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Comprehensive research concerned with the influence of flow state of artificial heart on living body by observation of microcirculation

Research Project

Project/Area Number 14104027
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University (2004-2005)
The University of Tokyo (2002-2003)

Principal Investigator

IMACHI Kou  Tohoku University, Biomedical Engineering Research Organization, Professor, 先進医工学研究機構, 教授 (10010076)

Co-Investigator(Kenkyū-buntansha) TAKIURA Koki  Tohoku University, Biomedical Engineering Research Organization, Associate Professor, 先進医工学研究機構, 助教授 (60375194)
YAMBE Tomoyuki  Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (70241578)
ABE Yusuke  University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (90193010)
MOCHIZUKI Shuichi  University of Tokyo, Graduate School of Medicine, Instructor, 大学院医学系研究科, 助手 (00345042)
SAITO Itsuro  University of Tokyo, Research Center for Advanced Science and Technology, Instructor, 先端科学技術研究センター, 助手 (80334225)
鎮西 恒雄  東京大学, 先端科学技術研究センター, 助教授 (20197643)
馬場 敦  国立精神・神経センター, 医師(研究職)
磯山 隆  東京大学, 大学院・医学系研究科, 講師 (20302789)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥102,180,000 (Direct Cost: ¥78,600,000、Indirect Cost: ¥23,580,000)
Fiscal Year 2005: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2004: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2003: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2002: ¥56,290,000 (Direct Cost: ¥43,300,000、Indirect Cost: ¥12,990,000)
KeywordsCCD / Microcirculation / Artificial heart / Pulsatile flow / Continuous flow / Flow rate of erythrocyte / Circulatory control / Probe to observe microcirculation / 赤血球速度
Research Abstract

Although many types of continuous flow ventricular assist devices have become to use clinically as the bridge to heart transplantation, no body knows whether the pulsatility of blood flow is essential for living body or not. We have succeeded the basic development to solve the problem ; undulation pump AH(UPAH) and CCD probe. UPAH can change instantaneously its flow patterns by computer control of motor rotational speed. CCD probe is implantable micro-camera to observe microcirculation chronically.
The objective of this study is to clarify the necessity of pulsatility for the living body by developing more completely UPTAH and CCD probe. The following outcome has been gotten in these 4 years :
1)UPAH
Blood compatibility, durability and size & weight were improved great deal. The goat implanted UPAH survived maximally 4 months without anticoagulant. The software to control blood waveform has also been developed.
2)CCD probe
High magnification, focus adjust system and miniaturization were the objective to be developed. A micro-lens, 2 mm in diameter and 2 mm long was developed. The lens was installed into a CCD camera having 8 mm in diameter and 60 mm long. Total magnification on 14 inch TV screen was 650 times, that was enough to observe the erythrocyte flow in a capillary vessel. It could be implanted in an animal without difficulty. Residual problem is focus adjusting system.
3)Microcirculation under UPAH
The blood flow pattern was changed instantaneously from pulsatile to continuous when UPAH goat recover from surgical stress. The microcirculation was observed at bulbar conjunctiva during experiment. Following phenomena were observed until now : (1)Capillary density that is the ratio of the flowing capillaries to total capillary number, was decreased 30%. (2)The erythrocyte flow rate in the capillary was decreased 75 and some of them did not recover after the flow pattern returned to pulsatile.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (50 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (36 results) Book (2 results) Publications (12 results)

  • [Journal Article] Influence of flow design on microcirculation in condition of undulation pump-left ventricule assist device testing2006

    • Author(s)
      P.Dobsak
    • Journal Title

      Artificial Organs 30(6)

      Pages: 476-485

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Artificial heart research and present status of clinical application in Japan2006

    • Author(s)
      K.Imachi
    • Journal Title

      ASAIO Journal 52(1)

      Pages: 9-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of flow design on microcirculation in condition of undulation pump-left ventricule assist device testing2006

    • Author(s)
      P.Dobsak, et al.
    • Journal Title

      Artificial Organs 30(6)(to be published)

      Pages: 476-485

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An implantable probe for chronic observation of microcirculation2006

    • Author(s)
      K.Imachi, et al.
    • Journal Title

      Preceding of World Congress on Medical Physics and Biomedical Engineering (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Compact ventricular assist device and total artificial heart using undulation pump2006

    • Author(s)
      K.Imachi, et al.
    • Journal Title

      Preceding of World Congress on Medical Physics and Biomedical Engineering (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Artificial Heart Research and Present Status of Clinical Application in Japan2005

