• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular, cellular and in vivo analyses of photoresponses and circadian rhythms in animals

Research Project

Project/Area Number 14104003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field 動物生理・代謝
Research InstitutionUniversity of Tokyo

Principal Investigator

FUKADA Yoshitaka  University of Tokyo, Graduate School of Science, Professor, 大学院理学系研究科, 教授 (80165258)

Co-Investigator(Kenkyū-buntansha) KOJIMA Daisuke  University of Tokyo, Graduate School of Science, Assistant Professor, 大学院理学系研究科, 助手 (60376530)
HIROTA Tsuyoshi  University of Tokyo, Graduate School of Science, Project Research Assistant, 大学院理学系研究科, 拠点形成特任教員 (50372412)
岡野 俊行  東京大学, 大学院・理学系研究科, 講師 (40272471)
和田 恭高  東京大学, 大学院・理学系研究科, リサーチフェロー (90376559)
仲村 厚志  東京大学, 大学院・理学系研究科, 特別研究員(PD)
Project Period (FY) 2002 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥111,930,000 (Direct Cost: ¥86,100,000、Indirect Cost: ¥25,830,000)
Fiscal Year 2006: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2005: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2004: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2003: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2002: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
KeywordsPineal gland / Suprachiasmatic nucleus / Photoreceptive molecule / Exorhodopsin / G-protein / MAPK / Peripheral clock / E4BP4 / 概日時計 / CREB / ゼブラフィッシュ / Per / グルコース / TIEG1 / Bmal1 / サーカディアンリズム / クリプトクローム / リン酸化 / GSK-3β / 視細胞 / ファルネシル化 / 明順応 / MAPキナーゼ / 転写調節 / カゼインキナーゼ1 / p38キナーゼ / カルシウム結合蛋白質 / BMAL1 / G11
Research Abstract

(1)Activation of Gil induced a phase-shift of the chick pineal circadian clock in a manner similar to that induced by light. In the promoter region of pinopsin gene, we identified a light-responsive element responsible for its light-dependent transcriptional activation.
(2)Farnesylation of retinal rod G-protein transducin plays an important role in not only the cellular light-signaling but also the light-adaptation. We found that GRK7-1 expressed in the zebrafish retinal cones shows opsin-phosphorylating activity dozens-fold higher than that of rod-specific GRK1A.
(3)Chick pineal and frog retinal MAPK was circadian-activated showing the peak activity at night. Within the mouse SCN, the profiles of the temporal and light activation of MAPK are both different between the dorsomedial and central regions of the SCN. We identified amino acid residues in BMAL1, CRY1 and CRY2 to be phosphorylated by MAPK and their phosphorylation-dependent functional changes. We also found that SCOP expressed abundantly in the SCN is a negative regulator of K-Ras and downstream MAPK. It was shown that p38 MAPK regulates the molecular clock in the daytime to have the phase-advancing effect.
(4)When the chicks entrained to 12L : 12D conditions were exposed to prolonged light extending into the early night, pineal E4BP4 protein was kept at a high level, which delayed the morning induction of Per2 and delayed the phase of the pineal clock. E4BP4 was phosphorylated by CKIε, leading to its proteasomal degradation.
(5)We found that glucose-stimulation of rat-1 cells resets the clock by a mechanism to which Tieg 1 and Vdup 1 contribute. TIEG 1 protein was in fact up-regulated upon glucose administration and it directly acts on the promoter of Bmall to inhibit the transcription.
(6)Within the promoter region of pineal opsin exorhodopsin gene, we identified a cis-acting element, PIPE, that drives pineal-specific gene expression in the zebrafish.

