| Project/Area Number |
14207017
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka University |
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Principal Investigator |
MORIMOTO Kanehisa Osaka University, Grad.Sch.of Med., Prof., 医学系研究科, 教授 (20143414)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Kunio Osaka University, Grad.Sch.of Med., Assist., 医学系研究科, 助手 (80346197)
TODA Masahiro Osaka University, Grad.Sch.of Med., Assist., 医学系研究科, 助手 (90362714)
LU Yuquan Osaka University, Grad.Sch.of Med., Assist., 医学系研究科, 助手 (90362722)
江副 智子 大阪大学, 医学系研究科, 助手 (40232954)
早川 和夫 (早川 和生) 大阪大学, 医学部, 教授 (70142594)
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| Project Period (FY) |
2002 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2005: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2004: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2003: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2002: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | Lifestyle / Natural killer cell activity / Chromosome aberration / Stress / Cortisol / Brain science / Aging / Preventive medicine / クロモグラニンA / ストレスホルモン / コーチゾール / 健康年令 |
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| Research Abstract |
The total environments to which individuals have been exposed throughout the lifestages from birth to the present time have been composing the individual and community lifestyles, or ways of daily living. Such lifestyles are known to determine the risks for development of cancers, circulatory diseases, and other chronic diseases. To establish new theory and practice programs for disease prevention and health promotion in the environmental medicine, we have quantitatively investigated correlations of lifestyle to comprehensive health potentials. The health potentials were assessed by both the ridit and multiphasic analysis of general health-check-up data, and the measurements of typical biomarkers such as lymphocyte chromosome alterations, natural-killer cell activities, and serum IgE levels.
The general health status was assessed by the ridit analysis of the incidence of abnormal values in blood-biochemistry, blood-pressure, and urine tests of multiphasic health check-ups. The general health was found to decrease with aging, but to vary a lot according to their lifestyles. For example, the mean level of somatic health of the persons having poor lifestyles in the 20's was about the same that of those with good lifestyles in the 40's. According to the results of follow-up of workers, the unhealthy workers were found to have had significantly higher risks for the developments of chronic diseases such as heart attack, liver disease, and diabetes.
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