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Regulatory Mechanism of Stress-Responsive Signal Transduction Pathway

Research Project

Project/Area Number 14086101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

SAITO Haruo  The University of Tokyo, The Institute of Medical Science, Professor (60114485)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Katsuji  Kanazawa University, Cancer Research Institute, Professor (60200937)
MAEDA Tatsuya  The University of Tokyo, Institute of Molecular and Cellular Bioscience, Associate Professor (90280627)
西田 栄介  京都大学, 大学院・生命科学研究科, 教授 (60143369)
秋山 徹  東京大学, 分子細胞生物学研究所, 教授 (70150745)
野澤 義則  (財)岐阜建国祭バイオ研究所, 所長(研究職) (10021362)
Project Period (FY) 2002 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2005: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2004: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordsgene / environment / enzyme / intracellular signal transduction / stress / 細胞内シグナル伝達 / ストレス応答 / MAPキナーゼ / 分子生物学 / 細胞生物学
Research Abstract

Stress-responsive signal transduction pathway is an important cellular defence mechanism. Its central core is the so-called Stress-Activated MAP Kinase cascade (SAPK cascade). Defects in mammalian SAPK pathways cause, not only abnormalities at the molecular and cellular levels, but also systemic diseases such as autoimmunity and cancer. In order to aide developments of new treatments for these difficult diseases, this project focused on various important subjects concerning SAPK pathways, using human, mouse, nematode, yeast, and cyanobacterium.
Through this project, the novel activation mechanisms of several MAP3K enzymes, namely mammalian MTK1 and ASK1/2 and yeast Ssk2 and Ste11, were elucidated. Furthermore, we obtained numerous new findings concerning positive and negative regulations of SAPK pathways by protein phosphatases, adaptor and binding proteins, and docking interactions. Studies using nematode has revealed new roles of SAPK pathways at systemic level, such as innate immunity, tolerance to oxidative stress, and tolerance to heavy metals. The regulatory mechanism of the yeast HOG osmoregulatory SAPK pathway has been elucidated to the point that it is now considered as one of the best understood signaling pathways.
Mammalian MAPK and SAPK pathways are intimately related to pathogenesis of various diseases such as autoimmunity, cancer, and infection. Thus, results from this projects are expected to aide developments of new treatments for these difficult diseases, by identifying prospective target molecules for drug development. Because the yeast SAPK pathway is an important determinant for virulence of pathogenic yeasts such as Blastomyces and Candida, the findings from this project will be also useful to develop new anti-fungal drugs.
In conclusion, this project not only contributed to advancement of the immediate field of SAPK signaling in mammalian, nematode, yeast and cyanobacterium, but it also had a significant influence on other related fields.

Report

(6 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (116 results)

All 2007 2006 2005 2004 2003 2002 Other

All Journal Article (103 results) Publications (13 results)

  • [Journal Article] Transmembrane mucins Hkrl and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.2007

    • Author(s)
      Tatebayashi, Kazuo
    • Journal Title

      The EMBO Journal 26

      Pages: 3521-3533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain.2007

    • Author(s)
      Miyake, Zenshi
    • Journal Title

      Molecular and Cellular Biology 27

      Pages: 2765-2776

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells.2007

    • Author(s)
      Bayarsaikhan, Munkhuu
    • Journal Title

      Biochemical and Biophysical Research Communications 353

      Pages: 357-362

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.2007

    • Author(s)
      Tatebayashi, K., Tanaka, K., Yang, H. -Y., Yamamoto, K., Matsushita, Y., Tomida, T., Imai, M., ^*Saito, H.
    • Journal Title

      EMBO J. 26

      Pages: 3521-3533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain.2007

    • Author(s)
      Miyake, Z., Takekawa, M., Ge, Q., ^*Saito, H.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 2765-2776

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells.2007

    • Author(s)
      Bayarsaikhan, M., Takino, T., Gantulga, D., Sato, H., Ito, T., ^*Yoshioka, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 353

      Pages: 357-362

    • NAID

      120000809366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylaion of the MTK1 kinase domain.2007

