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The physiological, pharmacological, and genetic mechanisms of activity and emotionality in mice and rats

Research Project

Project/Area Number 14310038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionUniversity of Tsukuba

Principal Investigator

MAKINO Junnshiro  University of Tsukuba, Institute of Psychology, Professor, 心理学系, 教授 (60015443)

Co-Investigator(Kenkyū-buntansha) TOMIHARA Kazuya  Kagoshima University, Faculty of Law, Economics, and Humanities, Associate Professor, 法文学部, 助教授 (00272146)
KATO Katsunori  University of Tsukuba, Institute of Psychology, Assistant Professor, 心理学系, 講師 (50261764)
ICHITANI Yukio  University of Tsukuba, Institute of Psychology, Associate Professor, 心理学系, 助教授 (80176289)
WADA Yumiko  The Institute of Physical and Chemical Research, Genomic Sciences Center, Researcher, ゲノム科学総合研究センター, 研究員 (70302362)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2003: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywordsopen-field behavior / selective breeding / activity / emotional reactivity / inbred mouse / anxiolytics / genome scan / dopaminergic system / 選択系 / 近交系 / マウス / ラット / ドーパミン系 / 雌親行動 / 行動遺伝学 / ジアゼパム / ブスピロン
Research Abstract

The following studies were performed in high and low-activity mouse strains (H and L) and Tsukuba high and low-emotional rat strains (THE and TLE)
Genome-wide scan : One hundred microsattelite markers were compared between H and L. Nine markers indicated polymorphisms. The genes producing the strain differences might be located close to them
Effects of anxiolytics on open-field behavior (OFB) : Under bright light, buspirone produced only sedation in H, L, and ICR, a base population of the selection, at a higher dose. Diazepam showed anxiolytic effects in H and ICR under bright light and also in L under dim light. The optimal dose was 3 to 10 times higher in H and L than in ICR. The GABA-BZD receptor complex might have been modified during the selection
Comparisons of OFB : Under bright light, H showed similar OFB to that of ICR and C57BL/6. The OFB of L resembled to that of DBA/2, though the activity of L was quite low like BALB and C3H. The OFB of L got similar to that of H under dim light. The strain differences between N and L might be produced from the different sensitivities to light. There was little effect of light in CBA, DBA, and ICR
Long-term observation of OFB : Thirty-min long observation under bright light indicated that OFB of male L became more similar to that of H with time, but that the strain differences remained
Effects of dopaminergic drugs on OFB : Apomorphine reduced, but methamphetamine increased activity dose-dependently in both H and L. The lack of a significant interaction of strain by drug suggested that the brain dopaminergic system might not differ between them
Food-carrying behavior : The food-carrying rate was higher in TLE than in THE. The different mechanisms might mediate the responses to novelty and predatory risk

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 高橋阿貴, 牧野順四郎: "高・低活動系マウスを中心としたオープンフィールド行動の系統比較"動物心理学研究. 52. 155 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋阿貴, 加藤克紀: "高・低活動系マウスのオープンフィールド行動における抗不安薬の効果"日本神経精神薬理学雑誌. 22. 322 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 小貫泰広, 加藤克紀, 牧野順四郎, 中津山英子: "Tsukuba情動系ラットにおける餌運搬行動"動物心理学研究. 53. 71-77 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Otobe, T., Makino, J.: "Impulsive choice in inbred strains of mice."Behavioural Processes. 印刷中. (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高橋阿貴, 加藤克紀: "高・低活動系マウスの暗条件オープンフィールド行動におけるdiazepamの効果"日本神経精神薬理学雑誌. 23. 330 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 一谷幸男, 吉原亨, 林和子: "ラット・マウスの空間認知・空間記憶における脳内グルタミン酸受容体の役割"生理心理学と精神生理学. 21. 5-17 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, A., Makino, J.: "Comparisons of open-field behavior between high and low-activity selection lines, ICR, and fiveinbred strains of mice. (in Japanese)"The Japanese Journal of Animal Psychology. 52. 155 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, A., Kate, K: "Effects of anxiolytics on open-field behavior in high and low-activity strains of mice. (in Japanese)"Japanese Journal of Neuropsychopharmacology. 22. 322 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Onuki, Y., Kate, K., Makino, J., Nakatsuyama, E.: "Food-carrying behavior in Tsukuba emotional strains of rats. (in Japanese with English abstract)"The Japanese Journal of Animal Psychology. 53. 71-77 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Otobe, T., Makino, J.: "Impulsive choice in inbred strains of mice"Behavioural Processes. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, A., Kate, K: "Effects of diazepam on open-field behavior under dim light in high and low-activity strains of mice. (in Japanese)"Japanese Journal of Neuropsychopharmacology. 23. 330 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ichitani, Y., Yoshihara, T., Hayashi, K.: "Spatial cognition and spatial memory n rats and mice : role of brain glutamate receptors. (in Japanese with English abstract)"Japanese Journal of Physiological Psychology and Psychophysiology. 21. 5-17 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 小貫泰広, 加藤克紀, 牧野順四郎, 中津山英子: "Tsukuba情動系ラットにおける餌運搬行動"動物心理学研究. 53. 71-77 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋阿貴, 加藤克紀: "高・低活動系マウスの暗条件オープンフィールド行動におけるdiazepamの効果"日本神経精神薬理学雑誌. 23. 330 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋阿貴, 牧野順四郎: "高・低活動系マウスの長侍間オープンフィールド行動"日本心理学会第67回大会発表論文集. 1037 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋阿貴, 牧野順四郎: "高・低活動系マウスを中心とした暗条件オープンフィールド行動の系統比較"動物心理学研究. 53. 113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 昌子浩孝, 加藤克紀: "高・低活動系マウスにおける雌親行動の系統比較"動物心理学研究. 53. 113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 一谷幸男, 吉原亨, 林和子: "ラット・マウスの空間認知・空間記憶における脳内グルタミン酸受容体の役割"生理心理学と精神生理学. 21. 5-17 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋阿貴, 牧野順四郎: "高・低活動系マウスを中心としたオープンフィールド行動・系統比較"動物心理学研究. 52巻2号. 155 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋阿貴, 加藤克紀: "高・低活動系マウスのオープンフィールド行動における抗不安薬の効果"日本神経精神薬理学雑誌. 22巻6号. 322 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 加藤 克紀: "マウスとラットにおける行動の構造と攻撃行動の遺伝"アンテックス. 14巻5号. 243-248 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 加藤 克紀: "能動的回避反応習得に伴う近交系マウスの行動変容"筑波大学心理学研究. 24号. 7-20 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kondo, Y., Sudo, T., Tomihara, K., Sakuma, Y.: "Activation of accessory olfactory bulb neurons during copulatory behavior after deprivation of vomeronasal inputs in male rat"Brain Research. 962巻. 232-236 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamada, K., Kawai, H., Iwasaki, T., Ichitomi, Y.: "Residential maze as a task for testing rats maze learning abirity: effects of hippocampus lesions and cholinergic recepter antagonists"Neuroreport. 13巻14号. 1759-1764 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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