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Study of Transdermal Delivery of Lidocaine by AC Iontophoresis : Interrelationship of frequency, voltage and the concentration of lidocaine in tissue.

Research Project

Project/Area Number 14207088
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

UMINO Masahiro  Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (90014125)

Co-Investigator(Kenkyū-buntansha) SHIBAJI Takao  Tokyo Medical and Dental University, Dental Hospital, assistant, 歯学部付属病院, 助手 (90323724)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2005: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2004: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2003: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2002: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Keywordsiontophoresis / alternating current / transport efficiency / local anesthesia / sinusoidal wave / non-ionized molecule / macromolecule / 交流電場 / ドラッグデリバリー / 経皮的送達 / 直流成分 / 交流成分 / 非イオン化物質 / ドラックデリバリー / AC / リドカイン
Research Abstract

Iontophoresis is one of electrical methods that have been employed to enhance drug transportation across the skin. This delivery method transports ionized substances through skin or mucous membranes utilizing an electrical force. Iontophoresis using direct current (DC) has been used as a drug delivery method based on the principle. However complications such as skin burning, itching and redness have been associated with DC iontophoresis. Furthermore, the operating time of DC iontophoresis is limited because of the polarization effect.
Alternating current produces less electrode polarization than DC and avoids side effects mentioned above. It was found that AC electric field transport drug more effectively across the skin. We proposed a theoretical model of the mechanism of high frequency AC iontophoresis.
We found that lidocaine could be transported through extirpated abdominal rat skin and cellophane membrane in vivo and in vitro. In vitro we used two cylindrical glass diffusion cells in parallel to the cellophane membrane and extirpated abdominal rat skin, In vivo we developed original drug delivery cell with two platinum circular plates to fit rat skin tightly.
The lodocaine concentration after the application of frequency and voltage increased than passive diffusion significantly.
A sinusoidal wave was used in these studies, but now we are trying to search for the best electrical condition, for example using a square wave.
To transport drugs more effectively we try to develop new cells and apply this system for another drug, non-ionized molecule and macromolecule and so on.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (20 results)

All 2005 2004 2003 2002 Other

All Journal Article (20 results)

  • [Journal Article] 広範囲周波数の交流通電によるリドカインのセロハン膜透過2005

    • Author(s)
      泉川仁美
    • Journal Title

      口腔病学会雑誌 72巻2号

      Pages: 37-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 無痛無針局所麻酔法の開発 臨床応用に向けて 変動電場通電時の感覚と周波数の関係2005

    • Author(s)
      木下樹, 芳賀浩昭, 大上沙央理, 泉川仁美, 芝地貴夫, 海野雅浩
    • Journal Title

      日本歯科医学会誌 24巻

      Pages: 87-92

    • NAID

      10015565831

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Lidocaine transport through living rat skin using alternating current2005

    • Author(s)
      Haga, H., Shibaji, T., Umino, M.
    • Journal Title

      Medical & Biological Engineering & Computing 43巻

      Pages: 622-629

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lidocaine Transportation through a Cellophane Membrane by Wide Range AC Frequencies.2005

    • Author(s)
      Izumikawa Hitomi
    • Journal Title

      The Journal of The Stomatological Society, Japan 72(2)

      Pages: 37-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lidocaine transport through living rat skin using alternating current2005

    • Author(s)
      Haga, H., Shibaji, T., Umino, M.
    • Journal Title

      Medical & Biological Engineering & Computing 43

      Pages: 622-629

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Needle Less and Pain Less Local Anesthesia The Influence about Pain Threshold and Feeling of the Skin Under AC Application of the Skin.2005

    • Author(s)
      Kinoshita, T., Haga, H., Ogami, S., Izumikawa, H., Shibaji, T., Umino, M.
    • Journal Title

      Journal of The Japanese Association for Dental Science 24

      Pages: 87-92

    • NAID

      10015565831

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lidocaine transport through living rat skin using alternating current2005

    • Author(s)
      H.Haga, T.Shibaji, M.Umino
    • Journal Title

      Medical & Biological Engineering & Computing 43巻5号

      Pages: 622-629

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 変動電場による非イオン化高分子物質移送の電圧依存性について2005

    • Author(s)
      大上 沙央理, 芳賀 浩昭, 海野 雅浩
    • Journal Title

      日本歯科麻酔学会雑誌 33巻4号

      Pages: 575-575

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ACによるイオントフォレーシスが効果を示した非定型歯痛(atypical odontalgia)2005

    • Author(s)
      高橋 正人, 芝地 貴夫, 海野 雅浩他
    • Journal Title

      日本歯科麻酔学会雑誌 33巻4号

      Pages: 635-635

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 抜歯後のアロディニアにACイオントフォレーシスが奏効した一症例2005

    • Author(s)
      大江 智可子, 芝地 貴夫, 海野 雅浩他
    • Journal Title

      日本歯科麻酔学会雑誌 33巻4号

      Pages: 635-635

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 変動電場による非イオン化高分子物質の移送2004

    • Author(s)
      大上沙央理, 芳賀浩昭, 海野雅浩
    • Journal Title

      日本歯科麻酔学会雑誌 32巻4号

      Pages: 539-539

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transdermal Delivery of Lidocaine in vitro by Alternating Current2003

    • Author(s)
      Kinosita, T., Shibaji, T., Umino, M.
    • Journal Title

      Journal of Medical and Dental Sciences 69巻1号

      Pages: 71-77

    • NAID

      110000076020

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transdermal Deliverry of Lidocaine In vitro by Alternating Current.2003

    • Author(s)
      Kinosita, T., Shibaji, T., Umino, M.
    • Journal Title

      Journal of Medical and Dental Sciences 50(1)

      Pages: 71-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ACイオントフォレーシスにおけるリドカインの透過効率 電圧,周波数との関係2003

    • Author(s)
      泉川仁美, 芝地貴夫, 芳賀浩昭, 木下樹, 海野雅浩
    • Journal Title

      日本歯科麻酔学会雑誌 31巻4号

      Pages: 409-409

    • Related Report
      2004 Annual Research Report
  • [Journal Article] in vivoにおける双円形型電極を用いたACイオントフォレーシス2003

    • Author(s)
      芳賀浩昭, 芝地貴夫, 泉川仁美, 木下樹, 海野雅浩
    • Journal Title

      日本歯科麻酔学会雑誌 31巻4号

      Pages: 408-408

    • Related Report
      2004 Annual Research Report
  • [Journal Article] リドカインのACイオントフォレーシスにおける電圧依存性と周波数依存性2003

    • Author(s)
      泉川仁美, 芝地貴夫, 芳賀浩昭, 木下樹, 海野雅浩
    • Journal Title

      Drug Delivery System 18巻3号

      Pages: 300-300

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Experimental and theoretical studies of effect of electrode polarization on capacitances of blood and potassium chloride solution2002

    • Author(s)
      Umino, M., Oda, N., Yasuhara, Y.
    • Journal Title

      Medical & Biological Engineering & Computing 40巻5号

      Pages: 533-541

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Experimental and theoretical studies of effect of electrode polarization on capacitances of blood and potassium chloride solution.2002

    • Author(s)
      Umino, M., Oda, N., Yasuhara, Y.
    • Journal Title

      Medical & Biological Engineering & Computing 40(5)

      Pages: 533-541

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 双円形型電極を用いたACイオントフォレーシス2002

    • Author(s)
      芳賀浩昭, 木下樹, 泉川仁美, 芝地貴夫, 海野雅浩
    • Journal Title

      日本歯科麻酔学会雑誌 30巻4号

      Pages: 455-455

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 無痛無針局所麻酔法

    • Author(s)
      木下樹, 芳賀浩昭, 大上沙央理, 泉川仁美, 芝地貴夫, 海野雅浩
    • Journal Title

      日本歯科医学会誌 (印刷中)

    • Related Report
      2004 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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