    • Author(s)
      Miyake, Zenshi
    • Journal Title

      Molecular and Cellular Biology 27

      Pages: 2765-2776

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.2006

    • Author(s)
      Tatebayashi, Kazuo
    • Journal Title

      The EMBO Journal 25

      Pages: 3033-3044

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification and characterization of Arabidopsis gibberellin receptors.2006

    • Author(s)
      Nakajima, Masatoshi
    • Journal Title

      The Plant Journal 46

      Pages: 880-889

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation.2006

    • Author(s)
      Zou, Hui Chao
    • Journal Title

      Clinical Cancer Research 12

      Pages: 6532-6539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis.2006

    • Author(s)
      Tatebayashi, Yoshitaka
    • Journal Title

      The FASEB Journal 20

      Pages: 762-764

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the b-subunit of coatomer complex, beta-COP.2006

    • Author(s)
      Hata, Shoji
    • Journal Title

      The Journal of Biological Chemistry 281

      Pages: 11214-11224

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.2006

    • Author(s)
      Takahara, Terunao
    • Journal Title

      The Journal of Biological Chemistry 281

      Pages: 28605-28614

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and distribution of JNK/SAPK-assoclated scaffold protein JSAP1 in developing and adult mouse brain.2006

    • Author(s)
      Miura, Eriko
    • Journal Title

      Journal of Neurochemistry 97

      Pages: 1431-1436

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae.2006

    • Author(s)
      Hayashi, Michio
    • Journal Title

      Journal of Biochemistry 139

      Pages: 797-803

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Selective expression of the scaffold protein JSAP1 in spermatogonia and spermatocytes.2006

    • Author(s)
      Bayarsaikhan, Munkhuu
    • Journal Title

      Reproduction 131

      Pages: 711-719

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification and characterization of mouse PSF1-binding protein, SLD5.2006

    • Author(s)
      Kong, Lingyu
    • Journal Title

      Biochemical and Biophysical Research Communications 27

      Pages: 2765-2776

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.2006

    • Author(s)
      Tatebayashi, K., Yamamoto, K., Tanaka, K., Tomida, T., Maruoka, T., Kasukawa, E., ^*Saito, H.
    • Journal Title

      EMBO J. 25

      Pages: 3033-3044

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification and characterization of Arabidopsis gibberellin receptors.2006

    • Author(s)
      ^*Nakajima, M., Shimada, A., Takashi, Y., Kim, Y-C., Park, S-H., Ueguchi-Tanaka, M., Suzuki, H., Kato, E., Iuchi, S., Kobayashi, M., Maeda, T., Matsuoka, M., Yamaguchi, I.
    • Journal Title

      Plant J. 46

      Pages: 880-889

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation.2006

    • Author(s)
      Zou, H. C., Adachi, M., Imai, K., Hareyama, M., Yoshioka, K., Zhao, S., ^*Shinomura, Y.
    • Journal Title

      Clin. Cancer Res. 12

      Pages: 6532-6539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis.2006

    • Author(s)
      Tatebayashi, Y., Planel, E., Chui, D.H., Sato, S., Miyasaka, T., Sahara, N., Murayama, M., Kikuchi, N., Yoshioka, K., Rivka, R., ^*Takashima, A.
    • Journal Title

      FASEB J. 20

      Pages: 762-764

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the b-subunit of coatomer complex, b-COP.2006

    • Author(s)
      Hata, S., Koyama, S., Kawahara, H., Doi, N., Maeda, T., Toyama-Sorimachi, N., Abe, K., Suzuki, K., ^*Sorimachi, H.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 11214-11224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.2006

    • Author(s)
      Takahara, T., Hara, K., Yonezawa, K., Sorimachi, H., ^*Maeda, T.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 28605-28614

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain.2006

    • Author(s)
      Miura, E., Fukaya, M., Sato, T., Sugihara, K., Asano M, Yoshioka, K., ^*Watanabe M.
    • Journal Title

