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Regulatory mechanisms and interactions of extracellular molecules

Research Project

Project/Area Number 14207076
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YANAGISHITA Masaki  Tokyo Medical and Dental University, Graduate School, Biochemistry, Professor, 大学院・医歯学総合研究科, 教授 (70132793)

Co-Investigator(Kenkyū-buntansha) SHINOMURA Tamayuki  Tokyo Medical and Dental University, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70206118)
YOKOYAMA Miki  Tokyo Medical and Dental University, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70191533)
INOUE Katarzyna Anna  Tokyo Medical and Dental University, Faculty of Dentistry, Educational Stuff, 歯学部, 教務職員 (90302877)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2005: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2004: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2003: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2002: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Keywordsextracellular matrix / proteoglycan / heparan sulfate / membrane domain / molecular interactions / degrading enzyme / complex carbohydrates / ヘパラネース
Research Abstract

In addition
to providing mechanical supports for various body structures in animals,
extracellular matrix also provides living environments for cells. Thus, it is involved in many crucial biological functions, including cell differentiation, proliferation, metabolism and regulated responses to environmental stimuli. Especially biological signals coming from outside cells are very important regulating fundamental cell functions. We have especially focused our attention on the analysis of molecular interactions between extracellular matrix molecules cellular molecules occurring at the cell surface, as a pertinent experimental system studying functional significance of extracellular matrix molecules. Specifically, a hypothesis that specialized plasma membrane domains are involved in the molecular interactions with extracellular matrix. A detergent-resistant plasma membrane preparation was made by solubilizing cell cultures with Triton X-100 followed by ultracentrifugation in a sucrose gradient. The presence of a specialized membrane domain was identified by colocalization of proteins, such as CD 38 and Lyn. A membrane domain preparation isolated from parathyroid cell sutures was examined by Western blot analyses probed with antibodies against heparan sulfate proteoglycans, which indicated significant enrichment syndecan-4 heparan sulfate proteoglycan and exclusion of syndecan-1. Further confirmation using MALDI-TOF mass spectroscopy has been on the way. Experiments also suggested that heparan sulfate proteoglycans participate in the structural stability of membrane domains. Effects of heparan sulfate degrading enzymes on the formation of membrane domains in the cell cultures in vitro are being studied. Future experiments will include detailed examination how heparan sulfate proteoglycans may be involved in the signal transduction and how they are contributing to the mechanical integrity of plasma membranes.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (107 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (79 results) Book (6 results) Publications (22 results)

  • [Journal Article] ラット卵巣顆粒膜細胞におけるプロテオグライカンの生合成に与えるp-nitrophenyl-xylosideの影響--Golgi装置の糖合成機能に関する解析2006

    • Author(s)
      柳下正樹ら
    • Journal Title

      口腔病学会雑誌 73

      Pages: 20-25

    • NAID

      10017549803

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation2006

    • Author(s)
      Kamiya, N.ら
    • Journal Title

      J. Biol. Chem. 281

      Pages: 2390-2400

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Screening for genes preferentially expressed in the early phase of chondrogenesis2006

    • Author(s)
      Shinomura, T.ら
    • Journal Title

      Biochem. Biophys. Res. Commun. 341

      Pages: 167-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of p-nitrophenyl-xyloside on the biosynthesis of proteoglycans in rat ovarian granulosa cells - analysis of carbohydrate biosynthesis in the Golgi apparatus2006

    • Author(s)
      Yanagishita, M., Tsuchida, S., Yokoyama, M., Inoue, K.-A.
    • Journal Title

      J.Stomatological Society 73

      Pages: 20-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation,2006

    • Author(s)
      Kamiya, N., Watanabe, H., Habuchi, H., Takagi, H, Shinomura, T., Shimizu, K., Kimata, K.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 2390-2400

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Screening for genes preferentially expressed in the early phase of chondrogenesis,2006

    • Author(s)
      Shinomura, T., Ito, K., Kimura, J.H., Hook, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 341

      Pages: 167-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Syndecan-1 Expression during the Formation of Junctional Epithelium2005

    • Author(s)
      Dias, R.A.ら
    • Journal Title

      J. Periodontol. 76

      Pages: 696-704

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress2005

    • Author(s)
      Ozaki, S.ら
    • Journal Title

      J. Period. Res. 40

      Pages: 110-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts2005

    • Author(s)
      Akashi, T.ら
    • Journal Title

      Pathobiology 72

      Pages: 250-259

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Identification of genes preferentially expressed in Articular Cartilage by Suppression Subtractive Hybridization2005

    • Author(s)
      Yoshimi, M.ら
    • Journal Title

      J. Med. Dent. Sci. 52

      Pages: 203-211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of genes preferentially expressed in periodontal ligament : Specific expression of a novel secreted protein, FDC-SP2005

    • Author(s)
      Nakamura, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 1197-1203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene trap screening for cell surface and extracellular matrix molecules produced by chondrocytes2005

    • Author(s)
      Shirasawa, S.ら
    • Journal Title

      J. Biochem. 137

      Pages: 79-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Syndecan-1 Expression during the Formation of Junctional Epithelium,2005

    • Author(s)
      Dias, R.A., Shibata, S., Hashimoto-Uoshima, M., Podyma-Inoue, K.A., Ishikawa, I., Yanagishita, M.
    • Journal Title

      J.Periodontol. 76

      Pages: 696-704

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress.2005

    • Author(s)
      Ozaki, S., Kaneko, S., Podyma-Inoue, K.A., Yanagishita, M., Soma, K.
    • Journal Title

      J.Period.Res. 40

      Pages: 110-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts.2005

    • Author(s)
      Akashi, T., Minami, J., Ishige, Y., Eishi, Y., Takizawa, T., Koike, M., Yanagishita, M.
    • Journal Title

      Pathobiology 72

      Pages: 250-259

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of genes preferentially expressed in Articular Cartilage by Suppression Subtractive Hybridization,2005

    • Author(s)
      Yoshimi, M, Miyaishi, O., Nakamura, S., Shirasawa, S., Kamochi, H., Miyatani, S., Ikawa, Y., Shinomura, T.
    • Journal Title

      J.Med.Dent.Sci. 52

      Pages: 203-211

    • NAID

      110003490709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of genes preferentially expressed in periodontal ligament : Specific expression of a novel secreted protein, FDC-SP,2005

    • Author(s)
      Nakamura, S., Terashima, T., Yoshida, T., Iseki, S., Takano, Y., Ishikawa, I., Shinomura, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 1197-1203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene trap screening for cell surface and extracellular matrix molecules produced by chondrocytes,2005

    • Author(s)
      Shirasawa, S., Yoshimi, M., Kamochi, H., Muneta, T., Kimura, J.H., Hook, M., Shinomura, T.
    • Journal Title

      J.Biochem. 137

      Pages: 79-85

    • NAID

      10017342666

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of occlusal stimuli on the remodelling of alveolar bone in a rat hypofunction/recovery model,2005

    • Author(s)
      Masafumi Enokida, Sawa Kaneko, Masaki Yanagishita, Kunimichi Soma
    • Journal Title

      Journal of Oral Biosciences 47

      Pages: 321-334

    • NAID

      10016884868

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Syndecan-1 Expression during the Formation of Junctional Epithelium2005

    • Author(s)
      Dias, R.A.ら
    • Journal Title

      J.Periodontol. 76

      Pages: 696-704

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress2005

    • Author(s)
      Ozaki, S.ら
    • Journal Title

      J.Period.Res. 40

      Pages: 110-117

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress2005

    • Author(s)
      Ozaki, S.ら
    • Journal Title

      J.Period.Res. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Syndecan-1 Expression during the Formation of Junctional Epithelium2005

    • Author(s)
      Dias.A.R.ら
    • Journal Title

      J.Period.Res. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ultrafiltration-based assay for heparanase activity2004

    • Author(s)
      Tsuchida, S.ら
    • Journal Title

      Anal. Biochem. 331

      Pages: 147-152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 口腔扁平上皮癌におけるヘパラナーゼの発現と頸部リンパ節転移の関連について2004

    • Author(s)
      生田稔ら
    • Journal Title

      頭頸部腫瘍 30

      Pages: 20-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Charge-based separation of detergent-resistant membranes of mouse splenic B cells2004

    • Author(s)
      Katsumata, O.ら
    • Journal Title

      Biochem. Biophys. Res. Commun. 319

      Pages: 826-831

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 「研究成果報告書概要(和文)」より2004

    • Author(s)
      Kasevayuth, K.ら
    • Journal Title

      Biochem. Biophys. Res. Commun. 324

      Pages: 205-211

    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト歯周組織細胞におけるプロテオグリカン生合成に対するサイトカインの効果について2004

    • Author(s)
      魚島マリコら
    • Journal Title

      日本歯科保存学雑誌 47

      Pages: 684-695

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ultrafiltration-based assay for heparanase activity.2004

    • Author(s)
      Tsuchida, S., Podyma-Inoue, K.A., Yanagishita, M.
    • Journal Title

      Anal.Biochem. 331

      Pages: 147-152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of heparanase and metastasis of oral squamous cell carcinoma to cervical lymph nodes2004

    • Author(s)
      Ikuta, M., Harada, H., Kurokawa, H., Omura, K., Yanagishita, M.
    • Journal Title

      Head and Neck Tumors 30

      Pages: 20-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Charge-based separation of detergent-resistant membranes of mouse splenic B cells.2004

    • Author(s)
      Katsumata, O., Kimura, T., Nagatsuka, Y., Hirabayashi, Y., Sugiya, H., Furuyama, S., Yanagishita, M., Hara-Yokoyama, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 319

      Pages: 826-831

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catabolism of heparan sulfate proteoglycans in Drosophila cell lines.2004

    • Author(s)
      Kasevayuth, K, Yanagishita, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 324

      Pages: 205-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of cytokines on the biosynthesis of proteoglycans by human periodontal cells2004

    • Author(s)
      Uoshima, M., Rubia Augusta Dias, Noguchi, K., Katarzyna Anna Podyma-Inoue, Yanagishita, M., Ishikawa, I.
    • Journal Title

      Jap.J. of Periodontology 47

      Pages: 684-695

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Charge-based characterization of detergent-resistant membranes of mouse splenic B cells by free flow electrophoresis2004

    • Author(s)
      Katsumata, O.ら
    • Journal Title

      Biochem.Biophys.Res.Commun. 319

      Pages: 826-831

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ultrafiltration-based assay for heparanase activity2004

    • Author(s)
      Tsuchida, S.ら
    • Journal Title

      Anal.Biochem. 331

      Pages: 147-152

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 口腔扁平上皮癌におけるヘパラーゼの発現と頸部リンパ節転移の関連について2004

    • Author(s)
      生田 稔ら
    • Journal Title

      頭頸部腫瘍 30

      Pages: 20-24

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Catabolism of Heparan Sulfate Proteoglycans in Drosophila cell lines2004

    • Author(s)
      Kasevayuth, K.ら
    • Journal Title

      Biochem.Biophys.Res.Commun. 324

      Pages: 205-211

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of cytokines on proteoglycan biosynthesis in human periodontal tissue cells2004

    • Author(s)
      Hashimoto-Uoshima, M.ら
    • Journal Title

      Jpn.J.Conserv.Dent. 47

      Pages: 684-695

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Charge-based separation of detergent-resistant membranes of mouse splenic B cells2004

    • Author(s)
      Katsumata, O.ら
    • Journal Title

      Biochem.Biophys.Res.Commun. 319

      Pages: 826-831

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Proteoglycan knock-out mice and osteoarthritis2004

    • Author(s)
      Sinomura, T.
    • Journal Title

      Clinical Calcium 14

      Pages: 58-63

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells2003

    • Author(s)
      Nagatsuka, Y.ら
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 100

      Pages: 7454-7459

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of orthodontic forces on the distribution of proteoglycans in rat hypofunctional periodontal ligament2003

    • Author(s)
      Esashika, M.ら
    • Journal Title

      J. Med. Dent. Sci. 50

      Pages: 183-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heparanase activities and the tumor invasion patterns in human squamous cell carcinoma xenografts2003

    • Author(s)
      Kurokawa, H.ら
    • Journal Title

      Cancer Science 94

      Pages: 277-285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD382003

    • Author(s)
      Hara-Yokoyama, M.ら
    • Journal Title

      Bioorganic and Medicinal Chemistry Letter 13

      Pages: 3441-3445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinct interaction of versican/PG-M with hyaluronan and link protein2003

    • Author(s)
      Matsumoto, K.ら
    • Journal Title

      J. Biol. Chem. 278

      Pages: 41205-41212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] オーバービュー : 線維化にかかわる細胞と分子2003

    • Author(s)
      柳下正樹
    • Journal Title

      臨床医学 35

      Pages: 306-310

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 線維化を担当する細胞と細胞外マトリックス2003

    • Author(s)
      柳下正樹
    • Journal Title

      Medical Science Digest 29

      Pages: 392-395

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of compressive forces on extracellular matrix in rat mandibular condylar cartilage2003

    • Author(s)
      Teramoto, M.ら
    • Journal Title

      J. Bone Miner. Metab. 21

      Pages: 276-286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells,2003

    • Author(s)
      Yasuko Nagatsuka, Miki Hara-Yokoyama, Takeshi Kasama, Masataka Takekoshi, Fumiko Maeda, Seiji Ihara, Shigeyoshi Fujiwara, Eriko Ohshima, Kumiko Ishii, Toshihide Kobayashi, Kazufumi Shimizu, Yoshio Hirabayashi
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 100

      Pages: 7454-7459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of orthodontic forces on the distribution of proteoglycans in rat hypofunctional periodontal ligament.2003

    • Author(s)
      Esashika, M., Kaneko, S., Yanagishita, M., Soma, K.
    • Journal Title

      J.Med.Dent.Sci. 50

      Pages: 183-194

    • NAID

      110000076033

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heparanase activities and the tumor invasion patterns inhuman squamous cell carcinoma xenografts,2003

    • Author(s)
      Kurokawa, H., Katsube, K., Podyma, K.A., Ikuta, M., Iseki, H., Jian, D., Nakajima, M., Akashi, T., Omura, K., Yanagishita, M.
    • Journal Title

      Cancer Science 94

      Pages: 277-285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38,2003

    • Author(s)
      Hara-Yokoyama, M., Ito, H., Ueno-Noto, K., Takano, K., Ishida H., Kiso, M.
    • Journal Title

      Bioorganic and Medicinal Chemistry Letter 13

      Pages: 3441-3445

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinct interaction of versican/PG-M with hyaluronan and link protein,2003

    • Author(s)
      Matsumoto, K., Shionyu, M., Go, M., Shimizu, K., Shinomura, T., Kimata, K., Watanabe, H.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 41205-41212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Overview : Cells and molecules involved in fibrosis2003

    • Author(s)
      Yanagishita, M.
    • Journal Title

      Clinical Medicine 35

      Pages: 306-310

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cells and extracellular matrix molecules involved in fibrosis and2003

    • Author(s)
      Yanagishita, M.
    • Journal Title

      Medical Science Digest 29

      Pages: 392-395

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of compressive forces on extracellular matrix in rat mandibular condylar cartilage.2003

    • Author(s)
      Teramoto, M., Kaneko, S., Shibata, S., Yanagishita, M., Soma, K.
    • Journal Title

      J.Bone Miner.Metab. 21

      Pages: 276-286

    • NAID

      10014444949

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells2002

    • Author(s)
      Dohke, Y.ら
    • Journal Title

      Biochem. Biophys. Res. Commun. 299

      Pages: 663-668

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oligomers of Glycamino Acid2002

    • Author(s)
      Schnaar, R.L.ら
    • Journal Title

      Biooorganic & Medicinal Chemistry 10

      Pages: 1999-2013

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of heparanase from a rat parathyroid cell line2002

    • Author(s)
      Podyma-Inoue, K.A.ら
    • Journal Title

      J. Biol. Chem. 277

      Pages: 32459-32465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblasts2002

    • Author(s)
      Hashimoto-Uoshima, M.ら
    • Journal Title

      J. Periodont. Res. 37

      Pages: 42-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Developmental changes and regional differences in histochemical localization of hyaluronan and versican in postnatal molar dental pulp2002

    • Author(s)
      Shibata, Sら
    • Journal Title

      International Endodontic Journal 35

      Pages: 159-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Affinity Binding of Glycosaminoglycans with β_2-Microblobulin2002

    • Author(s)
      Ohashi, K.ら
    • Journal Title

      Nephron 90

      Pages: 158-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biosynthesis of versican by rat dental pulp cells in culture2002

