| Project/Area Number |
14350039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied physics, general
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KOSE Katsumi University of Tsukuba, Institute of Applied Physics, Professor, 物理工学系, 教授 (60186690)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2003: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2002: ¥8,600,000 (Direct Cost: ¥8,600,000)
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| Keywords | MRI / NMR / MR microscope / Human embryo / embryo / 3D image / Super-parallel / super-conducting magnet / 胚子 / 3D画像 |
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| Research Abstract |
Kyoto University has a large human embryo collection (〜50,000 specimens), which were collected from 1961 to 1974. Because such a collection will never be obtained again, their nondestructive 3Dmeasurements are highly desired. Kyoto and Tsukuba Universities have therefore started a project acquiring 3D MR microscopic images of about 1,200 embryos in two years to create a 3D anatomical database for human embryology. Human embryo specimens were chemically fixed in Bouin's fluid and stored in 10% formalin solution. The embryos were imaged in the formalin to avoid susceptibility effect, with a four-or eight-channel super-parallel MR microscope using a 2.34 T/40 cm superconducting magnet. All of the embryos (about 100 speciments for each stage) were measured using a T_1 weighted 3D SE sequence. The image matrix was 128 x 128 x 256 throughout the whole stages but the voxel size was varied from (40μm)^3 to (150μm)^3. Many anatomical structures were clearly visualized in the 3D images. This result demonstrates usefulness of the anatomical image database in human embryology.
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