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Development of Transcranial Ultrasonography System for Diagnosing Brain and Brain function

Research Project

Project/Area Number 14370284
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Hyogo (2004)
Himeji Institute of Technology (2002-2003)

Principal Investigator

HATA Yutaka  University of Hyogo, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (20218473)

Co-Investigator(Kenkyū-buntansha) KONDO Katsuya  University of Hyogo, Graduate School of Engineering, Associate Professor, 助教授 (00295750)
KOBASHI Syoji  University of Hyogo, Graduate School of Engineering, Research Associate, 助教授 (00332966)
YANAGIDA Toshio  Osaka University, Graduate School of Frontier Bioscience, Professor, 大学院・生命機能研究科, 教授 (30089883)
KITAMURA Yuri T.  Osaka University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (90294074)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥5,300,000 (Direct Cost: ¥5,300,000)
KeywordsMedical System / Ultrasound System / Skull Visualization / Image Processing / Signal Processing / Fuzzy Logic / Brain Science / Real Time System
Research Abstract

Conventional transcranial sonography system can imago real-time intracranial blood flow and brain tissue non-invasively. However, skull prevents ultrasound and keeps us from disclosing a brain anatomy. The main factor is the acoustical mismatch between soft skin and the skull. The acoustic velocity in the skull is about 2800-3500 m/s whereas about 1600 m/s in soft skin. Additionally, porous layer of the skull prevents ultrasound from penetrating to intracranial tissue. Due to this, conventional sonography system is used only for neonates whose skull is not complete. However, in adults, available window of skull is restricted to the temporal bone. This limited size of the window keeps us from disclosing brain information. Any transcranial sonography system with placement free has not been developed.
This research attempts to develop a intracranial tissue visualization system with placement free. By visualizing shape of an intracranial tissue from all angles, it supports to diagnose the d … More isease with high accuracy. First, we confirmed that ultrasonic wave penetrated the human frontal bone (3-6 mm) or artificial bone (12 mm). We describe our developed ultrasonography system. Ultrasound probe acquires data of an intracranial tissue in human head. The ultrasonic pulsar receiver transmits and receives ultrasonic waves via the probe. The data of ultrasonic waveform is acquired by the personal computer. The aim of this study is to divide our wave into echo of skull surface, echo of skull bottom, and the surface of brain. To solve this problem, our experiment is done on the flat region of human skull, i.e., frontal region of head. We make an anatomical model consisting of skull surface, skull bottom, and brain surface by the anatomical knowledge. In our system, after we sequentially compares a triangle fuzzy membership function with full wave of raw echo waves, we extract every target echo with maximal matching score referring to the model. We thus identify every echo by the model and the fuzzy pattern matching. Finally, we visualize the surface and bottom of the skull and the brain surface. As the result of applying it to two human heads, we could identify all echoes of skin, skull surface, skull bottom and brain surface. The shape of skull and the soft tissue in all data was obtained. Average error of the skin thickness was 0.88 mm, and the average error of distance between skin and brain surface was 2.44 mm, these values are obtained by comparing with MRI data. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (30 results)

All 2004 2003 2002 Other

All Journal Article (20 results) Publications (10 results)

  • [Journal Article] Representation of Normality and Its Application to Development of Transcranial Sonography System2004

    • Author(s)
      Y.Hata, S.Kobashi, K.Kondo, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of Taiwan-Japan Symposium 2004

      Pages: 7-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transcranial Ultrasonography System Aided by Fuzzy Model2004

    • Author(s)
      Y.Hata, S.Kobashi, K.Kondo, O.Ishikawa, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of the Fifth International Forum on Multimedia and Image Processing

      Pages: 109-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] ファジィ論理を用いた超音波脳診断支援システムの開発2004

    • Author(s)
      畑 豊, 清水孝, 長宗高樹, 小橋昌司, 大和一晴, 喜多村祐里, 柳田敏雄
    • Journal Title

      多値論理とその応用研究会技術研究報告

      Pages: 47-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transcranial Ultrasonography System Aided by Fuzzy Logic2004

    • Author(s)
      Y.Hata, T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, K.Yamato, Y.T.Kitamura, T.Yanagida
    • Journal Title

      MVL04, IEICE (in Japanese)

      Pages: 47-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Representation of Normality and Its Application to Development of Transcranial Sonography System.2004

    • Author(s)
      Y.Hata, S.Kobashi, K.Kondo, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of Taiwan-Japan Symposium 2004

      Pages: 7-12

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Three-Dimensional Bone Shape Sonography System, Aided by Fuzzy Logic2003

    • Author(s)
      T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of The 8th Australian and New Zealand Conference on Intelligent Information Systems

      Pages: 63-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Skull and Brain Visualization by Transcranial Sonography System2003

    • Author(s)
      T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of The 8th Australian and New Zealand Conference on Intelligent Information Systems

      Pages: 427-432

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 超音波を用いた脳構造の知識に基づく脳表可視化2003

    • Author(s)
      清水孝, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄
    • Journal Title

      第2回情報科学技術フォーラム

      Pages: 423-424

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ファジィ論理を用いた超音波骨計上画像化システムの開発2003

    • Author(s)
      木村是, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄
    • Journal Title

      第2回情報科学技術フォーラム

      Pages: 421-422

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three-Dimensional Bone Shape Sonography System Aided by Fuzzy Logic2003

    • Author(s)
      T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of The 8th Australian and New Zealand Conference on Intelligent Information Systems

      Pages: 63-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain Tissue Visualization Based on Knowledge of Brain Model using Transcranial Sonography System2003

    • Author(s)
      T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      FIT 2003 (in Japanese)

      Pages: 423-424

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Development of Ultranic Imaging System for Bone Shape Using Fuzzy Inference2003

    • Author(s)
      T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      FIT 2003 (in Japanese)

      Pages: 421-422

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Challenge to the Development of a Transcranial Sonography System2002

    • Author(s)
      K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Knowledge-Based Intelligent Information Engineering Systems & Allied Technologies, KES2002 (IOS Press) