• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

AUTOMATED MICRO SEPARATION/ANALYSIS SYSTEM WITH FIBROUS MEDIA

Research Project

Project/Area Number 14340233
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionToyohashi University of Technology

Principal Investigator

JINNO Kiyokatsu  Toyohashi University of Technology, FACULTY OF ENGINEERING, Professor, 工学部, 教授 (60124731)

Co-Investigator(Kenkyū-buntansha) SAITO Yoshihiro  Toyohashi University of Technology, Research Associate, 工学部, 助手 (00303701)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2003: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2002: ¥10,000,000 (Direct Cost: ¥10,000,000)
KeywordsMINIATURIZATION / SAMPLE PREPARATION / SOLVENT-LESS / FIBROUS MEDIUM / CHROMATOGRAPHY / NOVEL STATIONARY PHASE / TOTAL ANALYSIS SYSTEM / HIGH THROUGHPUT ANALYSIS / マイクロ分離システム / マイクロ固相抽出 / キャピラリー分離 / ファイバー媒体 / 複合化システム / 自動化
Research Abstract

MINIATURIZATION OF THE SAMPLE PREPARATION PROCESS AND THE SUBSEQUENT CHROMATOGRAPHIC SEPARATION PROCESS HAS BEEN REGARDED AS ONE OF THE KEY TECHNOLOGIES INCLUDING AN EFFECTIVE ON-LINE COUPLING OF THESE TWO MAJOR ANALYTICAL PROCESSES. COMPARED WITH TRADITIONAL SOLVENT-SOLVENT EXTRACTION," THE MINIATURIZED, SAMPLE PREPARATION TECHNIQUES COULD SIGNIFICANTLY REDUCE THE USAGE OF ORGANIC SOLVENTS AS WELL AS OTHER CHEMICALS. DOWNSIZING OF THE CHROMATOGRAPHIC SEPARATION SHOULD BE ACCOMPLISHED AT THE SAME TIME TO MAXIMIZE THE ADVANTAGEOUS FEATURE OF THESE MINIATURIZED SAMPLE PREPARATION METHODS.
AS THE MINIATURIZED SAMPLE PREPARATION TECHNIQUE, THE AUTHORS HAVE DEVELOPED A NEW TYPE OF EXTRACTION METHOD, SO-CALLED "FIBER-IN-TUBE" SOLID-PHASE EXTRACTION (FIT-SPE), WHERE SEVERAL HUNDREDS OF FINE FILAMENTS OF SYNTHETIC FIBER WERE PACKED LONGITUDINALLY INTO A CAPILLARY. WITH THE FIT-SPE TECHNIQUE, AN AUTOMATED SAMPLE PREPARATION DEVICE HAS BEEN DEVELOPED AND THE APPLICATION FOR THE ANALYSIS OF TYPICA … More L COMPLEX SAMPLE MIXTURES SUCH AS ENVIRONMENTAL AND BIOLOGICAL SAMPLES. THE EXTRACTION CONDITIONS, SUCH AS EXTRACTION FLOWRATE AND TIME, TYPE OF FIBROUS MATERIALS USED, WERE SYSTEMATICALLY STUDIED AND ALSO SEVERAL PARAMETERS FOR THE AUTOMATION OF THE SAMPLE PREPARATION PROCESS WERE OPTIMIZED ALONG WITH THE DEVELOPMENT OF COMPUTER-CONTROLLING SYSTEM FOR THE EXTRACTION PROCESS.
FIBER-PACKED SEPARATION COLUMNS HAVE BEEN INTRODUCED FOR THE SEPARATION OF THE ABOVE SAMPLES IN LIQUID CHROMATOGRAPHY (LC), CAPILLARY ELECTROCHROMATOGRAPHY (CEC) AND GAS CHROMATOGRAPHY (GC). THE SUCCESSFUL COMBINATION OF THE MINIATURIZED SAMPLE PREPARATION WITH FIBROUS EXTRACTION MEDIUM AND THE MICROSCALE SEPARATION WITH FIBROUS SEPARATION MEDIUM ENABLES THE DEVELOPMENT OF HIGH PERFORMANCE MICROSCALE ANALYTICAL SYSTEM HAVING A HIGHER EFFICIENCY, COST-EFFECTIVE FEATURES AND ENVIRONMENTALLY-SAFELY CHARACTERS. THE RESULTS OBTAINED IN THIS PROJECT HAVE BEEN PRESENTED WORLD-WIDE IN MANY INTERNATIONAL JOURNALS, AS FOUND IN THE ATTACHED PUBLICATION LIST, AND ALSO IN SEVERAL INTERNATIONAL MEETINGS AS PLENARY OR INVITED LECTURES. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] Y.Saito: "Miniaturized Solid Phase Extraction as a Sample Preparation Technique for the Determination of Phthalates in Water"Analytical and Bioanalytical Chemistry. 373. 81-86 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "On-Line Coupling of Miniaturized Solid Phase Extraction and Microcolumn Liquid Phase Separations"Analytical and Bioanalytical Chemistry. 373. 325-331 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Liquid Chromatographic Retention Behavior of Polycyclic Aromatic Hydrocarbons on Newly-Synthesized Chitosan Stationary Phases Cross-Linked with Long Aliphatic Chains"Journal of Liquid Chromatography and Related Technologies. 25. 