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Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.

Research Project

Project/Area Number 14370063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKeio University

Principal Investigator

SUEMATSU Makoto  慶應大, 医学部, 教授 (00206385)

Co-Investigator(Kenkyū-buntansha) GODA Nobuhito  Keio University, School of Medicine, Associate Professor, 医学部, 講師 (00245549)
ONISHI Yasuyuki  Central Institute for Experimental Animals, Research Project Center, Senior Research Investigator, プロジェクト推進センター, 副部長 (70201382)
江川 毅  慶應義塾大学, 医学部, 助手 (10232935)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2002: ¥4,900,000 (Direct Cost: ¥4,900,000)
Keywordsheme oxygenase / carbon monoixde / soluble guanylate cyclase / nitric oxide / knockout mice / cystathionine β-synthase / シスタチオニン合成酵素 / 硫化水素 / アミノ酸置換体 / ノックアウト動物 / heme oxygenase / cystathionine β synthase / 胆汁分泌 / microcirculation / heme oxgenase / carbon monoxide / nitric oxide / hypoxia / soluble guanylate cyclase / conditional knock out mice / cystathionine beta synthase
Research Abstract

Heme oxygenase (HO), an enzyme capable to degrade protoheme IX into carbon monoxide (CO), free divalent iron, and biliverdin-IXα, plays important roles in the regulation of many cellular functions. However, the detailed molecular mechanisms of HO-dependent biological functions remain elusive. In this study, we aimed to establish new HO gene-targeting mice to address isozyme-specific roles, to find new targets of endogenous CO, and to examine effects of CO and other gaseous molecules such as nitric oxide (NO) on the same targeting molecules in vivo.
To circumvent embryonic lethality and infertility caused by an inactivation of the HO-1 gene, we constructed a new targeting vector containing exon2 of the gene flanked by loxP sequences, which can be deleted by Cre recombinase in a tissue-specific manner in vivo, in order to generate conditional HO-1 knockout mice. Two distinct ES cell clones, in which an appropriate homologous recombination occurred, were obtained so far, and chimeric mice … More have been generated.
To find novel targeting molecules of CO, we examined alterations of metabolites in mouse liver treated with acetaminophen (AAP), by which intrahepatic HO activity and consequent CO production were increased, using CE-MS. We found that the levels of S-adenosylmethionine, cysteine, glutathione, and taurine were significantly reduced by AAP treatment. On the other hand, great accumulation of methionine occurred in the affected liver. These results suggest that CO might suppress the flux into a transsulfuration pathway by binding to and inhibiting cystathionine β-synthase (CBS), a rate-limiting enzyme of the pathway. We next examined how CO inhibits CBS activity using the partially purified enzyme in vitro. Our findings showed that mili molar levels of CO could cleave the Fe of heme-cysteine bond and form a carboxy-heme complex, resulting in an inhibition of the enzyme activity.
To clarify the roles of CO and NO to regulate soluble guanylate cyclase (sGC) in vivo, we carried out immunohistochemical analyses to visualize the gas-mediated sGC activation by suppressing endogenous these gaseous molecules separately. Under conditions where CO was suppressed by ZnPP, all retinal cell layers homogenously exhibited enhancement of NO-dependent activation of sGC. On the other hand, under NO-suppressing conditions, eliminating CO abrogated the basal sGC activation in a layer-specific manner. These results suggest that endogenous CO plays a role in fine tuning the NO-dependent activation of sGC function by suppressing the maximum response as well as by modestly elevating the minimum response in particular layer of retina. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (79 results)

All 2005 2004 2003 2002 Other

All Journal Article (66 results) Publications (13 results)

  • [Journal Article] Activated leukocytes and endothelial cells enhance retention of ulteasound contrast micrispheres containing perfluoropropane in inflamed venules.2005

    • Author(s)
      Yasu, T.
    • Journal Title

      Int J Cardiol 98・2

      Pages: 245-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Purified cardiomyocytes from bone marroe mesencymal stem cells produce stable intracardiac in mice.2005

    • Author(s)
      Hattan, N
    • Journal Title

      Cardiovasc Res 65・2

      Pages: 334-344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules.2005

    • Author(s)
      Yasu T, Greener Y, Jablonski E, Killam AL, Fukuda S, Suematsu M, Tojo SJ, Schmid-Schonbein GW.
    • Journal Title

      Int J Cardiol 98・2

      Pages: 245-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice.2005

    • Author(s)
      Hattan, N
    • Journal Title

      Cardiovasc Res 65

      Pages: 334-344

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activated leukocytes and endothelial cells enhance retention of ultrasound and contrast microspheres containing perfluoropropane in inflamed venules.2005

    • Author(s)
      Yasu, T
    • Journal Title

      Int J Cardiol 98

      Pages: 245-252

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Possible participation of outer mitochondrial membrane cytonchrome B5 in steroidogenesis in zona glomerulosa of rat adrenal cortex.2004

    • Author(s)
      Mitani, F.
    • Journal Title

      Endocr Res 30・4

      Pages: 639-644

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxgen carriers) after massive intravenous doses by daily repeated infusions for 14 days.2004

    • Author(s)
      Sakai, H.
    • Journal Title

      J Pharmacol Exp Ther 311・3

      Pages: 874-884

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver.2004

    • Author(s)
      Kudo, A.
    • Journal Title

      Hepatology 39・4

      Pages: 1099-1109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pioglitazaone prevents alcohol-induced fatty liver in rats throughup-regulation of c-Met.2004

    • Author(s)
      Tomita, K.
    • Journal Title

      Gastronterology 126・3

      Pages: 873-885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatoyr dysfunction during endotoxemia in mice.2004

    • Author(s)
      Katagiri, H.
    • Journal Title

      Hepatology 39・1

      Pages: 139-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Possible participation of outer mitochondrial membrane cytonchrome B5 in steroidogenesis in zona glomerulosa of rat adrenal cortex.2004

    • Author(s)
      Mitani F, Ogishima T, Mukai K, Hoshino R, Watanabe K, Suematsu M.
    • Journal Title

      Endocr Res 30・4

      Pages: 639-644

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice.2004

    • Author(s)
      Hattan N, Kawaguchi H, Ando K, Kuwabara E, Fujita J, Murata M, Suematsu M, Mori H, Fukuda K.
    • Journal Title

      Cardiovasc Res 65・2

      Pages: 334-344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.2004

    • Author(s)
      Sakai H, Masada Y, Horinouchi H, Ikeda E, Sou K, Takeoka S, Suematsu M, Takaori M, Kobayashi K, Tsuchida E.
    • Journal Title

      J Pharmacol Exp Ther 311・3

      Pages: 874-884

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver.2004

    • Author(s)
      Kudo A, Kashiwagi S, Kajimura M, Yoshimura Y, Uchida K, Arii S, Suematsu M.
    • Journal Title

      Hepatology 39・4

      Pages: 1099-1109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met.2004

    • Author(s)
      Tomita K, Azuma T, Kitamura N, Nishida J, Tamiya G, Oka A, Inokuchi S, Nishimura T, Suematsu M, Ishii H.
    • Journal Title

      Gastroenterology 126・3

      Pages: 873-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.2004

    • Author(s)
      Katagiri H, Ito Y, Ishii K, Hayashi I, Suematsu M, Yamashina S, Murata T, Narumiya S, Kakita A, Majima M.
    • Journal Title

      Hepatology 39・1

      Pages: 139-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Involvement of thromboxane derived from cyclooxygenase-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice.2004

    • Author(s)
      Katagiri, H.
    • Journal Title

      Hepatology 39

      Pages: 139-150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pioglitazone prevents alcohol-induced fatty liver in rats through upregulation of c-Met.2004

    • Author(s)
      Tomita, K.
    • Journal Title

      Gastroenterology 126

      Pages: 873-885

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Kupffer cells alter organic anion transport via multidrug resistance protein 2 in the post-cold ischemic rat liver.2004

    • Author(s)
      Kudo, A
    • Journal Title

      Hepatology 39

      Pages: 1099-1109

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Possible participation of outer mitochondrial membrane cytonchrome B5 in steroidogenesis in zona glomerulosa of rat adrenal cortex.2004

