| Project/Area Number |
14350490
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
高分子合成
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| Research Institution | Kansai University |
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Principal Investigator |
OUCHI Tatsuro Kansai University, Faculty of Engineering, Applied Chemistry, Professor, 工学部, 教授 (60067650)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Yuichi Kansai University, Faculty of Engineering, Applied Chemistry, Associate Professor, 工学部, 助教授 (10213886)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2004: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | Polylactide / Biodegaradable Material / Branched Structure / Mechanical Property / Crystallinity / Polysaccharide / Polyglycidol / Young's Modulus / ポリデプシペプチド / セリン |
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| Research Abstract |
Since poly(L-lactide)(PLA) has a good biocompatibility, biodegradability and high mechanical strength, PLA has been clinically used as a degradable medical polymer material. However, it has been pointed out that the difficulty of control of degradation rate and low elasticity for linear PLA as a result of its too high crystallinity. In order to solve these problems, the introduction of branched atnicture into PLA were investigated.
Firstly, PLA-grafted polysaccharides having low sugar unit contents were synthesized and mechanical properties, degradabilities and functionalites of films prepared from them were basically investigated.
Secondly, branched PLAs with various lengths of graft chain were synthesized by bulk polymerization of lactide using polyglycidol as a macroinitiator. The properties of branched PLLA or PDLA and their stereocomplex were investigated through thermal analysis, tensile test. The branched PLLA or PDLA film exhibited a lower glass transition temperature (Tg), melting temperature (Tm), crystallinity, lower young's modulus, and higher strain at break compared to linear PLLAor PDLA film. The stereocomplex film showed high maximum stress and high Young's modulus keeping its high strain at break. Moreover, the usefulness of branched PLLAor PDLA as a plasticizer was investigated with 1:9 blend films prepared from the branched PLLA or branched PDLA and linear PLLA. The blend films showed higher strain at break compared with linear PLLA film. The properties of the blend films could be controlled by changing the molecular weight of branced PLA
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