2765-2777 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Polymer-Coated Synthetic Fibers Designed for Miniaturized Sample Preparation Process"Journal of Chromatography A. 975. 105-112 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Morishima: "Fiber-in-Tube Solid-Phase Extraction Using a Polyetheretherketone Capillary and, Effective On-Line Coupling with Microcolumn Liquid Chromatography"Chromatographia. 56. 585-590 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Imaizumi: "Polymer-Coated Fibrous Extraction Medium for Sample Preparation Coupled to Microcolumn Liquid-Phase Separations"Journal of Pharmaceutical and Biomedical Analysis. 30. 1801-1808 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Design and Characterization of Novel Stationary Phases Based on the Retention Behavior Studies for Various Aromatic Compounds"Journal of Separation Science. 26. 225-241 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Miniaturized Sample Preparation Combined with Liquid Phase Separations"Journal of Chromatography A. 1000. 53-67 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Polymer-Coated Fibrous Materials as the Stationary Phase in Packed Capillary Gas Chromatography"Analytical Chemistry. 75. 5525-5531 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Development of Miniaturized Sample Preparation with Fibrous Extraction Media"Journal of Chromatography A. 1025. 27-32 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Liquid Chromatographic Retention Behavior of Polycyclic Aromatic Hydrocarbons on a Novel Chitosan-Based Stationary Phase Synthesized with a Trifunctional Cross-Linker"Journal of Liquid Chromatography and Related Technologies. 27. 275-287 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Polymer-Coated Fibrous Stationary Phases in Packed Capillary Gas Chromatography"Analytical Sciences. 20. 335-339 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Fullerenes for Chromatographic Separation"Analytical Chemistry. 76(印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Drug Monitoring and Clinical Chemistry"Elsevier Science B.V.(Asmterdam, The Netherlands). 14 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "MINIATURIZED SOLID PHASE EXTRACTION AS A SAMPLE, PREPARATION TECHNIQUE FOR THE DETERMINATION OF PHTHALATES IN WATER"ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 373. 81-86 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "ON-LINE COUPLING OF MINIATURIZED SOLID PHASE EXTRACTION AND MICROCOLUMN LIQUID PHASE SEPARATIONS"ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 373. 325-331 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "LIQUID CHROMATOGRAPHIC RETENTION BEHAVIOR OF POLYCYCLIC AROMATIC HYDROCARBONS ON NEWLY-SYNTHESIZED CHITOSAN STATIONARY PHASES CROSS-LINKED WITH LONG ALIPHATIC CHAINS"JOURNAL OF LIQUID CHROMATOGRAPHY AND RELATED TECHNOLOGIES. 25. 2765-2777 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "POLYMER-COATED SYNTHETIC FIBERS DESIGNED FOR MINIATURIZED SAMPLE PREPARATION PROCESS"JOURNAL OF CHROMATOGRAPHY A. 975. 105-112 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.MORISHIMA: "FIBER-IN-TUBE SOLID-PHASE EXTRACTION USING A POLYETHERETHERKETONE CAPILLARY AND, EFFECTIVE ON-LINE COUPLING WITH MICROCOLUMN LIQUID CHROMATOGRAPHY"CHROMATOGRAPHIA. 56. 585-590 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.IMAIZUMI: "POLYMER-COATED FIBROUS. EXTRACTION MEDIUM FOR SAMPLE PREPARATION COUPLED TO MICROCOLUMN LIQUID-PHASE SEPARATIONS"JOURNAL OF PHARMACEUTICAL BIOMEDICAL ANALYSIS. 30. 1801-1808 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "DESIGN AND CHARACTERIZATION OF NOVEL STATIONARY PHASES BASED ON THE RETENTION BEHAVIOR STUDIES FOR VARIOUS AROMATIC COMPOUNDS"JOURNAL OF SEPARATION SCIENCE. 26. 225-241 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "MINIATURIZED SAMPLE PREPARATION COMBINED WITH LIQUID PHASE SEPARATIONS"JOURNAL OF CHROMATOGRAPHY A. 1000. 