Report

(6 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (155 results)

All 2007 2006 2005 2004 2003 2002 Other

All Journal Article (99 results) Book (30 results) Publications (26 results)

  • [Journal Article] A median third eye : Pineal gland retraces evolution of vertebrate photoreceptive organ.2007

    • Author(s)
      Hiroaki Mano
    • Journal Title

      Photochem. Photobiol. 83

      Pages: 11-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of photoreception and circadian clock systems in animals.2007

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Zool. Sci. 23

      Pages: 1118-1119

    • NAID

      130000017054

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in pre-ovulatory ovarian follicles.2007

    • Author(s)
      Nobuhiro Nakao
    • Journal Title

      Endocrinol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of melatonin in photoperiodic gonadal response of birds.2007

    • Author(s)
      Tomoko Yoshikawa
    • Journal Title

      Experimental Endocrinology and Reproductive Biology (eds. C. Haldar & M. Singaravel) (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A median third eye : Pineal gland retraces evolution of vertebrate photoreceptive organ2007

    • Author(s)
      Hiroaki Mano et al.
    • Journal Title

      Photochem.Photobiol 83

      Pages: 11-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of photoreception and circadian clock systems in animals2007

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Zool.Sci. 23

      Pages: 1118-1119

    • NAID

      130000017054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Shishitsushuushoku : Tanpakushitsu no kinouseigyoinshi2007

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Bunshisaibouchiryou Vol.6, No.1

      Pages: 43-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Seibutsu ha donoyouuni toki wo kizandeirunodarouka?2007

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Biophilia Vol.3, No.1

      Pages: 8-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A median third eye : Pineal gland retraces evolution of vertebrate photoreceptive organ.2007

    • Author(s)
      Hiroaki Mano
    • Journal Title

      Photochem.Photobiol. 83

      Pages: 11-18

    • Related Report
      2006 Annual Research Report
  • [Journal Article] GRK1 and GRK7 : Unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.2006

    • Author(s)
      Yasutaka Wada
    • Journal Title

      J. Neurochem. 98

      Pages: 824-837

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nucleus of the mouse.2006

    • Author(s)
      Nobuhiro Kurabayashi
    • Journal Title

      Chronobiology Int. 23

      Pages: 129-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.2006

    • Author(s)
      Yoko Kubo
    • Journal Title

      J. Neurochem. 97

      Pages: 1155-1165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland.2006

    • Author(s)
      Megumi Hatori
    • Journal Title

      J. Neurochem. 90

      Pages: 1790-1800

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] GRK1 and GRK7 : Unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones2006

    • Author(s)
      Yasutaka Wada et al.
    • Journal Title

      J.Neurochem. 98

      Pages: 824-837

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nucleus of the mouse2006

    • Author(s)
      Nobuhiro Kurabayashi et al.
    • Journal Title

      Chronobiology Int. 23

      Pages: 129-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland2006

    • Author(s)
      Yoko Kubo et al.
    • Journal Title

      J.Neurochem. 97

      Pages: 1155-1165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland2006

    • Author(s)
      Megumi Hatori et al.
    • Journal Title

      J.Neurochem. 96

      Pages: 1790-1800

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Doubutsu no hikarijuyou to seibutsudokei no bunshimekanisumu ni kansurukenkyu2006

    • Author(s)
      Yohitaka Fukada
    • Journal Title

      Seibutsukagaku News 8

      Pages: 17-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Seibutsudokeisisutemu heno bunshiapurouchi2006

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Jikken Igaku Vol.24, No.4

      Pages: 446-451

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tokeipanpakushitsu no Tadankairinsanka2006

    • Author(s)
      Tsuyoshi Hirota et al.
    • Journal Title

      Jikken Igaku Vol.24, No.4

      Pages: 452-459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Shitsurryoubunsekihou niyoru honyakugoshuushoku no seimitsukaiseki ~Hikarishigunarudentatsukei deno fanesiruka no yakuwari2006

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Saiboukougaku Vol.25, No.6

      Pages: 608-612

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] G tanpakushitsu no sentakutekifarunesiruka niyoru hikarisigunarudenntatsu no seigyo2006

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Seikagaku Vol.78, No.6

      Pages: 533-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Seibutsudokei no seikagaku2006

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Gakujutsugeppou Vol.59, No.12

      Pages: 17-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hikari kara tokeiidenshi heno bunshikikou2006

    • Author(s)
      Toshiyuki Okano et al.
    • Journal Title

      Igaku no Ayumi Vol.216

      Pages: 211-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nuclear of the mouse.2006

    • Author(s)
      Nobuhiro Kurabayashi
    • Journal Title

      Chronobiology Int. 23

      Pages: 129-134

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular cloning, mRNA expression, and immunocytochemical localization of a putarive blue-light photoreceptor CRY4 in the chicken pineal gland.2006

    • Author(s)
      Yoko Kubo
    • Journal Title

      J.Neurochem. 97

      Pages: 1155-1165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] GRK1 and GRK7 : Unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.2006

    • Author(s)
      Yasutaka Wada
    • Journal Title

      J.Neurochem. 98

      Pages: 824-837

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Roles of melatonin in photoperiodic gonadal response of birds.2006

    • Author(s)
      Tomoko Yoshikawa
    • Journal Title

      Experimental Endocrinology and Reproductive Biology (eds.C.Haldar & M.Singaravel) (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland.2006

    • Author(s)
      Megumi Hatori
    • Journal Title

      J.Neurochem. 90

      Pages: 1790-1800

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nucleus of the mouse.2006

    • Author(s)
      Nobuhiro Kurabayashi
    • Journal Title

      Chronobiology Int. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.2006

    • Author(s)
      Yoko Kubo
    • Journal Title

      J.Neurochem. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] GRK1 and GRK7:Unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.2006

    • Author(s)
      Yasutaka Wada
    • Journal Title

      J.Neurochem. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Farnesylation of retinal transducin underlies its translocation during light adaptation.2005

    • Author(s)
      Hidetoshi Kassai
    • Journal Title

      Neuron 47

      Pages: 529-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Ser557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by GSK-3β.2005

    • Author(s)
      Yuko Harada
    • Journal Title

      J. Biol. Chem. 280

      Pages: 31714-31721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Top-down analysis of protein isoprenylation by electrospray ionization hybrid quadrupole-TOF tandem mass spectrometry; the mouse T_γ protein.2005

    • Author(s)
      Hidetoshi Kassai
    • Journal Title

      Rapid Commun. Mass Spectrom. 19

      Pages: 269-274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Farnesylation of retinal transducin underlies its translocation during light adaptation2005

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Neuron 47

      Pages: 529-539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ser557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by GSK-3β2005

    • Author(s)
      Yuko Harada et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 31714-31721

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Top-down analysis of protein isoprenylation by electrospray ionization hybrid quadrupole-TOF tandem mass spectrometry ; the mouse Tγ protein2005

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Rapid Commun.Mass Spectrom. 19

      Pages: 269-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] G tanpakushitsu no shishitsushuushoku wo kaishita sigunarudenntatsu no chousetsu2005

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Jikken Igaku Vol.23, No.6

      Pages: 62-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Seibutsudokei sisutemu niokeru rinsankanoyakuwari2005

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Jikken Igaku Vol.23, No.11

      Pages: 137-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Shisaiboutransudushiin2005

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Seibutsuyakkakagaku Jikkenkouza 7-II

      Pages: 297-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hikariseitairizumuseigyo2005

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Hikarikagakukenkyuu no Saizensen

      Pages: 342-343

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tanpakushitsu no shishitsushuushoku2005

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Jikkenigaku Bessatsu,"Tanpakushitsu kaiseki purotokouru

      Pages: 186-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isopureniruka no kaiseki2005

    • Author(s)
      Hidetoshi Kassai et al.
    • Journal Title

      Jikkenigaku Bessatsu,"Tanpakushitsu kaiseki purotokouru"

      Pages: 216-224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ser557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by GSK-3β.2005

