| Project/Area Number |
14370162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | Niigata University |
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Principal Investigator |
ABO Toru Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (30005079)
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| Co-Investigator(Kenkyū-buntansha) |
SEKIKAWA Hiroho Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助教授 (50018694)
WATANABE Hisami University of the Ryukyus, Center of Molecular Biosciences Immunobiology Group, Professor, 遺伝子実験センター, 教授 (50143756)
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| Project Period (FY) |
2002 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | autoimmune disease / extrathymic T cells / B-1 cell / human liver lymphocyte / B-2 cell / liver transplantation / NZB / WF_1 mice / malaria |
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| Research Abstract |
Malarial parasites are intracellular pathogens and therefore invade erythrocytes and hepatocytes. In this respect, conventional T and B cells could not function against the parasites. Inversely, extrathymic T cells and B-1 cells attack such parasites by their autoreactivity and autoantibodies. These evidences were produced in both murine and human studies. We also found that erythropoiesis was induced in the liver of mice after malarial infection. It is speculated that fresh erythrocytes produced in the liver might be an important target for the parasites. TAP-1(-/-) mice with missing self were also used in this study and extrathymic T cells were abundant in these mice. Innate immunity mediated by extrathymic T cells is found to be importance to eliminate missing self. A similar phenomenon was also seen in mice with stress and in mice with amyloidosis. Granulocytes are also important in parallel with extrathymic T cells and B-1 cells. In 2004, anti-erythropoietin antibody was found to cure malaria when injected into mice with malaria. In 2005 final year, the activation of NKT cells by α-GalCer induced hepatic failure. This result indicated that overactivation of NKT cells is able to induce tissue damage. NK1.1-TCR^<int> cells are also found to be a major lymphocyte subset in malarial infection.
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