53-67 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "POLYMER-COATED FIBROUS MATERIALS AS THE STATIONARY PHASE IN PACKED CAPILLARY GAS CHROMATOGRAPHY"ANALYTICAL CHEMISTRY. 75. 5525-5531 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "DEVELOPMENT OF MINIATURIZED SAMPLE PREPARATION, WITH FIBROUS EXTRACTION MEDIA"JOURNAL OF CHROMATOGRAPHY A. 1025. 27-32 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "LIQUID CHROMATOGRAPHIC RETENTION BEHAVIOR OF POLYCYCLIC AROMATIC HYDROCARBONS ON A NOVEL CHITOSAN-BASED STATIONARY PHASE SYNTHESIZED WITH A TRIFUNCTIONAL CROSS-LINKER"JOURNAL OF LIQUID CHROMATOGRAPHY AND RELATED TECHNOLOGIES. 27. 275-287 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "POLYMER-COATED FIBROUS STATIONARY PHASES IN PACKED CAPILLARY GAS CHROMATOGRAPHY"ANALYTICAL SCIENCES. 20. 335-339 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.SAITO: "FULLERENES FOR CHROMATOGRAPHIC SEPARATION"ANALYTICAL CHEMISTRY. 76(in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Drug Monitorig and Clinical Chemistry"Elsevier Science B.V. (Amsterdam, The Netherlands). 14 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Saito: "Miniaturized Solid Phase Extraction as a Sample Preparation Technique for the Determination of Phthalates in Water"Analytical and Bioanalytical Chemistry. 373. 81-86 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "On-Line Coupling of Miniaturized Solid Phase Extraction and Microcolumn Liquid Phase Separations"Analytical and Bioanalytical Chemistry. 373. 325-331 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Liquid Chromatographic Retention Behavior of Polycyclic Aromatic Hydrocarbons on Newly-Synthesized Chitosan Stationary Phases Cross-Linked with Long Aliphatic Chains"Journal of Liquid Chromatography and Related Technologies. 25. 2765-2777 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Polymer-Coated Synthetic Fibers Designed for Miniaturized Sample Preparation Process"Journal of Chromatography A. 975. 105-112 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Morishima: "Fiber-in-Tube Solid-Phase Extraction Using a Polyetheretherketone Capillary and, Effective On-Line Coupling with Microcolumn Liquid Chromatography"Chromatographia. 56. 585-590 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Imaizumi: "Polymer-Coated Fibrous Extraction Medium for Sample Preparation Coupled to Microcolumn Liquid-Phase Separations"Journal of Pharmaceutical and Biomedical Analysis. 30. 1801-1808 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Design and Characterization of Novel Stationary Phases Based on the Retention Behavior Studies for Various Aromatic Compounds"Journal of Separation Science. 26. 225-241 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Miniaturized Sample Preparation Combined with Liquid Phase Separations"Journal of Chromatography A. 1000. 53-67 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Polymer-Coated Fibrous Materials as the Stationary Phase in Packed Capillary Gas Chromatography"Analytical Chemistry. 75. 5525-5531 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Development of Miniaturized Sample Preparation with Fibrous Extraction Media"Journal of Chromatography A. 1025. 27-32 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Liquid Chromatographic Retention Behavior of Polycyclic Aromatic Hydrocarbons on a Novel Chitosan-Based Stationary Phase Synthesized with a Trifunctional Cross-Linker"Journal of Liquid Chromatography and Related Technologies. 27. 275-287 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Polymer-Coated Fibrous Stationary Phases in Packed Capillary Gas Chromatography"Analytical Sciences. 20. 335-339 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Fullerenes for Chromatographic Separation"Analytical Chemistry. 