|Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
(1)In 2002, we collected baseline data from medical records of 22128 men who attended a checkup in a medical center. The data includes indices (present/past medical history, body height/weight, blood pressure, blood glucose, serum triglycerides and HDL-cholesterol)related to insulin-resistance syndrome≒metabolic syndrome (MS : diagnosed by four MS-factors : 1)obesity, 2)high blood pressure, 3)high blood glucose and 4)dyslipidemia), confounding factors (age, lifestyle and other blood indices) and occupational factors (job title, work-day, work-hour, holiday, work-system and work-activity). Same data from 14614, 17953 and 18066 men were collected in 2003, 2004 and 2005, respectively. All the data have been accumulated in a data base.
(2)Out of 22128 men in 2002, 15242 workers were selected as 'baseline healthy subjects' using the six following eligibility criteria; 1)age: 30-59 years, 2)full-time workers, 3)no present disease or medical treatment, 4)no history of diabetes, hypertension, h
yperlipidemia or malignancy, 5)fasted blood sample without hemolysis and 6)complete data on all required factors. In the 15242 workers, A)policemen/firefighters, service workers, manager/administrative workers, B)almost everyday working, C)short work-time per day (the results are probably due to older subjects). D)night workers, E)low work-activity were related with higher prevalence of the four MS-factors and MS.
(3)Out of the 15242 workers, 6739 workers had followed-up data after 3 years. In the 6739 workers, the prevalence of the four MS-factors have increased during the 3 years (+83 to +241 subjects). However, MS-factors and MS have decreased in some subjects. Relations of the changes in the prevalence of MS-factors with occupational factors will be fully analyzed. Age and lifestyle (drinking, smoking and exercise) are used as confounding factors in further analysis of data in(2)and(3).
(4)We carried out follow-up studies on incidence of diabetes (fasted blood glucose【greater than or equal】126mg/dl or medical treatment for diabetes during the follow-up) using past medical records accumulated (from 1988 to 2000) in the medical center, and the results have been presented in medical conferences and published in medical journals.
(5)The Ethics Committee of Nagoya City University Graduate School of Medical Sciences approved this study. Less