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Sono-cell therapy to coronary artery disease and heart failure

Research Project

Project/Area Number 14370233
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

OMURA Takashi (2005)  Osaka City University, Graduate School of Medicine, research associate, 大学院・医学研究科, 助手 (70295707)

吉川 純一 (2002-2004)  大阪市立大学, 大学院・医学研究科, 教授 (60275245)

Co-Investigator(Kenkyū-buntansha) YOSHIYAMA Minoru  Osaka City University, Graduate School of Medicine, associate professor, 大学院・医学研究科, 助教授 (30240956)
大村 崇  大阪市立大学, 大学院・医学研究科, 助手 (70295707)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsStem cell / sono-therapy / myocardial infarction / heart failure / Myocatrdial infarction / Remodeling / Cell therapy / Stem cell / Signal transduction / Echocardiography
Research Abstract

Cell transplantation offers the promise in the restoration of ventricular function after an extensive myocardial infarction, but the optimal cell therapy remains controversial. Vascular endothelial growth factor (VEGF) plays an important role in inducing angiogenesis. Mesenchymal stem cells (MSCs) may have potential for differentiation to several types of cells, including myocytes. We showed that transplantation of VEGF-expressing MSCs could effectively treat acute myocardial infarction (MI) by providing enhanced cardioprotection, followed by angiogenic effects in salvaging ischemic myocardium. Moreover, to examine the effects of microbubble destruction with ultrasound (MB) combined with bone marrow derived mononuclear cell transplantation (BMT) into ischaemic tissues in rat hind limb ischaemia. MB treatment increased vascular endothelial growth factor mRNA as assessed by real time polymerase chain reaction. At four weeks, the MB group had increases in laser Doppler blood flow index, angiographically detectable collateral vessels, and capillary to muscle fiber ratio in ischaemic limbs compared with the vehicle treated group. Secondly, rats were allocated to vehicle treatment, BMT (5×10(6) cells/rat), or a combination of MB and BMT (MB+BMT) at seven days after hind limb ischaemia. BMT treatment significantly increased LDBFI, angiographic score, and capillary to muscle fiber ratio compared with vehicle treatment. MB may be a useful technique to enhance BMT induced neovascularisation and improve the effect of cell therapy.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (28 results)

All 2006 2005 2004 Other

All Journal Article (16 results) Publications (12 results)

  • [Journal Article] Prevalence and clinical course of the juveniles with Brugada-type ECG in Japanese population.2006

    • Author(s)
      Oe H, Takagi M, Tanaka A, Namba M, Nishibori Y, Nishida Y, Kawarabayashi T, Yoshiyama M, Nishimoto M, Tanaka K, Yoshikawa J.
    • Journal Title

      Pacing Clin Electrophysiol. 28(6)

      Pages: 549-554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries.2005

    • Author(s)
      Fukuda D, Yoshiyama M, Shimada K, Yamashita H, Ehara S, Nakamura Y, Kamimori K, Tanaka A, Kawarabayashi T, Yoshikawa J.
    • Journal Title

      Heart. 10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Impaired coronary circulation in patients with apical hypertrophic2005

    • Author(s)
      Yoshida K, Hozumi T, Takemoto Y, Sugioka K, Watanabe H, Muro T, Yoshiyama M, Takeuchi K, Yoshikawa J.
    • Journal Title

      Echocardiography 22(9)

      Pages: 723-729

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Relation between reduction in ischaemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography.2005

    • Author(s)
      Abe Y, Imai T, Ohue K, Otsuka R, Komatsu R, Otsuka M, Sakanoue Y, Naruko T, Itoh A, Yoshiyama M, Haze K, Yoshikawa J.
    • Journal Title

      Heart 91(8)

      Pages: 92-1093

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel technique to detect total occlusion in the right coronary artery using retrograde flowby transthoracic Doppler echocardiography.2005

    • Author(s)
      Otsuka R, Watanabe H, Hirata K, Tokai K, Muro T, Hozumi T, Yoshiyama M, Yoshikawa J.
    • Journal Title

      J Am Soc Echocardiogr. 18(7)

      Pages: 704-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Impaired coronary circulation in patients with apical hypertrophic.2005

    • Author(s)
      Yoshida K, Hozumi T, Takemoto Y, Sugioka K, Watanabe H, Muro T, Yoshiyama M, Takeuchi K, Yoshikawa J.
    • Journal Title

      Echocardiography. 22(9)

      Pages: 723-729

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relation between reduction in ischaemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography.2005

    • Author(s)
      Abe Y, Imai T, Ohue K, Otsuka R, Komatsu R, Otsuka M, Sakanoue Y, Naruko T, Itoh A, Yoshiyama M, Haze K, Yoshikawa J.
    • Journal Title

      Heart. 91(8)

      Pages: 1092-1093

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel technique to detect total occlusion in the right coronary artery using retrograde flow by transthoracic Doppler echocardiography.2005

    • Author(s)
      Otsuka R, Watanabe H, Hirata K, Tokai K, Muro T, Hozumi T, Yoshiyama M, Yoshikawa J.
    • Journal Title

      J Am Soc Echocardiogr. 18(7)

      Pages: 704-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries2005

    • Author(s)
      Fukuda D, Yoshiyama M, Shimada K, Yamashita H, Ehara S, Nakamura Y, Kamimori K, Tanaka A, Kawarabayashi T, Yoshikawa J.
    • Journal Title

      Heart. 10

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relation between reduction in ischaemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography.2005

    • Author(s)
      Abe Y, Imai T, Ohue K, Otsuka R, Komatsu R, Otsuka M, Sakanoue Y, Naruka T, Itoh A, Yoshiyama M, Haze K, Yoshikawa J.
    • Journal Title

      Heart 91(8)

      Pages: 1092-1093

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Core Protein of Hepatitis C Virus Induces Cardiomyopathy.2005

    • Author(s)
      Omura T, Yoshiyama M, Hayashi T, Iwao H, Yoshikawa J et al.
    • Journal Title

      Circ Res. 96

      Pages: 148-150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression.2004

    • Author(s)
      Omura T, Yoshiyama M, Akioka K, Takeuchi K, Yoshikawa J et al.
    • Journal Title

      Arterioscler Thromb Vase Biol. 24

      Pages: 270-275

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of cellular cardiomyoplasty on ventricular remodeling assessed by Doppler echocardiography and topographic immunohistochemistry.2004

    • Author(s)
      Yoshiyama M, Hayashi T, Nakamura Y, Omura T, Yoshikawa J et al.
    • Journal Title

      Circ J. 68

      Pages: 580-586

    • NAID

      110002692160

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cardioprotective effect of SEA0400, a selective inhibitor of the Na(+)/Ca(2+) exchanger, on myocardial ischemia-reperfusion injury in rats.2004

    • Author(s)
      Yoshiyama M, Nakamura Y, Omura T, Iwao H, Yoshikawa J et al.
    • Journal Title

      J Pharmacol Sci. 95

      Pages: 196-202

    • NAID

      10013294783

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats 〜 〜.2004

    • Author(s)
      Matsumoto R, Yoshiyama M, Omura T, Kim S, Akioka K et al.
    • Journal Title

      Circ J. 68

      Pages: 376-382

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Additive improvement of left ventricular remodeling by aldosterone receptor blockade with eplerenone and angiotensin II type 1 receptor antagonist 〜 〜.2004

    • Author(s)
      Yoshiyama M, Omura T, Yoshikawa J.
    • Journal Title

      Nippon Yakurigaku Zasshi 124(2)

      Pages: 83-89

    • Related Report
      2004 Annual Research Report
  • [Publications] Omura T, Yoshiyama M, Matsumoto R, Akioka K, Takeuchi K, Yoshikawa J: "Involvement of Apoptosis Signal-Regulating Kinase-1 on Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression"Arterioscler Thromb Vasc Biol.. 24. 270-275 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukuda D, Shimada K, Tanaka A, Kawarabayashi T, Yoshiyama M, Yoshikawa J: "Circulating monocytes and in-stent neointima after coronary stent implantation"J Am Coll Cardiol.. 43. 18-23 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Izumi Y, Kim S, Yoshiyama M, Izumiya Y, Yoshikawa J, Iwao H: "Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia"Circulation. 108. 2812-2818 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura Y, Yoshiyama M, Omura T, Takeuchi K, Yoshikawa J.: "Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction"Cardiovasc Res.. 57. 48-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Izumiya Y, Kim S, Izumi Y, Yoshida K, Yoshiyama M, Matsuzawa A, Ichijo H: "Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling"Circ Res. 93. 874-883 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Omura T, Yoshiyama M, Kim S, Iwao H, Takeuchi K, Yoshikawa J: "Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine"Hypertension. 39. 81-86 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura Y, Yoshiyama M, Omura T, Yoshida K, Izumi Y, Takeuchi K, Kim S, Yoshikawa J: "Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction"Cardiovascular Research. 57. 48-54 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Muro T, Hozumi T, Watanabe H, Yamagishi H, Yoshiyama M, Takeuchi K, Yoshikawa J.: "Assessment of myocardial perfusion abnormalities by intravenous myocardial contr ast echocardiography with harmonic power Doppler imaging : comparison with positron emission tomography"Heart.. 89. 145-149 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shirai N, Yamagishi H, Yoshiyama M, Teragaki M, Akioka K, Takeuchi K, Yoshikawa J, Ochi H.: "Incremental value of assessment of regional wall motion for detection of multivessel coronary antery disease in exercise (201)Tl gated myocardi perfusion imaging"Journal of Nuclear Medicine. 43. 443 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Omura T, Yoshiyama M, Yoshida K, Nakamura Y, Kim S, Iwao H, Takeuchi K, Yoshikawa J: "Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine"Hypertension. 39. 81 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamura Y, Yoshiyama M, Omura T, Yoshida K, Kim S, Takeuchi K, Iwao H, Yoshikawa J.: "Transmitral inflow pattern assessed by Doppler echocardiography in angiotensin II type 1A receptor knockout mice with myocardial infarction"Circulation Jorunal. 66. 192 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Izutani S, Yoshiyama M, Omura T, Yoshida K, Nakamura Y, Kim S, Takeuchi K, Yoshikawa J: "Nipradilol can prevent left ventricular systolic and diastolic dysfunction after myocardial infarction in rats"Circulation Journal. 66. 289 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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