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A comprehensive study on risk factors of mild cognitive impairment (MCI)-aiming for a new strategy of dementia prevention

Research Project

Project/Area Number 14207021
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNational Institute for Longevity Sciences / National Center for Geriatrics and Gerontology

Principal Investigator

SHIMOKATA Hiroshi  National Institute for Longevity Sciences, Department of Epideniology, Head, (研究所)・疫学研究部, 部長 (10226269)

Co-Investigator(Kenkyū-buntansha) ANDO Fujiko  National Institute for Longevity Sciences, Department of Epideniology, Head, (研究所)・疫学研究部, 室長 (90333393)
NIINO Naoakira  Obirin University, Graduate School of International Studies, 大学院・国際学研究科, 教授 (40201686)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2005: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2004: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2003: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2002: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
KeywordsCognitive impairment / Intelligence test / Short-term memory / Aging / Verbal intelligence / Active intelligence / Longitudinal study / Genotype
Research Abstract

The purpose of this study is to clarify the actual condition of age-related cognitive impairment and its risk factors. The subjects were 2300 randomly selected community-living population. They were followed up every tow years from 1997. The fourth examination was finished in July 2006. The data of adult intelligence test (WAIS-R), cognitive function test (MMSE), memory test, and various indices of psychology were collected and released on the Internet as monograph. Incidence of mild cognitive impairment (MCI) and associations of cognitive function with genotype, clinical findings including of head MRI, life-style, and effect of aging were examined cross-sectionally and longitudinally. Incidence of MCI was 4.2 percent in the subjects aged 60 years and over. The incidence increased with age, and no gender difference was found. The genotypes of Klotho gene and Cholecystokinin A receptor gene influenced cognitive function of middle-aged and elderly individuals. The best combination of genotype to estimate of cognitive impairment was found by exhaustive analysis of genotypes. The effects of aging on verbal and active intelligence, and gender and aging differences in delayed episode memory were clarified. Intellectual activities such as reading books significantly prevent both verbal and active intelligence impairment, while sporting activity and domestic labor prevented only active intelligence impairment. Antioxidant vitamins had preventive effects for cognitive impairment. Smoking accelerated cognitive impairment. Cognitive function showed positive correlations with serum indices of health such as albumin, HDL-cholesterol and calcium levels, and negative correlations with serum indices of inflammation and disease markers. As for the head MRI findings, white matter lesions and lacuna infarction of cerebrum were associated with cognitive impairment.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (74 results)

All 2007 2006 2005 2004 2003 2002 Other

All Journal Article (52 results) Book (8 results) Patent(Industrial Property Rights) (1 results) Publications (13 results)

  • [Journal Article] Epidenilogical study in aging and geriatrics2007

    • Author(s)
      Shimokata H
    • Journal Title

      Geriatric Medicine (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cross-sectional study on episode memory in community -living middle-aged and elderly..2007

    • Author(s)
      Nishita Y, Fukukawa Y, Tange C, Ando A, Shimokata H
    • Journal Title

      J Jpn Mibyou System Association (in Jpn) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2006

    • Author(s)
      Shimokata H, Ando F, Niino N, Miyasaka K, Funakoshi A
    • Journal Title

      Annals of Epidemiology 15(3)

      Pages: 196-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 地域在住中高年者の抑うつ関連要因-日常活動能力に着目して-2006

    • Author(s)
      西田裕紀子, 新野直明, 安藤富士子, 下方浩史
    • Journal Title

      日本未病システム学会雑誌 12(1)

      Pages: 101-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Klotho gene promoter polymorphism and cognitive impairment2006

    • Author(s)
      Shimokata H, Ando H, Fukukawa Y, Nishita Y
    • Journal Title

      Geriatr Gerontol Int 6

      Pages: 136-141

    • NAID

      10017616368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 高齢者の生活習慣はどこまで是正すべきか2006

    • Author(s)
      下方浩史
    • Journal Title

      日本老年医学会雑誌 43(4)

      Pages: 462-464

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 知能の加齢変化2006

    • Author(s)
      安藤富士子, 福川康之, 西田裕紀子
    • Journal Title

      総合リハビリテーション 34(7)

      Pages: 643-648

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Klotho gene promoter polymorphism and cognitive impairment.2006

    • Author(s)
      Shimokata H, Ando F, Fukukawa Y, Nishita Y
    • Journal Title

      Geriatr Gerontol Int 6

      Pages: 136-141

    • NAID

      10017616368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The relationship between depression and activities of daily living in Japanese community-dwelling elderly.2006

    • Author(s)
      Nishita Y, Niino N, Ogasawara H, Ando A, Shimokata H
    • Journal Title

      J Jpn Mibyou System Association (in Jpn) 12(1)

      Pages: 101-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] How far should life-style be corrected in the elderly?2006

    • Author(s)
      Shimokata H
    • Journal Title

      Jpn J Geriat (in Jpn) 43(4)

      Pages: 462-464

    • NAID

      10018513626

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Age-related change in cognition.2006

    • Author(s)
      Ando F, Fukukawa Y, Nishita Y
    • Journal Title

      General Rehabilitation 34(7)

      Pages: 643-648

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Klotho gene promoter polymorphism and cognitive impairment2006

    • Author(s)
      Shimokata H, Ando F, Fukukawa Y, Nishita Y
    • Journal Title

      Geriatrics and Gerontology International (印刷中)

    • NAID

      10017616368

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 友人との死別が成人期の抑うつに及ぼす影響-年齢および家族サポートの調節効果-2005

    • Author(s)
      福川康之, 西田裕紀子, 中西千織, 坪井さとみ, 新野直明, 安藤富士子, 下方浩史
    • Journal Title

      心理学研究 76(1)

      Pages: 10-17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The effects of bereavement of friends on depression in adulthood : Age and family support as moderators.2005

    • Author(s)
      Fukukawa Y, Nishita Y, Nakashima C, Tsuboi S, Niino N, Ando F, Shimokata H
    • Journal Title

      The Japanese Journal of Psychology (in Jpn) 76(1)

      Pages: 10-17

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence.2005

    • Author(s)
      Shimokata H, Ando F, Niino N, Miyasaka K, Funakoshi A
    • Journal Title

      Ann Epidemiol 15(3)

      Pages: 196-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence.2005

    • Author(s)
      Shimokata H, Ando F, Niino N, Miyasaka K, Funakoshi A
    • Journal Title

      Annals of Epidemiology 15(3)

      Pages: 196-201

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Journal Article] the impact of health problems on depression and activities in middle-aged and older adults : Age and social interactions as moderators.2004

    • Author(s)
      Fukukawa Y, Nakashima C, Tsuboi S, Niino N, Ando F, Shimokata H et al.
    • Journal Title

      J Gerontol B Phychol Sci 59(1)

      Pages: 19-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cognitive Function in Japanese Elderly with Type 2 Diabetes Mellitus.2004

    • Author(s)
      Mogi N, Umegaki Hhosi Miura H, Kazuya M, Shimokata H, Ando F et al.
    • Journal Title

      J Diabetes Complications 18

      Pages: 42-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 地域在住の中高年者の抑うつに関連する要因 : その年齢差と性差2004

    • Author(s)
      坪井さとみ, 福川康之, 新野直明, 安藤富士子, 下方浩史
    • Journal Title

      心理学研究 75(2)

      Pages: 101-108

    • NAID

      130002027376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Werner helicaseの遺伝子変異と地域在住中高年者の血圧・心疾患2004

    • Author(s)
      安藤富士子, 藤澤道子, 新野直明, 下方浩史
    • Journal Title

      日本未病システム学会雑誌 10(1)

      Pages: 52-54

    • NAID

      130004185655

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Klotho遺伝子G-395A多型と認知機能障害2004

    • Author(s)
      下方浩史, 西田裕紀子, 新野直明, 安藤富士子
    • Journal Title

      日本未病システム学会雑誌 10(1)

      Pages: 49-61

    • NAID

      130004185654

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 痴呆症学-本邦の疫学統計2004

    • Author(s)
      下方浩史
    • Journal Title

      日本臨床 63(増刊4)

      Pages: 121-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interactions between health and psychological changes in Japanese the NILS-LSA.2004

    • Author(s)
      Shimokata H, Ando F, Fukukawa Y
    • Journal Title

      Geriatrics and Gerontology International 4(Suppl)

    • NAID

      10018027854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Clock Drawing Test as a Valid Screening Method for Mild Cognitive Impairment.2004

    • Author(s)
      Yamamoto S, Mogi N, Ando F, Umegaki H, Shimokata H et al.
    • Journal Title

      Dementia and Geriatric Congnitive Disorder 18

      Pages: 172-179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Age Differences in the Effect of Physical Activity on Depressive Symptoms.2004

    • Author(s)
      Fukukawa Y, Nakashima C, Tsuboi S, Kozakai R, Ando F, Simokata H et al.
    • Journal Title

      Psychology and Aging 19(2)

      Pages: 346-351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The impact of health problems on depression and activities in middle-aged and older adults : Age and social interactions as moderators.2004

    • Author(s)
      Fukukawa Y, Nakashima C, Tsuboi S, Niino N, Ando F, Kosugi S, Shimokata H
    • Journal Title

      J Gerontol B Psychol Sci 59(1)

      Pages: 19-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cognitive Function in Japanese Elderly with Type 2 Diabetes Mellitus.2004

    • Author(s)
      Mogi N, Umegaki H, Hattori A, Maeda N, Miura H, Kuzuya M, Shimokata H, Ando F, Iguchi A
    • Journal Title

      J Diabetes Complications 18

      Pages: 42-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Age and gender differences as factors related to depressive symptoms among community-dwelling middle-aged and elderly people.2004

    • Author(s)
      Tsuboi S, Fukukawa Y, Niino N, Ando F, Shimokata H.
    • Journal Title

      Shinrigaku Kenkyu (in Jpn) 75(2)

      Pages: 101-108

    • NAID

      130002027376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polymorphism of Werner helicase relates Blood Pressure, Heart diseases in the community-dwelling middle-aged and elderly.2004

    • Author(s)
      Ando F, Fujisawa M, Niino N, Shimokata H
    • Journal Title

      J Jpn Mibyou System Association. (in Jpn) 10(1)

      Pages: 52-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Koltho gene G-395A polymorphism and cognitive disturbance.2004

    • Author(s)
      Shimokata H, Nishita Y, Niino N, Ando F
    • Journal Title

      J Jpn Mibyou System Association. (in Jpn) 10(1)

      Pages: 49-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dementiology(3). Epidemiological statistics in Japan.2004

    • Author(s)
      Shimokata H
    • Journal Title

      Nippon Rinsho (in Jpn) 62(Suppl 4)

      Pages: 121-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interactions between health and psychological changes in Japanese : the NILS-LSA.2004

    • Author(s)
      Shimokata H, Ando F, Fukukawa Y
    • Journal Title

      Geriatrics and Gerontology International 4(Suppl)

    • NAID

      10018027854

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Clock Drawing Test as a Valid Screening Method for Mild Cognitive Impairment.2004

    • Author(s)
      Yamamoto S, Mogi N, Umegaki H, Suzuki Y, Ando F, Shimokata H, Iguchi A
    • Journal Title

      Dement Geriatr Cogn Disord 18

      Pages: 172-179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Age differences in the effect of physical activity on depressive symptoms.2004

    • Author(s)
      Fukukawa Y, Nakashima C, Tsuboi S, Kozakai R, Doyo W, Niino N, Ando F, Shimokata H
    • Journal Title

      Psychol Aging 19(2)

      Pages: 346-351

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interactions between health and psychological changes in Japanese - the NILS-LSA.2004

    • Author(s)
      Shimokata H, Ando F, Fukukawa Y
    • Journal Title

      Geriatrics and Gerontology International 4(Suppl)

    • NAID

      10018027854

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Clock Drawing Test as a Valid Screening Method for Mild Cognitive Impairment.2004

    • Author(s)
      Yamamoto S, Mogi N, Ando F, Umegaki H, Shimokata H, et al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorder 18

      Pages: 172-179

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 地域在住の中高年者の抑うつに関連する要因:その年齢差と性差2004

    • Author(s)
      坪井さとみ, 福川康之, 新野直明, 安藤富士子, 下方浩史
    • Journal Title

      心理学研究 75(2)

      Pages: 101-108

    • NAID

      130002027376

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Age Differences in the Effect of Physical Activity on Depressive Symptoms.2004

    • Author(s)
      Fukukawa Y, Nakashima C, Tsuboi S, Kozakai R, Ando F, Shimokata H, et al.
    • Journal Title

      Psychology and Aging 19(2)

      Pages: 346-351

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 疫学調査におけるMCI2003

    • Author(s)
      下方浩史, 藤澤道子, 安藤富士子
    • Journal Title

      Geriatric Medicine 20(3)

      Pages: 303-308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] MTHFR Gene polymorphism as Risk Factor for Silent Brain Infarcts and While Matter Lesions in Japanese General Population : NILS-LSA Study.2003

    • Author(s)
      Kohara K, Fujisawa M, Ando F, Tabara Y, Niino N, Miki T, Shimokata H
    • Journal Title

      Stroke 34(5)

      Pages: 1130-1135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] MTHFR Gene Polymorphism as Risk Factor for Silent Brain Infarcts and White Matter Lesions in Japanese General Population : NILS-LSA Study.2003

    • Author(s)
      Kohara K, Fujisawa M, Ando F, Tabara Y, Niino N, Miki T, Shimokata H
    • Journal Title

      Stroke 34(5)

      Pages: 1130-1135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of a polymorphism of the transforming growth factor-blgene with blood pressure in Japanese.2002

    • Author(s)
      Yamada Y, Fujisawa M, Ando F, Niino N, Tanaka M, Shimokata H
    • Journal Title

      Journal of Human Genetics 47

      Pages: 243-248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 高齢者臓器疾患は認知機能低下を招く2002

    • Author(s)
      藤澤道子, 安藤富士子, 下方浩史
    • Journal Title

      Geriatric Medicine 20(2)

      Pages: 241-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ホモシステインと痴呆2002

    • Author(s)
      藤澤道子, 安藤富士子, 下方浩史
    • Journal Title

      動脈硬化予防 1(2)

      Pages: 98-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] わが国における痴呆性疾患の疫学2002

    • Author(s)
      藤澤道子, 安藤富士子, 下方浩史
    • Journal Title

      クリニカ 29(3)

      Pages: 172-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of a polymorphism of the transforming growth factor b1 gene with blood pressure in Japanese.2002

    • Author(s)
      Yamada Y, Fujisawa M, Ando F, Niino N, Tanaka M, Shimokata H
    • Journal Title

      J Hum Genet 47

      Pages: 243-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Organ diseases in the elderly cause cognitive impairment.2002

    • Author(s)
      Fujisawa M, Ando F, Shimokata H
    • Journal Title

      Geriatric Medicine. (in Jpn) 20

      Pages: 241-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Homocysteine and dementia.2002

    • Author(s)
      Fujisawa M, Ando F, Shimokata H
    • Journal Title

      Atherosclerosis Prevention (in Jpn) 1(2)

      Pages: 98-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epidemiology of Dementia-related Disorders in Japan.2002

    • Author(s)
      Fujisawa M, Ando F, Shimokata H
    • Journal Title

      Clinica (in Jpn) 29(3)

      Pages: 172-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] MCI in the epidemiological survey.2002

    • Author(s)
      Shimokata H, Fujisawa M, Ando F
    • Journal Title

      Geriatric Medicine. (in Jpn) 20

      Pages: 303-308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 老化および老年病の疫学的研究

    • Author(s)
      下方浩史
    • Journal Title

      Geriatric Medicine 印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 地域在住中高年者・高齢者のエピソード記憶に関する横断的検討

    • Author(s)
      西田裕紀子, 福川康之, 丹下智香子, 安藤富士子, 下方浩史
    • Journal Title

      日本未病システム学会雑誌 印刷中

    • NAID

      130004185820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] EURODEM. 老年期痴呆ナビゲーター(平井俊策監修)2006

    • Author(s)
      下方浩史
    • Publisher
      メディカルレビュー社、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 老化に対する遺伝的要因と生活習慣の関わり。Advances in Aging and Health Research 2005のばそう健康寿命-老化と老年病を防ぎ、介護状態を予防する。2005

    • Author(s)
      下方浩史
    • Publisher
      長寿科学健康財団、愛知
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] The association of genetic factors and life-style with aging. Advances in Aging and Health Research 2005 - For extending healthy life-span, preventing aging, geriatric disease, and impairment (in Jpn)2005

    • Author(s)
      Shimokata H
    • Publisher
      Japan Foundation for Aging and Health. Aichi
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 老化に対する遺伝的要因と生活習慣の関わり.Advances in Aging and Health Research 2005のばそう健康寿命-老化と老年病を防ぎ、介護状態を予防する.2005

    • Author(s)
      下方浩史
    • Total Pages
      10
    • Publisher
      長寿科学健康財団.愛知.
    • Related Report
      2005 Annual Research Report
  • [Book] 老化に対する遺伝的要因と生活習慣の関わり.Advances in Aging and Health Research 2005 のばそう健康寿命-老化と老年病を防ぎ、介護状態を予防する2005

    • Author(s)
      下方浩史
    • Publisher
      長寿科学健康財団.愛知(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] Overview-廊下の縦断的研究の最近の展開(日本老年医学会編)、老年医学update20022003

    • Author(s)
      下方浩史, 安藤富士子
    • Publisher
      メディカルビュー社、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Overview-Recent Developments of Longitudinal Study of Aging. Geriatrics update 2002 (in Jpn) (eds. Japan Geriatric Society)2002

    • Author(s)
      Shimokata H, Ando F
    • Publisher
      Medicalview Co, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] EURODEM, Senile dementia navigator. (in Jpn)2002

    • Author(s)
      Shimokata H
    • Publisher
      Medicalview Co, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 血管障害性が関与する疾患の易罹患性の判定方法2004

    • Inventor(s)
      下方 浩史他
    • Industrial Property Rights Holder
      長寿医療センター他
    • Industrial Property Number
      2004-265760
    • Filing Date
      2004-09-13
    • Related Report
      2004 Annual Research Report
  • [Publications] Kohara K, Fujisawa M, Ando F, Tabara Y, Niino N, Miki T, Shimokata H: "MTHFR Gene Polymorphism as Risk Factor for Silent Brain Infarcts and White Matter Lesions in Japanese General Population : NILS-LSA Study."Stroke. 34(5). 1130-1135 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukukawa Y, Nakashima C, Tsuboi S, Niino N, Ando F, Shimokata H, et al.: "The impact of health problems on depression and activities in middle-aged and older adults : Age and social interactions as moderators."J Gerontol B Psychol Sci. 59(1). 19-26 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mogi N, Umegaki H, Miura H, Kuzuya M, Shimokata H, Ando F, et al.: "Cognitive Function in Japanese Elderly with Type 2 Diabetes Mellitus."J Diabetes Complications. 18. 42-46 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 坪井さとみ, 福川康之, 新野直明, 安藤富士子, 下方浩史: "地域在住の中高年者の抑うつに関連する要因:その年齢差と性差"心理学研究. 印刷中. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 下方浩史, 西田裕紀子, 新野直明, 安藤富士子: "Klotho遺伝子G-395A多型と認知機能障害"日本末病システム学会雑誌. 印刷中. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 下方浩史: "痴呆症学-本邦の疫学統計"日本臨床. 63(増刊4). 121-126 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kohara K, Fujisawa M, Ando F, Tabara Y, Niino N, Miki T, Shimokata H: "MTHFR Gene Polymorphism as Risk Factor for Silent Brain Infarcts and White Matter Lesions in Japanese General Population : NILS-LSA Study"Stroke. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamada Y, Fujisawa M, Ando F, Niino N, Tanaka M, Shimokata H: "Association of a polymorphism of the transforming growth factor-b1 gene with blood pressure in Japanese"Journal of Human Genetics. 47. 243-248 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 藤澤道子, 安藤富士子, 下方浩史: "高齢者臓器疾患は認知機能低下を招く"Geriatric Medicine. 20(2). 241-245 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 藤澤道子, 安藤富士子, 下方浩史: "ホモシステインと痴呆"動脈硬化予防. 1(2). 98-99 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 藤澤道子, 安藤富士子, 下方浩史: "わが国における痴呆性疾患の疫学"クリニカ. 29(3). 172-176 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 下方浩史, 藤澤道子, 安藤富士子: "疫学調査におけるMCI"Geriatric Medicine. 20(3). 303-308 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 下方浩史, 安藤富士子: "Overview-老化の縦断的研究の最近の展開 (日本老年医学会編)、老年医学 update 2002"メディカルビュー社、東京. 150-153 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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