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Cell death-inducing function and activation mechanism of Cl- channel

Research Project

Project/Area Number 14207002
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionNational Institute for Physiological Sciences (2004)
Okazaki National Research Institutes (2002-2003)

Principal Investigator

OKADA Yasunobu  National Institute for Physiological Sciences, Department of Cell Physiology, Professor, 細胞器官研究系, 教授 (10025661)

Co-Investigator(Kenkyū-buntansha) SABIROV Ravshan  National Institute for Physiological Sciences, Department of Cell Physiology, Associate Professor, 細胞器官研究系, 助教授 (60322632)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2004: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2003: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2002: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
KeywordsCl- channel / apoptosis / necrosis / cell volume regulation / lactacidosis / excitotoxicit / ischemia / cell death / ニューロン / 心筋細胞 / グリア
Research Abstract

Cell acidosis may induce the necrotic cell volume increase (NVI) due to NaCl accumulation within the cells by stimulation of Na+-H+ antiporter and C1--HC03- antiporter. Acidosis with lactate accumulation due to augmented glycolysis-fermentation reactions is known to be frequently associated with cerebral ischemia or trauma and to result in necrosis of glial and neuronal cells. Under such conditions called lactacidosis, cell swelling is strengthened by entry of lactate and proton via monocarboxylate transporters. In cultured glial C6 cells, persistent swelling was in fact induced by lactacidosis. Furthermore, the succeeding regulatory volume decrease (RVD) was impaired under lactacidosis conditions due to inhibition on volume-sensitive outwardly rectifying (VSOR) Cl- channels. When lactacidosis-resistant anion channels were exogenously introduced by applying an anion channel-forming toxin protein purified from Helicobacter pylori, VacA, glial cells restored the RVD. Furthermore, lactaci … More dosis-induced necrotic cell death was significantly rescued, when lactacidosis-resistant anion channels were exogenously introduced into C6 cells by pretreatment with the VacA protein. Thus, it is concluded that inhibition of volume-regulatory VSOR Cl- channels are involved in the NVI in glial cells.
Apoptotic volume decrease (AVD) is a pivotal event triggering a cell to undergo apoptosis and is induced by ionic effluxes resulting mainly from increased K+ and Cl- conductances. In human epithelia HeLa cells both mitochondrion- and death receptor-mediated apoptosis inducers (staurosporine and Fas ligand or TNFα) rapidly activate Cl- currents that show properties phenotypical of VSOR Cl- channel currents. Staurosporine rapidly increased the intracellular level of reactive oxygen species (ROS). A ROS scavenger and an NAD(P)H oxidase inhibitor blocked the current activation by staurosporine. A ROS scavenger also inhibited AVD, caspase-3 activation and apoptotic cell death induced by staurosporine. Thus, it is concluded that an apoptosis-triggering anion conductance is carried by the VSOR Cl- channel and that the channel activation upon apoptotic stimulation with staurosporine is mediated by reactive oxygen species.
Cultured mouse cortical neurons express the volume-sensitive outwardly rectifying (VSOR) anion channel. Under excitotoxic conditions, neurons suffered from pathological swelling and dendritic beading, called varicosity, and thereafter necrosis. Both whole-cell and single-channel recordings confirmed that the VSOR channel was activated by excitotoxicity. When a VSOR channel blocker was applied during exctitotoxic stimulation, varicosity formation and necrotic cell death were largely inhibited. Thus, it is concluded that the VSOR channel plays a role in excitotoxicity-induced varicosity formation and necrotic cell death. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (62 results)

All 2005 2004 2003 2002 Other

All Journal Article (42 results) Book (3 results) Patent(Industrial Property Rights) (5 results) Publications (12 results)

  • [Journal Article] HCO_3^- -independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes.2005

    • Author(s)
      S.Tanabe
    • Journal Title

      FEBS Lett. 579

      Pages: 517-522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ClC-3-independent sensitivity of apoptosis to Cl^- channel blockers in mouse cardiomyocytes.2005

    • Author(s)
      N.Takahashi
    • Journal Title

      Cell. Physiol. Biochem. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Volume-sensitive chloride channels in mouse cortical neurons : characterization and role in volume regulation.2005

    • Author(s)
      H.Inoue
    • Journal Title

      Eur. J. Neurosci. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] HCO3--independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes.2005

    • Author(s)
      S.Tanabe, X.-M.Wang, N.Takahashi, H.Uramoto, Y.Okada
    • Journal Title

      FEBS Lett 579

      Pages: 517-522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ClC-3-independent sensitivity of apoptosis to Cl- channel blockers in mouse cardiomyocytes.2005

    • Author(s)
      N.Takahashi, X.-M.Wang, S.Tanabe, H.Uramoto, K.Jishage, S.Uchida, S.Sasaki, Y.Okada
    • Journal Title

      Cell. Physiol. Biochem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Volume-sensitive chloride channels in mouse cortical neurons: characterization and role in volume regulation.2005

    • Author(s)
      H.Inoue, S.Mori, S.Morishima, Y Okada
    • Journal Title

      Eur. J. Neurosci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Essential role of anion channel in induction of apoptotic and necrotic cell death.2005

    • Author(s)
      Y.Okada, E.Maeno, T.Nabekura, S.Mori
    • Journal Title

      Ion Channels in the Pulmonary Vasculature" (ed. J. X.-J. Yuan)(Taylor & Francis: Boca Raton) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Volume-sensitive chloride channels in mouse cortical neurons : characterization and role in volume regulation.2005

    • Author(s)
      H.Inoue
    • Journal Title

      Eur.J.Neurosci. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ClC-3-independent sensitivity of apoptosis to Cl^- channel blockers in mouse cardiomyocytes.2005

    • Author(s)
      N.Takahashi
    • Journal Title

      Cell.Physiol.Biochem. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] HCO_3^--independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes.2005

    • Author(s)
      S.Tanabe
    • Journal Title

      FEBS Lett. 579

      Pages: 517-522

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl^- channel2004

    • Author(s)
      T.Shimizu
    • Journal Title

      Proc. Natl. Acad. Sci. USA 101

      Pages: 6770-6773

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dual roles of plasmalemmal chloride channels in induction of cell death.2004

    • Author(s)
      Y.Okada
    • Journal Title

      Pflugers Arch. Eur. J. Physiol. 448

      Pages: 287-295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischemic or hypoxic conditions.2004

    • Author(s)
      A.K.Dutta
    • Journal Title

      J. Physiol. (London) 559

      Pages: 799-812

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ClC-3-independent, PKC-dependent activity of vo ; ume-sensitive Cl^- channel in mouse ventricular cardiomyocytes.2004

    • Author(s)
      W.Gong
    • Journal Title

      Cell. Physiol. Biochem. 14

      Pages: 213-224

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl- channel.2004

    • Author(s)
      T.Shimizu, T.Numata, Y.Okada
    • Journal Title

      Proc. Natl. Acad. Sci. USA 101

      Pages: 6770-6773

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dual roles of plasmalemmal chloride channels in induction of cell death.2004

    • Author(s)
      Okada Y, Maeno E, Shimizu T, Manabe K, Mori S, Nabekura T
    • Journal Title

      Pflugers Arch. Eur. J. Physiol 448

      Pages: 287-295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischemic or hypoxic conditions.2004

    • Author(s)
      A.K.Dutta, R.Z.Sabirov, H.Uramoto, Y.Okada
    • Journal Title

      J. Physiol. (London) 559

      Pages: 799-812

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ClC-3-independent, PKC-dependent activity of volume-sensitive Cl- channel in mouse ventricular cardiomyocytes.2004

    • Author(s)
      W.Gong, H.Xu, T.Shimizu, S.Morishima, S.Tanabe, T.Tachibe, S.Uchida, S.Sasaki, Y Okada
    • Journal Title

      Cell. Physiol. Biochem 14

      Pages: 213-224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anion channel involved in induction of apoptosis and necrosis. In, "Cell Volume and Signaling" (Eds. Lauf PK & Adragna NC)2004

    • Author(s)
      Y.Okada, E.Maeno, S.Mori
    • Journal Title

      Springer, NY

      Pages: 205-209

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl^- channel.2004

    • Author(s)
      T.Shimizu
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 6770-6773

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dual roles of plasmalemmal chloride channels in induction of cell death.2004

    • Author(s)
      Y.Okada
    • Journal Title

      Pflugers Arch.Eur.J.Physiol. 448

      Pages: 287-295

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels.2003

    • Author(s)
      T.Nabekura
    • Journal Title

      Glia 41

      Pages: 247-259

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ischemia-induced enhancement of CFTR expression on the plasma membrance in neonatal rat ventricular myocytes.2003

    • Author(s)
      H.Uramoto
    • Journal Title

      Jpn. J. Physiol. 53

      Pages: 357-365

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation.2003

    • Author(s)
      F.Wehner
    • Journal Title

      FEBS Lett. 551

      Pages: 20-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Upregulation of swelling-activated Cl^- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells.2003

    • Author(s)
      I.F.Abdullaev
    • Journal Title

      J. Physiol. (London) 549

      Pages: 749-758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency.2003

    • Author(s)
      L.F.Barros
    • Journal Title

      Cell Death & Differentiation 10

      Pages: 687-697

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Macula densa cell signaling involves ATP release through a maxi anion channel.2003

    • Author(s)
      P.D.Bell
    • Journal Title

      Proc. Natl. Acad. Sci.USA 100

      Pages: 4322-4327

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels.2003

    • Author(s)
      T.Nabekura, S.Morishima, T.L.Cover, S.Mori, H.Kannan, S.Komune, Y.Okada
    • Journal Title

      Glia 41

      Pages: 247-259

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation.2003

    • Author(s)
      F.Wehner, T.Shimizu, R.Sabirov, Y.Okada
    • Journal Title

      FEBS Lett 551

      Pages: 20-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells.2003

    • Author(s)
      I.F.Abdullaev, R.Z.Sabirov, Y Okada
    • Journal Title

      J. Physiol. (London) 549

      Pages: 749-758

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency.2003

    • Author(s)
      L.F.Barros, T.Kanaseki, R.Sabirov, S.Morishima, J.Castro, C.X.Bittner, E.Maeno, Y.Ando-Akatsuka, Y.Okada
    • Journal Title

      Cell Death & Differentiation 10

      Pages: 687-697

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Macula densa cell signaling involves ATP release through a maxi anion channel.2003

    • Author(s)
      P.D.Bell, J.-Y.Lapointe, R.Z.Sabirov, S.Hayashi, J.Peti-Peterdi, K.Manabe, G Kovacs, Y.Okada
    • Journal Title

      Proc. Natl. Acad. Sci. USA 100

      Pages: 4322-4327

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] LTRPC2 Ca^<2+> -permeable channel activated by changes in redox status confers susceptibility to cell death.2002

    • Author(s)
      Y.Hara
    • Journal Title

      Molecular Cell 9

      Pages: 163-173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid.2002

    • Author(s)
      A.K.Dutta
    • Journal Title

      J. Physiol. (London) 542

      Pages: 803-816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Down-regulation of volume-sensitive Cl^- channels by CFTR is mediated by the second nucleotide-binding domain.2002

    • Author(s)
      Y.Ando-Akatsuka
    • Journal Title

      Pflugers Arch. Eur. J. Physiol. 445

      Pages: 177-186

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impaired activity of volume-sensitive anion channel during lactacidosis-induced swelling in neuronally differentiated NG108-15 cells.2002

    • Author(s)
      S.Mori
    • Journal Title

      Brain Res. 957

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] クロライドチャネルの新しい機能:ATP放出と細胞死誘導2002

    • Author(s)
      岡田泰伸
    • Journal Title

      生体の科学 53

      Pages: 323-330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.2002

    • Author(s)
      Y.Hara, M.Wakamori, M.Ishii, E.Maeno, M.Nishida, T.Yoshida, H.Yamada, S.Shimizu, E.Mori, J.Kudoh, N.Shimizu, H.Kurose, Y.Okada, K.Imoto, Y.Mori
    • Journal Title

      Molecular Cell 9

      Pages: 163-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid.2002

    • Author(s)
      A.K.Dutta, Y.Okada, R.Z.Sabirov
    • Journal Title

      J. Physiol. (London) 542

      Pages: 803-816

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impaired activity of volume-sensitive anion channel during lactacidosis-induced swelling in neuronally differentiated NG108-15 cells.2002

    • Author(s)
      S.Mori, S.Morishima, M.Takasaki, Y.Okada
    • Journal Title

      Brain Res 957

      Pages: 1-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes.2002

    • Author(s)
      H.Uramoto, N.Takahashi, A.K.Dutta, R.Z.Sabirov, Y.Ando-Akatsuka, S.Morishima, Y.Okada
    • Journal Title

      Jpn. J. Physiol 53

      Pages: 357-365

    • NAID

      80016436158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Down-regulation of volume-sensitive Cl- channels by CFTR is mediated by the second nucleotide-binding domain.

    • Author(s)
      Y.Ando-Akatsuka, I.F.Abdullaev, E.L.Lee, Y.Okada, R.Z.Sabirov
    • Journal Title

      Pflugers Arch. Eur. J. Physiol 445

      Pages: 177-186

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Essential role of anion channel in induction of apoptotic and necrotic cell death. In. "Ion Channels in the Pulmonary Vascuature" (ed. J. -J. Yuan)2005

    • Author(s)
      Y.Okada
    • Publisher
      Taylor & Francis : Boca Raton(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Prerequisite roles of anion channel in induction of apoptotic and necrotic cell death. Ion Channels in the Pulmonary Vasculature(ed.J.X.-J.Yuan)2005

    • Author(s)
      Y.Okada
    • Publisher
      Marcel Dekker, NY(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] Anion channel involved in induction of apoptosis and necrosis. In, "CellVolume and Signaling" (Eds. Lauf PK & Adragna NC)2004

    • Author(s)
      Y.Okada
    • Publisher
      Springer, NY
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 虚血後の再灌流性細胞死の抑制方法、および細胞死抑制剤2004

    • Inventor(s)
      岡田泰伸, 高橋信之
    • Industrial Property Rights Holder
      自然科学研究機構・科学技術振興機構
    • Filing Date
      2004-07-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 虚血性心臓傷害の新保護法2004

    • Inventor(s)
      岡田泰伸, 浦本裕美
    • Industrial Property Rights Holder
      自然科学研究機構, 科学技術振興機構
    • Filing Date
      2004-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法2004

    • Inventor(s)
      岡田泰伸, 井上 華
    • Industrial Property Rights Holder
      科学技術振興機構, 自然科学研究機構
    • Filing Date
      2004-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 遅発性神経細胞死を防御または救済するための薬剤および方法2004

    • Inventor(s)
      塩田清二, 大滝博和, 井上 華, 岡田泰伸
    • Industrial Property Rights Holder
      科学技術振興機構・昭和大学・自然科学研究機構
    • Filing Date
      2004-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 細胞死の抑制方法、細胞死抑制剤、及びその細胞死抑制剤を含む細胞死に起因する疾患の治療2002

    • Inventor(s)
      岡田泰伸, 森島 繁, 鍋倉 隆
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Industrial Property Number
      2002-346325
    • Filing Date
      2002-11-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] H.Uramoto, N.Takahashi, A.K.Dutta, R.Z.Sabirov, Y.Ando-Akatsuka, S.Morishima, Y.Okada: "Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes."Jpn.J.Physiol.. 53. 357-365 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] F.Wehner, T.Shimizu, R.Sabirov, Y.Okada: "Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation."FEBS Lett.. 551. 20-24 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.F.Abdullaev, R.Z.Sabirov, Y.Okada: "Upregulation of swelling-activated Cl^- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells."J.Physiol.(London). 549. 749-758 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] L.F.Barros, T.Kanaseki, R.Sabirov, S.Morishima, J.Castro, C.X.Bittner, E.Maeno, Y.Ando-Akatsuka, Y.Okada: "Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency."Cell Death & Differentiation. 10. 687-697 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] P.D.Bell, J.-Y.Lapointe, R.Z.Sabirov, S.Hayashi, J.Peti-Peterdi, K.Manabe, G.Kovacs, Y.Okada: "Macula densa cell signaling involves ATP release through a maxi anion channel."Proc.Natl.Acad.Sci.USA. 100. 4322-4327 (2003)

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  • [Publications] T.Nabekura, S.Morishima, T.L.Cover, S.Mori, H.Kannan, S.Komune, Y.Okada: "Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels."Glia. 41. 247-259 (2003)

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  • [Publications] Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y: "LTRPC2 Ca^<2+>-permeable channel activated by changes in redox status confers susceptibility to cell death"Molecular Cell. 9. 163-173 (2002)

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      2002 Annual Research Report
  • [Publications] Dutta AK, Okada Y, Sabirov RZ: "Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid"J. Physiol. (London). 542. 803-816 (2002)

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  • [Publications] Ando-Akatsuka Y, Abdullaev IF, Lee EL, Okada Y, Sabirov RZ: "Down-regulation of volume-sensitive Cl^-channels by CFTR is mediated by the second nucleotide-binding domain"Pflugers Arch. Eur. J. Physiol.. 445. 177-186 (2002)

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  • [Publications] Mori S, Morishima S, Takasaki M, Okada Y: "Impaired activity of volume-sensitive anion channel during lactacidosis-induced swelling in neuronally differentiated NG108-15"Brain Res.. 957. 1-11 (2002)

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      2002 Annual Research Report
  • [Publications] Nabekura T, Morishima S, Cover TL, Mori S, Kannan H, Komune S, Okada Y: "Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels"Glia. 41. 247-259 (2003)

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      2002 Annual Research Report
  • [Publications] 岡田泰伸, サビロブ ラブシャン, 清水貴浩: "クロライドチャネルの新しい機能 : ATP放出と細胞死誘導"生体の科学. 53. 323-330 (2002)

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Published: 2002-04-01   Modified: 2021-04-07  

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