• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Brain networks that produce word finding difficulty for person's name in old people

Research Project

Project/Area Number 14310047
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionTokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare

Principal Investigator

TATSUMI Itaru  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Cognition and Brain Science Research Group, PhD, Group Leader, 福祉振興財団・東京都老人総合研究所, 副参事研究員 (40073027)

Co-Investigator(Kenkyū-buntansha) ISHII Kenji  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Positron Medical Clinic, MD, Head, 福祉振興財団・東京都老人総合研究所, 副参事研究員 (10231135)
FUSHIMI Takao  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Cognition and Brain Science Research Group, PhD, Research Scientist, 福祉振興財団・東京都老人総合研究所, 研究員 (60260303)
SAKUMA Naoko  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Cognition and Brain Science Research Group, PhD, Research Assistant, 福祉振興財団・東京都老人総合研究所, 研究助手 (70152163)
IJUIN Mutsuo  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Cognition and Brain Science Research Group, PhD, Research Scientist, 福祉振興財団・東京都老人総合研究所, 研究員 (00250192)
KURETA Yoich  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Tokyo Metropolitan Institute of Gerontology, Language, Cognition and Brain Science Research Group, PhD, Research Scientist, 福祉振興財団・東京都老人総合研究所, 研究員 (60321874)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywordsword retrieval / aging / proper noun / common noun / brain activation / PET / brain atrophy / 想起 / 脳の萎縮 / 単語想起困難のメカニズム / 単語の想起 / 脳の萎縮部位 / 意味処理 / 感性情報処理 / 左側頭極 / 前頭極 / ブローカ野 / 単語の検索 / 具象性
Research Abstract

It is often said that while aging increases vocabulary, retrieval of words, especially proper names such as person's names, becomes difficult with increasing age. Indeed, our past research on word retrieval (verbal fluency task) revealed that the retrieval performance of elderly people was approximately 75 % of younger students for words representing animate (e.g., mammals, fishes, etc.) or inanimate (vehicles, tools, etc.), and only 55 % for proper names (names of politicians, actresses, etc).
In this project we did a PET activation study in which brain regions activated during verbal fluency tasks for semantic categories like animates, inanimate and proper names of famous persons, as well as phonological categories (retrieving words beginning with a pre-specified syllable) were explored. We found that in young normal subjects verbal fluency for animates, inanimate and phonological cues activated areas including inferoposterior region of the left temporal gyrus (BA 20,37) to a temporop … More arietal junction, and the left inferior frontal gyrus (BA44,45). Whereas the left temporal gyrus was interpreted to process word semantics, the left frontal gyrus was interpreted to play a role in selecting an appropriate word based on semantic and phonological information. In proper name retrieval, more rostal areas were activated, i.e., the anterior region of the left temporal cortex (BA22,38), and a region including the frontal pole and medial frontal cortex (BA10), the former associating deep semantic processing and the latter more controlled processing of word selection.
We also observed activated areas during verbal fluency for semantic categories (inanimate and proper names) and phonological cues in aged people, and found almost the same areas are activated, but their volumes tend to be smaller.
Recently, some researchers report that activated areas during language tasks like reading aloud words are different in elderly and young subjects, reflecting differential word or sentence processing in the two groups. However, atrophy of the brain grows with increasing age, and influence of atrophy on language and cognition has not been elucidated. We examined age-related brain shrinkage using a software called VBM(Voxel Based Morphometry) based on MRI brain images of 77 young and 23 old people. It was found that the normal elderly did not show a uniform atrophy regardless of the brain region, rather they showed restricted atrophy in a region surrounding the Syrvian fissure, inferior frontal to inferior parietal region, anteromedial frontal area of both hemispheres, and superior cerebellum. It was found that the left inferoposterior temporal gyrus is an only region that does not overlap with the age-related shrinkage, suggesting that deficient verbal fluency in the elderly is attributable at least in part to brain atrophy. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (56 results)

All 2005 2004 2003 Other

All Journal Article (20 results) Book (10 results) Publications (26 results)

  • [Journal Article] 日本語の読みの機構とその障害-漢字・仮名の乖離を超えて-2005

    • Author(s)
      伏見貴夫
    • Journal Title

      電子情報通信学会 技術研究報告 104(585)

      Pages: 49-54

    • NAID

      110003234109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Mechanisms and disorders of word reading in Japanese language-Beyond dissociation of Kanji and Kana-Technical Report of The Institute of Electronics2005

    • Author(s)
      Fushimi T.
    • Journal Title

      Information and Communication Engineering (in Japanese) 104(585)

      Pages: 49-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 音声知覚・理解・意味処理・音声生成にかかわる脳のネットワーク2004

    • Author(s)
      辰巳 格
    • Journal Title

      音声研究 8(3)

      Pages: 15-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 成人における言語機能の加齢変化2004

    • Author(s)
      辰巳 格
    • Journal Title

      電子情報通信学会 技術研究報告 TL2004-15

      Pages: 25-30

    • NAID

      40020282769

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 日本語版Alzheimer's Disease Assessment Scale (ADAS-J cog.)の単語記憶課題拡張版の作成2004

    • Author(s)
      権藤恭之, 伏見貴夫, 佐久間尚子, 天野成昭, 辰巳 格, 本間 昭
    • Journal Title

      老年精神医学雑誌 15(8)

      Pages: 965-975

    • NAID

      40006399611

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The eye movements of Japanese pure alexic patients during single word and nonword reading2004

    • Author(s)
      Kaneko M, Fushimi T, Uno A, Haruhara N
    • Journal Title

      Neurocase 10(5)

      Pages: 366-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 認知心理学における最近のトピック-語の文法とその障害-2004

    • Author(s)
      伏見貴夫, 伊集院睦雄, 佐久間尚子, 辰巳格, 春原則子, 小森憲治郎, 新貝尚子
    • Journal Title

      神経心理学 20・1

      Pages: 51-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain networks for speech perception to speech production.2004

    • Author(s)
      Tatsumi IF.
    • Journal Title

      Journal of the Phonetic Society of Japan (in Japanese) 8-3

      Pages: 15-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aging of language function in adulthood.2004

    • Author(s)
      Tatsumi IF.
    • Journal Title

      Technical Report of The Institute of Electronics, Information and Communication Engineering (in Japanese) TL2004-15

      Pages: 25-30

    • NAID

      40020282769

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parallel tests for word memory of Alzheimer's Disease Assessment Scale of Japanese version (ADAS-J cog.).2004

    • Author(s)
      Gondo Y, Fushimi T, Sakuma N, Amano S, Tatsumi IF, Homma A.
    • Journal Title

      Japanese Journal of Geriatric Psychiatry (in Japanese) 15(8)

      Pages: 965-975

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Current topics in cognitive neuropsychology-Word-forming rules and their disorder-2004

    • Author(s)
      Fushimi T, Ijuin M, Sakuma N, Tatsumi IF, Haruhara N, Komori K, Shinkai T.
    • Journal Title

      Japanese Journal of Neuropsychology (in Japanese) 20(1)

      Pages: 51-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The eye movements of Japanese pure alexic patients during single word and nonword reading.2004

    • Author(s)
      Kaneko M, Fushimi T, Uno A, Haruhara N.
    • Journal Title

      Neurocase (in English) 10(5)

      Pages: 366-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 日本語版Alzheimer's Disease Assessment Scale(ADAS-J cog.)の単語記憶課題拡張版の作成2004

    • Author(s)
      権藤恭之, 伏見貴夫, 佐久間尚子, 天野成昭, 辰巳 格, 本間 昭
    • Journal Title

      老年精神医学雑 15(8)

      Pages: 965-975

    • NAID

      40006399611

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 認知心理学における最近のトピック-語の文法とその障害-2004

    • Author(s)
      伏見貴夫, 伊集院睦雄, 佐久間尚子, 辰巳格, 春原則子, 小森憲治郎, 新貝尚子
    • Journal Title

      神経心理学 20

      Pages: 51-62

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Surface dyslexia in a Japanese patient with semantic dementia : Evidence for similarity-based orthography-to-phonology translation2003

    • Author(s)
      Fushimi T, Komori K, Ikeda M, Patterson K, Ijuin M, Tanabe H
    • Journal Title

      Neuropsychologia 41・12

      Pages: 1644-1658

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Normal and pathological aging of higher brain functions and universal design.2003

    • Author(s)
      Suga M, Tatsumi IF.
    • Journal Title

      Human Interface (in Japanese) 5(4)

      Pages: 13-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surface dyslexia in a Japanese patient with semantic dementia : Evidence for similarity-based orthography-to-phonology translation.2003

    • Author(s)
      Fushimi T, Komori K, Ikeda M, Patterson K, Ijuin M, Tanabe H.
    • Journal Title

      Neuropsychologia (in English) 41(12)

      Pages: 1644-1658

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 認知神経心理学と高次脳機能障害

    • Author(s)
      伊集院睦雄
    • Journal Title

      精神認知とOT 2(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cognitive neuropsychology and higher cortical function disorder.

    • Author(s)
      Ijuin, M.
    • Journal Title

      Japanese Journal of Occupational Therapy for Mental and Cognitive Disorder (in Japanese) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 認知神経心理学と高次脳機能障害

    • Author(s)
      伊集院睦雄
    • Journal Title

      精神認知とOT 2(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Book] 日本語の語彙特性第8巻「心像性」2005

    • Author(s)
      佐久間尚子, 伏見貴夫, 伊集院睦雄, 田中, 辰巳格, 天野成昭, 近藤公久
    • Total Pages
      2000
    • Publisher
      三省堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「ことばの聞き取り、理解、および生成」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      辰巳 格(分担)
    • Total Pages
      300
    • Publisher
      医学書院(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「語の文法とその障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伏見 貴夫(分担)
    • Total Pages
      300
    • Publisher
      医学書院(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「音韻処理と語彙障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伏見 貴夫(分担)
    • Total Pages
      300
    • Publisher
      医学書院(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「単語の読み書き障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伊集院 睦雄(分担)
    • Total Pages
      300
    • Publisher
      医学書院(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 「ことばの聞き取り、理解、および生成」in『コミユニケーション障害の新しい視点と治療理論』 (笹沼澄子編)

    • Author(s)
      辰巳 格(分担)
    • Total Pages
      400
    • Publisher
      医学書院(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] 「語の文法とその障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伏見 貴夫(分担)
    • Total Pages
      400
    • Publisher
      医学書院(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] 「音韻処理と語彙障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伏見 貴夫(分担)
    • Total Pages
      400
    • Publisher
      医学書院(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] 「単語の読み書き障害」in『コミュニケーション障害の新しい視点と治療理論』(笹沼澄子編)

    • Author(s)
      伊集院 睦雄(分担)
    • Total Pages
      400
    • Publisher
      医学書院(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Book] 日本語の語彙特性第8巻「心像性」

    • Author(s)
      佐久間尚子, 伏見貴夫, 伊集院睦雄, 田中, 辰巳格, 天野成昭, 近藤公久
    • Total Pages
      2000
    • Publisher
      三省堂(印刷中)
    • Related Report
      2004 Annual Research Report
  • [Publications] 伊集院睦雄, 辰巳格: "健常成人と後天性失読症例の音読モデル研究の立場から-二重経路モデルとトライアングル・モデル"LD研究. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] 伏見貴夫, 伊集院睦雄, 佐久間尚子, 辰巳格, 春原則子, ほか: "認知心理学における最近のトピック-語の文法とその障害-"神経心理学. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] 須賀昌昭, 辰巳 格: "高次脳機能の健常加齢・病的加齢と、ユニバーサル・デザイン"ヒューマンインタフェース学会誌. 5(4). 13-16 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 佐久間尚子, 田中正行, 伏見貴夫, 伊集院睦雄, 辰巳格, ほか: "48カテゴリーによる健常高齢者の語想起能力の検討"電子情報通信学会技術報告書. TL2003-13. 73-78 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fushimi T, Komori K, Ikeda M, Patterson K, Ijuin M, Tanabe H.: "Surface dyslexia in a Japanese patient with semantic dementia : Evidence for similarity-based orthography-to-phonology translation"Neuropsychologia. 41. 1644-1658 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 新貝尚子, 伏見貴夫: "小児失語症例における失読パターン:単語属性効果の検討による失読機序の分析"高次脳機能研究. 23. 138-148 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 伊集院睦雄, 辰巳 格(分担): "語聾への認知神経心理学的アプローチ.高次神経機能障害の臨床実践入門(宇野彰編)"新興医学出版社(印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] 辰巳 格(分担): "認知神経心理学的アプローチ-話し言葉の障害-『よくわかる失語症と高次脳機能障害』(鹿島晴雄, 種村 純編)"永井書店. (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 渡辺眞澄, 筧 一彦, 伊藤友彦, 辰巳 格(分担): "失文法における統語と形態の障害メカニズム『よくわかる失語症と高次脳機能障害』(鹿島晴雄, 種村 純編)"永井書店. (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fushimi T, Komori K, Ikeda M, Patterson K, Ijuin M, Tanabe H: "Surface dyslexia in a Japanese patient with semantic dementia : Evidence for similarity-based orthography-to-phonology translation"Neuropsychologia. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 伊集院睦雄, 伏見貴夫, 辰巳格: "日本語における表層性失読の発現メカニズム-シミュレーション研究による検討-"神経心理学. 18,2. 101-110 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishiwata,....Ishii, K., et al.: "Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography"Annual Nuclear Medicine. 16. 377-382 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Xu, B.,....Ishii, K., et al.: "Neuroimaging reveals automatic speech coding during perception of written word meaning"NeuroImage. 17. 859-870 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石井賢二: "形態画像とPETによる機能画像の比較-脳血管障害について-"MEDICAL REHABILITATION. 18. 83-90 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石井賢二: "脳神経領域におけるクリニカルPETの展望-脳変性疾患の鑑別にどこまで役立つか-"医学の歩み. 202. 381-384 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石井賢二: "加齢と痴呆における脳萎縮と脳機能低下の関係"老人病研究所紀要. 11. 24-27 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石井賢二: "広がるPETの臨床応用-脳疾患-"日経メディカル. 12. 143-146 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 伊集院睦雄, 伏見貴夫, 辰巳格: "ニューラル・ネットワークによる漢字語音読のモデル"認知科学. 9,2. 187-199 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 新貝尚子, 伏見貴夫: "小児失語症例における失読パターン:単語属性効果の検討による失読機序の分析"失語症研究. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格: "加齢とコミュニケーションと脳"言語. 31,7. 42-48 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格, 伏見貴夫, 佐久間尚子, …石井賢二, …田中正之, 権藤恭之: "単語の想起と発話にかかわる脳内ネットワークとその加齢変化"電子情報通信学会技術報告. TL2002-31. 37-42 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格, 渡辺真澄, 種村純, 長谷川恒雄, 佐々木浩三: "動詞の活用語尾と語幹末音素が保たれたジャーゴン失語-動詞の活用に「規則処理/例外処理」は必須か?-"平成9〜12年度科学研究費補助金 特定領域研究(A)研究成果報告書「心の発達:認知的成長の機構」. 399-411 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格: "認知神経心理学的アプローチ 鹿島晴夫、種村純編「よくわかる失語症と高次機能障害」"医学書院(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] 伏見貴夫, 伊集院睦雄, 辰巳 格: "読み書きの認知モデル 宇野彰(編著)「高次神経機能障害の臨床-実践入門-」"新興医学出版社. 123 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格: "ここまで来た認知神経心理学 宇野彰・波多野和夫編『高次神経機能障害の臨床はここまで変わった』"医学書院. 166 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 辰巳 格: "あれが、あれして、あれだから・・・ 歳とともに変わることばと脳 桐谷 滋編『心の発達、ことばの発達-子どもはなにをどのように学ぶのか』"クバプロ. 151 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi