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Analysis of Regulatory Mechanism of Hepatic Autophagy and Its Contribution to Nutritional Science

Research Project

Project/Area Number 14360072
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

KADOWAKI Motoni  NIIGATA UNIVERSITY, Faculty of Agriculture, Professor, 農学部, 教授 (90126029)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Fumiaki  Utsunomiya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10269243)
FUJIMURA Shinobu  NIIGATA UNIVERSITY, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (20282999)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2003: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2002: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsAutophagy / Liver / Proteolysis / Amino Acid / LC3 / Rice Protein / Signaling / 膜融合
Research Abstract

1.Nutritional Role of Hepatic Autophagy
In order to investigate if food protein affects autophagic proteolysis in the liver in the steady state, casein, soybean protein, rice protein, wheat protein, potato protein and ovalbumin, were compared. Animal protein tended to increase the proteolytic rate compared to vegetable protein, but rice protein exceptionally increased the rate, which suggests some special role.
2.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 門脇 基二: "筋肉におけるバルク蛋白質分解-大いなる例外か-"医学のあゆみ. 200(4). 301-304 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kadowaki, M, Kanazawa, T: "Amino acids as regulators of proteolysis"Journal of Nutrition. 133. 2052S-2056S (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibata, M.et al.: "Nucleotide sequence of myostatin gene and its developmental expression in skeletal muscles of Japanese Black cattle"Animal Science Journal. 74. 383-390 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 金澤 匠, 門脇 基二: "アミノ酸によるオートファジーの調節-タンパク質分解系を中心に-"栄養評価と治療. 20. 483-486 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 門脇 基二, 金澤 匠: "肝オートファジーのシグナリング機構"生体の科学. 54. 528-533 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanazawa, T.et al.: "Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes"Journal of Biological Chemistry. 279. 8452-8459 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kadowaki M.: "Bulk proteolysis in skeletal muscle."Igaku no ayumi. 2004(4). 301-304 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kadowaki, M., Kanazawa, T.: "Amino acids as regulators of proteolysis."Journal of Nutrition. 133. 2052S-2506S (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibaba, M.et al.: "Nucleotide sequence of myostatin gene and its developmental expression in skeletal muscle of Japanese Black cattle."Animal Science Journal. 74. 383-390 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanazawa, T., Kadowaki, M.: "Regulation of autophagy by amino acids."Eiyo Hyouka to chiryo. 20. 483-486 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kadowaki, M., Kanazawa, T.: "Signaling mechanism of hepatic autophagy."Seitai no Kagaku. 54. 528-533 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanazawa, T.et al.: "Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes."Journal of Biological Chemistry. 279. 8452-8459 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kadowaki, T.KANAZAYA: "Amino acids as regulators of proteolysis"Journal of Nutrition. 133. 2052S-2056S (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M SHIBATA et al.: "Nucleotide sequence of myostatin gene and its developmental expression in skeletal muscles of Japanese Black cattle"Animal Science Journal. 74. 383-390 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.KANAZAWA et al.: "Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes"Journal of Biological Chemistry. 279(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 金澤 匠, 門脇 基二: "アミノ酸によるオートファジーの調節-蛋白質分解系を中心に-"栄養評価と治療. 20. 483-386 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 門脇 基二, 金澤 匠: "肝オートファジーのシグナリング機構"生体の科学. 54. 528-533 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 門脇基二: "筋肉におけるバルク蛋白質分解-大いなる例外か-"医学のあゆみ. 200(4). 301-304 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 門脇基二, 三浦州平: "筋肉タンパク質分解系におけるオートファジーとプロテアソームの比較"必須アミノ酸研究. 164号. 37-41 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Motoni Kadowaki: "Amino Acids As Regulators of Proteolysis"Journal of Nutrition. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshizawa F., et al.: "Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP denletion"Biochem. Biophys. Res. Commun.. 298. 235-239 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshizawa F., et al.: "Oral administration of leucine stimulates phosphorylation of4E-BP1 and S6K1 in skeletal muscle but not in liver"J. Nutr. Sci. Vitaminol.. 48. 59-64 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagasawa, T., et al.: "Rapid suppression of protein degradation in skeletal muscle after oral feeding of leucine in rats"J. Nutr. Biochem.. 13. 121-127 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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