76(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito: "Drug Monitoring and Clinical Chemistry"Elsevier Science B.V.(Amsterdam, The Netherlands). 14 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Saito, K.Jinno: "Miniaturized Sample Preparation Combined with Liquid Phase Separations"Journal of Chromatography 4. 1000(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, K.Jinno: "Polymer-Coated Fibrous Materials as the Stationary Phase in Packed Capillary gas Chromatography and the Applications for Sample Preparation in Environmental Analysis"Chinese Journal of Environmental Chemistry. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, H.Ohta, K.Jinno: "Design and Characterization of Novel Stationary Phases Based on the Retention Behavior for Various Aromatic Compounds"Journal of Separation Science. 26(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito: "Miniaturization of Separation Systems and Its Application"Chromatography. 24. 7-17 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Imaizumi, Y.Saito, M.Hayashi, T.Takeichi, H.Wada, K.Jinno: "Polymer-Coated Fibrous Extraction Medium for Sample Preparation Coupled to Microcolumn Liquid-Phase Separations"Journal of Pharmaceutical and Biomedical Analysis. 30. 1801-1808 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Kiso, K.Kuzawa, Y.Saito, T.Yamada, M.Nagai, Y-J.Jung, K.-S.Min: "A Spot Test for Aqueous Phosphate by Color Band formation"Analytical and Bioanalytical Chemistry. 374. 1212-1217 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Morishita, Y.Saito, C.Fujimoto, T.Takeichi, K.Jinno: "Fiber-in-tube Solid-Phase Extraction Using a Polyetheretherketone Capillary and, Effective On-Line Coupling with Microcolumn Liquid Chromatography"Chromatographia. 56. 585-590 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, M.Nojiri, M.Imaizumi, Y.Nakao, Y.Morishita, H.Kanchara, H.Matsuura, K.Kotera, H.Wada, K.Jinno: "Polymer-Coated Synthetic Fibers Designed for Miniaturized Sample Preparation Process"Journal of Chromatograohy 4. 975. 105-112 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, M.Nojiri, Y.shimizu, K.Jinno: "Liquid Chromatographic Retention Behavior of Polycyclic Aromatic Hydrocarbons on Newly-Synthesized Chitosan Stationary Phases Cross-Linked with Long Aliphatic Chains"Journal of Liquid Chromatography and Related Technologies. 25. 2765-2777 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, K.Jinno: "On-Line Coupling of Miniaturized Solid Phase Extraction and Microcolumn Liquid Phase Separations"Analytical and Bioanalytical Chemistry. 373. 325-331 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.saito, Y.Nkano, M.Imaizumi, Y.Morishita, Y.Kiso, K.Jinno: "Miniaturized Solid Phase Extraction as a Sample Preparation Technique for the Determination of Phthalates in Water"Analytical and Bioanalytical Chemistry. 373. 81-86 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, M.Kawazoe, M.Imaizumi, Y.Morishita, Y.Nakao, K.Hatano, M.Hayashida, K.Jinno: "Miniaturized Sample Preparation and Separation Methods for environmental and Drug Analysis"Analytical Sciences. 18. 7-17 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, M.Imaizumi, T.Takeichi, K.Jinno: "Miniaturized Fiber-in-Tube Solid Phase Extraction as the Sample Preconcentration Method for Microcolumn Liquid Phase Separations"Analytical and Bioanalytical Chemistry. 372. 164-168 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, K.Jinno: "The Use of Fibrous Polymer Materials in Capillary Electrochromatography"Chromatography. 22. 151-158 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Saito, M.Hayashida, K.Jinno: "Drug Monitoring and Clinical Chemistry"Elsevier Science B.V., Amsterdam, The Netherlands. 25 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 神野清勝, 齊戸美弘: "HPLCにおける最適条件の設定とトラブル対策"技術情報協会. 10 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi