Efficient Utilization of Fisheries Biproducts. Exploration of miomedial Resoures from Deep-Sea Spong

• Project/Area Number: 14360119
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fisheries chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: FUSETANI Nobuhiro The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (70012010)
• Co-Investigator(Kenkyū-buntansha): NAKAO Yoichi The University of Tokyo, Graduate School of Agricultural and Life Sciences, Assistant, 大学院・農学生命科学研究科, 助手 (60282696) ; MATSUNAGA Shigeki The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate Professor, 大学院・農学生命科学研究科, 助教授 (60183951)
• Project Period (FY): 2002 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥17,200,000 (Direct Cost: ¥17,200,000); Fiscal Year 2003: ¥4,100,000 (Direct Cost: ¥4,100,000); Fiscal Year 2002: ¥13,100,000 (Direct Cost: ¥13,100,000)
• Keywords: Deep-Sea / Sponge / Biomedical / Bioactive / Cytotoxic / Structure elucidation / 深海海綿 / 漁業混獲物 / theopederin / セスタテルペン / マクロライド / 構造解析 / 抗菌・抗カビ性 / 酵素阻害活性 / タカシガニ漁

Research Abstract

In order to explore the possibility of discovering new compounds with biomedical importance from deep-sea sponges, we collected 78 samples at Shinsone, near Oshima Island and examined the biological activities of their extracts. More than 70% of the extracts exhibited either cytotoxic, antimicrobial, or enzyme inhibitory activity, demonstrating the importance of deep-sea sponges in natural products drug discovery. We have isolated the following compounds from the collected specimens.
1.Theopederin K from Discodermia japonica
2.Shinsonefuran from Stoeba extensa
3.Novel macrolides from Poecillastra sp.
Isolation of cytotoxic constituents from another deep-sea sponge collected off Heda, Izu, is in progress.

Research Products

• [Publications] Phuwapraisirisan et al.: "Shinsonefuran, a cytotoxic furanosesterterpene with a novel carbon skeleton, from the deep-sea sponge stoeba extensa."Tetrahedron Lett.. 45. 2125-2128 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Phuwa@raisirisan, P., et al.: "Shinsonefuran, a cytotoxic furanosestertenpene with a novel carbon skelton, from the deep-sea sponge Stoeba extensa"Tetrahedron Letters. 45. 2125-2128 (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] P.Phuwapuraisirisan, S.Matsunaga他2名: "Shinsonefuran, a cytotoxic furanosesterterpene with a novel carbon skeleton, from a deep-sea sponge Stoeba extensa."Tetrahedron Letters. 45・10. 2125-2128 (2004)