| Project/Area Number |
14340212
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Okazaki National Research Institutes |
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Principal Investigator |
FUJII Hiroshi Okazaki National Research Institutes, Center for Integrative Bioscience, Associate Professor, 統合バイオサイエンスセンター, 助教授 (80228957)
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| Co-Investigator(Kenkyū-buntansha) |
KURAHASHI Takuya Okazaki National Research Institutes, Institute for Molecular Science, Assistant Professor, 分子科学研究所, 助手 (90353432)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2003: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥11,200,000 (Direct Cost: ¥11,200,000)
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| Keywords | Bioinorganic Chemistry / Oxygen Activation / Non-Heme Enzyme / High Valnet Iron / Oxidation / Reaction Intermediate / Saren Complex / 酵素活性化 / サレン |
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| Research Abstract |
High-valent iron-oxo species are proposed to be the key reactive intermediate in oxidation reactions catalyzed by both heme and non-heme iron enzymes. In the case of heme enzymes, porphyrin model complexes have been extensively investigated, and oxo-iron (IV) porphyrin π-cation radical have been characterized as the most probable candidate for the active species. However, it is still unclear whether such high-valent iron-oxo species are generated from mononuclear non-heme iron active sites, in which there is no electron pool that can replace the large π-conjugation of the porphyrin ring. It is thus worth challenging to prepare transient oxidizing species from a mononuclear non-heme iron model complex for a detailed study of the electronic structure in comparison with the heme case. To this end, we have prepared a salen iron complex having a mesityl substituent, as a model for mononuclear iron enzymes. We have also tried to make a transient intermediate generated from the sterically hindered salen iron complex and m-chloroperoxybenzoic acid (mCPBA).
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