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Intraocular pressure and glaucoma at working places-combined study of visual function, lifestyle and a pharmacological trial

Research Project

Project/Area Number 14370151
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNational Institute of Industrial Health, Japan

Principal Investigator

SUZUKI Ryo  NATIONAL INSTITUTE OF INDUSTRIAL HEALTH, Yuugai-Hyouka, PRINCIPAL INVESTIGATOR, 有害性評価研究部, 主任研究官 (50163027)

Co-Investigator(Kenkyū-buntansha) ARAKI Shunichi  NATIONAL INSTITUTE OF INDUSTRIAL HEALTH, PRESIDENT, 理事長 (00111493)
OHTANI Katsumi  NATIONAL INSTITUTE OF INDUSTRIAL HEALTH, INVESTIGATOR, 有害性評価研究部, 主任研究官 (50333373)
ARAIE Makoto  TOKYO UNIVERSITY SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学研究科, 教授 (00092122)
HATTORI Yukio  YAMAGUCHIVERSITY SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (80144955)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2003: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥11,100,000 (Direct Cost: ¥11,100,000)
Keywordsindustrial medicine / industrial ophthalmology / glaucoma / intraocular pressure / visual rehabilitation / ocular fatigue / working places / VDT / 緑内障の社会学的研究 / 職域
Research Abstract

PURPOSE :
As an occupational health study, re-evaluation of normal intraocular pressure (IOP) was attempted to investigate possible background factors that contribute to variations in IOP. IOP increases with age among Western populations, while in the Japanese IOP has been confirmed to decrease with aging. Such paradoxical results cannot be reasonably explained without considering systemic conditions and social medicine.
PARTICIP ANTS, MAIN OUTCOME MEASURES and TESTING :
We studied IOPs of 1709 subjects in our vision and health program. The IOPs are 12.5±2.9 mmHg, corrected vision was 0.39±0.25, systolic blood pressure (BP) 134±22, diastolic BP 72±12. The participants underwent an interview and detailed eye examination that included logarithm of minimum angle of resolution visual acuity, refraction, slit-lamp biomicroscopy, explanation tonometry, gonioscopy, dilation, cataract grading, and fundus evaluation.
Relating several states such as myopia and cardiovascular systems, statistical sig … More nificance was observed between age and corrected vision (-0.069^<**>, 3306), between systolic BP and IOPs (0.177^<**>, 3292), between refractive error and IOPs (-0.118^<**>, 2674), respectively.
Myopia : While elevated IOP is associated with myopia in adults, its potential influence on the eyes have been controversial, because number of people were not statistically meaningful. Myopic condition was : <-20 (n=8), -20≦ < -10 (n=76), -10≦ <-5 (n=168), -5≦ <-2 (n=393), -2≦ <-1 (n=249), -1(890), 1≦ (n=890), and the IOPs of each group was changed in a regular fashion.
CONCLUSION and FUTURE PROBLEM :
For preventing high IOP, gene analysis and pharmacological study was done in 2002-2003, and these were reported as 4 reports. As a future problem, it is open to question whether any apparent association between intraocular pressure and age was fully accounted for through the correlation between systolic BP and age. This research was done with care by two doctors who were either an associate professor (principal investigator) or an assistant professor. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] 鈴木 亮: "緑内障、緑内障遺伝子および社会医学的意義"分子・細胞・治療. 1. 434-439 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "「目の疲れ」の先端医学および社会学的対応"分子細胞治療. 1. 532-539 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "緑内障遺伝子と社会医学。新しい治療と検査シリーズ"あたらしい眼科. 19. 1173-1175 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼圧に乃ぼす種々の運動効果の比較"分子細胞治療. 2・2. 171-177 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "血圧と運動後の眼圧の相関"分子細胞治療. 2・3. 303-309 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Ohtani K, Suzuki Reiko, Kunimoto M: "Physical and pharmacological trials to prevent increase of intraocular pressure."13^<th> Afro-Asian Congress of Ophthalmology, Istanbul. (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Kunimoto M, Fujikura Y: "Reduction of intraocular pressure after a short-time exercise and a longer physical training."Brit Med J. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuda A, Suzuki R, Ueno S, Minamoto A, Neriishi K: "Intraocular pressures and other medical features of people who have a certificate of atomic bomb exposure."13^<th> Afro-Asian Congress of Ophthalmology, Istanbul. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 小川康恭: "廃棄物焼却施設内作業におけるダイオキシン類ばく露防止対策 -作業指揮者テキスト-"中央労働災害防止協会. 130 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼の先端医学。社会医学的立場から。"分子細胞治療. 1(2). 236-242 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "緑内障、緑内障遺伝子および社会医学的意義。"分子細胞治療. 1. 434-439 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "「目の疲れ」の先端医学および社会学的対応。"分子細胞治療. 1. 532-539 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼房水の流出に関する生体の予防医学的意義。"分子細胞治療. 1. 643-647 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "医学の方法と基礎、臨床、社会医学について。"分子細胞治療. 2(1). 76-81 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "緑内障遺伝子と社会医学。新しい治療と検査シリーズ"あたらしい眼科. 19. 1173-1175 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼圧に及ぼす種々の運動効果の比較。"分子細胞治療. 2(2). 171-177 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "血圧と眼圧について。基礎、臨床、社会医学的観点から。"分子細胞治療. 2(3). 303-309 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "先端医学と白内障手術。"分子細胞治療. 2(5). 421-428 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮, 藤倉義久: "水晶体の加齢、ギャップ結合とHAM8抗原。"2(5). 553-558 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "瞳孔と社会医学。感覚器の基礎、臨床、社会医学。"分子細胞治療. 2(6). 684-690 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 荒記俊一, 鈴木 亮, 平田衞: "第2章 : 室内環境に関連する病態(2)中毒、中毒総論"室内空気質健康影響研究会報告書(厚生労働省). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 平田 衞, 荒記俊一, 鈴木 亮: "シックビルディング症候群、シックハウス症候群-労働衛生学の見地から。"アレルギー・免疫. 10. 1610-1615 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼の性差と社会医学。感覚器の基礎、臨床、社会医学。"分子細胞治療. 3(1). 130-134.24 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "左顔前美人と表情の眼科学(眼瞼学からの一考察)。"分子細胞治療. 3. 247-250 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Ogawa Y, Okuda: "Ocular dominancy and asymmetrical visual field disturbance."Invest Ophthalmol Vis Sci.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Kunimoto M, Ueno S, Inoue M: "Reduction of intraocular pressure after combined short-time exercise and longer physical training."Invest Ophthalmol Vis Sci.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R: "Participated in NIOSH/JICA project. News Letter.p1."NIOSH/JICA project. vol.7. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Ueno S, Inoue M, Kiuchi Y, Yasuda H: "Reduction of intraocular pressure after a short-time exercise and a longer physical training."27^<th> International Congress on Occupational Health. FP48.2. 167 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno S, Yokoyama K, Nakagawa M, Suzuki R, Araki S: "Effects of pH on force and stiffness of slow and fast muscle."27^<th> International Congress on Occupational Health. PO 18.9. 183 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yasuda A, Suzuki R, Ueno S, Minamoto A, Neriishi K, Suzuki Reiko: "Intraocular pressures and other medical features of people who have a certificate of atomic bomb exposure."13^<th> Afro-Asian Congress of Ophthalmology, Istanbul, 2004.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohtani K, Suzuki R, Kobayashi H, Suzuki Reiko: "Drugs and Methods for Increasing Outflow Facility, thereby Reducing Intraocular Pressure. Istanbul"13^<th> Afro-Asian Congress of Ophthalmology, 2004.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki R, Ohtani K, Suzuki Reiko, Kunimoto M: "Physical and pharmacological trials to prevent increase of intraocular pressure. Istanbul"13^<th> Afro-Asian Congress of Ophthalmology, 2004.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "眼の副交感神経系。日本眼科学体系(増田寛次郎監修)"南江堂. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "瞳孔の病理(臼井正彦監修)"診断と治療社. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 鈴木 亮: "医学の方法と基礎、臨床、社会医学について"分子・細胞・治療. 2・1. 76-81 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮: "眼圧に及ぼす種々の運動効果の比較"分子細胞治療. 2・2. 171-177 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮: "血圧と運動後の眼圧の相関"分子細胞治療. 2・3. 303-309 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮: "先端医学と白内障手術,感覚器の基礎,臨床,社会医学"分子細胞治療. 2・4. 421-428 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮, 藤倉義久: "水晶体の加齢現象に及ぼすギャップ結合とHAM8抗原の諸問題"分子細胞治療. 2・5. 553-558 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮: "瞳孔と社会医学.感覚器の基礎,臨床,社会医学"分子細胞治療. 2・6. 684-690 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ryo Suzuki, Yoshiaki Kunimoto, Yoshi Fujikura, Hiromu Mishima: "Reduction of intraocular pressure after a short-time exercise and a longer physical training."Brit Med J. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木 亮: "眼の先端科学.社会医学的立場から.先端医学"分子・細胞・治療. 1・2. 236-242 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮: "ミオシリン遺伝子の検出.その社会医学的意義"分子・細胞・治療. 1・4. 434-439 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮: "「目の疲れ」の統計.社会医学的対応"分子・細胞・治療. 1・5. 532-539 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮: "眼房水の流出測定結果および予防医学的意義"分子・細胞・治療. 1・6. 643-648 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮: "医学の方法と社会医学"分子・細胞・治療. 2・1. 76-82 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮, 服部幸夫: "緑内障遺伝子と社会医学"新しい治療と検査シリーズ. 13A. 32-36 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 亮: "副交感神経薬.眼科学体系新版"増田寛次郎監修,東京,中山書店. 10(197-206) (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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