    • Author(s)
      Yuko Harada
    • Journal Title

      J.Biol.Chem. 280

      Pages: 31714-31721

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Top-down analysis of protein isoprenylation by electrospray ionization hybrid quadrupole-TOF tandem mass spectrometry ; the mouse T2005

    • Author(s)
      Hidetoshi Kassai
    • Journal Title

      Papid Commun. Mass Spectrom. 19

      Pages: 269-274

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Analysis of the molecular interaction of the farnesyl moiety of transducin through use of a photoreactive farnesyl analog.2004

    • Author(s)
      Ken'ichi Hagiwara
    • Journal Title

      Biochemistry 43

      Pages: 300-309

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase.2004

    • Author(s)
      Kamon Sanada
    • Journal Title

      Genes Cells 9

      Pages: 697-708

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Negative control of circadian clock regulator E4BP4 by casein kinase Iε-mediatedphosphorylation.2004

    • Author(s)
      Masao Doi
    • Journal Title

      Curr. Biol. 14

      Pages: 975-980

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals.2004

    • Author(s)
      Tsuyoshi Hirota
    • Journal Title

      Zool. Sci. 21

      Pages: 359-368

    • NAID

      110006282406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Production of N-lauroylated G protein α-subunit in Sf9 insect cells : The type of N-acyl group of Gα influences G protein-mediated signal transduction.2004

    • Author(s)
      Yuichi Hashimoto
    • Journal Title

      J. Biochem. 135

      Pages: 319-329

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of the molecular interaction of the farnesyl moiety of transducin through use of a photoreactive farnesyl analog2004

    • Author(s)
      Kenichi Hagiwara et al.
    • Journal Title

      Biochemistry 43

      Pages: 300-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase2004

    • Author(s)
      Kamon Sanada et al.
    • Journal Title

      Genes Cells 9

      Pages: 697-708

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Negative control of circadian clock regulator E4BP4 by casein kinase Iε-mediated phosphorylation2004

    • Author(s)
      Masao Doi et al.
    • Journal Title

      Curr.Biol. 14

      Pages: 975-980

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals2004

    • Author(s)
      Tsuyoshi Hirota et al.
    • Journal Title

      Zool.Sci. 21

      Pages: 359-368

    • NAID

      110006282406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Production of N-lauroylated G protein α-subunit in Sf9 insect cells : The type of N-acyl group of Go influences G protein-mediated signal transduction2004

    • Author(s)
      Yuichi Hashimoto et al.
    • Journal Title

      J.Biochem. 135

      Pages: 319-329

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tokeiidennshisouron2004

    • Author(s)
      Toshiyuki Okano et al.
    • Journal Title

      Tokeiiidenshi no bunshiseibutsugaku

      Pages: 41-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gaijitsuhikarijuyoutai toha nanika2004

    • Author(s)
      Daisuke Kojima et al.
    • Journal Title

      Tokeiiidenshi no bunshiseibutsugaku

      Pages: 41-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adenirusansirakuuze2004

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Tanpakushitsukagakukouza 4-II

      Pages: 341-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Production of N-lauroylated G protein α-subunit in Sf9 insect cells : The type of N-acy1 group of Gα influences G protein-mediated signal transducti2004

    • Author(s)
      Yuichi Hashimoto
    • Journal Title

      J.Biochem. 135

      Pages: 319-329

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals.2004

    • Author(s)
      Tsuyoshi Hirota
    • Journal Title

      Zool.Sci. 21

      Pages: 359-368

    • NAID

      110006282406

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Negative control of circadian clock regulator E4BP4 by casein kinase Iε-mediatedphosphorylation.2004

    • Author(s)
      Masao Doi
    • Journal Title

      Curr.Biol. 14

      Pages: 975-980

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Purification and immunohistochemical analysis of calcium-binding proteins expressed in the chick pineal gland.2003

    • Author(s)
      Fumiko Shimizu
    • Journal Title

      J. Pineal Res. 34

      Pages: 208-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.2003

    • Author(s)
      Kimiko Shimizu
    • Journal Title

      J. Biol. Chem. 278

      Pages: 14920-14925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Spatial and temporal regulation of mitogen-activated protein kinase phosphorylation in the mouse suprachiasmatic nucleus.2003

    • Author(s)
      Michio Nakaya
    • Journal Title

      Biochem. Biophys. Res. Commun. 305

      Pages: 494-501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock.2003

    • Author(s)
      Yuichiro Hayashi
    • Journal Title

      J. Biol. Chem. 278

      Pages: 25166-25171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of gonadal steroids on pineal morphogenesis and cell differentiation of the embryonic quail studied under a cell culture condition.2003

    • Author(s)
      Chandana Haldar
    • Journal Title

      Dev. Brain Res. 145

      Pages: 71-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular oscillation behind the clockface.2003

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      J. Biochem. 134

      Pages: 773-775

    • NAID

      10012059368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chicktacking pineal clock.2003

    • Author(s)
      Toshiyuki Okano
    • Journal Title

      J. Biochem. 134

      Pages: 791-797

    • NAID

      50000393688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Purification and immunohistochemical analysis of calcium-binding proteins expressed in the chick pineal gland2003

    • Author(s)
      Fumiko Shimizu et al.
    • Journal Title

      J.Pineal Res. 34

      Pages: 208-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway2003

    • Author(s)
      Kimiko Shimizu et al.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 14920-14925

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Spatial and temporal regulation of mitogen-activated protein kinase phosphorylation in the mouse suprachiasmatic nucleus2003

    • Author(s)
      Michio Nakaya et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 305

      Pages: 494-501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] p38 Mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock2003

    • Author(s)
      Yuichiro Hayashi et al.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 25166-25171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of gonadal steroids on pineal morphogenesis and cell differentiation of the embryonic quail studied under cell culture conditions2003

    • Author(s)
      Chandana Haldar et al.
    • Journal Title

      Dev.Brain Res. 145

      Pages: 71-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular oscillation behind the clockface2003

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      J.Biochem. 134

      Pages: 773-775

    • NAID

      10012059368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chicktacking pineal clock2003

    • Author(s)
      Toshiyuki Okano et al.
    • Journal Title

      J.Biochem. 134

      Pages: 791-797

    • NAID

      50000393688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Shoukatai no hikarijuyou to gaijitsudokeisisutemu2003

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Nou to Shinkei Vol.55, No.1

      Pages: 13-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Shikakuijoushou2003

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Zusetsu Bunshibyoutaigaku 3

      Pages: 378-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Circadian clock system in the pineal gland.2002

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      Mol. Neurobiol. 25

      Pages: 19-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1.2002

    • Author(s)
      Kamon Sanada
    • Journal Title

      J. Biol. Chem. 277

      Pages: 267-211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A negative regulatory element required for light-dependent pinopsin gene expression.2002

    • Author(s)
      Yoko Takanaka
    • Journal Title

      J. Neurosci. 22

      Pages: 4357-4363

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Light-dependent changes in the chick pineal temperature and the expression of cHsp90α gene : A potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock.2002

    • Author(s)
      Masao Doi
    • Journal Title

      Zool. Sci. 19

      Pages: 633-641

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock.2002

    • Author(s)
      Takaoki Kasahara
    • Journal Title

      J. Neurosci. 22

      Pages: 7321-7325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts.2002

    • Author(s)
      Tsuyoshi Hirota
    • Journal Title

      J. Biol. Chem. 277

      Pages: 44244-44251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pineal expression-promoting element (PIPE), a cis-acting element, direcs pineal-specific gene expression in zebrafish.2002

    • Author(s)
      Yoichi Asaoka
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 99

      Pages: 15456-15461

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Circadian clock system in the pineal gland2002

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Mol.Neurobiol. 25

      Pages: 19-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL12002

    • Author(s)
      Kamon Sanada et al.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 267-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A negative regulatory element required for light-dependent pinopsin gene expression2002

    • Author(s)
      Yoko Takanaka et al.
    • Journal Title

      J.Neurosci. 22

      Pages: 4357-4363

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Light-dependent changes in the chick pineal temperature and the expression of cHsp90a gene : A potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock2002

    • Author(s)
      Masao Doi et al.
    • Journal Title

      Zool.Sci. 19

      Pages: 633-641

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock2002

    • Author(s)
      Takaoki Kasahara et al.
    • Journal Title

      J.Neurosci. 22

      Pages: 7321-7325

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts2002

    • Author(s)
      Tsuyoshi Hirota et al.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 44244-44251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pineal expression-promoting element (PIPE), a cis-acting element, directs pineal-specific gene expression in zebrafish2002

    • Author(s)
      Yoichi Asaoka et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 99

      Pages: 15456-15461

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nounaihikarijuyou to tainaidokei no jikokuchousetsu2002

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Gendaikagaku No.370

      Pages: 24-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tainaidokei no jikoku wo chousetsusuru idenshi no hakken2002

    • Author(s)
      Toshiyuki Okano et al.
    • Journal Title

      Seibutsu no Kagaku. Iden Vol.56, No.2

      Pages: 26-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tainaidokei to meratoninngousei2002

    • Author(s)
      Yoshitaka Fukada et al.
    • Journal Title

      Genddaiiryo Vol.34, No.6

      Pages: 35-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in pre-ovulatory ovarian follicles

    • Author(s)
      Nobuhiro Nakao et al.
    • Journal Title

      Endocrinol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of melatonin in photoperiodic gonadal response of birds

    • Author(s)
      Tomoko Yoshikawa et al.
    • Journal Title

      Experimental Endocrinology and Reproductive Biology (C.Haldar & M.Singaravel eds.) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Joshou : Kankakukei to Seibutsudokei no taihi to renkan

    • Author(s)
      Yoshitaka Fukada
    • Journal Title

      21seiki no doubutsukagaku : 9 "Doubutsu no kankaku to rizumu" (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dairokushou : Gaijitsueizumu no bunshikikou

    • Author(s)
      Toshiyuki Okano et al.
    • Journal Title

      21seiki no doubutsukagaku : 9 "Doubutsu no kankaku to rizumu" (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 分子細胞治療 特集『蛋白質修飾』の「脂質修飾 : タンパク質の機能制御因子」の項を分担執筆2007

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      先端医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Book] Biophilia 特集『眠りのサイエンス』の「生物はどのように時間を刻んでいるのだろうか?~生物時計~」の項を分担執筆2007

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      株式会社アドスリー
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] シリーズ21世紀の動物科学 : 第9巻『動物の感覚とリズム』の序章 : 感覚系と生物時計の対比と連関の項を分担執筆2007

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      培風館(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] シリーズ21世紀の動物科学 : 第9巻『動物の感覚とリズム』の第6章 : 概日リズムの分子機構の項を分担執筆2007

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      株式会社アドスリー(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『生物科学ニュース』の「動物の光受容と生物時計の分子メカニズムに関する研究(平成18年度 日本動物学会賞 受賞研究内容)」の項を執筆2007

    • Author(s)
      深田 吉孝
    • Publisher
      日本動物学会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Biophilia 特集『眠りのサイエンス』の「生物はどのように時間を刻んでいるのだろうか?〜生物時計〜」の項を分担執筆2007

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      株式会社アドスリー
    • Related Report
      2006 Annual Research Report
  • [Book] 実験医学 特集『ここまでわかった生物時計の分子ネットワーク』の「生物時計システムへの分子アプローチ」の項を分担執筆2006

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 実験医学 特集『ここまでわかった生物時計の分子ネットワーク』の「時計タンパク質の多段階リン酸化」の項を分担執筆2006

    • Author(s)
      広田 毅(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 細胞工学 特集『プロテオミクスの細胞機能解析への挑戦』の「質量分析法による翻訳後修飾の精密解析~光シグナル伝達系でのファルネシル化の役割~」の項を分担執筆2006

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      秀潤社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 「Gタンパク質の選択的ファルネシル化による光シグナル伝達の制御」の項を分担執筆2006

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      生化学
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Book] 特集『時間生物学』の「生物時計の生化学」の項を分担執筆2006

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      学術月報
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Book] 医学のあゆみ 特集『時計遺伝子』の「光から時計遺伝子への分子機構」の項を分担執筆2006

    • Author(s)
      岡野 俊行(分担執筆)
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 細胞工学 特集『プロテオミクスの細胞機能解析への挑戦』の「質量分析法による翻訳後修飾の精密解析〜光シグナル伝達系でのファルネシル化の役割〜」の項を分担執筆2006

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      秀潤社
    • Related Report
      2006 Annual Research Report
  • [Book] 実験医学増刊号『ダイナミックに新展開する脂質研究』の「Gタンパク質の脂質修飾を介したシグナル伝達の調節」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 実験医学 増刊号『シグナル伝達研究2005-'06』の「生物時計システムにおけるリン酸化の役割」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 『生物薬科科学実験講座 第7巻-II』の「情報伝達物質[II]シグナル伝達系と細胞機能」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 『光科学研究の最前線』の「光生体リズム制御」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      強光子場科学研究懇談会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] 実験医学 別冊『タンパク質の修飾解析プロトコール』の「タンパク質の脂質修飾」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 実験医学 別冊『タンパク質の翻訳修飾解析プロトコール』~脂質修飾の解析~の「イソプレニル化の解析」の項を分担執筆2005

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 実験医学 別冊『タンパク質の翻訳後修飾解析プロトコール』〜脂質修飾の解析〜の「イソプレニル化の解析」の項を分担執筆2005

    • Author(s)
      葛西 秀俊(分担執筆)
    • Publisher
      羊土社
    • Related Report
      2005 Annual Research Report
  • [Book] 実験医学増刊号『ダイナミックに新展開する脂質研究』の「Gタンパク質の脂質修飾を介したシグナル伝達の調節」の項を分担執筆2005

    • Author(s)
      深田 吉孝(分担執筆)
    • Total Pages
      238
    • Publisher
      羊土杜
    • Related Report
      2004 Annual Research Report
  • [Book] 『時計遺伝子の分子生物学』の「時計遺伝子総論 : 脊椎動物」の項を分担執筆(岡村均、深田吉孝編)2004

    • Author(s)
      岡野 俊行(分担執筆)
    • Publisher
      シュプリンガーフェアラーク東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『時計遺伝子の分子生物学』の「概日光受容体とは何か」の項を分担執筆(岡村均、深田吉孝 編)2004

    • Author(s)
      小島 大輔(分担執筆)
    • Publisher
      シュプリンガーフェアラーク東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] タンパク質化学講座 第4巻-II『酵素-リアーゼ(II)』の「アデニル酸シクラーゼ」の項を分担執筆2004

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] タンパク質化学講座 第4巻-II『酵素-リアーゼ(II)』の「アデニル酸シクラーゼ」の項を分担執筆2004

    • Author(s)
      深田 吉孝(分担執筆)
    • Total Pages
      372
    • Publisher
      広川書店
    • Related Report
      2004 Annual Research Report
  • [Book] 『脳と神経』55(1)の「松果体の光受容と概日時計システム」の項を分担執筆2003

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『図説 分子病態学』改訂3版 の「視覚異常症」の項を分担執筆2003

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『現代化学』370の「脳内光受容と体内時計の時刻調節」の項を分担執筆2002

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      東京化学同人
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『生物の科学 遺伝』56の「体内時計の時刻を調節する遺伝子の発見」の項を分担執筆2002

    • Author(s)
      岡野 俊行(分担執筆)
    • Publisher
      裳華房
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 『現代医療』34(6)の「体内時計とメラトニン合成」の項を分担執筆2002

    • Author(s)
      深田 吉孝(分担執筆)
    • Publisher
      現代医療社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] Fumiko Shimizu: "Purification and immunohistochemical analysis of calcium-binding proteins expressed in the chick pineal gland."J.Pineal Res.. 34. 208-216 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimiko Shimizu: "Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway."J.Biol.Chem.. 278. 14920-14925 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Michio Nakaya: "Spatial and temporal regulation of mitogen-activated protein kinase phosphorylation in the mouse suprachiasmatic nucleus."Biochem.Biophys.Res.Commun.. 305. 494-501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yuichiro Hayashi: "p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock."J.Biol.Chem.. 278. 25166-25171 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Chandana Haldar: "Effects of gonadal steroids on pineal morphogenesis and cell differentiation of the embryonic quail studied under a cell culture condition."Dev.Brain Res.. 145. 71-79 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshitaka Fukada: "Molecular oscillation behind the clockface."J.Biochem.. 134. 773-775 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshiyuki Okano: "Chicktacking circadian clock."J.Biochem.. 134. 791-797 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ken'ichi Hagiwara: "Analysis of the molecular interaction of the farnesyl moiety of transducin through use of a photoreactive farnesyl analog."Biochemistry. 43. 300-309 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yuichi Hashimoto: "Production of N-lauroylated G protein α-subunit in Sf9 insect cells : The type of N-acyl group of Gα influences G protein-mediated signal transduction."J.Biochem.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 深田 吉孝: "松果体の光受容と概日時計システム"脳と神経. 55(1). 13-24 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 深田 吉孝(分担執筆): "『図説分子病態学』 改訂3版(一瀬白帝・鈴木宏治編)の「視覚異常」の項を分担執筆"中外医学社. 502(6) (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡野 俊行(分担執筆): "『時計遺伝子の分子生物学』(岡村均、深田吉孝編)の「時計遺伝子総論:脊椎動物」の項を分担執筆"シュプリンガーフェアラーク東京. 204(8) (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小島 大輔(分担執筆): "『時計遺伝子の分子生物学』(岡村均、深田吉孝編)の「概日光受容体とは何か」の項を分担執筆"シュプリンガーフェアラーク東京. 204(8) (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 深田吉孝(分担執筆): "タンパク質化学講座第4巻『酵素-リアーゼ』(泉井桂編)の「アデニル酸シクラーゼ」の項を分担執筆"廣川書店(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sanada K.: "Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1"J.Biol.Chem.. 277. 267-271 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takanaka Y.: "A negative regulatory element required for light-dependent pinopsin gene expression"J.Neurosci.. 22. 4357-4363 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Doi M.: "Light-dependent changes in the chick pineal temperature and the expression of cHsP90α gene : a potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock"Zool.Sci.. 19. 633-641 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kasahara T.: "Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock"J.Neurosci.. 22. 7321-7325 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirota T.: "Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts"J.Biol.Chem.. 277. 44244-44251 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Asaoka Y.: "Pineal expression-promoting element(PIPE),a cis-acting element, direcs pineal-specific gene expression in zebrafish"Proc.Natl.Acad.Sci.USA.. 99. 15456-15461 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shimizu F.: "Purification and immunohistochemical analysis of calcium-binding proteins expressed in the chick pineal gland"J.Pineal Res.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shimizu K.: "SCOP, a Novel Binding Partner of K-Ras in the Membrane Rafts, Negatively Regulates MAPK Pathway"J.Biol.Chem.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fukada Y.: "Circadian clock system in the pineal gland"Mol.Neurobiol.. 25. 19-30 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 深田吉孝: "脳内光受容と体内時計の時刻調節"現代化学. 370. 24-29 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 岡野俊行: "体内時計の時刻を調節する遺伝子の発見"生物の科学遺伝. 56. 26-28 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 深田吉孝: "体内時計とメラトニン合成"現代医療. 34(6). 35-40 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi