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Protein & carbohydrate supplementation during aerobic training increased plasma volume and thermoregulatory capacity in younger and older men

Research Project

Project/Area Number 14370021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionShinshu University

Principal Investigator

NOSE Hiroshi  Shinshu University, Graduate School of Medicine, Associate Professor, 大学院・医学研究科, 教授 (40128715)

Co-Investigator(Kenkyū-buntansha) YANAGIDAIRA Yasunori  Shinshu University, Graduate School of Medicine, Associate Professor, 大学院・医学研究科, 講師 (10020760)
DOI Tatsuya  Ohtsuka Pharmaceutical Co., Saga Research Institute of Nutrition, Vice Director, 佐賀栄養研究所, 副所長
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥7,300,000 (Direct Cost: ¥7,300,000)
Keywordsolder men / younger men / protein supplementation / thermoregulatin / plasma volume / plasma protein content / endurance training / 耐久性トレーニング / アルブミン / サプリメント / 運動トレーニング
Research Abstract

In 2002, we studied the effects of a bout of exercise on plasma volume and plasma protein content 24 hrs after the exercise in younger and older men. Moreover, we studied the effects of protein and carbohydrate (CHO) supplementation immediately after the exercise on exercise induced plasma volume (PV) expansion. We found that the PV increased in the younger men while not in the older men. However, the supplementation increased PV and plasma protein content in both groups.
In 2003, we studied the effects of protein and CHO supplementation during 2-month endurance training on thermoregulatory capacity in older men. The supplementation significantly enhanced cutaneous vasodilation and sweating rate at a given increase in esophageal temperature.
In 2004, we examined whether the supplementation enhanced the improvement of thamoregulatory capacity after 10-day endurance training in younger men. As we hypothesized, we found that the improvement of thermoregulatory capacity was enhanced in the supplementation group. However, we failed to find any significant differences in the increases in PV, maximal aerobic power, and cardiac output at a given intensity of exercise between the groups with and without supplementation.
These results suggest that the supplementation of protein and CHO during endurance training enhanced thermoregulatory capacity in older and younger men. However, it remains unknown whether it is caused by enhanced PV expansion due to greater ircrease in plasma protein content.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (35 results)

All 2005 2004 2003 2002 2000 Other

All Journal Article (18 results) Book (4 results) Patent(Industrial Property Rights) (3 results) Publications (10 results)

  • [Journal Article] Ten-day endurance training atttenuates thehyperosmotic suppression of cutaneous vasodilation during exercise but not sweating.2005

    • Author(s)
      Ichinose et al.
    • Journal Title

      J.Appl.Physiol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acute hyperosmolality attenuates suppression of cutaneous vasodilation with increased exercise intensity.2005

    • Author(s)
      Ichinose et al.
    • Journal Title

      J.Appl.Physiol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Variation of α-adrenergic vasoconstrictor response changes baroreflex sensitivity. Exercise, Nutrition, and Environmental Stress2005

    • Author(s)
      S.Masuki et al.
    • Journal Title

      (Cooper Publishing Group, Traverse City, MI) vol.4(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ten-day endurance training atttenuates the hyperosmotic suppression Of cutaneous vasodilation during exercise but not sweating.2005

    • Author(s)
      Ichinose et al.
    • Journal Title

      J.Appl.Physiol. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Acute hyperosmolality attenuates suppression of cutaneous vasodilation with increased exercise intensity.2005

    • Author(s)
      Mitono et al.
    • Journal Title

      J.Appl.Physiol. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regional differences in the expression of Fos-like immunoreactivity after central salt loading in conscious rats : modulation by endogenous vasopressin and role of the area postrema.2004

    • Author(s)
      K.Kato et al.
    • Journal Title

      Brain Res. 1022

      Pages: 182-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Triaxial accelerometry to evaluate walking efficiency in older subjects2003

    • Author(s)
      Iwashita et al.
    • Journal Title

      Med.Sci.Sports, Exer. 35

      Pages: 1766-1772

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Arterial baroreflex control of muscle blood flow at the onset of Voluntary locomotion in mice.2003

    • Author(s)
      Masuki et al.
    • Journal Title

      J.Physiol.(Lond.) 553.1

      Pages: 191-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilation in calponin knockout mice.2003

    • Author(s)
      Masuki et al.
    • Journal Title

      J.Physiol.(Lond.) 553.1

      Pages: 203-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Triaxial accelerometer to evaluate working efficiency in older subjects2003

    • Author(s)
      S.Iwashita et al.
    • Journal Title

      Medicine & Science in Sports & Exercise 35

      Pages: 1766-1772

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced barorefex sensitivity in free-moving calponin knockout mice2003

    • Author(s)
      S, Masuki et al.
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol. 284

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Arterial baroreflex control of muscle blood flow at the onset of voluantary locomotion in mice2003

    • Author(s)
      S.Masuki et al.
    • Journal Title

      J.Physiol.(Lond.) 553

      Pages: 191-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilation in calponin knockout mice.2003

    • Author(s)
      S.Masuki et al.
    • Journal Title

      J.Physiol.(Lond.) 553

      Pages: 203-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of exercise training on thermoregulatory capacity and blood volume in older men.2002

    • Author(s)
      Okazaki et al.
    • Journal Title

      J.Appl.Physiol. 93

      Pages: 1630-1637

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Effects of exercise training on thermoregulatory and blood volume in older men.2002

    • Author(s)
      K.Okazaki et al.
    • Journal Title

      J.Appl.Physiol. 93

      Pages: 1630-1637

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ten-day endurance training attenuates the hyperosmotic suppression of cutaneous Vasodilation during exercise but not sweating.

    • Author(s)
      T.Ichinose et al.
    • Journal Title

      J.Appl.Physiol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acute hypoosmolality attenuates suppression of cutaneous vasodilation with increased exercise intensity.

    • Author(s)
      H.Mitono et al.
    • Journal Title

      J.Appl.Physiol. (in revision.)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reduced α-adrenergic vasoconstriction and enhanced baroreflex sensitivity in Cry-Deficient mice lacking biological clock.

    • Author(s)
      S.Masuki et al.
    • Journal Title

      J.Physiol. (in revision.)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Exercise, Nutrition, and Environmental Stress, vol.42005

    • Author(s)
      Nose H.et al.
    • Total Pages
      300
    • Publisher
      Cooper Publishings(In press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Effects of hyperosmolality on maintenance of arterial pressure in dehydrated and exercising men in a hot environment.2005

    • Author(s)
      Y Kamijo, H, Nose.
    • Publisher
      Cooper Publishing Group, Traverse City, MI (in press)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Exercise, Nutrition, and Environmental Stress, vol.42005

    • Author(s)
      Nose H.et al.
    • Total Pages
      300
    • Publisher
      Cooper Publishings (In press)
    • Related Report
      2004 Annual Research Report
  • [Book] Exercise, Nutrition, and Environmental Stress vol.32003

    • Author(s)
      H.Nose et al.
    • Publisher
      Cooper Publishing Group, Traverse City, MI
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 血漿量増加促進剤2003

    • Inventor(s)
      能勢 博 他
    • Industrial Property Rights Holder
      大塚製薬(株)
    • Industrial Property Number
      2003-332955
    • Filing Date
      2003-09-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 血漿量増加促進剤2003

    • Inventor(s)
      能勢 博他
    • Industrial Property Rights Holder
      大塚製薬(株)
    • Industrial Property Number
      2003-332955
    • Filing Date
      2003-09-25
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 運動カロリー測定方法及び装置2000

    • Inventor(s)
      能勢 博
    • Industrial Property Rights Holder
      エスペック(株)
    • Filing Date
      2000-03-14
    • Acquisition Date
      2004-07-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] K.Okazaki et al.: "Effects of exercise training on thermoregulatory and blood volume in older men"J.Appl.Physiol.. 93. 1630-1637 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Iwashita et al.: "Triaxial accelerometry to Evaluate Walking Efficiency in older subjects"Med.Sci.in Sports and Exer.. 35. 1766-1772 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Okazaki et al.: "Protein & CHO intake after a bout of intense exercise increased plasma volume and protein content in younger and older men"The FASEB J,. 17. A943 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Okazaki et al.: "The mechainsms for improring thermoregulation by exercise training in older men & their application to development of nutritional supplement"Jpn.J.physiol.. 53. S85 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Okazaki et al.: "Effects of protein & CHO supplement after a bout of exercise on plasma volume and protein content in younger and older men"Jpn.J.physiol.. 53. S305 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Okazaki et al.: "Protein & CHO supplementation during aerobic training increased plasma volume and thormorogulatory capacity in older men"The FASEB J.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nose H, et al.: "Exercise, Nutrition, and Environmental Stress (Vol.3)"Coopor Publishings. 283 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okazaki, K et al.: "Effects of exercise training on thermoregulatory responses and blood volume in older men"J. Appl. Physiol.. 93(7). 1630-1637 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masuki, S et al.: "Enhanced baroreflex sensitivity in free moving calponin knockout mice"Am. J. Physiol.. 248(3). H939-H946 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iwashita, S.et al.: "Triaxial accelerometry to evaluate walking economy in older subjects"Medicine and Science in Sports and Exercise. (in press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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