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Comprehensive Basic Research for Development of Advanced, Innovative Permanent Artificial Heart Systems

Research Project

Project/Area Number 14208103
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKATANI Setsuo  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (40154786)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Tohru  Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (10101875)
ARAI Hirokuni  Tokyo Medical and Dental University, University Medical Hospital, Instructor, 医学部附属病院, 講師 (50202718)
SHINSHI Tadahiko  Tokyo institute of Technology, Institute of Precision Control Engineering, Associate Professor, 精密工学研究所, 助教授 (60272720)
SHIMOKOHBE Akira  Tokyo institute of Technology, Institute of Precision control Engineering, Professor, 精密工学研究所, 教授 (40016796)
IWASAKI Yasuhiko  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 (90280990)
大内 克洋  東京医科歯科大学, 生体材料工学研究所, 助手 (20322084)
中村 真人  東京医科歯科大学, 生体材料工学研究所, 助教授 (90301803)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥52,520,000 (Direct Cost: ¥40,400,000、Indirect Cost: ¥12,120,000)
Fiscal Year 2004: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2003: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2002: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
KeywordsPulsatile Ventricular Assist Device / Total Artificial Heart / Magnetic levitated Centrifugal Blood Pump / Hydrodynamic Levitated Centrifugal Blood Pump / Computational Fluid Dynamics / Flow Visualization / Blood Cell Biomechanics / Optical Scattering / 解剖学的適合性 / 磁気軸受 / マイクロプロセッサ / 経皮エネルギー伝送 / ナノテクノロジー / 数値流体解析 / 電気機械カプリング / 耐久試験 / 補助人工心臓 / 磁気軸受け / 動圧軸受け / 連続流血液ポンプ / 全置換型人工心臓(TAH) / 補助人工心臓(VAD) / CFD数値解析 / ナノ表面修飾 / 抗血栓性 / オーダーメード人工心臓
Research Abstract

In this research, basic research covering following items was conducted ;
1.In the pulsatile artificial heart that is based on the electromechanical principle, the durability of the roller screw mechanism was improved by coating the friction surface with a diamond-like-carbon coating. The ventricular assist device continued to operate for duration of 13 months in the 37 degree C bath. The failure in the ball bearing that supports the roller screw movement caused termination of the study.
2.Magnetic levitation (MagLev) mechanism was investigated to achieve a mechanical contact-free centrifugal blood pump. A two-degree-freedom MagLev system was developed to attain a disposable extracorporeal blood pump and an implantable system. The power requirement in the MagLev system was reduced to less than 1.0watt with controllability being less than 20 micron meter. The hemolytic performance of the MagLev centrifugal blood pump was improved by a factor of 6-7 in comparison to the clinical standard B … More PX-80.
3.The computational fluid dynamics (CFD) analysis was conducted to evaluate the mechanical design of the MagLev centrifugal blood pump designed in section 2. Flow visualization was also carried out to verify the numerical predictions to optimize the pump design.
4.Basic research was also extended to evaluate the deformation and recovery response of red blood cells under cyclically reversing shear flow. A specially built shear flow generator was used to simulate a condition similar to that inside the centrifugal blood pumps. The results of the study can be used to improve the blood pump design.
5.The optical reflectance sensor utilizing the fiber-optics was developed to detect thrombus formation inside the cardiovascular devices. Its application in oxygenators and blood pumps will be investigated.
6.A surgical navigation system was developed to assist implantation of the artificial heart system. The CT images and CAD data of the device were used to construct the proper implantation scheme of the device in patients prior to surgery. The prototype was tested in calf for VAD implantation. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (39 results)

All 2006 2005 2004 2002 Other

All Journal Article (28 results) Book (1 results) Patent(Industrial Property Rights) (2 results) Publications (8 results)

  • [Journal Article] A compact highly efficient and low hemolytic centrifugal blood pump with a magnetically levitated impeller.2006

    • Author(s)
      Asama J, Shinshi T, Hoshi H, Takatani S, Shimokohbe A
    • Journal Title

      Artif Organs 30(3)

      Pages: 184-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Detection of Left ventricular function from the Mag-Lev impeller behavior2006

    • Author(s)
      Hoshi H, Asama J, Shinshi T, Shimokohbe A, Takatani S
    • Journal Title

      Artif Organs 30(5)

      Pages: 324-338

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Guest Editorial ; Progress of rotary blood pumps2006

    • Author(s)
      Takatani S
    • Journal Title

      Artif Orgns 30(5)

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computational fluid dynamics (CFD) analysis of the pediatric Tiny centrifugal blood pumps2006

    • Author(s)
      Kido K, Hoshi H, Watanabe N, Kataoka H, Ohuchi K, Asama J, Shinshi T, Yoshikawa M, Takatani S
    • Journal Title

      Artif Organs 30(5)

      Pages: 391-398

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Currently available ventricular assist devices (VAD) : Capabilities, limitations and future perspectives.2006

    • Author(s)
      Ohuchi K, Takatani S
    • Journal Title

      Expert Review of Medical Devices 3(2)

      Pages: 195-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Feasibility of a miniature centrifugal rotary blood pump for low flow circulation in children and infants.2005

    • Author(s)
      Takatani S, Hoshi H, Tajima K, Kataoka H, Ohuchi K, Asama J, Shinshi T, Yoshikawa M
    • Journal Title

      ASAIO J 51(5)

      Pages: 557-562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Disposable, Maglev Centrifugal Blood Pump : Design and in vitro Performance2005

    • Author(s)
      Hoshi H, Asama J, Shinshi T, Ohuchi K, Mizuno T, Arai H, Shimokohbe A, Takatani S
    • Journal Title

      Artif Organs 29(7)

      Pages: 520-526

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Measurement of The Rotor Motion and Corresponding Hemolysis of A Centrifugal Blood Pump with A Magnetic and Hydrodynamic Hybrid Bearing2005

    • Author(s)
      H.Kataoka, Y.Kimura, H.Fujita, S.Takatani
    • Journal Title

      Artif Organs 29(7)

      Pages: 547-556

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] New Method for the Detection of Thrombus Formation in Cardiovascular Devices : Optical Sensor Evaluation in a Flow Chamber Model.2005

    • Author(s)
      Yasuda T, Sekimoto K, Taga I, Funakubo A, Fukui Y, Takatani, S
    • Journal Title

      ASAIO J 51(1)

      Pages: 110-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanical circulatory support devices (NCSD) in Japan : Current status and future directions2005

    • Author(s)
      Takatani S, Matsuda H, Hanatani A, Nojiri C, Yamazaki K, Motomura T, Ohuchi K, Sakamoto T, Yamane T
    • Journal Title

      J Artif Organs 8(1)

      Pages: 13-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanical and biocompatible properties of the modified segmented polyurethane by photopolymerization and crosslinking with 2-methacryloyloxyethyl phosphorylcholine polymer.2005

    • Author(s)
      K.Kobayashi, K.Ohuchi, H.Hoshi, N.Morimoto, Y.Iwasaki, S.Takatani
    • Journal Title

      J Artif Organs 8(4)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Feasibility of a miniature centrifugal rotary blood pump for low flow circulation in children and infants.2005

    • Author(s)
      Takatani S, Hoshi H, Tajima K, Kataoka H, Ohuchi K, Asama J, Shinshi T, Yoshikawa M.
    • Journal Title

      ASAIO J 51(5)

      Pages: 557-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Disposable, Maglev Centrifugal Blood Pump : Design and in vitro Performance.2005

    • Author(s)
      Hoshi H, Asama J, Shinshi T, Ohuchi K, Mizuno T, Arai H, Shimokohbe A, Takatani S.
    • Journal Title

      Artif Organs 29(7)

      Pages: 520-526

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Measurement of The Rotor Motion and Corresponding Hemolysis of A Centrifugal Blood Pumps with A Magnetic and Hydrodynamic Hybrid Bearing2005

    • Author(s)
      H.Kataoka, Y.Kimura, H.Fujita S.Takatani
    • Journal Title

      Artif Organs 29(7)

      Pages: 547-556

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] New Method for the Detection of Thrombus Formation in Cardiovascular Devices : Optical Sensor Evaluation in a Flow Chamber Model.2005

    • Author(s)
      Yasuda T, Sekinioto, K, Taga I, Funakubo, A, Fukui, Y, Takatani, S.
    • Journal Title

      ASAIO J 51(1)

      Pages: 110-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanical circulatory support devices (NCSD) in Japan : Current status and future direction.2005

    • Author(s)
      Takatani S, Matsuda H, Hanatani A, Nojiri C, Yamazaki K, Motomura T, Ohuchi K, Sakamoto T, Yamane T.
    • Journal Title

      J Artif Organs 8(1)

      Pages: 13-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Magnetically suspended centrifugal blood pump with a radial magnetic driver2005

    • Author(s)
      Hoshi H, Kataoka H, Ohuchi K, Asama J, Shinshi T, Shimokohbe A, Takatani S
    • Journal Title

      ASAIO J 51・1

      Pages: 60-64

    • Related Report
      2004 Annual Research Report
  • [Journal Article] New Method for the Detection of Thrombus Formation in Cardiovascular Devices : Optical Sensor Evaluation in a Flow chamber Model.2005

    • Author(s)
      Y Toshitaka, Sekimoto K, Taga, I, Funakubo, A, Fukui, Y, Takatani, S
    • Journal Title

      ASAIO J 51・1

      Pages: 116-120

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanical circulatory support devices (MCSD) in Japan : Current status and future directions.2005

    • Author(s)
      Takatani S, Matsuda H, Hanatani A, Nojiri C, Yamazaki K, Motomura T, Yamane T
    • Journal Title

      J Artif Organs

    • NAID

      10015652559

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Disposable magnetic bearing centrifugal blood pump for extracorporeal circulation support2005

    • Author(s)
      Hoshi H, Asama J, Ohuchi K, Shinshi T, Shimokohbe A, Takatani S
    • Journal Title

      Artif Organs

    • Related Report
      2004 Annual Research Report
  • [Journal Article] New design for a compact centrifugal blood pump with a maganetically levitated rotor2004

    • Author(s)
      Asama J, Shinshi T, Hoshi H, Takatani S, Shimokohbe A.
    • Journal Title

      Artif Organs 29(1)

      Pages: 26-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Magnetically levitated non-contact rotary centrifugal blood pump.2004

    • Author(s)
      Takatani S.
    • Journal Title

      Annual Reports of the Institute of Biomaterials and Bioengineering 38

      Pages: 38-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantification of the secondary flow in a radial coupled centrifugal blood pump based on particle tracking velocimetry2004

    • Author(s)
      Watanabe N, Masuda T, lida T, Kataoka H, Fujimoto T, Takatani S.
    • Journal Title

      ASAIO J 50(6)

      Pages: 550-556

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The design of core-type transcutaneous energy transmission systems for artificial heart.2004

    • Author(s)
      Iwawaki K, Watada M, Takatani S, Um YS.
    • Journal Title

      IEEE Indust Electr Soc Nov 2-6

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A New Design for A Compact Centrifugal Blood Pump With A Magnetically Levitated Rotor.2004

    • Author(s)
      Asama J, Shinshi T, Hoshi H, Takatani S, Shimokohbe A
    • Journal Title

      ASAIO J 50・6

      Pages: 550-556

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of hemolysis on oxygen and hematocrit measurements by near infrared reflectance spectroscopy.2002

    • Author(s)
      Neudel F, Takatani S, Reul H, Rau G.
    • Journal Title

      Medical Engineering and Physics 24

      Pages: 301-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Beyond implantable first generation cardiac prostheses for treatment of end-stage cardiac patients with clinical results in a multicenter.2002

    • Author(s)
      Takatani S
    • Journal Title

      Ann Thorac Cardiovasc Surg Oct;8(5)

      Pages: 253-263

    • NAID

      10018967935

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] One-piece ultracompact totally implantable electro-mechanical TAH for permanent use.2002

    • Author(s)
      Takatani S, Sakamoto T, Ohuchi K, Nakamura M, Mizuno T, Arai H
    • Journal Title

      ASAIO J 48(5)

      Pages: 538-545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「人工臓器・再生医療の最先端」先端医療シリーズ372005

    • Author(s)
      大内克洋, 高谷節雄
    • Publisher
      東京医科歯科大学式全置換型人工心臓の開発研究
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 遠心ポンプの流量及び揚程測定方法、装置、及び、拍動する循環系の循環状態評価装置2005

    • Inventor(s)
      星英男, 高谷節雄, 進士忠彦, 朝間淳一
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Number
      2005-232501
    • Filing Date
      2005-08-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 血液ポンプおよび動圧軸受2005

    • Inventor(s)
      星 英男, 高谷 節雄, 吉川 雅治, 八名 純三
    • Industrial Property Rights Holder
      星 英男, 高谷 節雄, 日機装株式会社
    • Industrial Property Number
      2005-032890
    • Filing Date
      2005-02-09
    • Related Report
      2004 Annual Research Report
  • [Publications] 安田利貴: "光散乱による溶血に至る前の赤血球の形状に関する検討"ライフサポート. 15(2). 47-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohuchi K: "Computer Simulation Analysis of Shock Intensity- and Phase- Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle"Environmental Science. 47. 69-71 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takatani S: "Totally Implantable, compact, permanent electromechanical pulsatile VAD with reliable mechanical and anti-thrombogenic performances."Artif Organs. 27(4). 342 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawano H: "Effects of Impeller Design Upon Hydrodynamic and Hemolytic Performances of the Centrifugal Blood Pump"Artif Organs. 27(4). 344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi K: "Optimized Motor Control Enhances Mechanical Reliability of Pulsatile Electromechanical VAD"Artif Organs. 27(4). 344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iida T: Artif Organs. 27(4). 344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takatani Setsuo: "Beyond Implantble First Generation Cardiac Prostheses for Treatment of End-stage Cardiac Patients with Cinical Results in a Multicenter"Annals of Thoracic and Cardiovascular Surgery. 8(5). 253-263 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takatani S, Sakamoto T, Ouchi K, Nakamura M, Mizuno T, Arai H: "One Piece Ultracompact Totally Imaplantable Electromechanical Total Artificial Heart for Permanent Use"ASAIOJ. 48(5). 538-545 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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