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Immunogene therapy for hepatocellular carcinoma : combination with local gene therapy

Research Project

Project/Area Number 14370185
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKagawa University

Principal Investigator

KURIYAMA Shigeki  Kagawa University, Third Department of Internal Medicine, Professor, 医学部, 教授 (50244710)

Co-Investigator(Kenkyū-buntansha) KUROKOHCHI Kazutaka  Kagawa University, Third Department of Internal Medicine, Research Assistant, 医学部, 助手 (10294753)
MASAKI Tsutomu  Kagawa University, Third Department of Internal Medicine, Research Assistant, 医学部, 助手 (30335848)
YOSHIJI Hitoshi  Nara Medical University, Third Department of Internal Medicine, Research Assistant, 医学部, 助手 (40336855)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2004: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2002: ¥6,500,000 (Direct Cost: ¥6,500,000)
Keywordsgene therapy / hepatocellular carcinoma / adenovirus / retrovirus / immunity / cell cycle / tumor suppressor gene / vascularization / 自殺遺伝子 / アデノウイルス / レトロウイルス
Research Abstract

To establish clinically applicable gene therapy for hepatocellular carcinoma (HCC), we carried out several basic researches. Firstly, to examine molecules that play important roles in hepatocarcinogenesis, we assessed the expression of cell cycle-related molecules during the natural HCC development in Long-Evans Cinnamon rats, an animal HCC model. It was shown that the expression of cyclin-dependent kinase 4 (Cdk4) and p46 Shc was increased significantly during hepatocarcinogenesis, while that of cyclin D1 and Cdk6 was not. Furthermore, analyses of human HCC and the adjacent non-HCC cirrhotic liver samples revealed that the expression of p18^<INK4c> was decreased significantly in human HCC compared with the adjacent cirrhotic tissues. It was also shown that the prognosis of patients with HCC negative for p18^<INK4c> was significantly poorer compared with those with HCC positive for p18^<INK4c>. Secondly, we demonstrated that the inhibition of vascular endothelial growth factor receptors in HCC resulted in attenuation of HCC development in rodents. Thirdly, we demonstrated that repetitive intrabiliary administration of adenoviral vectors could induce repetitive transgene expression in rat livers without any immunosuppressive strategies. These results support the feasibility of gene therapy for HCC, because candidates of target molecules for genetic manipulation and delivery routes of recombinant adenovirus were suggested.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (87 results)

All 2005 2004 Other

All Journal Article (35 results) Book (2 results) Publications (50 results)

  • [Journal Article] Adenovirus-mediated gene transfer into rat livers : Comparative study of retrograde intrabiliary and antegrade intraportal administration.2005

    • Author(s)
      Kuriyama S, Yoshiji H, 11others
    • Journal Title

      Oncol Rep 13

      Pages: 69-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful laparoscopic radiofrequency ablation of hepatocellular carcinoma adhered to the mesentery after transcatheter arterial embolization.2005

    • Author(s)
      Kurokohchi K, Masaki T, 12others (14^<th>)
    • Journal Title

      Oncol Rep 13

      Pages: 65-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic polymorphisma influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis.2005

    • Author(s)
      Kimura Y, Selmi C, 11others (7^<th>)
    • Journal Title

      Hepatology 41

      Pages: 55-63

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Adenovirus-mediated gene transfer into rat livers : Comparative study of retrograde intrabiliary and antegrade intraportal administration.2005

    • Author(s)
      Kuriyama S, Yoshiji H, 11 others
    • Journal Title

      Oncol Rep 13

      Pages: 69-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful laparoscopic radiofrequency ablation of hepatocellular carcinoma adhered to the mesentery after transcatheter arterial embolization.2005

    • Author(s)
      Kurokohchi K, Masaki T, 12 others (14^<th>)
    • Journal Title

      Oncol Rep 13

      Pages: 65-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic polymorphisma influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis.2005

    • Author(s)
      Kimura Y, Selmi C, 11 others (7^<th>)
    • Journal Title

      Hepatology 41

      Pages: 55-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Adenovirus-mediated gene transfer into rat livers : Comparative study of retrograde intrabiliary and antegrade intraportal administration.2005

    • Author(s)
      Kuriyama S, Yoshiji H
    • Journal Title

      Oncol Rep 13

      Pages: 69-74

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Successful laparoscopic radiofrequency ablation of hepatocellular carcinoma adhered to the mesentery after transcatheter arterial embolization.2005

    • Author(s)
      Kurokohchi K, Masaki T
    • Journal Title

      Oncol Rep 13

      Pages: 65-68

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic polymorphisma influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis.2005

    • Author(s)
      Kimura Y, Selmi C
    • Journal Title

      Hepatology 41

      Pages: 55-63

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enlargement of thermal ablation zone by the combination of ethanol injection and radiofrequency ablation in excised bovine liver.2004

    • Author(s)
      Watanabe S, Kurokohchi K, 10 others(12^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 279-284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity : Study of regenerating rat liver.2004

    • Author(s)
      Jin Y, Masaki T, Yoshida S, 8 others (11^<th>)
    • Journal Title

      Int J Mot Med 13

      Pages: 721-728

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma.2004

    • Author(s)
      Kurokohchi K, Masaki T, 10 Others (12^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 381-387

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats.2004

    • Author(s)
      Kita Y, Masaki T, 8 others (10^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 1205-1211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Proliferative capability of hepatocytes and expression of G1-related cell cycle molecules in the development of liver cirrhosis in rats.2004

    • Author(s)
      Funakoshi F, Masaki T, 7 others (9^<th>)
    • Journal Title

      Int J Mol Med 13

      Pages: 779-787

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice.2004

    • Author(s)
      Yoshiji H, Kuriyama S, 12 others
    • Journal Title

      Hepatology 39

      Pages: 1517-1524

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Involvement of the vascular endothelial growth factor receptor-1 in murine hepatocellular carcinoma development.2004

    • Author(s)
      Yoshiji H, Kuriyama S, 10 others
    • Journal Title

      J Hepatol 41

      Pages: 97-103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Fulminant hepatic failure caused by malignant melanoma of unknown primary origin.2004

    • Author(s)
      Tanaka M, Watanabe S, 6 others (8^<th>)
    • Journal Title

      J Gastroenterol 39

      Pages: 804-806

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Reduced expression of cell cycle regulator p18INK4C in human hepatocellular carcinoma.2004

    • Author(s)
      Morishita A, Masaki T, 15 others (17^<th>)
    • Journal Title

      Hepatology 40

      Pages: 677-686

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies.2004

    • Author(s)
      Tominaga K, Kuriyama S, 9others
    • Journal Title

      Gut 53

      Pages: 1167-1173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells : Study of LEC rats.2004

    • Author(s)
      Yoshida S, Masaki T, 10 others (12^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 1089-1096

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Angiotensin-I converting enzyme inhibitors as potential anti-angiogenic agents for cancer therapy.2004

    • Author(s)
      Yoshiji H, Kuriyama S, 2 others
    • Journal Title

      Current Cancer Drug Targets 4

      Pages: 555-567

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.2004

    • Author(s)
      Li JQ, Wu F, Masaki T, 7others (9^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efficacy of combination therapies of percutaneous or laparoscopic ethanol-lipiodol injection and radiofrequency ablation.2004

    • Author(s)
      Kurokohchi K, Masaki T, 10 others (12^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 1737-1743

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] TOPICS 肝癌に対する遺伝子治療2004

    • Author(s)
      栗山 茂樹
    • Journal Title

      HEPATICA 23

      Pages: 30-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Enlargement of thermal ablation zone by the combination of ethanol injection and radio frequency ablation in excised bovine liver.2004

    • Author(s)
      Watanabe S, Kurokohchi K, 10 others(12^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 279-284

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity : Study of regenerating rat liver.2004

    • Author(s)
      Jin Y, Masaki T, Yoshida S, 8 others (11^<th>)
    • Journal Title

      Int J Mol Med 13

      Pages: 721-728

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma.2004

    • Author(s)
      Kurokohchi K, Masaki T, 10 others (12^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 381-387

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies.2004

    • Author(s)
      Tominaga K, Kuriyama S, 9 others
    • Journal Title

      Gut 53

      Pages: 1167-1173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorecta tumors.2004

    • Author(s)
      Li JQ, Wu F, Masaki T, 7 others (9^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 87-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efficacy of combination therapies of percutaneous or laparoscopic ethanol-lipiodol injection and radio frequency ablation.2004

    • Author(s)
      Kurokohchi K, Masaki T, 10 others (12^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 1737-1743

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enlargement of thermal ablation zone by the combination of ethanol injection and radiofrequency ablation in excised bovine liver.2004

    • Author(s)
      Watanabe S, Kurokohchi K, 10 others (12^<th>)
    • Journal Title

      Int.J Oncol 24

      Pages: 279-284

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma2004

    • Author(s)
      Kurokohchi K, Masaki T, 10 Others (11^<th>)
    • Journal Title

      Int J Oncol 24

      Pages: 381-387

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reduced expression of cell cycle regulator p181NK4C in human hepatocellular carcinoma.2004

    • Author(s)
      Morishita A, Masaki T, 15 others (17^<th>)
    • Journal Title

      Hepatology 40

      Pages: 677-686

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.2004

    • Author(s)
      Li JQ, Wu F, Masaki T, 7 others (9^<th>)
    • Journal Title

      Int J Oncol 25

      Pages: 87-95

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Efficacy of combination therapies of percutaneous, or laparoscopic ethanol-lipiodol injection and radiofrequency ablation.2004

    • Author(s)
      Kurokohchi K, Masaki T
    • Journal Title

      Int J Oncol 25

      Pages: 1737-1743

    • Related Report
      2004 Annual Research Report
  • [Book] II.生理と病態(戸田剛太郎、税所宏光、寺野彰、幕内雅敏編)2004

    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] II.生理と病態2004

    • Publisher
      中外医学社
    • Related Report
      2004 Annual Research Report
  • [Publications] Masaki T, Shiratori Y, Rengifo W, 9 Others(last).: "Cyclins and cyclin-dependent kinases : comparative study of hepatocellular carcinoma versus cirrhosis."Hepatology. 37. 534-543 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morishita A, Murota M, Fujita J, 6 Others(last).: "Autoreactive helper T cells specific for cytokeratin 19 in patients with autoimmune hepatitis."Hepatol Res. 25. 415-422 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murota M, Watanabe S, Fujita J, 10 Others(last).: "Aberrant cytokeratin expression and high susceptibility to apoptosis in autoimmune hepatitis."Hepatol Res. 25. 271-280 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kobara H, Uchida N, Tsutsui K, 4 Others(last).: "Abnormal bile flow in patients with achalasia."J Gastroenterol. 38. 327-331 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kurokohchi K, Masaki T, Arima K, 8 Others(last).: "CD28-negative CD8-positive cytotoxic T lymphocytes mediate Hepatocellular damage in hepatitis C virus infection."J Clin Immunol. 23. 518-527 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wakabayashi H, Ushiyama T, Ishimura K, 6 Others(8^<th>).: "Significance of reduction surgery in multidisciplinary treatment of advanced hepatocellular carcinoma with multiple intrahepatic lesions."J Surg Oncol. 82. 98-103 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 8 Others.: "Angiotensin-II induces the tissue inhibitor of metalloproteinases-1 through the protein kinase-C signaling pathway in rat liver fibrosis development."Hepatol Res. 27. 51-56 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iihara N, Kurokohchi K, Tsukamoto T, 5 Others(5^<th>).: "Hypoglycaemia in patients with liver diseases administered levothyroxine."J Clin Pharm Ther. 28. 355-361 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Li J-Q, Wu F, Usuki H, 9 Others(9^<th>).: "Loss of p57^<KIP2> is associated with colorectal carcinogenesis."Int J Oncol. 23. 1537-1543 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida N, Tsutsui K, Ezaki T, 10 Others(last).: "Combination of assay of human telomerase reverse transcriptase mRNA and cytology using bile obtained by endoscopic transpapillary catheterization into the gallbladder for diagnosis of gallbladder carcinoma."Am J Gastroenterol. 98. 2415-2419 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noguchi R, Yoshiji H, Kuriyama S, 11 Others.: "Combination of interferon-β and the angiotensin-converting enzyme inhibitor, perindopril, attenuates murine hepatocellular carcinoma development and angiogenesis."Clin Cancer Res. 9. 6038-6045 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida N, Tsutsui K, Kobara H, 8 Others(last).: "A case of gallbladder carcinoma diagnosed preoperatively by the detection of human telomerase reverse transcriptase mRNA in endoscopically obtained gallbladder bile."Endoscopy. 35. 185-188 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 11 Others.: "Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis."Gut. 52. 1347-1354 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Li J-Q, Kubo A, Wu F, 11 Others(last).: "Cyclin B1,unlike cyclin G1,increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes."Int J Oncol. 22. 1101-1110 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 8 Others.: "Extracellular matrix remodeling may predominate over hepatocyte injury in hepatocellular carcinoma development."Oncol Rep. 10. 957-962 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikenaka Y, Yoshiji H, Kuriyama S, 8 Others.: "Tissue inhibitor of metalloproteinases-1(TIMP-1) inhibits tumor growth and angiogenesis in the timp-1 transgenic mouse model."Int J Cancer. 105. 340-346 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 8 Others.: "The copper-chelating agent, trientine, attenuates liver enzymealtered preneoplastic lesions in rats by angiogenesis suppression."Oncol Rep. 10. 1369-1373 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masaki T, Igarashi K, Tokuda M, 11 Others(last).: "pp60c-src activation in lung adenocarcinoma."Eur J Cancer. 39. 1447-1455 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe S, Uchida N, Masaki T, 7 Others(6^<th>).: "Measurement of left portal vein blood flow velocity by doppler sonography in a patient with acute fatty liver of pregnancy."J Med Ultrasound. 30. 57-61 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida N, Tsutsui K, Ezaki T, 5 others(last).: "Conversion from external nasobiliary drainage to internal drainage using endoscopically available scissor forceps."Hepato Gastroenterol. 50. 1891-1893 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsujimoto T, Kuriyama S, Yoshiji H, 4 Others.: "Ultrasonographic findings of amebic colitis."J Gastroenterol. 38. 82-86 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akahane T, Kuriyama S, Matsumoto M, 5 Others.: "Pancreatic pleural effusion with a pancreaticopleural fistula diagnosed by magnetic resonance cholangiopancreatography and cured by somatostatin analogue treatment."Abdom Imaging. 28. 92-95 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida N, Ezaki T, Fukuma H, 10 Others(last).: "Concomitant colitis associated with primary sclerosing cholangitis."J Gastroenterol. 38. 482-487 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuriyama S, Tsujinoue H, Yoshiji H: "Immune response to suicide gene therapy. In : Methods in Molecular Medicine vol. 90 (Springer CJ ed.)"Humana Press, Totowa, New Jersey, USA. 353-369 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 栗山茂樹, 吉治仁志, 正木 勉ほか12名: "AFP遺伝子の制御領域を含むキメラ制御因子を用いた肝癌細胞選択的遺伝子発現の誘導 IN:臨床応用を目指した消化器分子生物学(小俣政男 編)"アークメディア、東京. 93-99 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Fukui H: "Renin-angiotensin system and hepatocellular carcinoma : Role of angiogenesis. In : Recent Reserarch Development in Cancer Vol 5 (Mukhtar H, Labrie F, eds.)"Transworld Research Network, Kerela, India. 39-51 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 栗山茂樹: "消化器癌に対する遺伝子治療の現状In:肝・胆・膵疾患の最新医療(戸田剛太郎、沖田 極、松野正紀:編集主幹.井廻道夫、河田純男、熊田博光、小菅智男、幕内雅敏、門田守人:編集委員.)"先端医療技術研究所、東京. 13-19 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshida S, Kurokohchi K, Arima K, 7 Others (last): "Clinical significance of lens culinaris agglutinin-reactive fraction of serum α-fetoprotein in patients with hepatocellular carcinoma"Int J Oncol. 20. 305-309 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wu F, Nishioka M, Fujita J, 4 Others (last): "Expression of cytokeratin 19 in human hepatocellular carcinoma cell lines"Int J Oncol. 20. 31-37 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uchida N, Ezaki T, Fukuma H, 12 Others (last): "Conversion of endoscopic nasobiliary drainage to internal drainage by means of endoscopic scissor forceps"Endoscopy. 34. 180 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakai S, Masaki T, Shiratori Y, 5 Others (last): "Expression of p57^<KIP2> in hepatocellular carcinoma : relationship between tumor differentiation and patient survival"Int J Oncol. 20. 769-775 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 9 Others: "Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma"Hepatology. 35. 834-842 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Deguchi A, Arima K, Masaki T, 7 Others (last): "Enhanced expression of bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis"Int J Mol Med. 9. 571-577 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akahane M, Kuriyama S, Ohgushi H, 7 Others: "Enhancing and suppressing effects of dexamethasone on transgene expression in vitro."Int J Mol Med. 10. 107-112 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Watanabe S, Sasahara K, Kinekawa F, 8 Others (last): "Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer"Oncol Rep. 9. 1063-1068 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kurokohchi K, Watanabe S, Masaki T, 8 Others (last): "Combination therapy of percutaneous ethanol injection and radiofrequency ablation against hepatocellular carcinomas difficult to treat"Int J Oncol. 21. 611-615 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wu F, Fujita J, Murota M, 5 Others (last): "CYFRA 21-1 is released in TNF-α-induced apoptosis in the hepatocellular carcinoma cell line HuH-7"Int J Oncol. 21. 441-445 (2002)

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  • [Publications] Kurokouchi K, Watanabe S, Masaki T, 6 Others (last): "Combined use of percutaneous ethanol injection and radiofrequency ablation for the effective treatment of hepatocellular carcinoma"Int J Oncol. 21. 841-846 (2002)

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  • [Publications] Yoshiji H, Yoshii J, Ikenaka Y, 7 Others (9th): "Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats"J Hepatol. 37. 22-30 (2002)

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  • [Publications] Deguchi K, Sasaki I, Tsukaguchi M, 4 Others (last): "Abnormalities of rate-corrected QT intervals in Parkinson's disease-a comparison with multiple system atrophy and progressive supranuclear palsy"J Neurol Sci. 199. 31-37 (2002)

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  • [Publications] Ishizaka S, Shiroi A, Kanda S, 6 Others (6th): "Development of hepatocytes from ES cells after transfection with the HNF-3β gene"FASEB J. 16. 1444-1446 (2002)

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  • [Publications] Ohgi T, Masaki T, Nakai S, 8 Others (last): "Expression of p33^<ING1> in hepatocellular carcinoma : relationships to tumor differentiation and cyclin E kinase activity"Scand J Gastroenterol. 37. 1440-1448 (2002)

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  • [Publications] Wu F.Li J, Miki H, 5 Others (last): "p107 Expression in colorectal tumours rises during carcinogenesis and falls during invasion"Eur J Cancer. 38. 1838-1848 (2002)

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  • [Publications] Yoshiji H, Kuriyama S, Yoshii J, 8 Others: "Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse"Hepatology. 36. 850-860 (2002)

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  • [Publications] Morishita A, Murota M, Fujita J, 6 Others(last): "Autoreactive helper T cells specific for cytokeratin 19 in patients with autoimmune hepatitis"Hepatol Res. (in press). (2002)

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  • [Publications] Murota M, Watanabe S, Fujita J, 10 Others(last): "Aberrant cytokeratin expression and high susceptibility to apoptosis in autoimmune hepatitis"Hepatol Res. (in press). (2002)

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  • [Publications] Kobara H, Uchida N, Tsutsui K, 4 Others(last): "Abnormal bile flow in patients with achalasia"J Gastroenterol. (in press). (2002)

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  • [Publications] Uchida N, Ezaki T, Fukuma H, 10 Others(last): "Concomitant colitis associated with primary sclerosing cholangitis"J Gastroenterol. (in press). (2002)

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  • [Publications] Akahane M, Ohgushi H, Kuriyama S, 3 Others: "Lacz gene transfer to cultured bone marrow cells with hydroxyapatite.In : BIOCERAMICS Volume 14(Brown S, Clarke I, Williams P, eds.)"Trans Tech Publications Ltd, Zurich, Switzerland. 223-226 (2002)

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  • [Publications] Kuriyama S, Tsujinoue H, Nakatani T, 2 Others: "Gene therapy for hepatocellular carcinoma : recent advancements and problems to overcome. In : Molecular Biology and Immunology in Hepatology(Tsuji T, Higashi T, Zeniya M, Mayer zum Buschenfelde K-H, eds.)"Elsevier Science, Amsterdam. 147-168 (2002)

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Published: 2002-04-01   Modified: 2016-04-21  

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