    • Author(s)
      Kou Imachi
    • Journal Title

      ASAIO Journal 52(1)

      Pages: 9-16

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Advancement of an implantable ventricular assist system using undulation pump under multi-institutional cooperative project2005

    • Author(s)
      K Imachi
    • Journal Title

      Artificial Organs 29(9)

      Pages: 726-726

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Real time imaging of hemolysis in in vitro with chemical luminescence2005

    • Author(s)
      Shuichi Mochizuki
    • Journal Title

      ASAIO Journal 51(2)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A small size pulsatile ventricular assist device using an undulation pump2005

    • Author(s)
      Yusuke Abe
    • Journal Title

      ASAIO Journal 51(2)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of implantable probe for observation of microcirculation2005

    • Author(s)
      Kou Imachi
    • Journal Title

      Proceedinds of 8^<th> Japan-Poland Seminar on New Engineering Methods Supporting Human Life

      Pages: 33-33

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 屈曲光学系を使用した小型埋込式微小循環観察プローブの開発2005

    • Author(s)
      望月修一
    • Journal Title

      生体医工学 43(Suppl)

      Pages: 596-596

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microcirculation of the bulbar conjunctiva in the goat implanted with a total artificial heart : Effects of pulsatile and nonpulsatile flow2004

    • Author(s)
      A.Baba
    • Journal Title

      ASAIO Journal 50(4)

      Pages: 321-327

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microcirculation of the bulbar conjunctiva in the goat implanted with a total artificial heart : Effects of pulsatile and nonpulsatile flow2004

    • Author(s)
      A.Baba, et al.
    • Journal Title

      ASAIO Journal 50(4)

      Pages: 321-327

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microcirculation of the bulbar conjunctiva in the goat implanted with a total artificial heart : Effects of pulsatile and nonpulsatile flow2004

    • Author(s)
      A.Baba, K.Imachi, et al.
    • Journal Title

      ASAIO Journal 50(4)

      Pages: 321-327

    • Related Report
      2004 Annual Research Report
  • [Journal Article] R込型微小循環観察プローブの開発・マイクロレンズと光源の検討2004

    • Author(s)
      井街 宏, 他
    • Journal Title

      生体医工学 42(Suppl)

      Pages: 288-288

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 屈曲工学系を使用した小型埋込式微小循環観察プローブの開発2004

    • Author(s)
      望月修一, 井街 宏, 他
    • Journal Title

      生体医工学 43(Suppl.)(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Progress in the control system of the undulation pump total artificial heart2003

    • Author(s)
      I.Saito
    • Journal Title

      Artificial Organs 27(1)

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A study on energy supply method for a transcutaneous energy transmission system2003

    • Author(s)
      T.Ozeki
    • Journal Title

      Artificial Organs 27(1)

      Pages: 68-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Third model of the undulation pump total artificial heart2003

    • Author(s)
      Y.Abe
    • Journal Title

      ASAIO Journal 49(1)

      Pages: 123-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Advance in animal experiments with the undulation pump total artificial heart : 50 and 54 day survival periods with 1/R control2003

    • Author(s)
      Y.Abe
    • Journal Title

      ASAIO Journal 49(3)

      Pages: 325-332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathophysiologic study of goats with undulation pump total artificial heart : Those that survived for more than 1 month2003

    • Author(s)
      A.Baba
    • Journal Title

      ASAIO Journal 49(4)

      Pages: 463-468

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Progress in the control system of the undulation pump total artificial heart2003

    • Author(s)
      I.Saito, et al.
    • Journal Title

      Artificial Organs 27(1)

      Pages: 27-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A study on energy supply method for a transcutaneous energy transmission system2003

    • Author(s)
      T.Ozeki, et al.
    • Journal Title

      Artificial Organs 27(1)

      Pages: 67-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Third model of the undulation pump total artificial heart2003

    • Author(s)
      Y.Abe, et al.
    • Journal Title

      ASAIO Journal 49(1)

      Pages: 123-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Advance in animal experiments with the undulation pump total artificial heart : 50 and 54 day survival periods with 1/R control2003

    • Author(s)
      Y.Abe, et al.
    • Journal Title

      ASAIO Journal 49(3)

      Pages: 325-332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of pulsatile and nonpulsatile flow in microvessels of the bulbar conjunctiva in the goat with an undulation pump artificial heart2003

    • Author(s)
      A.Baba, et al.
    • Journal Title

      Artificial Organs 27(10)

      Pages: 875-881

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathophysiologic study of goats with undulation pump total artificial heart : Those that survived for more than 1 month2003

