biocentre Sumposium
  • Place of Presentation: Manchester
  • Year and Date: 2006-10-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNAアプタマー創製の基礎と現状と将来 (2006)
  • Author(s): 中村義一
  • Organizer: ゲノム創薬フォーラム第16回談話会
  • Place of Presentation: 東京
  • Year and Date: 2006-07-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Selection and characterization of RNA aptamers specific to eIF4AIII of eIF4A family proteins. (2006)
  • Author(s): Endo, K., Oguro, A., Nakamura, Y.
  • Organizer: Cold Spring Harbor meeting on "Translational Control"
  • Place of Presentation: Cold Spring Harbor
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A genetic analysis for translation termnination factor eRF3 of・p. carinii. (2006)
  • Author(s): Wada, M., Nakamura, Y., Ito, K.
  • Organizer: Cold Spring Harbor meeting on "Translational Control"
  • Place of Presentation: Cold Spring Harbor
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New property of eIFlA revealed by analyses with RNA aptamer. (2006)
  • Author(s): Oguro, A., Nakamura, Y.
  • Organizer: Cold Spring Harbor meeting on "Translational Control"
  • Place of Presentation: Cold Spring Harbor
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Reduced activity of release factors induces mRNA cleavage at stop codons resulting in nonstop mRNAs that are recognized tmRNA system in E. coli. (2006)
  • Author(s): Li, X., Yokota, T., Ito, K., Nakamura, Y., Aiba, K.
  • Organizer: Cold Spring Harbor meeting on "Molecular Genetics of Bacteria and Phages"
  • Place of Presentation: Cold Spring Harbor
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNA antibodies to translation initiation factors eIF4E, eIF4G, eIFlA and eIF4A. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: Jacques-Monod Conference "Multiple functions of RNA in gene regulation"
  • Place of Presentation: Roscoff, France
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Solution structures of two hairpin loops of an RNA aptamer against mammalian initiation factor 4A. (2006)
  • Author(s): Sakamoto, T., Oguro, A., Kawai, G., Ohtsu, T., Nakamura, Y.
  • Organizer: International RNA Society meeting
  • Place of Presentation: Seattle
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High specificity RNA aptamer to human immunoglobulin G : fundamental characters and application to affinity resin. (2006)
  • Author(s): Miyakawa, S., Nakamura, Y.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A genetic analysis for translation termination factor eRF3 of P . carinii. (2006)
  • Author(s): Wada, M., Nakamura, Y., Ito, K.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ribosome-associated chaperone Zuol affects release factor [PSI^+]prion in yeast. (2006)
  • Author(s): Hara, H., Kurahashi, H., Nakamura, Y.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functionality and biogenetis of N-terminal prion domain of yeast release factor eRF3. (2006)
  • Author(s): Nakamura, Y., Kurahashi, H., Kodama。H., Hara, H., Ito, K.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel role of the N-terminal extension domain of eRF3 in regulating its protein stability through factor binding. (2006)
  • Author(s): Kodama, H., Nakamura, Y., Ito, K.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aptamer as RNA-made super-antibody : basics and therapeutic potential. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: The 8th International Engelhardt Conference on Molecular Biology "RNA-Protein Interaction"
  • Place of Presentation: Moscow Region
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aptamer as RNA-made super-antibody for therapeutics. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: 9th Inemational Conference "Drug and Gene-based Therapeutics"
  • Place of Presentation: Crete
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結因子の新規な機能性とその機能構造 (2006)
  • Author(s): 小玉裕之, 和田美紀, 中村義一, 伊藤耕一
  • Organizer: 第6回日本蛋白質化学会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A genetic analysis of stop codon recognition mechanism of class l eukaryotic release factor, eRFl. (2006)
  • Author(s): Saito, K., Nakamura, Y., Ito, K.
  • Organizer: 第20回国際生化学分子生物学会議(第79回日本生化学会大会・第29回日本分子生物学会年会合同)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic analyses of species-specific interaction among surveillancecomplex components for nonsense-mediated mRNA decay. (2006)
  • Author(s): Wada, M., Murakami, S., Nakamura, y., Ito, K.
  • Organizer: 第20回国際生化学分子生物学会議(第79回日本生化学会大会・第29回日本分子生物学会年会合同)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identification of RF3 domain for peptidyl-tRNA drop-off. (2006)
  • Author(s): Watanabe, Y., Ito, K., Nakamura, Y.
  • Organizer: 第20回国際生化学分子生物学会議(第79回日本生化学会大会・第29回日本分子生物学会年年会合同)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Movel mechanism, to regulate the polypeptide chain release factor 3(eRF3)activity through its cis-acting N-terminal domain in Saccharomyees cerevisiae. (2006)
  • Author(s): Kodama, H., Nakamura。Y., Ito, K.
  • Organizer: 第20回国際生化学分子生物学会議(第79回日本生化学会大会・第29回日本分子生物学会年会合同)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MTG8のTAF domainに結合するRNAアプタマーの創製 (2006)
  • Author(s): 福永淳一, 田中陽一郎, 赤木究, 中村義一, 神津知子
  • Organizer: 第8回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 淡路
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNAアプタマーを用いたeIFIAの機能解析 (2006)
  • Author(s): 小黒明広, 中村義一
  • Organizer: 第8回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 淡路
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNAと創薬 (2006)
  • Author(s): 中村義一
  • Organizer: 第65回日本癌学会学術総会シンポジウム
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Solution structures of two hairpin loops of an RNA aptamer againstmammalian initiation factor 4A. (2006)
  • Author(s): Sakamoto, T., Oguro, A., Kawai, G., Ohtsu, T., Nakamura, Y.
  • Organizer: 第45回NMR検討会
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A genetic analysis for translation termnination factor eRF3 of P. carinii. (2006)
  • Author(s): Wada, M., Nakamura, Y., Ito, K.
  • Organizer: Cold Spring Harbor meeting on "Translational Control"
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] New property of eIF1 A revealed by analyses with RNA aptamer. (2006)
  • Author(s): Oguro, A., Nakamura, Y.
  • Organizer: Cold Spring Harbor meeting on "Translational Control"
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] RNA antibodies to translation initiation factors eIF4E, eIF4G, eIF1A and eIF4A. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: Jacques-Monod Conference Multiple functions of RNA in gene regulation
  • Place of Presentation: Roscoff, France
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A genetic analysis for translation termination factor eRF3 of P. carinii. (2006)
  • Author(s): Wada, M., Nakamura, Y., Ito, K.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ribosome-associated chaperone Zuo1 affects release factor [PSI^+] prion in yeast. (2006)
  • Author(s): Hara, H., Kurahashi, H., Nakamura, Y.
  • Organizer: RNA 2006 Izu symposium on "Functional RNAs and Regulatory Machinery"
  • Place of Presentation: Ohito
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Aptamer as RNA-made super-antibody : basics and therapeutic potential. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: The 8th International Engelhardt Conference on Molecular Biology "RNA Protein Interaction"
  • Place of Presentation: Moscow Region
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Aptamer as RNA-made super-antibody for therapeutics. (2006)
  • Author(s): Nakamura, Y.
  • Organizer: 9th Inernational Conference "Drug and Gene-based Therapeutics"
  • Place of Presentation: Crete
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] RNA antibody. (2005)
  • Author(s): Nakamura, Y.
  • Organizer: A-IMBN SCA Joint Biosymposium.
  • Place of Presentation: Hanoi, Vietnam
  • Year and Date: 2005-05-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Variation of microRNAs during TPA-induced differentiaiton of HL-60 cells. (2005)
  • Author(s): K. Kasashima, Y. Nakamura, T. Kozu
  • Organizer: Keystone Symposium on "RNA in Gene Regulation".
  • Place of Presentation: Breckenridge, CO
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. (2005)
  • Author(s): Mochizuki, K., Oguro, A., Ohtsu, T., Sonenberg, N., Nakamura, Y.
  • Organizer: 10th Annual RNA Conference.
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNA aptamers selected against the receptor activator of NF-kB(RANK)acquire general affinity to proteins of the tumor-necrosiss factor (TNF) receptor family. (2005)
  • Author(s): Mori, T., Ohtsu, T., Oguro, A., Nakamura, Y.
  • Organizer: 10th Annual RNA Conference. Banff
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High affinity RNAs against eukaryotic initiation factor 4G inhibit translation in vitro : Potential tools to control translation initiation. (2005)
  • Author(s): Miyakawa, S., Oguro, A., Ohtsu, T., Imataka, H., Sonenberg, N., Nakamura, Y.
  • Organizer: 10th Annual RNA Conference.
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNA aptamers targeting C-termini of KRAS oncoprotein. (2005)
  • Author(s): Tanaka, Y., Oguro, A., Ohtsu, T., Akagi, K., Nakamura, Y., Kozu, T.
  • Organizer: 10th Annual RNA Conference.
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High affinity RNA against eIF1A as a new research tool for translation initiation. (2005)
  • Author(s): Oguro, A., Nakamura, Y.
  • Organizer: EMBO Conference on Protein Synthesis and Translational Control.
  • Place of Presentation: EMBL Heidelberg
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation and functional analyses of ribosomal protein mutations that affect translation termination. (2005)
  • Author(s): Sato, H., Ito, K., Nakamura, Y.
  • Organizer: EMBO Conference on Protein Synthesis and Translational Control.
  • Place of Presentation: EMBL Heidelberg
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular basis of yeast [PSI]prion transmission. (2005)
  • Author(s): 中村義一, Crist, C. G., 原英之, 倉橋洋史
  • Organizer: IMSUT International Symposium on Emergingand Re-emerging Infectious Diseases
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel method to generate aptamers against recombinant targets displayed on the cell surface. (2005)
  • Author(s): Ohuchi, S., Ohtsu, T., Nakamura, Y.
  • Organizer: 第4回国際核酸化学シンポジウム
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 精製蛋白質を必要としない抗蛋白質アプタマーの取得法 (2005)
  • Author(s): 大内将司, 大津敬, 中村義一
  • Organizer: 第7回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 弘前
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] eIFlAに対するRNAアプタマーの翻訳阻害機構の解析 (2005)
  • Author(s): 小黒明広, 中村義一
  • Organizer: 第7回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 弘前
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム構築に働くU50 snoRNAとc-Mycによるそのホスト遺伝子の転写調節 (2005)
  • Author(s): 添野雄一, 藤田和也, 青葉孝昭, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNA super-antibody (2005)
  • Author(s): 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオン[PSI^+]を指標にしたAAA+シャペロンHsp104の突然変異探索 (2005)
  • Author(s): 倉橋洋史, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオン[PSI^+]維持におけるHsp104の作用機構は熱耐性における脱凝集機構とは異なる (2005)
  • Author(s): 高橋愛子, 原英之, 倉橋洋史, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンSup35の解析 プリオン伝搬における「種の壁」の分子機構 (2005)
  • Author(s): 原英之, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] eIF4AIII特異的に結合するRNAアプタマーの取得 (2005)
  • Author(s): 遠藤慧, 小黒明広, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳開始因子eIF4Eの機能を特異的に阻害するRNAアプタマーの酵母細胞での発現とその生育抑制効果の検証 (2005)
  • Author(s): 望月潔隆, 小黒明広, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 転写因子AMLlのRUNTドメインに結合するRNAアプタマー (2005)
  • Author(s): 田中陽一郎, 福永淳一, 赤木究, 中村義一, 神津知子
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 転写因子AMLIのRUNTドメインに結合するRNAアプタマーの利用 (2005)
  • Author(s): 福永淳一, 田中陽一郎, 赤木究, 中村義一, 神津知子
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ペプチジノレtRNAのドロップオフ促進作用に関わる翻訳終結因子RF3の機能ドメイン解明 (2005)
  • Author(s): 渡辺裕也, 伊藤耕一, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム蛋白質L11による翻訳終結制御機構の解明 (2005)
  • Author(s): 佐藤華江, 伊藤耕一, 中村義一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 出芽酵母GTP結合性ペプチド鎖解離因子eRF3におけるN末端シス領域を介した新規な機能制御機構 (2005)
  • Author(s): 小玉裕之, 中村義一, 伊藤耕一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結因子eRF3の終結反応とmRNA品質管理機構における機能的関連性の検証 (2005)
  • Author(s): 村上沙織, 和田美紀, 中村義一, 伊藤耕一
  • Organizer: 第28回分子生物学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Variation of microRNAs during TPA-induced differentiaiton of HL-60 cells. (2005)
  • Author(s): K. Kasashima, Y. Nakamura, T. Kozu
  • Organizer: Keystone Symposium on "RNA in Gene Regulation."
  • Place of Presentation: Breckenridge, CO
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] RNA aptamers selected against the receptor activator of NF-kB (RANK) acquire general affinity to proteins of the tumor-necrosiss factor (TNF) receptor family. (2005)
  • Author(s): Mori, T., Ohtsu, T., Oguro, A., Nakamura, Y.
  • Organizer: 10th Annual RNA Conference.
  • Place of Presentation: Banff, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] High affinity RNA against eIF1 A as a new research tool for translation initiation. (2005)
  • Author(s): Oguro, A., Nakamura, Y.
  • Organizer: EMBO Conference on Protein Synthesis and Translational Control.
  • Place of Presentation: EMBL Heidelberg
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Yeast [PSI^+]priori : molecular basis and functional disorder. (2004)
  • Author(s): Nakamura, Y.
  • Organizer: FASEB Summer Research Conference on"Posttranscriptional Control of Gene Expression".
  • Place of Presentation: Tucson, Arizona
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional coordination of the G domain and tRNA-mimic domain of EF-G with RRF for ribosome disassembly. (2004)
  • Author(s): Nakamura, Y., Fujiwara, T., Yamamai, T., Ito, K.
  • Organizer: Cold Spring Harbor Translational Control meeting
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Species barrier in yeast [PSI] prion transmission. (2004)
  • Author(s): Hara, H., Nakayashiki, T., Nakamura, Y.
  • Organizer: International Symposium of Prion Deiseases for Food and Drag Safety
  • Place of Presentation: Sendai
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular memory pf [PSI] prion strain in s. cerevisiae is dependent on the primary structure of the prion domain. (2004)
  • Author(s): Crist, C. G., Nakayshiki, T., Kurahashi, H., Nakamura, Y.
  • Organizer: International Symposium of Priori Deiseases for Food and Drag Safety.
  • Place of Presentation: Sendai
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNAルネッサンスとRNA創薬 (2004)
  • Author(s): 中村義一
  • Organizer: 国際バイオEXPO
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳開始因子eIF4Aに結合するアプタマーの2つのヘアピン構造 (2004)
  • Author(s): 坂本泰一, 小黒明広, 河合剛太, Nahum Sonenberg, 大津敬, 中村義一
  • Organizer: 第6回RNAミーティング・(日本RNA学会年会)
  • Place of Presentation: 熊本
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HL-60細胞の分化過程で発現が変動するmicroRNAのカタログ (2004)
  • Author(s): 笠島克己, 中村義一, 神津知子
  • Organizer: 第6回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 熊本
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] eIF4Eに結合するRNAアプタマーによる翻訳阻害の分子機構 (2004)
  • Author(s): 望月潔隆, 小黒明広, 大津敬, Nahum Sonenberg, 中村義一
  • Organizer: 第6回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 熊本
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳制御機構に関わるリボソーム変異の分離と解析 (2004)
  • Author(s): 佐藤華江, 伊藤耕一, 中村義一
  • Organizer: 第6回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 熊本
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結因子の活性低下による終始コドンにおけるmRNAの切断とトランス翻訳 (2004)
  • Author(s): 横田晃章, 春原隆, 伊藤耕一, 稲田利文, 中村義一, 饗場弘二
  • Organizer: 第6回RNAミーティング(日本RNA学会年会)
  • Place of Presentation: 熊本
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNAルネッサンスと分子擬態 (2004)
  • Author(s): 中村義一
  • Organizer: 第16回高遠分子細胞生物学シンポジウム
  • Place of Presentation: 高遠
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳開始因子eIF4Gに結合するRNAアプタマーのin vitroにおける翻訳阻害 (2004)
  • Author(s): 宮川伸, 小黒明広, 大津敬, 今高寛晃, Nahum Sonenberg, 中村義一
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] KRASのC端を標的としたRNAアプタマー (2004)
  • Author(s): 田中陽一郎, 小黒明広, 大津敬, 赤木究, 中村義一, 神津知子
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genome RNA technology and leukemia (2004)
  • Author(s): 笠嶋克巳, 迫田絵里, 中村義一, 神津知子
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオン[PSI]に関わる因子の網羅的スクリーニング (2004)
  • Author(s): 倉橋洋史, 中村義一
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pneumocystis cariniiのペプチド鎖解離因子eRF3の機能ドメイン検索 (2004)
  • Author(s): 和田美紀, 伊藤耕一, 中村義一
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム再生に特異的に関わるEF-Gの機能領域の検索 (2004)
  • Author(s): 山見徹, 伊藤耕一, 中村義一
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 出芽酵母Sacchromyces cerevisiaeにおけるペプチド鎖解離因子(eRF3)安定化へのトランス因子の寄与 (2004)
  • Author(s): 小玉裕之, 倉橋洋史, 中屋敷徹, 伊藤耕一, 中村義一
  • Organizer: 第27回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Yeast [PSI^+] prion : molecular basis and functional disorder. (2004)
  • Author(s): Nakamura, Y.
  • Organizer: FASEB Summer Research Conference on "Posttranscriptional Control of Gene Expression."
  • Place of Presentation: Tucson, Arizona
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Functional coordination of the G domain and tRNA-mimic domain of EF-G with RRF for ribosome disassembly. (2004)
  • Author(s): Nakamura, Y., Fujiwara, T., Yamamai, T., Ito, K.
  • Organizer: Cold Spring Harbor Translational Control meeting.
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular memory pf [PSI] prion strain in S. cerevisiae is dependent on the primary structure of the prion domain. (2004)
  • Author(s): Crist, C. G., Nakayshiki, T., Kurahashi, H., Nakamura, Y.
  • Organizer: International Symposium of Prion Deiseases for Food and Drag Safety.
  • Place of Presentation: Sendai
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stop codon decoding by peptide anticodon. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Biophysics Symposium 2003 on Translation
  • Place of Presentation: Royal Academy of Sciences, Stockholm
  • Year and Date: 2003-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stop codon decoding by peptide anticodon. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Biophysics Symposium 2003 on Translation.
  • Place of Presentation: Royal Academy of Sciences, Stockholm
  • Year and Date: 2003-09-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Making Sense or Nonsense of Mimic in Translation Termination. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Jaques Monod Conference on "Non-coding RNA : their role in translation and gene regulation"
  • Place of Presentation: Aussois, France
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular Mimicry between Protein and tRNA. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Conference on Molecular Biology and Biochemistry・
  • Place of Presentation: Hanoi, Vietnam
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Making sense of mimic in translation termination. (2003)
  • Author(s): Nakamura。Y
  • Organizer: 10th FAOBMB Congress (Symposium)
  • Place of Presentation: Bangalore, India
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The action of ribosomal recycling factor is translocation independent. (2003)
  • Author(s): Nakamura, Y., Fujiwara, T., Yamami, T., Ito, K.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science".
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation and functional analyses of ribosomal protein mutations that affect translation termination efficiency. (2003)
  • Author(s): Sato, H., Nakamura, Y., Ito, K.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science".
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Glutamine content of [PSI+]prion affects frequency of co-aggregation with other prions : Implication for cross-seeding・ (2003)
  • Author(s): Nakayashiki, T., Nakamura, Y.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science".
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RNA as medicine - applications of aptamers against eularyotic initiation factors. (2003)
  • Author(s): Ohtsu, T., Oguro, A., Sonenberg, N., Nakamura。Y.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science".
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Species discrimination in yeast [PSI+]prion transmission. (2003)
  • Author(s): Hara, H., Nakayashiki, T., Nakamura, Y.
  • Organizer: 6th Asian-Pacific IMBN Conference.
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオン (2003)
  • Author(s): 中村義一
  • Organizer: 大阪大学微生物病研究所 感染症フォーラム
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンSup35の解析プリオン伝搬の分子機構 (2003)
  • Author(s): 原英之, 中屋敷徹, 中村義一
  • Organizer: 第26回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aquifax aeolicusバボソーム再生因子(RRF)のEF-G相互作用ドメインの解析 (2003)
  • Author(s): 山見徹, 伊藤耕一, 中村義一
  • Organizer: 第26回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結制御機構に関わるリボソーム変異の分離と解析 (2003)
  • Author(s): 佐藤華江, 伊藤耕一, 中村義一
  • Organizer: 第26回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 研究者同士のコミュニケーションが持つ意味 (2003)
  • Author(s): 塩見春彦, 中村義一
  • Organizer: 第26回日本分子生物学会年会(シンポジウム)
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pneumocystis cariniiのペプチド鎖解離因子eRFの機能検索 (2003)
  • Author(s): 和田美紀, 伊藤耕一, 中村義一
  • Organizer: 第26回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Making Sense or Nonsense of Mimic in Translation Termination. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Jaques Monod Conference on "Non-coding RNA : their role in translation and generegulation."
  • Place of Presentation: Aussois, France
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular Mimicry between Protein and tRNA. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: Conference on Molecular Biology and Biochemistry.
  • Place of Presentation: Hanoi, Vietnam
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Making sense of mimic in translation termination. (2003)
  • Author(s): Nakamura, Y.
  • Organizer: 10th FAOBMB Congress (Symposium).
  • Place of Presentation: Bangalore, India
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The action of ribosomal recycling factor is translocation independent. (2003)
  • Author(s): Nakamura, Y., Fujiwara, T., Yamami, T., Ito, K.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science."
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation and functional analyses of ribosomal protein mutations that affect translation termination efficiency. (2003)
  • Author(s): Sato, H., Nakamura, Y., Ito, K.
  • Organizer: International Conference RNA2003Kyoto The New Frontier of RNA Science.
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Glutamine content of [PSI+] prion affects frequency of co-aggregation with other prions : Implication for cross-seeding. (2003)
  • Author(s): Nakayashiki, T., Nakamura, Y.
  • Organizer: International Conference RNA2003Kyoto The New Frontier of RNA Science.
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] RNA as medicine-applications of aptamers against eularyotic initiation factors. (2003)
  • Author(s): Ohtsu, T., Oguro, A., Sonenberg, N., Nakamura, Y.
  • Organizer: International Conference RNA2003Kyoto "The New Frontier of RNA Science."
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Species discrimination in yeast [PSI+] prion transmission. (2003)
  • Author(s): Hara, H., Nakayashiki, T., Nakamura, Y.
  • Organizer: 6th Asian-Pacific IMBN Conference.
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular basis of yeast prion propagation and species barrier. (2002)
  • Author(s): Nakamura。Y.
  • Organizer: NUS-IMCB-IMSUT Joint Symposium on Integrative Biotechnology.
  • Place of Presentation: Singapore
  • Year and Date: 2002-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンの分子生物学 (2002)
  • Author(s): 中村義一
  • Organizer: 日本獣医学会
  • Place of Presentation: 東京
  • Year and Date: 2002-07-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンの学理と展開 (2002)
  • Author(s): 中村義一
  • Organizer: 日本動物細胞工学会
  • Place of Presentation: 東京
  • Year and Date: 2002-07-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Peptide determinants and modulators for deciphering stop codons in prokaryotes and eukaryotes. (2002)
  • Author(s): Nakamura, Y., Uno, M., Ito, K
  • Organizer: The Ribosome Meeting 2002 : The Dynamics of Ribosome Structure and Function.
  • Place of Presentation: Queenstown, New Zealand
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vitro dissection of ribosomal occupancy of ribosome recycling factor and elongation factor G. (2002)
  • Author(s): Fujiwara, T., Ito, K., Nakamura, Y.
  • Organizer: The Ribosome Meeting 2002 : The Dynamics of Ribosome Structure and Function.
  • Place of Presentation: Queenstown, New Zealand
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional interaction between tRNA- mimicry domains of ribosome recycling factor and elongation factor G. (2002)
  • Author(s): Ito, K., Fujiwara, T., Toyoda, T., Nakamura, Y.
  • Organizer: The Ribosome Meeting 2002 : The Dynamics of Ribosome Structure and Function.
  • Place of Presentation: Queenstown, New Zealand.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of translation termination. (2002)
  • Author(s): Nakamura, Y.
  • Organizer: FASEB Summer Research Conference on "Posttranscriptional Control of Gene Expression"
  • Place of Presentation: Tucson. Arizona
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ominipotent decoding potential of release factor eRFl from variant-code organisms and modulation by TAS tripeptide in domain 1. (2002)
  • Author(s): Nakamura, Y., Ito, K., Frolova, L., Seit-Nebi, A., Kisselev, L.
  • Organizer: CSH Translational Control meeting
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vitro dissection of ribosomal occupancy of ribosome recycling factor and elongation factor G. (2002)
  • Author(s): Fujiwara, T., Ito, K., Nakamura, Y.
  • Organizer: CSH Translational Control meeting.
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High affinity RNA for initiation factor 4A helicase binds selectively compact form of eIF4A and hinders cap dependent translaiton by blocking ATP hydrolysis. (2002)
  • Author(s): Oguro, A., Ohtsu, T., Svitkin, Y., Sonenberg, N., Nakamura, Y.
  • Organizer: CSH Translational Control meeting.
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Making sense or nonsense of molecular mimic in translation termination. (2002)
  • Author(s): Nakamura, Y.
  • Organizer: 5th A-IMBN Conference.
  • Place of Presentation: Shanghai, China
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳系における分子擬態 (2002)
  • Author(s): 中村義一
  • Organizer: 日本農芸化学会シンポジウム
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム再生因子の構造遺伝学 (2002)
  • Author(s): 中村義一, 藤原俊伸, 豊田友彦, 伊藤耕一
  • Organizer: 第75回日本生化学会大会シンポジウム
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pneumocystis cariniiのペプチド鎖解離因子eRFの機能ドメイン検索 (2002)
  • Author(s): 和田美紀, 伊藤耕一, 中村義一
  • Organizer: 第25回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム再生因子RRFと翻訳伸長因子EF-Gのリボソーム結合性の解析 (2002)
  • Author(s): 藤原俊伸, 伊藤耕一, 中村義一
  • Organizer: 第25回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結制御機構に関わるリボソーム変異の分離と解析 (2002)
  • Author(s): 佐藤華江, 伊藤耕一, 中村義一
  • Organizer: 第25回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Aquifax aeolicusリボソーム再生因子(RRF)の機能ドメイン解析 (2002)
  • Author(s): 山見徹, 伊藤耕一, 藤原俊伸, 中村義一
  • Organizer: 第25回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳開始因子eIF4Eに結合するRNAアプタマーによる翻訳阻害 (2002)
  • Author(s): 望月潔隆, 小黒明広, 大津敬, Nahum Sonenberg, 中村義一
  • Organizer: 第25回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ominipotent decoding potential of release factor eRF1 from variant-code organisms and modulation by TAS tripeptide in domain 1. (2002)
  • Author(s): Nakamura, Y., Ito, K., Frolova, L., Seit-Nebi, A., Kisselev, L.
  • Organizer: CSH Translational Control meeting
  • Place of Presentation: Cold Spring Harbor Laboratory, NY
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] U50HG, an intronic U50 snoRNA host gene isolated from human malignant lymphoma ; structural analysis of mouse U50HG homologue, mU50HG. (2001)
  • Author(s): Tanaka, R., Satoh, H., Morishita, Y., Watanabe, T., Nakamura, Y., Mori, S.
  • Organizer: 17th Wilhelm Berahard's Workshop
  • Place of Presentation: Arcachon, France
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Novel Yeast [PSI^+]Prions' that Are Crosstransmissible and Susceptible beyond a Species Barrier. (2001)
  • Author(s): Nakamura, Y., Crist, C, Hara, H., Nakayashiki, T.
  • Organizer: The 4th Symposium of Asia-pacific international Molecular Biology Network
  • Place of Presentation: Taipei, ROC
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒト悪性リンパ腫の染色体転座点からイントロンに機能性の低分子RNA (snoRNA U50)をコードする新規遺伝子U50HGを単離した (2001)
  • Author(s): 田中りつこ, 佐藤均, 森下保幸, 中村義一, 渡辺俊樹, 森茂郎
  • Organizer: 第41回日本リンパ網内系年会
  • Place of Presentation: 秋田
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳開始因eIF4Alに対するRNAアプタマーの解析 (2001)
  • Author(s): 小黒明広, 大津敬, Svitkin, Y., Sonenberg, N., 中村義一
  • Organizer: 第3回日本RNA学会年会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SELEXを利用した翻訳開始因子の制御と癌化の抑制 (2001)
  • Author(s): 大津敬, 小黒明広, Svitkin, Y., Sonenberg, N., 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンSup35pの解析 : グルタミン/アスパラ ギンに富んだ配列の役割 (2001)
  • Author(s): 中屋敷徹, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンSup35pの解析 : プリオン特性におけるオリゴペプチドリピートの役割 (2001)
  • Author(s): Colin Crist, 中屋敷徹, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 酵母プリオンSup35pの解析 : プリオン伝搬の分子機構 (2001)
  • Author(s): 原英之, 中屋敷徹, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 翻訳終結過程におけるリボソーム再生因子(RRF)の作用機序の解析 (2001)
  • Author(s): 藤原俊伸, 伊藤耕一, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pneumocystis cariniiのペプチド鎖解離因子eRFl及びeRF3の機能性解析 (2001)
  • Author(s): 和田美紀, 伊藤耕一, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リボソーム再生因子(RRF)の異種間比較解析による機能ドメイン検索 (2001)
  • Author(s): 山見徹, 伊藤耕一, 藤原俊伸, 中村義一
  • Organizer: 第24回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] U50HG, an intronic U50 snoRNA host gene isolated from human malignant lymphoma ; structural analysis of mouse U50HG homologue, mU50HG. (2001)
  • Author(s): Tanaka, R., Satoh, H., Morishita, Y., Watanabe, T., Nakamura, Y., Mori, S.
  • Organizer: 17th Wilhelm Bemhard's Workshop
  • Place of Presentation: Arcachon, France
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Novel Yeast [PSI^+] 'Prions' that Are Crosstransmissible and Susceptible beyond a Species Barrier. (2001)
  • Author(s): Nakamura, Y., Crist, C, Hara, H., Nakayashiki, T.
  • Organizer: The 4th Symposium of Asia-pacific international Molecular Biology Network
  • Place of Presentation: Taipei, ROC
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] RNAルネッサンスー遺伝子新革命 (2006)
  • Author(s): 田原総一朗, 中村義一
  • Publisher: 医薬経済社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 生命科学(柳田充弘, 佐藤文彦, 石川冬木編) (2004)
  • Author(s): 小黒明広, 中村義一
  • Total Pages: 9
  • Publisher: 東京化学同人
• [Book] ヒトゲノム(榊佳之他編)、Molecular Medicine (2004)
  • Author(s): 大内将司, 中村義一
  • Total Pages: 12
  • Publisher: 中山書店
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.ims.u-tokyo.ac.jp/molbiol/index.html
• [Patent(Industrial Property Rights)] 翻訳開始因子eIFlAに結合するリボ核酸 (2007)
  • Inventor(s): 中村義一, 小黒明広, 大津敬
  • Industrial Property Rights Holder: 株式会社リボミック
  • Patent Publication Number: 2007-028932
  • Filing Date: 2007-02-08
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 腫瘍成長因子β受容体Ill型に結合する核酸リガンド (2007)
  • Inventor(s): 中村義一, 大内将司
  • Industrial Property Rights Holder: 株式会社リボミック
  • Patent Publication Number: 2007-043917
  • Filing Date: 2007-02-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 免疫グロブリンGに結合する核酸とその利用法 (2007)
  • Inventor(s): 中村義一, 宮川伸
  • Industrial Property Rights Holder: 株式会社リボミック
  • Filing Date: 2007-01-11
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 翻訳開始因子eIF4Eに結合するリガンド (2007)
  • Inventor(s): 中村義一, 望月潔隆, 小黒明広, 他
  • Industrial Property Rights Holder: 株式会社リボミック
  • Acquisition Date: 2007-04-06
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ミッドカインに対するアプタマー及びその使用 (2006)
  • Inventor(s): 中村義一, 宮川伸, 藤原将寿, 他
  • Industrial Property Rights Holder: 株式会社リボミック
  • Industrial Property Number: 2006-308482
  • Filing Date: 2006-11-14
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 調節性T細胞の機能異常に基づく疾患の治療方法及び予防治療 (2006)
  • Inventor(s): 錫村明生, 中村義一, 宮川伸, 藤原将寿, 他
  • Industrial Property Rights Holder: 株式会社リボミック
  • Filing Date: 2006-11-14
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 腫瘍壊死因子受容体ファミリータンパク質に結合する核酸リガンド (2005)
  • Inventor(s): 中村義一, 森正, 小黒明広, 大津敬
  • Industrial Property Rights Holder: 株式会社リボミック
  • Industrial Property Number: 2005-024709
  • Filing Date: 2005-02-01
