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Developmental study of the specific prescription program for the improvement of mental health trouble in human

Research Project

Project/Area Number 14208005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionNational Institute of Fitness and Sports in Kanoya

Principal Investigator

SHIBAYAMA Hidetaro  National Institute of Fitness and Sports in Kanoya, President, 学長 (00162644)

Co-Investigator(Kenkyū-buntansha) KURATA Hiroshi  National Institute of Fitness and Sports in Kanoya, Vice President, 副学長 (80056895)
SAITO Kazuto  National Institute of Fitness and Sports in Kanoya, Health Service Center, Professor, 保健管理センター, 教授 (50170494)
TAKEKURA Hiroaki  National Institute of Health and Nutrition, Sports Performance, Professor, 体育学部, 教授 (00206963)
MIYACHI Motohiko  National Institute of Health and Nutrition, Division of Health Promotion and Exercise, Chief, 健康増進研究部, 室長 (60229870)
FUJIMOTO Toshihiko  Tohoku University, Center for the Advancement of Higher Education, Lecturer, 高等教育開発推進センター, 講師 (00229048)
田巻 弘之  鹿屋体育大学, 体育学部, 助教授 (40253926)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2005: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2004: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2003: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2002: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Keywordsmental health / stress / exercise prescription / skeletal muscle / autonomic nervous function / brain / positron emission tomography / 疲労 / 脳 / 糖 / 最大酸素摂取量 / 乳酸 / 情動 / 脳活動 / エネルギー代謝 / 遊離脂肪酸 / 扁桃体 / 橋網様体 / 随意運動 / 大脳基底核 / 視床 / 大脳辺縁系 / 精神活動 / 循環機能 / 脳波 / 心拍数 / 血圧 / 血流量
Research Abstract

The overall purpose of this study was to obtain experimental evidences to develop a specific prescription program for the people who have a trouble in mental health. We observed the effects of several exercise combined-programs on the brain tissue, cardiovascular systems, autonomic nervous function, and skeletal muscles of human subjects and experimental animals. The main results of the human studies are summarized as follows.
We investigated the effects of exercise on myocardial glucose uptake and whether the pattern of glucose uptake is the same as in skeletal muscle. Glucose uptake was measured using positron emission topography (PET) and 2-[^<18>F] fluoro-2-deoxy-D-glucose. As compared to the resting state, exercise doubled myocardial glucose uptake at the 30% and 55% intensity levels, while at the 75% intensity level glucose uptake was reduced significantly compared to the lower exercise intensities. At rest and during low-intensity exercise, myocardial glucose uptake was inversely … More associated with circulating levels of free fatty acids. However, during higher exercise intensities when plasma lactate concentrations increased significantly, this association disappeared. This finding suggests that the increased myocardial energy that is needed during high-intensity exercise is supplied by substrates other than glucose.
Reductions in the compliance of central arteries exert a number of adverse effects on systemic cardiovascular function and diseases. Using the cross-sectional study design, we determined the relation between chronic resistance training and carotid arterial compliance. (1)resistance exercise training is associated with the smaller central arterial compliance in health middle-aged men ; (2)age-related reductions in arterial compliance was greater in resistance-trained men than in sedentary men ; (3)the lower arterial compliance in the resistance-trained men is associated with left ventricular hypertrophy. In marked contrast to the beneficial effect of regular aerobic exercise, the present findings are not consistent with the idea that resistance exercise training exerts beneficial influences on arterial wall buffering functions. Less

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (39 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (29 results) Publications (10 results)

  • [Journal Article] Fluctuations in carotid arterial distensibility during the menstrual cycle do not influence cardiovagal baroreflex sensitivity.2006

    • Author(s)
      Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T, Onodera, S., Mesaki, N.
    • Journal Title

      Acta Physiol (Oxf). 186

      Pages: 103-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Variations in carotid arterial compliance during the menstrual cycle.2006

    • Author(s)
      Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T, Onodera, S., Mesaki, N.
    • Journal Title

      Exp.Physiol. (Epub ahead of print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Habitual exercise induced resistance to oxidative stress.2005

    • Author(s)
      Nakatani, K, 他11名
    • Journal Title

      Free Radical Res. 39

      Pages: 905-911

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 神経・筋収縮における細胞内情報伝達機構2005

    • Author(s)
      竹倉宏明, 西沢富江
    • Journal Title

      体育の科学 55

      Pages: 925-931

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Lack of age-related decreases in basal whole leg blood flow in resistance-trained men.2005

    • Author(s)
      Miyachi M.他4名
    • Journal Title

      J.Appl.Physiol. 99

      Pages: 1384-1390

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man.2005

    • Author(s)
      Ueno, L.M.他7名
    • Journal Title

      Braz.J.Med.Biol.Res. 38

      Pages: 629-637

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] High intensity exercise decreases global brain glucose uptake in humans.2005