    • Author(s)
      A.Baba, et al.
    • Journal Title

      ASAIO Journal 49(4)

      Pages: 463-468

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Principle of the rotary undulation pump2002

    • Author(s)
      Y.Abe
    • Journal Title

      J Artificial Organs 5(2)

      Pages: 84-90

    • NAID

      50000574148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ripple reduction of the undulation pump total artificial heart2002

    • Author(s)
      I.Saito
    • Journal Title

      Artificial Organs 26(1)

      Pages: 40-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Durabilityu, enhancement with sufficient blood compatibility2002

    • Author(s)
      K.Iwasaki
    • Journal Title

      ASAIO Journal 48(5)

      Pages: 532-537

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of pulsatile and nonpulsatile flow in microvessels of the bulbar conjunctiva in the goat with an undulation pump artificial heart2002

    • Author(s)
      A.Baba
    • Journal Title

      Artificial Organs 37(10)

      Pages: 875-881

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Principle of the rotary undulation pump2002

    • Author(s)
      Y.Abe, et al.
    • Journal Title

      J Artificial Organs 5(2)

      Pages: 84-90

    • NAID

      50000574148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ripple reduction of the undulation pump total artificial heart2002

    • Author(s)
      I.Saito, et al.
    • Journal Title

      Artificial Organs 26(1)

      Pages: 40-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] improved jellyfish valve : Durability enhancement with sufficient blood compatibility2002

    • Author(s)
      K.Iwasaki, et al.
    • Journal Title

      ASAIO Journal 48(5)

      Pages: 532-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An implantable probe for chronic observation of microcirculation

    • Author(s)
      K.Imachi
    • Journal Title

      Proceeding of World Congress on Medical Physics and Biomedical Engineering 2006

      Pages: 2219-2223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Compact ventricular assist device and total artificial heart using undulation pump

    • Author(s)
      K.Imachi
    • Journal Title

      Proceeding of World Congress on Medical Physics and Biomedical Engineering 2006

      Pages: 3021-3025

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 人工心臓の開発、人体にやさしい医療材料(2005第19回「大学と科学」公開シンポジウム講演収録集 (中島英雄 編))2005

    • Author(s)
      井街 宏
    • Total Pages
      215
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 人工心臓の開発、人体にやさしい医療材料(2005第19回「大学と科学」公開シンポジウム講演収録集 中島英雄 編)2005

    • Author(s)
      井街 宏
    • Total Pages
      210
    • Publisher
      クバプロ
    • Related Report
      2005 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "Evaluation of pulsatile and non-pulsatile flow in capillaries of the bulbar conjunctiva in the goat implanted a total artificial heart"ASAIO Journal. 49(2). 148 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "Effect of pulsatility on conjunctival microcirculation of the goat with implanted an undulation pump total artificial heart"Cardiovascular Engineering. Proceeding. 31 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "Evaluation of pulsatile and nonpulsatile flow in microvessels of the bulbar conjunctiva in the goat with an undulation pump artificial heart"Artificial Organs. 27(10). 875-881 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Abe, K.Imachi, et al.: "Third model of the undulation pump total artificial heart"ASAIO Journal. 49(1). 325-332 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Abe, K.Imachi, et al.: "Advance in animal experiments with the undulation pump total artificial heart : 50 and 54 day survival periods with 1/R control"ASAIO Journal. 49(3). 123-127 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "The microcirculation of the bulbar conjunctiva in the goat implanted a total artificial heart : Effect of pulsatile and non-pulsatile flow"ASAIO Journal. 50(in press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Imachi, et al.: "Development of CCD probe for chronic observation of microcirculatior"International Congress on Biological and Medical Engineering. Abstract. 85 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "Influence of the flow patterns on the microcirculation of the bulbar conjunctiva in the goat implanted a total artificial heart"asaio Journal. 48(2). 143 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] A.Baba, K.Imachi, et al.: "Measuring the microcirculation of the bulbar conjunctiva in the goat implanted an artificial heart"10th Congress of the International Society for Rotary Blood Pumps. Abstract. A4 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 井街 宏, 他: "埋込型微小循環観察プローブの開発と動物への埋込実験"生体医工学. 40(特別号). 220 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 馬場 敦, 井街 宏, 他: "完全置換型人工心臓を埋め込んだ実験動物の微小循環"生体医工学. 40(特別号). 215 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 馬場 敦, 井街 宏, 他: "人工心臓が微小循環に与える影響について"人工臓器. 31(2). S-181 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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