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The pathogenesis of Type 1 diabetes in children-the role of endogenous retrovirus infection in relation with disposition, environment and auto-immunity

Research Project

Project/Area Number 14370251
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

MATSUURA Nobuo  Kitasato Univ., School of Medicine, Professor, 医学部, 教授 (50002332)

Co-Investigator(Kenkyū-buntansha) JINNO Yoshihiro  Ryukyu University School of Medicine, Department of Molecular Biology, Professor, 医学部・附属沖縄アジア医学研究センター・分子生物研究分野, 教授 (20179097)
KAZAHARI Kouji  Kitasato Univ., School of Medicine, Research Assistant, 医学部, 助手 (90214288)
YOKOTA Yukifum  Kitasato Univ., School of Medicine, Associate Professor, 医学部, 講師 (40158366)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsType 1 diabetes mellitus / Susceptibility gene(s) / HLA-DQ gene / HLA-DR gene / SPIDDM / Entero-virus mRNA / IDDMK1,2-22 gene / Super-antigen / エンテロウイルスmRNA / HLA抗原遺伝子 / 膵島関連自己抗体 / GAD抗体 IA-2抗体 / 内因性レトロウイルス / IDDMK1,2-22 / 緩徐進行型1型糖尿病 / VP4領域遺伝子 / GAD抗体
Research Abstract

We have studied the following projects during these two years 1) Isolation of Enterovirus m RNA from newly diagnosis of ketosis-phone type 1 diabetic children : 95 serum and 26 mononuclear cells samples from newly diagnosis type 1 diabetes were tried to extract entero-virus mRNA(VP4), however non of the serum samples nor mononuclear cells were failed to isolate virus mRNA. 2) We identified two nonsynonymous A/G polymorphisms in the superantigen-coding region of IDDMK_<1.2>22 at the 290-and 461-nucleotide position from the initial methione coden. Dr.Conrad B was interested in relation to super -antigen activity and this polymorphism and asked us to collaborate with type 1 diabetic children. However, in some reason, these collaborate studies were finally not succeeded due to their reasons. 3) Clinical and genetic characteristic of slowly progressing type 1 diabetes(SPIDDM) in children : We have analyzed HLA DQ-β, -αgene, DR-βgene, in children with acute-onset type 1 diabetes, SPIDDM, NIDDM and normal controls to identified the pathogenesis of SPIDDM. We found that age at onset of SPIDDM is much elder than acute onset and positivity of islet antibodies was almost same. HLA genes were different from NIDDM and controls. DRB1 0405-DQB1 0401 is popular and will be a subtype of type 1 diabetes mellitus.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (76 results)

All Other

All Publications (76 results)