    • Author(s)
      Mitani, F
    • Journal Title

      Endocr Res 30

      Pages: 639-644

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.2003

    • Author(s)
      Nagano, S
    • Journal Title

      Biochemistry 42・49

      Pages: 14507-14514

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bilirubin rinse : A simple protactant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning.2003

    • Author(s)
      Kato, Y
    • Journal Title

      Hepatology 38・2

      Pages: 364-373

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid llbeta-hydroxylase in adrenocortical cells.2003

    • Author(s)
      Mukai, K
    • Journal Title

      J Biol Chem 278・19

      Pages: 17084-17092

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

    • Author(s)
      Egawa, T
    • Journal Title

      J Biol Chem 278・43

      Pages: 41597-41606

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quartet signal transducers in gas biology.2003

    • Author(s)
      Sumematsu, M
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 435-437

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanistic probing of gaseous signal transduction in microcirculation.2003

    • Author(s)
      Sumematsu, M
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 485-492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aberrant utilization of nitric oxide and regulation of soluble guanylate cyclase in rat diabetic retinopathy.2003

    • Author(s)
      Schaefer, S
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 457-465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXalpha into bile in the perfused rat liver.2003

    • Author(s)
      Norimuzu, S
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 449-456

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny.2003

    • Author(s)
      Waranabe, T
    • Journal Title

      Arch Histol Cytol 66・2

      Pages: 155-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonizad iNOS-knout mice.2003

    • Author(s)
      Miyazawa, M
    • Journal Title

      Free Radic Biol Med 34・12

      Pages: 1621-1630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leygig Cells.2003

    • Author(s)
      Ogishima, T
    • Journal Title

      J Biol Chem 278・23

      Pages: 21204-21211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The undifferentiated call zone is a atem cell zone in adult ray adrenal cortex.2003

    • Author(s)
      Mitani, F
    • Journal Title

      Biochim Biophys Acta 1619・3

      Pages: 317-324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina.2003

    • Author(s)
      Kajimura, M
    • Journal Title

      FASEB J 17・3

      Pages: 506-508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction.2003

    • Author(s)
      Murai, M
    • Journal Title

      Nat Immunol 4・2

      Pages: 154-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human serum albumin incorporating synthetic heme : red blood cell substitute without hypertension by nitrc oxide scavenging.2003

    • Author(s)
      Tsuchida, E
    • Journal Title

      J Biomed Materr Res A 64・2

      Pages: 257-261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.2003

    • Author(s)
      Nagano S, Shimada H, Tarumi A, Hishiki T, Kimata-Ariga Y, Egawa T, Suematsu M. Park SY, Adachi S, Shiro Y, Ishimura Y.
    • Journal Title

      Biochemistry 42・49

      Pages: 14507-14514

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bilirubin rinse : A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning.2003

    • Author(s)
      Kato Y, Shimazu M, Kondo M, Uchida K, Kumamoto Y, Wakabayashi G, Kitajima M, Suematsu M.
    • Journal Title

      Hepatology 38・2

      Pages: 364-373

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta-hydroxylase in adrenocortical cells.2003

    • Author(s)
      Mukai K, Mitani F, Nagasawa H, Suzuki R, Suzuki T, Suematsu M, Ishimura Y.
    • Journal Title

      J Biol Chem 278・19

      Pages: 17084-17092

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

    • Author(s)
      Egawa T, Yoshioka S, Takahashi S, Hori H, Nagano S, Shimada H, Ishimori K, Morishima I, Suematsu M, Ishimura Y.
    • Journal Title

      J Biol Chem 278・43

      Pages: 41597-41606

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quartet signal transducers in gas biology.2003

    • Author(s)
      Suematsu M.
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 435-437

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanistic probing of gaseous signal transduction in microcirculation.2003

    • Author(s)
      Suematsu M, Suganuma K, Kashiwagi S.
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 485-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aberrant utilization of nitric oxide and regulation of soluble guanylate cyclase in rat diabetic retinopathy.2003

    • Author(s)
      Schaefer S, Kajimura M, Tsuyama S, Uchida K, Sato E, Inoue M, Suematsu M, Watanabe K.
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 457-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXalpha into bile in the perfused rat liver.2003

    • Author(s)
      Norimizu S, Kudo A, Kajimura M, Ishikawa K, Taniai H, Yamaguchi T, Fujii K, Arii S, Nimura Y, Suematsu M.
    • Journal Title

      Antioxid Redox Signal 5・4

      Pages: 449-456

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny.2003

    • Author(s)
      Watanabe T, Hasegawa G, Yamamoto T, Hatakeyama K, Suematsu M, Naito M.
    • Journal Title

      Arch Histol Cytol 66・2

      Pages: 155-162

    • NAID

      10011992787

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice.2003

    • Author(s)
      Miyazawa M, Suzuki H, Masaoka T, Kai A, Suematsu M, Nagata H, Miura S, Ishii H.
    • Journal Title

      Free Radic Biol Med 34・12

      Pages: 1621-1630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells.2003

    • Author(s)
      Ogishima T, Kinoshita JY, Mitani F, Suematsu M, Ito A.
    • Journal Title

      J Biol Chem 278・23

      Pages: 21204-21211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex.2003

    • Author(s)
      Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y.
    • Journal Title

      Biochim Biophys Acta 1619・3

      Pages: 317-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina.2003

    • Author(s)
      Kajimura M, Shimoyama M, Tsuyama S, Suzuki T, Kozaki S, Takenaka S, Tsubota K, Oguchi Y, Suematsu M.
    • Journal Title

      FASEB J 17・3

      Pages: 506-508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction.2003

    • Author(s)
      Murai M, Yoneyama H, Ezaki T, Suematsu M, Terashima Y, Harada A, Hamada H, Asakura H, Ishikawa H, Matsushima K.
    • Journal Title

      Nat Immunol 4・2

      Pages: 154-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human serum albumin incorporating synthetic heme : red blood cell substitute without hypertension by nitric oxide scavenging.2003

    • Author(s)
      Tsuchida E, Komatsu T, Matsukawa Y, Nakagawa A, Sakai H, Kobayashi K, Suematsu M.
    • Journal Title

      J Biomed Mater Res A. 64・2

      Pages: 257-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nonendothelial siurce of nitric oxide in arteriles but not in venules : alternative source revealed in vivo by diaminofluorescein microfluorofraphy.2002

    • Author(s)
      Kashiwagi, S
    • Journal Title

      Circ Res 91・12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The protective role of Kupffer cells in the ischemia-reperfused rat liver.2002

    • Author(s)
      Kobayashi, T
    • Journal Title

      Arch Histol Cytol 65・3

      Pages: 251-261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Organ design for generation and reception of CO : lessons from the liver2002

    • Author(s)
      Kajimura, M
    • Journal Title

      Antioxid Redox Signal 4・4

      Pages: 633-637

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhession through platelet-dependent mechanisms.2002

    • Author(s)
      Morisaki, H
    • Journal Title

      Anesthesiology 97・3

      Pages: 701-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Stabilization of mast calls by heme oxygenase-1 : an anti-inflammatory role.2002

    • Author(s)
      Takamiya, R
    • Journal Title

      Am J Physiol Heart Circ Physiol 283・3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The inflammatory aspecty aspect of the micriciculation in hypertensin : oxdative stress, leukocytes/endothelial interaction, apoptosis.2002

    • Author(s)
      Suematsu, M
    • Journal Title

      Microcirculation 9・4

      Pages: 259-276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] COHb : a stress-inducad maeker reflecting surgical insults?2002

    • Author(s)
      Suematsu, M
    • Journal Title

      J Gastroenterol Hepatol 17・5

      Pages: 519-520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] No difference in the level of gastric mucosal cell apoptosis and proliferation in Helicobacter pylori-colonizad p53 heterrozygous knockout mine.2002

    • Author(s)
      Suzuki, H
    • Journal Title

      Aliment Pharmacol Tjer 16・12

      Pages: 158-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nonendothelial source of nitric oxide in arterioles but not in venules : alternative source revealed in vivo by diaminofluorescein microfluorography.2002

    • Author(s)
      Kashiwagi S, Kajimura M, Yoshimura Y, Suematsu M.
    • Journal Title

      Circ Res 91・12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The protective role of Kupffer cells in the ischemia-reperfused rat liver.2002

    • Author(s)
      Kobayashi T, Hirano K, Yamamoto T, Hasegawa G, Hatakeyama K, Suematsu M, Naito M.
    • Journal Title

      Arch Histol Cytol 65・3

      Pages: 251-261

    • NAID

      50000651396

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Organ design for generation and reception of CO : lessons from the liver.2002

    • Author(s)
      Kajimura M, Goda N, Suematsu M.
    • Journal Title

      Antioxid Redox Signal 4・4

      Pages: 633-637

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms.2002

    • Author(s)
      Morisaki H, Katayama T, Kotake Y, Ito M, Handa M, Ikeda Y, Takeda J, Suematsu M.
    • Journal Title

      Anesthesiology 97・3

      Pages: 701-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Stabilization of mast cells by heme oxygenase-1 : an anti-inflammatory role.2002

    • Author(s)
      Takamiya R, Murakami M, Kajimura M, Goda N, Makino N, Takamiya Y, Yamaguchi T, Ishimura Y, Hozumi N, Suematsu M.
    • Journal Title

      Am J Physiol Heart Circ Physiol 283・3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The inflammatory aspect of the microcirculation in hypertension : oxidative stress, leukocytes/endothelial interaction, apoptosis.2002

    • Author(s)
      Suematsu M, Suzuki H, Delano FA, Schmid-Schonbein GW.
    • Journal Title

      Microcirculation 9・4

      Pages: 259-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] COHb : a stress-induced marker reflecting surgical insults?2002

    • Author(s)
      Suematsu M.
    • Journal Title

      J Gastroenterol Hepatol 17・5

      Pages: 519-520

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] No difference in the level of gastric mucosal cell apoptosis and proliferation in Helicobacter pylori-colonized p53 heterozygous knockout mice.2002

    • Author(s)
      Suzuki H, Miyazawa M, Kai A, Suzuki M, Suematsu M, Miura S, Ishii H.
    • Journal Title

      Aliment Pharmacol Ther 16・12

      Pages: 158-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Katagiri, H.: "Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice."Hepatology. 39・1. 139-150 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagano, S: "Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam."Biochemistry. 42・49. 14507-14514 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato, Y: "Bilirubin rinse : A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning."Hepatology. 38・2. 364-373 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mukai, K: "An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta -hydroxylase in adrenocortical cells."J Biol Chem.. 278・19. 17084-17092 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Egawa, T: "Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide."J Biol Chem.. 278・43. 41597-41606 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suematsu, M: "Quartet signal transducers in gas biology."Antioxid Redox Signal.. 5・4. 435-437 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murai, M., Yoneyama, H., Ezaki, T., Suematsu, M., et al.: "Subendothelial dome of gut Peyer's patches is the essential anatomical site in initiating acute graft-versus-host disease"Nat. Immunol.. 4. 154-160 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kashiwagi, S., Kajimura, M., Yoshimura, Y., Suematsu, M.: "Nonendothelial source of nitric oxide in arterioles but not in venules: Alternative source revealed in vivo by diaminofluorescein microfluorography"Circulation Research (Ultrarapid Communication). 91. e55-e64 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kajimura, M., Shimoyama, M., Tsuyama, S., Suematsu, M., et al.: "Visualization of gaseous monoxide reception by soluble guanylate cyclase in rat retina"FASEB Journal (on line). fje. fj.02-0359fje (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Goda, N., Ryan, HE, et al.: "Hypoxia-inducible factor lalpha is essential for cell cycle arrest during hypoxia"Mol Cell Biol.. 23(1). 359-369 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takamiya, R., Murakami, M., et al.: "Stabilization of mast cells by heme oxygenase-1 : an anti-inflammatory role"Am J Physiol Heart Circ Physiol. 283. H861-H870 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ozawa, N., Goda, N., et al.: "Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress"J. Clin. Invest.. 109. 457-467 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori, R., Kashiba, M., et al.: "Gene transfer of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity"J. Biol. Chem.. 277. 10712-10718 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2017-05-19  

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