| Project/Area Number |
14256001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
ITO Akira Asahikawa Medical College, Department of Parasitology, Professor, 医学部, 教授 (70054020)
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| Co-Investigator(Kenkyū-buntansha) |
KOHGO Yutaka Asahikawa Medical College, Department of Third International Medicine, Professor, 医学部, 教授 (10133183)
SATO Naoki Hokkaido University Hospital, First Department of Surgery, Associate Professor, 医学部, 助教授 (70205946)
OKAMOTO Munehiro Tottori University, Department of Laboratory Animal Science, School of Veterinary Medicine, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (70177096)
NAKAYA Kazuhiro Asahikawa Medical College, Animal Laboratory for Medical Research, Associate Professor, 医学部, 助教授 (70109388)
YAMASAKI Hiroshi Asahikawa Medical College, Department of Parasitology, Associate Professor, 医学部, 助教授 (00138207)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Fiscal Year 2004: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2003: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2002: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | alveolar echinococcosis / cystic echinococcosis / neurocysticercosis / molecular epidemiology / sero-epidemiology / mitochondrial DNA / microsatellite DNA / molecular evolution / copro-DNA |
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| Research Abstract |
The most important finding through this year project is the finding and description of a new species, Echinococcus shiquicus from the Tibetan plateau, China where two other well-known species, E.granulosus and E.multilocularis, are co-distributed (Xiao N et al.2005,2006). The life cycle of the new species is completed between the Tibetan fox (Vulpes ferrilata) and the plateau pika (Ochotona curzoniae). It has a very unique morphology through its developmental stages. The data of mitochondrial and nuclear DNA sequences provided E.shiquicus to be a valid taxon and to be the most primitive among the three species. There is no evidence of pathogenicity to humans yet. Molecular studies using mitochondrial DNA and microsatellite DNA have been started for the establishment of standard tools for future analysis of human hepatic lesions, since it is essential to differentiate the species and genotypes of these three species. Serodiagnostic studies have greatly been advanced for detection of alveolar echinococcosis (AE) and cystic echinococcosis (CE) using recombinant Em18 and recombinant Antigen B (Mamuti W et al.2006a,b). These tools were applied for epidemiological survey in China (Li T et al.2005).
On taeniasis/cysticercosis, epidemiological surveys have been carried out in Indonesia (Wandra T et al.2006a,b), China (Li T et al.unpublished) and Thailand (Thairungroj et al.unpublished) and new findings of the risk factors are revealed. In order to publish the ongoing projects, the Asahikawa International Symposium on Taeniasis/cysticercosis and echinococcosis focused on Asia and the Pacific, sponsored by the Ministry of Education, Japan contributed great. The proceedings with 52 review chapters of a total of 312 pages have just been published as a supplement of Parasitology International 55,2006. All our activities through the ongoing projects have been published in this issue.
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