    • Author(s)
      Kemppainen, J.他8名
    • Journal Title

      L.Pysiol.(Lond.) 568

      Pages: 323-332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities.2005

    • Author(s)
      Hannukainen J.他9名
    • Journal Title

      Int.J.Sports Med. 26

      Pages: 727-731

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities.2005

    • Author(s)
      Hannukainen J., Kalliokoski KK., Nuutila P., Fujimoto T., Kemppainen J., Viljanen T., Laaksonen MS., Parkkola R, Knuuti J., Kjaer M.
    • Journal Title

      Int.J.Sports Med. 26

      Pages: 727-731

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High intensity exercise decreases global brain glucose uptake in humans.2005

    • Author(s)
      Kemppainen, J., Aalto, S., Fujimoto, T., Kalliokoski KK., Langsjo J., Oikonen V., Rinne J., Nuutila P., Knuuti J.
    • Journal Title

      J.Physiol.(Lond.) 568

      Pages: 323-332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lack of age-related decreases in basal whole leg blood flow in resistance-trained men.2005

    • Author(s)
      Miyachi, M., Tanaka, H., Kawano, H., Okajima, M., Tabata, I.
    • Journal Title

      J.Appl.Physiol. 99

      Pages: 1384-1390

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Habitual exercise induced resistance to oxidative stress.2005

    • Author(s)
      Nakatani, K., Komatsu, M., Kato, Y., Yamanaka, T., Takekura, H, Wagatsuma, A., Aoyama, K., Xu, B., Hirano, T., Kasai, H., Ando, S., Takeuchi, T.
    • Journal Title

      Free Radical Res. 39

      Pages: 905-911

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man.2005

    • Author(s)
      Ueno, L.M., Miyachi, M., Matsui, T., Takahashi, K., Yamazaki, K., Hayashi, K., Onodera, S., Moritani, T.
    • Journal Title

      Braz.J.Med.Biol.Res. 38

      Pages: 629-637

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Habitual exercise induced resistance to oxidative stress.2005

    • Author(s)
      Nakatani, K.他11名
    • Journal Title

      Free Radical Res. 39

      Pages: 905-911

    • Related Report
      2005 Annual Research Report
  • [Journal Article] High intensity exercise decreases global brain glucose uptake in humans.2005

    • Author(s)
      Kemppainen, J.他8名
    • Journal Title

      J.Physiol.(Lond.) 568

      Pages: 323-332

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of DHP-receptor arrays in skeletal muscle.2004

    • Author(s)
      Takekura, H., Paoini, C., Franzini-Armstrong, C., Kugler, G., Grabner, M., Flucher, B.E.
    • Journal Title

      Mol.Biol.Cell. 15

      Pages: 5408-5419

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Changes in localization and orientation of triads following selective elimination of cytoskeletal protein in rat skinned muscle fiber.2004

    • Author(s)
      McGrath, K., Nishizawa, T., Yamashita, S., Tamaki, H., Saito, K., Takekura, H.
    • Journal Title

      Ann.Fitness Sports Sci. 32

      Pages: 1-9

    • NAID

      110001079898

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 異なる負荷強度での等尺性収縮持続時の協働筋の活動様式2004

    • Author(s)
      田巻弘之, 北田耕司, 桐本 光, 我妻 玲, 荻田 太, 竹倉宏明, 芝山秀太郎
    • Journal Title

      日本生理人類学会誌 9

      Pages: 53-58

    • NAID

      110002510474

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 坐骨神経切除によるラット脛骨骨幹端の骨梁構造変化並びに骨格筋の萎縮2004

    • Author(s)
      田巻弘之, 我妻 玲, 春日規克, 竹倉宏明
    • Journal Title

      体力科学 53

      Pages: 403-410

    • NAID

      110001915584

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Changes in localization and orientation of triads following selective elimination of cytoskeletal protein in rat skinned muscle fiber.2004

    • Author(s)
      McGrath, K., Nishizawa, T., Yamashita, S., Tamaki, H., Saito, K., Takekura.H.
    • Journal Title

      Ann.Fitness Sports Sci. 32

      Pages: 1-9

    • NAID

      110001079898

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 加齢による動脈機能の低下と運動2004

    • Author(s)
      宮地元彦
    • Journal Title

      体育の科学 54

      Pages: 693-699

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unfavorable effects of resistance training on central arterial compliance : a randomized intervention study.2004

    • Author(s)
      Miyachi, M., Kawano, H., Sugawara, J., Takahashi, K., Hayashi, K., Yamazaki, K., Tabata, I., Tanaka, H.
    • Journal Title

      Circulation 110

      Pages: 2858-2863

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dissociation between the time courses of femoral artery blood flow and pulmonary VO2 during repeated bouts of heavy knee extension exercise in humans.2004

    • Author(s)
      Fukuba, Y., Ohe, Y., Miura, A., Kitano, A., Endo, M., Sato, H., Miyachi, M., Koga, S., Fukuda, O.
    • Journal Title

      Exp.Physiol. 89

      Pages: 245-253

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Skeletal muscle glucose uptake response to exercise in trained and untrained men.2003

    • Author(s)
      Fujimoto, T., Kemppainen J., Kalliokoski KK., Nuutila P., Ito M., Knuuti J.
    • Journal Title

      Med.Sci.Sports Exerc. 35

      Pages: 777-783

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regional brain metabolism during ergometer exercise.2003

    • Author(s)
      Khondkar, S., Fujimoto, T., Ishii K., Yamaguchi K., Mehedi M., Targino R.Santos, Watanuki S., Itoh M.
    • Journal Title

      J.Int.Soc.Life info.Sci. 21

      Pages: 263-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] FDG-PET imaging of lower extremity muscular activity during level walking.2003

    • Author(s)
      Oi, N., Iwaya, T., Itoh, M., Yamaguchi, K., Tobimatsu, Y., Fujimoto, T.
    • Journal Title

      J.Orthop.Sci. 8

      Pages: 55-61

    • NAID

      50000735410

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasticity of the transverse tubules following denervation and subsequent reinnervation in rat slow and fast muscle fibres.2003

    • Author(s)
      Takekura, H., Tamaki, H., Nishizawa, T., Kasuga, N.
    • Journal Title

      J.Muscle Res.Cell Motility 24

      Pages: 439-451

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Degeneration and regeneration of neuromuscular junction achitectures in rat skeletal muscle fibres damaged by bupivacaine hydrochloride.2003

    • Author(s)
      Nishizawa, T., Tamaki, H., Kasuga, N., Takekura, H.
    • Journal Title

      J.Muscle Res.Cell Motility 24

      Pages: 527-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Myocardial and skeletal muscle glucose uptake during exercise in humans., 542, 403-412.2002

    • Author(s)
      Kemppainen, J., Fujimoto, T., Kalliokoski KK., Viljanen T., Nuutila P., Knuuti J.
    • Journal Title

      J.Physiol.(Lond.) 542

      Pages: 403-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Fujimoto, T., Kemppainen, J., Kalliokoski, K.K., Nuutila, P., Ito, M.: "Skeletal muscle glucose uptake response to exercise in trained and untrained men."Med.Sci.Sports Exerc.. 35. 777-783 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oi, N., Iwaya, T., Itoh, M., Yamaguchi, K., Tobimatsu, Y., Fujimoto, T.: "FDG-PET imaging of lower extremity muscular activity during level walking."J.Orthop.Sci.. 8. 55-61 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishizawa, T., Tamaki, H., Kasuga, N., Takekura, H.: "Degeneration and regeneration of neuromuscular junction achitectures in rat skeletal muscle fibres damaged by bupivacaine hydrochloride."J.Muscle Res.Cell Motility. 24. 527-537 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyachi, M., Donato, A.J., Yamamoto, K., Takahashi, K., Gates, P.E., Moreau, K.L., Tanaka, H.: "Greater age-related reductions in central arterial compliance inresistance-trained men."Hypertension. 41. 130-135 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋康輝, 宮地元彦, 藤本広平, 高本健彦, 山崎健, 松枝秀二, 山元健太, 柚木脩: "最大酸素摂取量と左心室および大動脈形態との関係"体育学研究. 48. 691-703 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugawara, J., Tanabe, T, Miyachi, M., Yamamoto, K., Takahashi, K., Iemitsu, M., Otsuki, T., Homma, S., Maeda, S., Ajisaka, R., Matsuda M.: "Non-invasive assessment of cardiac output during exercise in healthy young humans : comparison between model flow method and doppler echocardiography method."Acta Physiol.Scand.. 179. 361-366 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyachi, M., Denato, A.J., Yamamoto, K., Takahashi, K., Gates, P.E., Moreau, K.L., Tanaka, H.: "Greater age-related reductions in central arterial compliance in resistance-trained men"Hypertension. 41. 130-135 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takekura, H., Franzini-Armstrong, C.: "The structure of Ca^<2+> release units in arthropod body muscle indicates an indirect mechanism for excitation-contraction coupling"Biophys.J.. 83. 2742-2753 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kemppainen, J., Fujimoto, T., Kalliokoski, K.K., Viljanen, T., Nuutila, P., Knuuti, J.: "Myocardial and skeletal muscle glucose uptake during exercise in humans"J.Physiol.. 15. 403-412 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 藤本敏彦, 伊藤正敏: "非侵襲的手法による筋の糖・脂質代謝と運動"体育の科学. 52. 429-435 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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