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The protective roles of IL-18 in host defense against gastro-intestinal nematode infection by in duction of Th2 responses.

Research Project

Project/Area Number 14370086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 寄生虫学(含医用動物学)
Research InstitutionHyogo College of Medicine

Principal Investigator

YOSHIMOTO Tomohiro  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60241171)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Kenji  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60172350)
TSUTSUI Hiroko  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (40236914)
YASUDA Koubun  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 助手 (50333539)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2003: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2002: ¥6,900,000 (Direct Cost: ¥6,900,000)
KeywordsIL-18 / Th2 response / mucosal mast cells / mMCP-1 / gastrro-intesinal nematbde / host defense
Research Abstract

IL-18 enhances the IL-12-deriven Th1 immune responses, but it can also stimulate Th2 immune response in the absence of IL-12. Here we show that IL-18 plus IL-2 treatment of mice induces Th2 cytokines(IL-3,IL-4,IL-9 and IL-13), intestinal mucosal mast cells(MMC) and the release of MMC-specific mouse mast cell protease-1(mMCP-1), resulting in extremely rapid expulsion of adult worms of gastrointestinal nematode Strongyloides venezuelensis(S.venezuelensis). This induction is dependent on CD4+ T cells, but not on stat6. Wild-type mice infected with S.venezuelensis L3 significantly increase in serum levels of IL-18. Furthermore, when IL-18-/-mice are infected with S.venezuelensis L3, worm expulsion is significantly delayed as compared with wild-type mice. These findings establish a role for IL-18 in immunity to gastrointestinal nematode by induction of functional intestinal MMC.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Yoshimoto, T., Min, B., et al.: "Non-redundant roles for CD1d-restricted NKT cells and conventional CD4^+ T cells in the induction of IgE antibodies in response to IL-18 treatment of mice."J.Exp.Med.. 197. 997-1005 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugimoto, T, Yoshimoto, T., et al.: "Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse."J.Exp.Med.. 199. 535-545 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 善本知広, 中西憲司: "IL-18と好塩基球"アレルギー科. 13. 505-511 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 善本知広, 中西憲司: "IL-18によるIgE産生誘導の分子機構"臨床免疫. 38. 164-170 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 善本知広, 筒井ひろ子, 中西憲司: "IL-18によるTh1/Th2免疫応答の制御"Annu.Rev. 免疫2003. 78-88 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 善本知広, 中西憲司: "寄生虫感染症と免疫"内科. 91. 341-344 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsutsui, H., Yoshimoto, T., et al.: "IL-18 and IL-18 Receptor Knockout Mouse."Human Press, Totowa, New Jersey. 19 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimori, Y., Yoshimoto, T., Matsui, K., Tsutsui, H., Okamoto, T., Kashiwamura, S., Hada, T., Okamura H., Kakishita, E., Hara H., Nakanishi K.: "Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host diseases after alogenic bone marrow transplantation."J.Interferon.Cytokine.Res.. 22. 751-754 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoshimoto, T., Min, B., Sugimoto, T., Hayashi, N., Ishikawa, Y., Sasaki, Y., Hata, H., Takeda, K., Okumura, K., Kaer, L.V., Paul, W.E., Nakanishi, K.: "Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to Interleukin 18 treatment of mice."J Exp Med.. 197. 997-1006 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugumoto T, Ysohimoto T, Ishiklawa Y, Hayashi, N., Fujimoto, J., Nakanishi, K.: "IL-18 acts on memory Th1 cells to induce airway inflammation and hyperresponsiveness in a naive host mouse."J.ExMed.. 199. 535-545 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimoto, M., Tsutsui, H., Xinshou, O., Tokumoto, M., watanabe, D., Shima, Y., Yoshimoto, T., Hirakata, H., Kawase, I., Nakanishi, K., Kishimoto, T., Naka, T.: "Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune duseases."Int.Immunol.. 16. 303-314 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamura, H., Lotze, M.T., Tsutsui, H., Kashiwamura, S-I., Ueda, H., Yoshimoto, T., Nakanishi, K.: "Interleukin-18. [IL-1F4] The cytokine handbook (4^<th> edition),(Thomson, A.W. and Lotze, M.T., eds)"Elsevier Science Ltd., London. 709-733 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsutsui, H., Yoshimoto, T., Okamura, H., Akira, S., Nakanishi, K.: "IL-18 and IL-18 Receptor Knockout Mouse. Cytokine Knockouts (Giamila Fantuzzi, eds)"Human Press, Totowa, New Jersey. 303-322 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsutsui, H., Yoshimoto, T., Okamura, H., Nakanishi, K.: "Interlukin-18. Encyclopedia of Hormones(HL.Henry and AW.Norman, eds.)"Elsevier Science. 493-500 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugimoto, T., Yoshimoto, T., et al.: "Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse."J.Exp.Med.. 199(4). 535-545 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshimoto T., Min, B., et al.: "Non-redundant roles for CD1d-restricted NKT cells and conventional CD4^+ T cells in the induction of IglE antibodies in response to IL-18 treatment of mice."J.Exp.Med.. 197. 997-1005 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 善本知広, 中西憲司: "アトピー性皮膚炎とサイトカイン"Annual Review 免疫 2004. 139-150 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujimori, Y., Yoshimoto, T., et al.: "Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation."J.Interferon.Cytokine.Res.. 22. 751-754 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 善本知広, 中西憲司: "寄生虫感染症と免疫"内科. 91. 341-344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 善本知広: "新しいアトピーの概念:IL-18による自然型アトピーの誘導"兵医大医会誌(Acta Med.Hyogo). 28. 139-150 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsutsui, H., Yoshimoto, T.: "Cytokine Knockouts"Human Press, Totowa, New Jersey. 471 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 善本知広, 中西憲司: "IL-18と好塩基球"アレルギー科. 13. 505-511 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 善本知広, 中西憲司: "IL-18によるIgE産生誘導の分子機構"臨床免疫. 38. 164-170 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 善本知広, 筒井ひろ子, 中西憲司: "IL-18によるTh1/Th2免疫応答の制御"Annu. Rev. 免疫2003. 78-88 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中西憲司, 筒井ひろ子, 善本知広: "免疫研究の最前線:IL-18とアトピー性炎症"蛋白、核酸、酵素. 38. 164-170 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 善本知広, 中西憲司: "アレルギー:免疫学コア講義"南山堂(木本雅夫、坂口薫雄、山下優毅編集). 6 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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