    • Author(s)
      Yoneda, S.ら
    • Journal Title

      Archives of Oral Biology 47

      Pages: 435-442

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of an Anti-Decorin Monoclonal Antibody, and Its Utility2002

    • Author(s)
      Sawada, H.ら
    • Journal Title

      J. Biochem. 132

      Pages: 997-1002

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 糖鎖コドンの高次構造認識機構の解明2002

    • Author(s)
      横山三紀
    • Journal Title

      タンパク質 核酸 酵素 47

      Pages: 187-188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 「モデル生物」を使った結合組織分子の研究2002

    • Author(s)
      中西伸夫ら
    • Journal Title

      口腔病学会雑誌 69

      Pages: 49-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IgG-Fc受容体の架橋刺激における膜ドメインの役割、チロシンリン酸化反応の開始と活性酸素産生における重要性2002

    • Author(s)
      勝俣治ら
    • Journal Title

      タンパク質 核酸 酵素 47

      Pages: 379-384

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of phospholipase D in the cAMP-regulated exocytosis of rat parotid acinar cells.2002

    • Author(s)
      Dohke, Y., Fujita-Yoshigaki, J., Sugiya, H., Furuyama, S., Hara-Yokoyama, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 299

      Pages: 663-668

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oligomers of Glycamino Acid.2002

    • Author(s)
      Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R.L., Yanagishita, M., Hildreth, J.E.K., Shimada, I., Ichikawa, Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry 10

      Pages: 1999-2013

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of heparanase from a rat parathyroid cell line.2002

    • Author(s)
      Podyma-Inoue, K.A., Yokote, H., Sakaguchi, K., Ikuta, M., Yanagishita, M.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 32459-32465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblasts.2002

    • Author(s)
      Hashimoto-Uoshima, M., Noguchi, M., Suzuki, K., Murata, A., Yanagishita, M., Ishikawa, I.
    • Journal Title

      J.Periodont.Res. 37

      Pages: 42-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Developmental changes and regional differences in histochemical localization of hyaluronan and versican in postnatal molar dental pulp.2002

    • Author(s)
      Shibata, S., Yoneda, S., Yanagishita, M., Yamashita, Y.
    • Journal Title

      International Endodontic Journal. 35

      Pages: 159-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Affinity Binding of Glycosaminoglycans with β_2-Microglobulin2002

    • Author(s)
      Ohashi, K., Kisilevsky, R., Yanagishita, M.
    • Journal Title

      Nephron 90

      Pages: 158-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biosynthesis of versican by rat dental pulp cells in culture,2002

    • Author(s)
      Yoneda, S., Shibata, S., Yamashita, Y., Yanagishita, M.
    • Journal Title

      Archives of Oral Biology 47

      Pages: 435-442

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential gene trap : Anew strategy for identifying genes regulated during cartilage differentiation in2002

    • Author(s)
      Shinomura, T., Ito, K., Hook, M.
    • Journal Title

      The Many Faces of Osteoarthritis (eds. Hascall V.C. & Kuettner, K.E.)(Birkhuser Verlag, Basel)

      Pages: 309-311

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of an Anti-Decorin Monoclonal Antibody, and Its Utility,2002

    • Author(s)
      Sawada, H., Shinomura, T., Kimata, K., Takeuchi, J., Tsuji, T., Watanabe, H.
    • Journal Title

      J.Biochem. 132

      Pages: 997-1002

    • NAID

      10010654494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High-level recognition system of carbohydrate-codon2002

    • Author(s)
      Yokoyama, M.
    • Journal Title

      P.N.E. 47

      Pages: 187-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular investigation of connective tissues using "model organisms"2002

    • Author(s)
      Nakanishi, N., Yanagishita, M.
    • Journal Title

      J.Stomatological Society 69

      Pages: 49-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of membrane domain in IgG-Fc receptor cross-linking : Importance of tyrosine phosphorylation and generation of active oxygen species2002

    • Author(s)
      Katsumata, O., Yokoyama, M.
    • Journal Title

      P.N.E. 47

      Pages: 379-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 未来を開く糖鎖科学2005

    • Author(s)
      柳下正樹(分担)
    • Total Pages
      467
    • Publisher
      金芳堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Degradation of hyaluronan and its abnormality In, "Glycoscience and the future" (Nagai, K., ed.)2005

    • Author(s)
      Yanagishita, M.
    • Publisher
      Kinpodo, Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 未来を開く糖鎖科学2005

    • Author(s)
      柳下 正樹(共著)
    • Total Pages
      467
    • Publisher
      金芳堂
    • Related Report
      2005 Annual Research Report
  • [Book] 「ゲノム情報を越えた生命の不思議-糖鎖」2003

    • Author(s)
      柳下正樹(分担)
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Regulation of cellular information by carbohydrates In, "Wonder of life beyond the gene - Carbohydrates" (Taniguchi, N. ed.)2003

    • Author(s)
      Yanagishita, M.
    • Publisher
      Kuba Production, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] The Many Faces of Osteoarthritis2002

    • Author(s)
      Shinomura, T.ら(分担)
    • Publisher
      Birkhuser Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Matsumoto, K.: "Distinct interaction of version/PG-M with hyaluronan and link protein"J.Biol.Chem.. 278. 41205-41212 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoyama-Hara, M.: "Complex gangliosides as cell surface inhibitors for the ecto-NAD^+ glycohydrolase of CD38"Methods in Enzymology. 363. 319-324 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagatsuka, Y.: "Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomains induces granulocytic differentiation of HL60 cells"Proc.Natl.Acad.Sci.U.S.A.. 100. 7454-7459 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoyama-Hara, M.: "Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activities of leukocyte cell surface"Bioorganic & Medicinal Chemistry Letter. 13. 3441-3445 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 柳下正樹: "線維化を担当する細胞と細胞外マトリックス"Medical Science Digest. 29. 392-395 (2003)

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      2003 Annual Research Report
  • [Publications] Esashika, M.: "Influence of orthodontic forces on the distribution of proteoglycans in rat hypofunctional periodontal ligament"J.Med.Dent.Sci.. 50. 183-194 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Teramoto, M.: "Effect of compressive forces on extracellular matrix in rat mandibular condylar cartilage"J.Bone Miner.Metab.. 21. 276-286 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kurokawa, H.: "Heparanase activities and tumor invasion patterns in human squamous cell carcinoma xenografts"Cancer Science. 94. 277-285 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 柳下正樹: "オーバービュー:線維化にかかわる細胞と分子"現代医療. 35. 306-310 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoneda, S.: "Biosymthesis of versican by rat dental pulp cells in culture"Arch. Oral Biol. 47. 435-442 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohashi, K.: "Affinity binding of glycosaminoglycans with B_2-microglobulin"Nephron. 90. 158-168 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibata, S: "Developmental changes and regional differences in histochemical localization of hyaluronam and versican"Intl. Endodont. J.. 35. 159-165 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Podyma-Inoue, K.A.: "Characterization of heparanase from a rat parathyroid cell line"J.Biol. Chem.. 277. 32459-32465 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hashimoto-Uoshima, M.: "Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblast"J. Period. Res.. 37. 42-49 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Dogke, Y.: "Involvement of phospholipase D in the CAMP-refulated exocytosis of rat parotid acinar cells"Biochem. Biophys. Ros. Commun.. 299. 663-668 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suhara, Y.: "Oligomers of glycamino Acid"Bioorganic & Medicinal Chemistry. 10. 1999-2013 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 横山三紀: "糖鎖コドンの高次構造確認機構の解明"タンパク質・核酸・酵素. 47. 187-188 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 勝俣 治: "IgG・Fc受容体の架橋刺激における膜ドメインの役割、チロシンリン酸化反応の開始と活性酸素産生における重要性"タンパク質・核酸・酵素. 47. 379-384 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 柳下正樹: "オーバービュー:線維化にかかわる細胞と分子"臨床医学. 35. 306-310 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 柳下正樹: "細胞情報をとりしきる糖鎖"ゲノム情報を越えた生命の不思議-糖鎖. (印刷中). (2003)

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      2002 Annual Research Report
  • [Publications] Teramoto, M.: "Effect of compressive forces on extracellular matrix in rat mandibular condyle cartilage"J. Bone Miner. Metab. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kurokawa, H.: "Heparanase and tumor invasion patterns in human oral squamous cell carcinoma xenografts"Cancer Science. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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