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] RUNTドメインに結合するリボ核酸 (2005)
  • Inventor(s): 中村義一, 田中陽一郎, 神津知子, 福永淳
  • Industrial Property Rights Holder: 株式会社リボミック
  • Industrial Property Number: 2005-328757
  • Filing Date: 2005-11-14
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 翻訳開始因子eIF4Gに結合するリボ核酸 (2004)
  • Inventor(s): 中村義一, 宮川伸, 小黒明広, 大津敬
  • Industrial Property Rights Holder: 株式会社リボミック
  • Industrial Property Number: 2004-336905
  • Filing Date: 2004-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 翻訳開始因子に特異的に結合する核酸リガンド (2002)
  • Inventor(s): 中村義一, 大津敬, 小黒明広
  • Industrial Property Rights Holder: 株式会社リボミック
  • Patent Publication Number: 2002-300885
  • Filing Date: 2002-10-15
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Crist, C.: "〔PHI^+〕, a novel Sup35-prion variant propagated with non-Gln/Asn oligopeptide repeats in the absence of the chaperone protein Hsp104"Genes Cells. 8. 603-618 (2003)
• [Publications] Oguro, A.: "RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis"RNA. 9. 394-407 (2003)
• [Publications] Polacek, N.: "The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination"Mol.Cell. 11. 103-112 (2003)
• [Publications] Nakamura, Y.: "Making sense of mimic in translation termination"Trends Biochem.Sci.. 28. 99-105 (2003)
• [Publications] Blake, B.K.: "Backbone ^1H, ^<13>C, and ^<15>N assignments of the ribosome recycling factor from Thermus thermophilus"J.Biomol.NMR. 24. 81-82 (2002)
• [Publications] Laursen, B.S.: "Characterization of mutations in the GTP-binding domain of IF2 resulting in cold-sensitive growth of Escherichia coli"J.Mol.Biol.. 326. 543-551 (2003)
• [Publications] Karamysheva, Z.N.: "Antizyme frameshifting as a functional probe of eukaryotic translational termination"Nucl.Acids Res.. 31. 5949-5956 (2003)
• [Publications] Hara, H.: "Prion domain interaction responsible for species discrimination in yeast 〔PSI^+〕transmission"Genes Cells. 8. 925-939 (2003)
• [Publications] Kong, C.: "Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S.Pombe"Mol.Cell. (In Press). (2004)
• [Publications] Fujiwara, T.: "Ribosome recycling factor disassembles the posttermination ribosomal complex independent of the ribosomal translocase activity of elongation factor G"Mol.Microbiol.. (In Press). (2004)
• [Publications] Oguro, A.: "High affinity RNA initiation factor 4A helicase binds selectively compact form of eIF4A and hinders cap-dependent translation by blocking ATP hydrolysis"RNA. (In Press). (2003)
• [Publications] Laursen, B.S.: "Characterization of mutations in the GTP-binding domain of IF2 resulting in cold-sensitive growth of Escherichia coli"J. Mol. Biol.. 326. 543-551 (2003)
• [Publications] Nakamura, Y.: "Making sense of mimic in translation termination"Trends Biochem. Sci.. 28. 99-105 (2003)
• [Publications] Polacek, N.: "The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination"Mol. Cell. 11. 103-112 (2003)
• [Publications] Blake, B.K.: "Backbone ^1H,^<13>C, and ^<15>N assignments of the ribosome recycling factor from Thermus thermophilus"J. Biomol. NMR. 24. 81-82 (2002)
• [Publications] Ito, K.: "Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within the domain 1"Proc. Natl. Acad. Sci. USA. 99. 8494-8499 (2002)
• [Publications] Ito, K.: "Elongation factor G participates in ribosome disassembly by interacting with ribosome recycling factor at their tRNA-mimicry domains"Mol. Cell. 9. 1263-1272 (2002)
• [Publications] Nevskaya, N.: "Structure of ribosomal protein L1 from M ethanococcus thermolithotrophicus. Functionally important structural invariants on L1 surface"Acta Cryst.. D58. 1023-1029 (2002)
• [Publications] Nakamura, Y.: "A tripeptide discriminator for stop codon recognition"FEBS Lett.. 514. 30-33 (2002)
• [Publications] Kervestin, S: "Isolation and expression of two genes encoding eukaryotic release factor 1 (eRF1) from paramecium tetraurelia"J. Euk. Microbiol.. 49. 374-382 (2002)
• [Publications] Nakamura, Y.: "Protein tRNA mimicry in translation termination"Cold Spring Harbor Symp. Quant. Biol.. 66. 469-475 (2002)
• [Publications] Uno, M.: "Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors"Proc. Natl. Acad. Sci. USA. 99. 1819-1824 (2002)