      J. Neurochem. 97

      Pages: 1431-1436

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae.2006

    • Author(s)
      Hayashi, M., ^*Maeda, T.
    • Journal Title

      J. Biochem. 139

      Pages: 797-803

    • NAID

      10018846005

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective expression of the scaffold protein JSAP1 in spermatogonia and spermatocytes.2006

    • Author(s)
      Bayarsaikhan, M., Shiratsuchi, A., Gantulga, D., Nakanishi, Y., ^*Yoshioka, K.
    • Journal Title

      Reproduction 131

      Pages: 711-719

    • NAID

      120000812724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification and characterization of mouse PSF1-binding protein, SLD5.2006

    • Author(s)
      Kong, L., Ueno, M., Itoh, M., Yoshioka, K., ^*Takakura, N.
    • Journal Title

      Biochem. Biophys. Res. Commun. 339

      Pages: 1204-1207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.2006

    • Author(s)
      Tatebayashi, Kazuo
    • Journal Title

      EMBO Journal 25

      Pages: 3033-3044

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSPA1 in developing and adult mouse brain.2006

    • Author(s)
      Miura, Eriko
    • Journal Title

      Journal of Neurochemistry 97

      Pages: 1431-1436

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selective expression of the scaffold protein JSPA1 in spermatogonia and spematocytes.2006

    • Author(s)
      Bayarsaikhan, Munkhuu
    • Journal Title

      Reproduction 131

      Pages: 711-719

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification and characterization of mouse PSF1-binding protein, SLD5.2006

    • Author(s)
      Kong, Lingyu
    • Journal Title

      Biochemical and Biophysical Research Communications 339

      Pages: 1204-1207

    • Related Report
      2006 Annual Research Report
  • [Journal Article] c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis.2006

    • Author(s)
      Tatebayashi, Yoshitaka
    • Journal Title

      FASEB Journal 20

      Pages: 762-764

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.2006

    • Author(s)
      Takahara, Terunao
    • Journal Title

      Journal of Biological Chemistry 281

      Pages: 28605-28614

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.2006

    • Author(s)
      Ono, Yasuko
    • Journal Title

      Journal of Biological Chemistry 281

      Pages: 18519-18531

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification and characterization of Arabidopsis gibberellin receptors.2006

    • Author(s)
      Nakajima, Masatoshi
    • Journal Title

      Plant Journal 46

      Pages: 880-889

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the b-subunit of coatomer complex, b-COP.2006

    • Author(s)
      Hata, Shoji
    • Journal Title

      Journal of Biological Chemistry 281

      Pages: 11214-11224

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conserved docking site is essential for activation of mammalian MAP kinase by specific MAP kinase kinase kinases.2005

    • Author(s)
      Takekawa, Mutsuhiro
    • Journal Title

      Molecular Cell 18

      Pages: 295-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.2005

    • Author(s)
      Nam, Hyun-Joo
    • Journal Title

      The Journal of Experimental Medicine 201

      Pages: 441-452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway.2005

    • Author(s)
      Hayashi, Michio
    • Journal Title

      Molecular and Cellular Biology 25

      Pages: 9478-9490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Convergence of cell cycle regulation and growth factor signals on GRASP65.2005

    • Author(s)
      Yoshimura, Shin-ichiro
    • Journal Title

      The Journal of Biological Chemistry 280

      Pages: 23048-23056

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] JSAP1/JIP3 cooperates with FAK to regulate c-Jun N-terminal kinase and cell migration.2005

    • Author(s)
      Takino, Takahisa
    • Journal Title

      The Journal of Biological Chemistry 280

      Pages: 37772-37781

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aspergillus nidulans HOG pathway is activated only by two-component signaling pathway in response to osmotic stress.2005

    • Author(s)
      Furukawa, Kentaro
    • Journal Title

      Molecular Microbiology 56

      Pages: 1246-1261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dictyostelium discoideum requires an Alix/AIP1 homolog, DdAlix, for morphogenesis in alkaline environments.2005

    • Author(s)
      Ohkouchi, Susumu
    • Journal Title

      FEBS Letters 579

      Pages: 1745-1750

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1.2005

    • Author(s)
      Sato, Tokiharu
    • Journal Title

      Biochemical and Biophysical Research Communications 338

      Pages: 1152-1157

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.2005

    • Author(s)
      Takekawa, M., Tatebayashi, K., ^*Saito, H.
    • Journal Title

      Mol. Cell 18

      Pages: 295-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.2005

    • Author(s)
      Nam, H. -J., Poy, F., ^*Saito, H., Frederick, C.A.
    • Journal Title

      J. Exp. Med. 201

      Pages: 441-452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway.2005

    • Author(s)
      Hayashi, M., Fukuzawa, T., Sorimachi, H., ^*Maeda, T.
    • Journal Title

      Mol. Cell. Biol. 25

      Pages: 9478-9490

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Convergence of cell cycle regulation and growth factor signals on GRASP65.2005

    • Author(s)
      Yoshimura, S., Yoshioka, K., Barr, F. A., Lowe, M., Nakayama, K., Ohkuma, S., ^*Nakamura, N.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 23048-23056

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] JSAP1/JIP3 cooperates with FAK to regulate c-Jun N-terminal kinase and cell migration.2005

    • Author(s)
      ^*Takino, T., Nakada, M., Miyamori, H., Watanabe, Y., Sato, T., Gantulga D., Yoshioka, K., Yamada, K. M., Sato, H.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 37772-37781

    • NAID

      120000814860

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aspergillus nidulans HOG pathway is activated only by two-component signaling pathway in response to osmotic stress.2005

    • Author(s)
      Furukawa, K., Hoshi, Y., Maeda, T., Nakajima, T., ^*Abe, K.
    • Journal Title

      Mol. Microbiol. 56

      Pages: 1246-1261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dictyostelium discoideum requires an Alix/AIP1 homolog, DdAlix, for morphogenesis in alkaline environments.2005

    • Author(s)
      Ohkouchi, S., Saito, H., Aruga, F., Maeda, T., Shibata, H., ^*Maki, M.
    • Journal Title

      FEBS Lett. 579

      Pages: 1745-1750

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1.2005

    • Author(s)
      Sato, T., Hidaka, K., Iwanaga, A., Ito, M., Asano, M., Nakabeppu, Y., Morisaki, T., ^*Yoshioka, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 1152-1157

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Conserved docking site is essential for activation of mammalian MAP kinase by specific MAP kinase kinase kinases2005

    • Author(s)
      Takekawa, Mutsuhiro
    • Journal Title

      Molecular Cell 18-3

      Pages: 295-306

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP12005

    • Author(s)
      Sato, Tokiharu
    • Journal Title

      Biochemical and Biophysical Research Communications 338-2

      Pages: 1152-1157

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway2005

    • Author(s)
      Hayashi, Michio
    • Journal Title

      Molecular and Cellular Biology 25

      Pages: 9478-9490

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structural basis for the function and regulation of the receptor Protein tyrosine phosphatase CD452005

    • Author(s)
      Nam, Hyun-Joo
    • Journal Title

      Journal of Experimental Medicine 201

      Pages: 441-452

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.2004

    • Author(s)
      Akiyama, Shoko
    • Journal Title

      The Journal of Biological Chemistry 279

      Pages: 36616-36620

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Critical roles of c-Jun signaling in regulation of N=AT family and RANKL-regulated osteoclast differentiation.2004

    • Author(s)
      Ikeda, Fumiyo
    • Journal Title

      The Journal of Clinical Investigation 114

      Pages: 475-484

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of the osmoregulatory HOG MAPK cascade in yeast.2004

    • Author(s)
      Saito, Haruo
    • Journal Title

      Journal of Biochemistry 136

      Pages: 267-272

    • NAID

      10016201785

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold protein JSAP1 is transported to growth cones of neuritis independent of JNK signaling pathways in PC12h cells.2004

    • Author(s)
      Sato, Shinji
    • Journal Title

      Gene 329

      Pages: 51-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Membrane type l matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-regulated kinase activation and cell migration.2004

