| Project/Area Number |
14360179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tottori University |
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Principal Investigator |
HARADA Etsumori National University Corporation Tottori University, Faculty of Agriculture, Professor, 農学部, 教授 (90001536)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Hiroshi Kobe Univ., Graduate school of Science and Technology, Professor, 大学院・自然科学研究科, 教授 (40125307)
SATOH Hiroshi National University Corporation Tottori University, Faculty of Agriculture, Professor, 農学部, 教授 (20301286)
TAKEUCHI Takashi National University Corporation Tottori University, Faculty of Agriculture, Research Associate, 農学部, 助手 (20216849)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2003: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2002: ¥7,200,000 (Direct Cost: ¥7,200,000)
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| Keywords | Lactoferrin / Colostrum / Transportation / Cerebrospinal fluid / Stress / Anti-nociception / Opioid / Nitric oxide / 一酸化炭素 |
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| Research Abstract |
We demonstrated that lactoferrin(LF) contained in milk was transported into the blood circulation from the intestinal lumen and into the CSF via LF receptor located on intestinal epithelial cell or choroidal plexus not only newborn but also young adult animals. Accordingly, it can be hypothesized that some constituents of colostrum, especially LF are transported into the brain intestitium and thereafter induce physiological functions of the brain after colostral suckling in neonates and the LF administered adult animals. Interestingly, the intraduodenally infused bLF was transported into the blood circulation via the lymphatic pathway, not via portal circulation in adult rats.
In addition, we found the following novel functions of bovine milk derived LF.
(1)Suppressive effect on anxiety induced by maternal separation.
(2)Anti-nociceptive effects mediated by nitric oxide in the rat spinal cord.
(3)Nitric oxide-dependent hypotensive effect.
(4)Anti-inflammatory effects. Reduction of inflammation and nociception in rat adjuvant arthritis.
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