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Basic research to develop a patient-friendly method for calculus fragmentation

Research Project

Project/Area Number 14350054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionToyohashi University

Principal Investigator

HOMMA Hiroomi  Toyohashi University, International Cooperation Center for Engineering Education Development, Professor, 工学教育国際協力研究センター, 教授 (70016583)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Satoshi  Asahikawa Medical College, the urology department, Lecturer, 医学部, 講師 (40230354)
GUNAWAN Fergyanto  Toyohashi University, Mechanical Engineering, Research Associate, 工学部, 教務職員 (80314102)
KANTO Yasuhiro  Toyohashi University, Mechanical Engineering, Associate Professor, 工学部, 助教授 (60177764)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2003: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥9,300,000 (Direct Cost: ¥9,300,000)
KeywordsCalculus / ESWL / Stress wave / FEM / Failure analysis / 体外衝撃波結石破砕装置 / 石膏 / 脆性破壊 / 腎臓損傷 / 体外衝撃波結石破壊
Research Abstract

From this research, the followings are deduced as the conclusion.
1.In case where a calculus is broken by stress pulse impingement such as ESWL, the amplitude of the incident stress wave must be very large if the duration of the pulse is very short like 1 to 3 μsec. In ESWL, such short stress pulses are transmitted into calculi. Therefore, development of equipment that can transmit longer stress pulses into calculi is necessary for patient-friendly calculus fragmentation. Now, the equipment using ultrasonic wave is under development in my laboratory.
2.Numerical, analysis indicates that dual stress pulse impingement onto a calculus generates higher tensile stress over the wide region inside the calculus. It means that low impingement pressure can be used for calculus fragmentation, which can reduce the risk of the kidney tissue injury. However, in practice, it is very difficult for two same-phase stress pulses to reach a calculus simultaneously though a human body from two opposite sources. We need further investigation for realizing this idea.
3.For an SWL experimental sample, a renal of a pig is used. In the renal exposed by shock waves of intensity used for actual treatment, the cell structure was damaged so that phosphatidylserines were removed from the cell structure. This damage might cause to nucleate a renal calculus

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] H.Homma, S.Mihradi, T.Takeuchi: "Fragmentation of Kidney Stone by Shock Wave - Experimental Approach"Advances in Fracture and Failure Prevention ; Key Engineering Materials. Vols.261-263. 301-306 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Mihradi, H.Homma: "日本機械学会2004年次大会"Numerical Analysis of Kidney Stone Fragmentation by Short Pulse Impingement : Effect of Geometry. (9月発表予定). 56-61 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山口 聡, 加藤祐司, 中園周作, 奥山光彦, 徳光正行, 高下紀子, 八竹 直: "Shock Waveにより尿路上皮細胞障害とCrystal-cell interactionに与える影響の検討"日本尿路結石症学会誌. Vol2 No.1. 177-177 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山口 聡, 奥山光彦, 加藤祐司, 佐賀祐司, 金子茂男, 八竹 直, 藤澤 真, 新堀大介: "衝撃波による尿路上皮細胞障害とCrystal-cell interactionに対する影響の検討"第17回Endourology and ESML学会総会. 99-99 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山口 聡: "尿路上皮細胞障害と結石再発の関連性について"日本泌尿器科学会雑誌. Vol.95 No.2. (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Homma, S.Mihradi, T.Takeuchi: "Fragmentation of Kidney Stone by Shock Wave-Experimental Approach"Key Engineering Materials. Vol.261-263. 301-306 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Mihradi, H.Homma, Y.Kanto: "Numerical Analysis of Kidney Stone"JSME International Journal. Vol.47(accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Yamaguchi, Y.Katoh, S.Nakazono, M.Okuyama, M.Tokuyama, N.Takasita, N.Yatake: "Damage of epithelium cell by shock wave and its effect On crystal-cell interaction"Journal of Japanese Society on Urolithiasis Research. Vol.2 No.1. 56-61 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Homma, S.Mihradi, T.Takeuchi: "Fragmentation of Kidney Stone by Shock Wave - Experimental Approach"Advances in Fracture and Failure Prevention ; Key Engineering Materials. Vols.261-263. 301-306 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Mihradi, H.Homma: "日本機械学会2004年次大会9月発表予定"Numerical Analysis of Kidney Stone Fragmentation by Short Pulse Impingement : Effect of Geometry.

    • Related Report
      2003 Annual Research Report
  • [Publications] 本間寛臣: "衝撃波による結石破砕のメカニズムについて"日本尿路結石症学会誌. 1巻1号. 27-38 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Homma, T.Takeuchi: "Fragmentation of Kidney Stone by Shock Wave-Experimental Approach"Proc. Of 3^<rd> Inter. Conf. On Numerical Analysis in Engineering. 6-1-6-8 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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