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Heart surgery for the 21st century : Establishment of beating-heart surgery using real-time three-dimensional echocardiography

Research Project

Project/Area Number 14207051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TAKAMOTO Shinichi  The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (60137833)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Arata  The University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部附属病院, 助教授 (70190874)
MOTOMURA Noboru  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (40332580)
MOROTA Tetsuro  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (10332587)
大塚 俊哉  都立府中病院, 部長(研究職) (80262004)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2005: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2004: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2003: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2002: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywordsbeating heart operation / three dimensional echography / 2D array / real-time 3 dimensional echocardiography / suturing device with ultrasonic transducer / Integral Videography / 三次元空間位置測定装置 / 拍動下心臓内手術 / 心臓内視鏡縫合器 / リアルタイム三次元超音波装置 / 械機スキャン
Research Abstract

For four years, we have been developing echocardiography-guided beating-heart surgery techniques requiring no cardiopulmonary bypass.
In 2002, we devised 1)an endoscope through which lesions in heart chambers could be observed after insertion of a transparent tube with a closed end, and 2)a semi-automatic jaw-type suturing device whereby a straight needle secured in the distal jaw is transferred to the proximal jaw when the jaws are manually closed by pulling the thread down.
Our development, in 2003,of echographic equipment using a 2D array matrix transducer on an SSD-5500 (Aloka Co., Ltd) made possible real-time 3-dimensional echocardiography (RT3DE), in which forceps and suture devices are displayed in real time in the three-dimensional image.
In 2004, improvement of the performance of the RT3DE equipment and development of a suturing device with an ultrasound transducer were our targets, and real-time Integral Videography (IV) images were created to guide the surgery. One drawback was that the transducer was too large to be applied directly to the heart through the small incision required for RT3DE-guided beating-heart surgery, and so further technical development of the RT3DE system was essential.
In 2005, a suturing device with an ultrasound transducer was produced with the cooperation of Mizuho Co., Ltd., and Aloka Co., Ltd. This device was inserted into the cardiac cavity and guided to the surgical site using the RT3DE image. This site was clearly displayed on a screen and identified with the ultrasonic transducer attached to the tip of the suture device. Our subsequent success with these modifications suggested that a combination of the RT3DE with this novel suturing device would be useful for beating-heart surgery.
Our current aims are the construction of a navigation system using IV images and the establishment of echocardiography-guided surgery.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (39 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (27 results) Patent(Industrial Property Rights) (4 results) Publications (8 results)

  • [Journal Article] Three-dimensional echo-guided beating heart surgery without cardiopulmonary bypass : Atrial septal defect closure in a swine model2005

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 130

      Pages: 1348-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echo-guided beating heart surgery without cardiopulmonary bypass : Atrial septal defect closure in a swine model.2005

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 130

      Pages: 1348-1357

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echo-guided beating heart surgery without cardiopulmonary bypass : Atrial septal defect closure in a swine model2005

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery 130

      Pages: 1348-1357

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 新しい治療体系 Off-pump心内操作術2004

    • Author(s)
      末松 義弘
    • Journal Title

      現代医療 36

      Pages: 187-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echocardiography-guided atrial septectomy : an experimental study2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 128

      Pages: 53-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echocardiography-guided beating-heart surgery without cardiopulmonary bypass : a feasibility study2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 128

      Pages: 579-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Robotic pediatric cardiac surgery : present and future perspectives2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      American Journal of Surgery 188(suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Off-pump intracardiac surgery.2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Gendai Iryo 36

      Pages: 187-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echocardiography-guided atrial septectomy : An experimental study.2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 128

      Pages: 53-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Three-dimensional echocardiography-guided beating-heart surgery without cardiopulmonary bypass : A feasibility study.2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 128

      Pages: 579-587

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Robotic pediatric cardiac surgery : present and future perspectives.2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      American Journal of Surgery 188(4A suppl)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Off-pump intracardiac surgery2004

    • Author(s)
      末松 義弘
    • Journal Title

      臨床医学 36

      Pages: 187-194

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Three- dimensional echocardiography-guided atrial septectomy : an experimental study2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      J Thorac Cardiovasc Surg 128

      Pages: 53-59

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Three-dimensional echocardiography-guided beating-heart surgery without cardiopulmonary bypass : a feasibility study2004

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      J Thorac Cardiovase Surg 128

      Pages: 579-587

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Semi-automatic suturing device for minimally invasive cardiac surgery2003

    • Author(s)
      末松 義弘
    • Journal Title

      胸部外科 56

      Pages: 203-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Beating Atrial Septal Defect Closure Monitored by Epicardial Real-time Three-dimensional Echocardiography without Cardiopulmonary Bypass2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Circulation 107

      Pages: 785-90

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Future technologic innovations for intraoperative visualization of native coronary artery and graft anastomoses.2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 126

      Pages: 304-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 循環器系疾患に対する低侵襲最先端医療の開発 心臓外科領域における超音波工学の術中応用2003

    • Author(s)
      末松 義弘
    • Journal Title

      東京都医師会雑誌 56

      Pages: 633-633

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 拍動下心臓内手術への挑戦 リアルタイム三次元超音波・内視鏡誘導型自動吻合器の術中応用2003

    • Author(s)
      末松 義弘
    • Journal Title

      日本外科学会雑誌 104

      Pages: 168-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Semi-automatic suturing device for minimally invasive cardiac surgery.2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Kyobu Geka 56

      Pages: 203-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Beating Atrial Septal Defect Closure Monitored by Epicardial Real-Time Three-Dimensional Echocardiography Without Cardiopulmonary Bypass.2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Circulation 107

      Pages: 785-790

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Forefront of minimally invasive cardiovascular surgery development : Application of the ultrasonic engineering to the cardiac surgery.2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Journal of Tokyo Medical Association 56

      Pages: 633-633

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Real-time three-dimensional echocardiography image guided beating heart surgery using semi-automatic endoscopic suturing device.2003

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Japanese Journal of Surgery 104

      Pages: 168-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 拍動下心内修復術の試み2002

    • Author(s)
      末松 義弘
    • Journal Title

      日本外科学会雑誌 103

      Pages: 222-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Beating heart surgery without cardiopulmonary bypass.2002

    • Author(s)
      Yoshihiro Suematsu
    • Journal Title

      Japanese Journal of Surgery 103

      Pages: 222-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] リアルタイム三次元超音波の術中応用2001

    • Author(s)
      高本 眞一
    • Journal Title

      超音波医学 28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Real-time three-dimensional echocardiography guided surgery.2001

    • Author(s)
      Shinichi Takamoto
    • Journal Title

      Japanese Journal of Medical Ultrasonics 28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 心臓内縫合装置2002

    • Inventor(s)
      高本眞一, 末松義弘, 宮川克也, 片岡秀彰
    • Patent Publication Number
      2003-305046
    • Filing Date
      2002-04-15
    • Acquisition Date
      2003-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 縫合器及び縫合方法2002

    • Inventor(s)
      高本眞一, 末松義弘
    • Patent Publication Number
      2004-105406
    • Filing Date
      2002-09-18
    • Acquisition Date
      2004-04-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 内視鏡誘導型自動吻合器2001

    • Inventor(s)
      高本眞一, 末松義弘
    • Patent Publication Number
      2003-000605
    • Filing Date
      2001-06-20
    • Acquisition Date
      2003-01-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 心臓内縫合装置2001

    • Inventor(s)
      高本眞一, 末松義弘, 宮川克也, 岸上兆一
    • Patent Publication Number
      2003-102735
    • Filing Date
      2001-10-01
    • Acquisition Date
      2003-04-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] 末松 義弘: "Semi-automatic suturing device for minimally invasive cardiac surgery"胸部外科. 56. 203-206 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihiro Suematsu: "Beating Atrial Septal Defect Closure Monitored by Epicardial Real-time Three-dimensional Echocardiography without Cardiopulmonary Bypass"Circulation. 107. 785-790 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 末松 義弘: "Off-pump intracardiac surgery"臨床医学. 36. 187-194 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshihiro Suematsu: "Power Doppler Imaging of the Internal Mammary Artery during CABG without Cardiopulmonary Bypass"Asian Cardiovascular and Thoracic Annals. 10. 89-91 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshihiro Suematsu: "Ultrasonic Evaluation of Graft Anastmoses During Coronary Artery Bypass Grafting without Cardiopulmonary Bypass"Annals of Thoracic Surgery. 74. 273-275 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshihiro Suematsu: "Real-time Three-dimensional Echocardiography Evaluation of Graft Anastmoses During Coronary Artery Bypass Grafting : Preliminary Experience"Interactive Cardiovascular and Thoracic Surgery. 1. 52-54 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 末松義弘: "Semi-automatic suturing device for minimally invasive cardiac surgery"胸部外科. 56. 203-206 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshihiro Suematsu: "Beating Atrial Septal Defect Closure Monitored by Epicardial Real-time Three-dimensional Echocardiography without Cardiopulmonary Bypass"Circulation. 107. 785-790 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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