| Project/Area Number |
14207078
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Kagoshima University |
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Principal Investigator |
MAJIMA Hideyuki Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (60165701)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tsuyoshi Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (90136888)
OZAWA Toshihiko National Institute of Radiological Sciences, Redox Regulation Research Group, Researcher, 研究員 (40160858)
MARUYAMA Ikuro Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (20082282)
TOMITA Kazuo Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院・医歯学総合研究科, 助手 (60347094)
SUENAGA Shigeaki Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (00136889)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2003: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2002: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
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| Keywords | Radiosensitivity / Mitochondria / Radiation response gene / DNA array method |
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| Research Abstract |
We examined whether lack of mitochondrial DNA affects gene expression using DNA microarray analysis, to compare mRNA expression between Rho 0 cells and the parental cells, 143B. The results showed that lack of mitochondrial DNA could cause significant increases in chaperon genes in Rho 0 cells.
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