    • Author(s)
      Takino, Takahisa
    • Journal Title

      Cancer Research 64

      Pages: 1044-1049

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.2004

    • Author(s)
      Tsuruta, Fuminori
    • Journal Title

      The EMBO Journal 23

      Pages: 1889-1899

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold proteins in mammalian MAP kinase cascades.2004

    • Author(s)
      Yoshioka, Katsuji
    • Journal Title

      The Journal of Biochemistry 135

      Pages: 657-661

    • NAID

      10016200147

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells.2004

    • Author(s)
      Akiyama, S., Yonezawa, T., Kudo, T., Li, M. G., Wang, H., Ito, M., Yoshioka, K., Ninomiya-Tsuji, J., Matsumoto, K., Kanamaru, R., ^*Tamura, S., ^*Kobayashi, T.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 36616-36620

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.2004

    • Author(s)
      Ikeda, F., ^*Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, S. V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., Kukita, T., Yoshioka, K., Rao, A., Yoneda, T.
    • Journal Title

      J. Clin. Invest. 114

      Pages: 475-484

    • NAID

      120001106909

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of the osmoregulatory HOG MAPK cascade in yeast.2004

    • Author(s)
      ^*Saito, H., Tatebayashi, K.
    • Journal Title

      J. Biochem. (Tokyo) 136

      Pages: 267-272

    • NAID

      10016201785

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells.2004

    • Author(s)
      Sato, S., Ito, M., Ito, T., ^*Yoshioka, K.
    • Journal Title

      Gene 329

      Pages: 51-60

    • NAID

      120000813384

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-regulated kinase activation and cell migration.2004

    • Author(s)
      Takino, T., Miyamori, H., Watanabe, Y., Yoshioka, K., Seiki, M., ^*Sato, H.
    • Journal Title

      Cancer Res. 64

      Pages: 1044-1049

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.2004

    • Author(s)
      Tsuruta, F., Sunayama, J., Mori, Y., Hattori, S., Shimizu, S., Tsujimoto, Y., Yoshioka, K., Masuyama, N., ^*Gotoh, Y.
    • Journal Title

      EMBO J. 23

      Pages: 1889-1899

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold proteins in mammalian MAP kinase cascades.2004

    • Author(s)
      ^*Yoshioka, K.
    • Journal Title

      J. Biochem. (Tokyo) 135

      Pages: 657-661

    • NAID

      10016200147

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of the osmoregulatory HOG MAPK cascade in yeast2004

    • Author(s)
      Saito, Haruo
    • Journal Title

      Journal of Biochemistry 136

      Pages: 276-272

    • NAID

      10016201785

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Scaffold proteins in mammalian MAP kinase cascades2004

    • Author(s)
      Yoshioka, Katsuji
    • Journal Title

      Journal of Biochemistry 135

      Pages: 657-661

    • NAID

      10016200147

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells2004

    • Author(s)
      Akiyama, Shoko
    • Journal Title

      Journal of Biological Chemistry 279

      Pages: 36616-36620

    • Related Report
      2004 Annual Research Report
  • [Journal Article] JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins2004

    • Author(s)
      Tsuruta, Fuminori
    • Journal Title

      EMBO Journal 23

      Pages: 1889-1899

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells2004

    • Author(s)
      Sato, Shinji
    • Journal Title

      Gene 329

      Pages: 51-60

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Caspase-mediated cleavage of JN during stress-induced apoptosis.2003

    • Author(s)
      Enomoto, Atsushi
    • Journal Title

      Biochemical and Biophysical Research Communications 306

      Pages: 837-842

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold proteins of the cJun-NH2-terminal kinase (JNK)signaling pathways in neuronal cells.2003

    • Author(s)
      Ito, Michikiko
    • Journal Title

      Recent Res. Devel. Biochem. 4

      Pages: 271-282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo.2003

    • Author(s)
      Krueger, Neil x
    • Journal Title

      Molecular and Cellular Biology 23

      Pages: 6909-6921

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure.2003

    • Author(s)
      Reiser, Vladimir
    • Journal Title

      The Journal of Cell Biology 161

      Pages: 1035-1040

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Sln1-Ypd1-Ssk1 multistep phosphorelay system that regulates an osmosensing MAP kinase cascade in yeast.2003

    • Author(s)
      Saito, Haruo
    • Journal Title

      “Histidine kinases in signal transduction, "edited by Inouye, M., and Dutta, R., Academic Press, San Diego

      Pages: 397-419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.2003

    • Author(s)
      Sato, Naoto
    • Journal Title

      Molecular and Cellular Biology 23

      Pages: 6662-6671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway・2003

    • Author(s)
      Tatebayashi, Kazuo
    • Journal Title

      The EMBO Journal 22

      Pages: 3624-3634

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro development of mouse embryonic stem cells lacking JNK/stress-activatedprotein kinase-associated protein (JSAP1)scaffold protein revealed itsrequirement during early embryonic neurogenesis.2003

    • Author(s)
      Xu, Ping
    • Journal Title

      The Journal of Biological Chemistry 278

      Pages: 48422-48433

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Caspase-mediated cleavage of JNK during stress-induced apoptosis.2003

    • Author(s)
      Enomoto, A., Suzuki, N., Morita, A., Ito, M., Liu, C. Q., Matsumoto, Y., Yoshioka, K., Shiba, T., ^*Hosoi, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun. 306

      Pages: 837-842

    • NAID

      130005442879

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Scaffold proteins of the cJun-NH2-terminal kinase (JNK) signaling pathways in neuronal cells.2003

    • Author(s)
      Ito, M., ^*Yoshioka, K.
    • Journal Title

      Recent Res. Devel. Biochem. 4

      Pages: 271-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo.2003

    • Author(s)
      Krueger, N. X., Reddy, R. S., Johnson, K., Bateman, J., Kaufmann, N., Scalice, D., Van Vactor, D., ^*Saito, H.
    • Journal Title

      Mol. Cell. Biol. 23

      Pages: 6909-6921

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure.2003

    • Author(s)
      Reiser, V., Raitt, D. C., ^*Saito, H.
    • Journal Title

      J. Cell Biol. 161

      Pages: 1035-1040

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Sln1-Ypd1-Ssk1 multistep phosphorelay system that regulates an osmosensing MAP kinase cascade in yeast.2003

    • Author(s)
      ^*Saito, H.
    • Journal Title

      In Histidine kinases in signal transduction, ((Inouye, M., & Dutta, R., Eds). Academic Press, San Diego. )

      Pages: 397-419

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.2003

    • Author(s)
      Sato, N., Kawahara, H., Toh-e, A., ^*Maeda, T.
    • Journal Title

      Mol. Cell. Biol. 23

      Pages: 6662-6671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.2003

    • Author(s)
      Tatebayashi, K., Takekawa, M., ^*Saito, H.
    • Journal Title

      EMBO J. 22

      Pages: 3624-3634

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis.2003

    • Author(s)
      Xu, P., Yoshioka, K., Yoshimura, D., Tominaga, Y., Nishioka, T., Ito, M., ^*Nakabeppu, Y.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 48422-48433

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of MTK1/MEKK4 kinase activity by its N-terminal domain and Gadd45 binding.2002

    • Author(s)
      Mita, Hiroaki
    • Journal Title

      Molecular and Cellular Biology 22

      Pages: 4544-4555

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aberrant tau phosphorylation by glycogen synthase kinase-3βand JNK3 induces oligomeric tau fibrils in COS-7 cells.2002

    • Author(s)
      Sato, Shinji
    • Journal Title

      The Journal of Biological Chemistry 277

      Pages: 42060-42065

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Smad-dependent GADD45βexpression mediates delayed activation of p38 MAP kinase by TGF-β.2002

    • Author(s)
      Takekawa, Mutsuhiro
    • Journal Title

      The EMBO Journal 21

      Pages: 6473-6482

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.2002

    • Author(s)
      Takino, Takahisa.
    • Journal Title

      Oncogene 21

      Pages: 6488-6497

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.2002

    • Author(s)
      Tsujikawa, Kazutake
    • Journal Title

      Molecular Cancer Research 1

      Pages: 155-163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of MTK1/MEKK4 kinase activity by its N-terminal domain and GADD45 binding.2002

    • Author(s)
      Mita, H., Tsutsui, J., Takekawa, M., Witten, E. A., ^*Saito, H.
    • Journal Title

      Mol. Cell. Biol. 22

      Pages: 4544-4555

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aberrant tau phosphorylation by glycogen synthase kinase-3b and JNK3 induces oligomeric tau fibrils in COS-7 cells.2002

    • Author(s)
      Sato, S., Tatebayashi, Y., Akagi, T., Chui, D. -H., Murayama, M., Miyasaka, T., Planel, E., Tanemura, K., Sun, X., Hashikawa, T., Yoshioka, K., Ishiguro, K., ^*Takashima, A.
    • Journal Title

      J. Biol. Chem. 277

      Pages: 42060-42065

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Smad-dependent GADD45b expression mediates delayed activation of p38 MAP kinase by TGF-b.2002

    • Author(s)
      Takekawa, M., Tatebayashi, K., Itoh, F., Adachi, M., Imai, K., ^*Saito, H.
    • Journal Title

      EMBO J. 21

      Pages: 6473-6482

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.2002

    • Author(s)
      Takino, T., Yoshioka, K., Miyamori, H., Yamada, K.M., ^*Sato, H.
    • Journal Title

      Oncogene 21

      Pages: 6488-6497

    • NAID

      120000814771

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.2002

    • Author(s)
      Tsujikawa, K., Ichijo, T., Moriyama, K., Tadotsu, N., Sakamoto, K., Sakane, N., Fukada, S., Furukawa, T., Saito, H., ^*Yamamoto, H.
    • Journal Title

      Mol. Cancer Res. 1

      Pages: 155-163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective Expression of the scaffold protein JSPA1 in spermatogonia and spermatocytes

    • Author(s)
      Bayarsaikhan, Munkhuu
    • Journal Title

      Reproduction (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the β-subunit of coatomer complex, β-COP

    • Author(s)
      Hata, Shoji
    • Journal Title

      Journal of Biological Chemistry (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Publications] Reiser, Vladimir: "Yeast osmosensor Slnl and plant cytokinin receptor Crel respond to changes in turgor pressure."Journal of Cell Biology. 161. 1035-1040 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tatebayashi, Kazuo: "A docking site determining specificity of Pbs2 MAPKKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway."EMBO Journal. 22. 3624-3634 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Krueger, Neil X.: "Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo."Molecular and Cellular Biology. 23. 6909-6921 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Enomoto, Atsushi: "Caspase-mediated cleavage of JNK during stress-induced apoptosis."Biochemical and Biophysical Research Communication. 306. 837-842 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, Naoto: "Phosphorelay-regulated degradation of the yeast Ssklp response regulator by the ubiquitin-proteasome system."Molecular and Cellular Biology. 23. 6662-6671 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Xu, Ping: "In vitro development of mouse embryonic stem cells lacking JNK/ stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis."Journal of Biological Chemistry. 278. 48422-48433 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mita, Hiroaki: "Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding"Molecular and Cellular Biology. 22. 4544-4555 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takekawa, Mutsuhiro: "Smad-dependent GADD45β expression mediates delayed activation ofp38 MAP kinase by TGF-β"EMBO Journal. 21. 6473-6482 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsuura, Hiroshi: "Phosphorylation-dependent scaffolding role of JASP1/JIP3 in the ASK1-JNK signaling pathway"Journal of Biological Chemistry. 277. 40703-40709 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato, Shinji: "Aberrant Tau phosphorylation by Glycogen Synthase Kinases-3β and JNK3 induces oligomeric Tau fibrils in COS-7 cells"Journal of Biological Chemistry. 277. 42060-42065 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takino, Takahisa: "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phoshorylatged"Oncogene. 21. 6488-6497 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 武川 睦寛: "ストレス反応MAPキナーゼ"蛋白質核酸酵素. 47. 1379-1389 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inouye, Masayori: "HISTIDINE KINASES IN SIGNAL TRANSDUCTION"Academic Press. 520 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2018-03-28  

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