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A survey on occupational factors and insulin resistance

Research Project

Project/Area Number 14370141
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagoya City University

Principal Investigator

NAGAYA Teruo  Nagoya City University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (40144018)

Co-Investigator(Kenkyū-buntansha) TOKUDOME Shinkan  Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (00037441)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsOccupation / shift work / work-hour / holidays / insulin resistance / diabetes / serum indices / epidemiology
Research Abstract

(1)In 2002, we collected baseline data from medical records of 22128 men who attended a checkup in a medical center. The data includes indices (present/past medical history, body height/weight, blood pressure, blood glucose, serum triglycerides and HDL-cholesterol)related to insulin-resistance syndrome≒metabolic syndrome (MS : diagnosed by four MS-factors : 1)obesity, 2)high blood pressure, 3)high blood glucose and 4)dyslipidemia), confounding factors (age, lifestyle and other blood indices) and occupational factors (job title, work-day, work-hour, holiday, work-system and work-activity). Same data from 14614, 17953 and 18066 men were collected in 2003, 2004 and 2005, respectively. All the data have been accumulated in a data base.
(2)Out of 22128 men in 2002, 15242 workers were selected as 'baseline healthy subjects' using the six following eligibility criteria; 1)age: 30-59 years, 2)full-time workers, 3)no present disease or medical treatment, 4)no history of diabetes, hypertension, h … More yperlipidemia or malignancy, 5)fasted blood sample without hemolysis and 6)complete data on all required factors. In the 15242 workers, A)policemen/firefighters, service workers, manager/administrative workers, B)almost everyday working, C)short work-time per day (the results are probably due to older subjects). D)night workers, E)low work-activity were related with higher prevalence of the four MS-factors and MS.
(3)Out of the 15242 workers, 6739 workers had followed-up data after 3 years. In the 6739 workers, the prevalence of the four MS-factors have increased during the 3 years (+83 to +241 subjects). However, MS-factors and MS have decreased in some subjects. Relations of the changes in the prevalence of MS-factors with occupational factors will be fully analyzed. Age and lifestyle (drinking, smoking and exercise) are used as confounding factors in further analysis of data in(2)and(3).
(4)We carried out follow-up studies on incidence of diabetes (fasted blood glucose【greater than or equal】126mg/dl or medical treatment for diabetes during the follow-up) using past medical records accumulated (from 1988 to 2000) in the medical center, and the results have been presented in medical conferences and published in medical journals.
(5)The Ethics Committee of Nagoya City University Graduate School of Medical Sciences approved this study. Less

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (41 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (39 results) Book (1 results) Publications (1 results)

  • [Journal Article] Policemen and firefighters have increased risk for type-2 diabetes mellitus probably due to their large body mass index : a follow-up study in Japanese men2006

    • Author(s)
      Nagaya T
    • Journal Title

      American Journal of Industrial Medicine 49(1)

      Pages: 30-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Policemen and firefighters have increased risk for type-2 diabetes mellitus probably due to their large body mass index : a follow-up study in Japanese men2006

    • Author(s)
      Nagaya T et al.
    • Journal Title

      American Journal of Industrial Medicine 49

      Pages: 30-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Policemen and firefighters have increased risk for type-2 diabetes mellitus probably due to their large body mass index: a follow-up study in Japanese men2006

    • Author(s)
      Nagaya T
    • Journal Title

      American Journal of Industrial Medicine 49(1)

      Pages: 30-35

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus : a follow-up study in a Japanese population2005

    • Author(s)
      Nagaya T
    • Journal Title

      Diabetic Medicine 22(8)

      Pages: 1107-1111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer : a case-control study in an Indian population2005

    • Author(s)
      Wang J
    • Journal Title

      International Journal of Cancer 118(4)

      Pages: 991-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma carotenoid, alpha-tocopherol and retinol concentrations and risk of colorectal adenomas : A case-control study in Japan2005

    • Author(s)
      Jiang J
    • Journal Title

      Cancer Letters 226(2)

      Pages: 133-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus : a follow-up study in a Japanese population2005

    • Author(s)
      Nagaya T et al.
    • Journal Title

      Diabetic Medicine 22

      Pages: 1107-1111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer : a case-control study in an Indian population2005

    • Author(s)
      Wang J et al.
    • Journal Title

      International Journal of Cancer 118

      Pages: 991-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma carotenoid, alpha-tocopherol and retinol concentrations and risk of colorectal adenomas : A case-control study in Japan2005

    • Author(s)
      Jiang J et al.
    • Journal Title

      Cancer Letters 226

      Pages: 133-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus: a follow-up study in a Japanese population2005

    • Author(s)
      Nagaya T
    • Journal Title

      Diabetic Medicine 22(8)

      Pages: 1107-1111

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population2005

    • Author(s)
      Wang J
    • Journal Title

      International Journal of Cancer 118(4)

      Pages: 991-997

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Plasma carotenoid, alpha-tocopherol and retinol concentrations and risk of colorectal adenomas: A case-control study in Japan2005

    • Author(s)
      Jiang J
    • Journal Title

      Cancer Letters 226(2)

      Pages: 133-141

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A chronological decrease in type A behavior patterns among Japanese male workers in 1995-19992004

    • Author(s)
      Kojima M
    • Journal Title

      Journal of Occupational Health 46(2)

      Pages: 171-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A chronological decrease in type A behavior patterns among Japanese male workers in 1995-19992004

    • Author(s)
      Kojima M et al.
    • Journal Title

      Journal of Occupational Health 46

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A chronological decrease in type A behavior patterns among Japanese male workers in 1995-1999.2004

    • Author(s)
      Kojima M, Nagaya T et al.
    • Journal Title

      J Occupational Health 46(2)

      Pages: 171-174

    • NAID

      110003722938

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alexithymia, depression and social support among Japanese workers2003

    • Author(s)
      Kojima M
    • Journal Title

      Psychotherapy and Psychosomatics 72(6)

      Pages: 307-314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes : a cross-sectional study2003

    • Author(s)
      Kuriki K
    • Journal Title

      Journal of Nutrition 133(11)

      Pages: 3643-3650

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians2003

    • Author(s)
      Tokudome Y
    • Journal Title

      European Journal of Epidemiology 18(10)

      Pages: 945-953

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nature of Japanese Diet : variations in intake of nutrients and foods2003

    • Author(s)
      Tokudome Y
    • Journal Title

      Journal of Community Nutrition 5(2)

      Pages: 72-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Alexithymia, depression and social support among Japanese workers2003

    • Author(s)
      Kojima M et al.
    • Journal Title

      Psychotherapy and Psychosomatics 72

      Pages: 307-314

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes : a cross-sectional study2003

    • Author(s)
      Kuriki K et al.
    • Journal Title

      Journal of Nutrition 133

      Pages: 3643-3650

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians2003

    • Author(s)
      Tokudome Y, et al.
    • Journal Title

      European Journal of Epidemiology 18

      Pages: 945-953

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nature of Japanese Diet : variations in intake of nutrients and foods2003

    • Author(s)
      Tokudome Y, et al.
    • Journal Title

      Journal of Community Nutrition 5

      Pages: 72-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Alexithymia, depression and social support among Japanese workers.2003

    • Author(s)
      Kijima M, Senda Y, Nagaya T et al.
    • Journal Title

      Psychother Psychosom 72(6)

      Pages: 307-314

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes : a cross-sectional study2003

    • Author(s)
      Kuriki K, Nagaya T et al.
    • Journal Title

      J Nutrition 133(11)

      Pages: 3643-3650

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians.2003

    • Author(s)
      Tokudome Y, Kuriki K et al.
    • Journal Title

      Eur J Epidemiol 18(10)

      Pages: 945-953

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Markers of insulin resistance in day and shift workers aged 30-59 years2002

    • Author(s)
      Nagaya T
    • Journal Title

      International Archives of Occupational and Environmental Health 75(8)

      Pages: 562-568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cross-cultural validation of the Beck Depress ion Inventory-II in Japan2002

    • Author(s)
      Kojima M
    • Journal Title

      Psychiatry Research 110(3)

      Pages: 291-299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Daily, weekly, seasonal, within- and between-individual variation in nutrient intake according to four season consecutive 7 day weighed diet records in Japanese female dietitians2002

    • Author(s)
      Tokudome Y
    • Journal Title

      Journal of Epidemiology 12(2)

      Pages: 85-92

    • NAID

      130000797517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correspondence re : Terry et al., No association between fat and fatty acids intake and risk of colorectal cancer. Cancer Epidemiol. Biomark. Prev., 10 : 913-914,20012002

    • Author(s)
      Tokudome S
    • Journal Title

      Cancer Epidemiology, Biomarkers and Prevention 11(2)

      Pages: 217-218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reproducibility of a semi-quantitative food frequency questionnaire in Japanese female dietitians2002

    • Author(s)
      Imaeda N
    • Journal Title

      Journal of Epidemiology 12(1)

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Markers of insulin resistance in day and shift workers aged 30-59 years2002

    • Author(s)
      Nagaya T et al.
    • Journal Title

      International Archives of Occupational and Environmental Health 75

      Pages: 562-568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cross-cultural validation of the Beck Depression Inventory-II in Japan2002

    • Author(s)
      Kojima M et al.
    • Journal Title

      Psychiatry Research 110

      Pages: 291-299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Daily, weekly, seasonal, within-and between-individual variation in nutrient intake according to four season consecutive 7 day weighed diet records in Japanese female dietitians2002

    • Author(s)
      Tokudome Y et al.
    • Journal Title

      Journal of Epidemiology 12

      Pages: 85-92

    • NAID

      130000797517

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correspondence re : Terry et al., No association between fat and fatty acids intake and risk of colorectal cancer. Cancer Epidemiol.Biomark.Prev., 10 : 913-914, 20012002

    • Author(s)
      Tokudome S et al.
    • Journal Title

      Cancer Epidemiology, Biomarkers and Prevention 11

      Pages: 217-218

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reproducibility of a semi-quantitative food frequency questionnaire in Japanese female dietitians2002

    • Author(s)
      Imaeda N et al.
    • Journal Title

      Journal of Epidemiology 12

      Pages: 45-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Incidence of type-2 diabetes mellitus in a large population of Japanese male white-collar workers

    • Author(s)
      Nagaya T
    • Journal Title

      Diabetes Research and Clinical Practice (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Incidence of type-2 diabetes mellitus in a large population of Japanese male white-collar workers

    • Author(s)
      Nagaya T et al.
    • Journal Title

      Diabetes Research and Clinical Practice (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increases in body mass index (weight/height^2), even within the non-obese level, raise risk for type-2 diabetes mellitus : a follow-up study in Japanese.

    • Author(s)
      Nagaya T.et al.
    • Journal Title

      Diabetic Medicine (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] 公衆衛生学(管理栄養士養成シリーズ)(圓藤吟史 編)(分担執筆)2004

    • Author(s)
      木村美恵子, 徳留信實
    • Total Pages
      222
    • Publisher
      化学同人
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Nagaya T et al.: "Markers of insulin resistance in day and shift workers aged 30-59 years"International Archives of Occupational and Environmental Health. 76,8. 562-568 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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