  • [Publications] Ahmed S, et al.: "Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population."Genes Immunity. 3. 96-101 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wafaa M, et al.: "Association study of the NRAMP1 gene polymorphism and early-onset type 1 diabetes."Immunogenetics. 54. 282-285 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama S, et al.: "Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese type 1 diabetes mellitus : a randomized controlled study (JAPAN-IDDM)."Diabetes Res Clin Prac. 55. 113-121 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] R.W.Holl, et al.: "Insulin Injection Regimens and Metabolic Control in an International Survey of Adolescents with Type-1-Diabetes over 3 years : Results from the Hvidore Study Group."Eur J Pediatr. 162. 22-29 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bessuny WM, et al.: "A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes."Immunogenetics. 55. 149-156 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bessuny WM, et al.: "Association study between interleukin-12 receptor β1/β2 genes and type 1 diabetes or asthma in the Japanese population."Immunogenetics. 55. 189-192 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki Y, et al.: "Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus."Diab Res Clin Pract. 60. 139-141 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokota Y, et al.: "Screening of Diabetes by Urine Glucose Testing at School."Pediatr Diabetes. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yuuki T, et al.: "Obesity and eating behaviors in Japanese school children aged 9-15, and their relationship to those their mothers."Kitasato Med. (in printing).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 宮本茂樹, 他: "1型糖尿病患者の突然死-本邦における"dead in bed syndrome"について-"小児科臨床. 33. 369-371 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 宮本茂樹, 他: "養護学校通学中でインスリン療法を行っている小児糖尿病の現状と問題点"小児科診療. 56(8). 1767-1769 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 浦上達彦, 他: "小児1型糖尿病に対する超速効型インスリンの至適治療法に関する検討"ホルモンと臨床. 51(11). 967-971 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 浦上達彦, 他: "小児1型糖尿病における超速効型インスリン使用の実態調査"日児誌. 107(11). 1491-1496 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 野元けい子, 他: "PCR-SBT法によるHLA遺伝子タイピング-小児期発症1型糖尿病の多様性との関連について"糖尿病. 47(1). 27-34 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中村伸枝, 他: "高校生の生活の満足度(QOL)質問紙の検討.小中学生の満足度との比較"小児保健研究. (投稿中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 結城暎子, 他: "母子の食行動と肥満との関係についての検討"小児保健研究. (投稿中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "低血糖症候群"日本医師会雑誌.特別号「内分泌疾患診療マニュアル」. 127(12). s262-s265 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "小児糖尿病治療の原則.新時代の糖尿病学(3)"日本臨床. 60(増9). 707-711 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "インスリンアナログの使用法は?"肥満と糖尿病. 2(2). 46-48 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "小児1型糖尿病の現状は?"肥満と糖尿病. 2(3). 56-58 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 横田行史, 他: "学校検尿による糖尿病スクリーニングの現状と問題点"日本マス・スクリーニング学会誌. 13(1). 7-13 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 横田行史, 他: "小児糖尿病患者の治療ポイント(1)-(3).糖尿病診療ガイダンス.小児の糖尿病In糖尿病診療Q&Aマニュアル,第3版(片山茂裕,河盛隆造編集)"Medical View社. 9 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫, 他: "お母さんのためのやさしい小児糖尿病の自己管理"医薬ジャーナル(大阪市). 43 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 飯高喜久雄, 他: "腎疾患児.新・学校生徒管理指導のしおり.学校・学校医用"日本学校保健会-心臓・腎蔵等管理指導小委員会. 10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 学童糖尿病検診研究会: "尿糖陽性児童生徒の事後措置ガイドブック"ノボノルディスクファーマ(株). 29 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "糖尿病In小児科学 第2版(白木和夫、前川喜平監修)"医学書院. 12 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 村上睦美: "腎蔵疾患・糖尿病の子どもの学校生活。「養護教諭-毎日の執務とその工夫-」(吉田瑩一郎編集)"第一法規出版(東京). 28 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "おしっこは甘いか?-子どもの糖尿病-.小児疾患のとらえ方.目で見るベットサイドの病態生理(別所文雄,水谷修紀, 松井 陽, 榊原洋一編)"文光堂(東京). 14 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 飯高喜久雄, 他: "新・学校検尿のすべて-計画から事後措置まで-"日本学校保健会. 139 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 飯高喜久雄, 他: "新・学校心臓検診の実際-スクリーニングから管理まで-"日本学校保健会. 164 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "特別な配慮を必要とする糖尿病.1.小児・ヤング糖尿病.In糖尿病の治療マニュアル.第5版(東京女子医科大学糖尿病センター編)"医歯薬出版出版社(東京). 8 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "体重と身長の異常Inダイナミックメディシン(下條文武,齋藤 康監修)"西村書店(東京). 3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "小児糖尿病Inライフステージ別の糖尿病の療養指導.(日本糖尿病学会編)"第37回糖尿病学の進歩. 3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 松浦信夫: "小児糖尿病.III食事療法.In糖尿病最新の治療2004-2006(河盛隆造,岩本安彦編)"南江堂(東京). 3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ahmed S, Ihara K, Bassuny RK, et al.: "Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population."Genes Immunity. 3. 96-101 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wafaa M.B, Ihara K, Matsuura N, et al.: "Association study of the NRAMP1 gene polymorphism and early-onset type 1 diabetes."Immunogenetics. 54. 282-285 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama S, Kikkawa R, et al.: "Effect of captopril or imidapril on the progression of diabetic nephropathy in Japanese type 1 diabetes mellitus : a randomized controlled study (JAPAN-IDDM)."Diabetes Res Clin Prac. 55. 113-121 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] R.W.Holl, G.F.Swift, et al.: "Insulin Injection Regimens and Metabolic Control in an International Survey of Adolescents with Type-1-Diabetes over 3 years : Results from the Hvidore Study Grou"Eur J Pediatr. 162. 22-29 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bessuny WM, Ihara K, et al.: "A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes."Immunogenetics. 55. 149-156 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bassuny WM, Ihara K, et al.: "Association study between interleukin-12 receptor β1/β2 genes and type 1 diabetes or asthma in the Japanese population."Immunogenetics. 55. 189-192 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki Y, Matsuura, N Suzuki S, Muramatsu T, et al.: "Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus."Diab Res Clin Pract. 60. 139-141 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokota Y, Kikuchi N, Matsuura N: "Screening of Diabetes by Urine Glucose Testing at School."Pediatr Diabetes. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yuuki T, Kikuchi N, Matsuura N: "Obesity and eating behaviors in Japanese school children aged 9-15, and their relationship to those their mothers."Kitasato Med.. (in printing).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] R.W.Holl, P.G.F.Swift, H.B.Mortensen, H.Lynggaard, P.Hogaard, et al.: "Insulin Injection Regimens and Metabolic Control in an International Survey of Adolescents with Type-1-Diabetes over 3 years : Results from the Hvidore Study Group."Eur J Pediatr. 162. 22-29 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Bessuny WM, Ihara K, Sasaki Y, Kuromaru R, et al.: "A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes."Immunogenetics. 55. 149-156 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Bassuny WM, Ihara K, Kimura J, Ichikawa S, et al.: "Association study between interleukin-12 receptor β1/β2 genes and type 1 diabetes or asthma in the Japanese population."Immunogenetics. 55. 189-192 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y Suzuki, N.Matsuura, S.Suzuki, T.Muramatsu, M.Taniyama, et al.: "Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus."Diab Res Clin Pract. 60. 139-141 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokota Y, Kikuchi N, Matsuura N: "Screening of Diabetes by Urine Glucose Testing at School."Pediatr Diabetes. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Yuuki T, Kikuchi N, Matsuura N: "Obesity and eating behaviors in Japanese school children aged 9-15, and their relationship to those their mothers."Kitasato Med.. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 宮本茂樹, 染谷知宏, 菊池信行, 三木裕子, 森 哲夫, 他: "養護学校通学中でインスリン療法を行っている小児糖尿病の現状と問題点"小児科診療. 56(8). 1767-1769 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 浦上達彦, 宮本茂樹, 川村智行, 杉原茂孝, 雨宮 伸, 他: "小児1型糖尿病に対する超速効型インスリンの至適治療法に関する検討"ホルモンと臨床. 51(11). 967-971 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 浦上達彦, 宮本茂樹, 川村智行, 杉原茂孝, 雨宮 伸, 他: "小児1型糖尿病における超速効型インスリン使用の実態調査"日児誌. 107(11). 1491-1496 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 野元けい子, 大津成之, 田久保憲行, 横田行史, 松浦信夫: "PCR-SBT法によるHLA遺伝子タイピング-小児期発症1型糖尿病の多様性との関連について"糖尿病. 47(1). 27-34 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "インスリンアナログの使用法は?"肥満と糖尿病. 2(2). 46-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "小児1型糖尿病の現状は?"肥満と糖尿病. 2(3). 56-58 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 横田行史, 菊池信行, 松浦信夫: "学校検尿による糖尿病スクリーニングの現状と問題点"日本マス・スクリーニング学会誌. 13(1). 7-13 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "おしっこは甘いか?-子どもの糖尿病-。小児疾患のとらえ方。眼で見るベットサイドの病態生理(別所文雄、水谷修紀、松井 陽、榊原洋一編)"文光堂、東京. 266-279 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 飯高喜久雄, 上原建夫, 梅島功至, 柏光佐子, 菊池敏夫, 他: "新・学校検尿のすべて -計画から事後措置まで-"日本学校保健会. 1-139 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 飯高喜久雄, 上原建夫, 梅島功至, 柏光佐子, 菊池敏夫, 他: "新・学校心臓検診の実際 -スクリーニングから管理まで-"日本学校保健会. 1-164 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "特別な配慮を必要とする糖尿病。1.小児・ヤング糖尿病。糖尿病の治療マニュアル。第5版(東京女子医科大学糖尿病センター編)"医歯薬出版出版社。東京. 230-237 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "体重と身長の異常。ダイナミックメディシン(下条文武、齋藤 康監修)"西村書店、東京. 3.14-3.16 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "小児糖尿病:ライフステージ別の糖尿病の療養指導"第37回糖尿病学の進歩。日本糖尿病学会編. 87-89 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松浦信夫: "小児糖尿病。III食事療法。糖尿病最新の治療2004-2006(河盛隆造、岩本安彦編)"南江堂、東京. 71-73 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ahmed S: "Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population"Genes Immunity. 3. 96-101 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wafaa M: "Association study of the NRAMP1 gene polymorphism and early-onset type 1 diabetes"Immunogenetics. 54. 282-285 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Holl RW: "Insulin Injection Regimens and Metabolic Control in an International Survey of Adolescents with Type-1-Diabetes over 3 years : Results from the Hvidore Study Group"Eur J Pediatr. 162. 22-29 (2003)

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  • [Publications] 宮本茂樹: "1型糖尿病患者の突然死-本邦における"dead in bed syndrome"について-"小児科臨床. 33(3). 369-371 (2002)

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  • [Publications] 松浦信夫: "HNF-1α遺伝子異常によるMODY母子例の臨床的検討"糖尿病と妊娠. 2(1). 89-91 (2002)

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  • [Publications] 松浦信夫: "低血糖症候群"日本医師会雑誌。 特別号「内分泌疾患診療マニュアル」. 127(12). 262-265 (2002)

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  • [Publications] 松浦信夫: "小児糖尿病治療の原則。 新時代の糖尿病学(3)"日本臨床. 60(増9). 707-711 (2002)

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  • [Publications] 横田行史: "小児糖尿病患者の治療ポイント(1)-(3)。糖尿病診療ガイダンス.小児の糖尿病 In糖尿病診療Q&Aマニュアル,第3版"Medical View社 片山茂裕、河盛隆造(編集). 9 (2002)

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  • [Publications] 飯高喜久雄: "心臓手帳-児童・生徒用-"日本学校保健会(編集). 40 (2002)

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  • [Publications] 飯高喜久雄: "腎疾患児。新・学校生徒管理指導のしおり。学校・学校医用"日本学校保健会-心臓・腎臓等管理指導小委員会. 10 (2002)

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  • [Publications] 学童糖尿病検診研究会: "尿糖陽性児童生徒の事後措置ガイドブック"ノボルディスクファーマ(株). 29 (2002)

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  • [Publications] 松浦信夫: "インスリン治療の新しい展開 : 超速攻型インスリン導入を迎えて。3.小児1型糖尿病における有用性。In糖尿病学の進歩2002"日本糖尿病学会(編集). 4 (2002)

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  • [Publications] 村上睦美: "腎臓疾患・糖尿病の子どもの学校生活。「養護教諭-毎日の執務とその工夫」-"第一法規出版(東京) 吉田瑩一郎(編集). 28 (2002)

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Published: 2002-04-01   Modified: 2016-04-21  

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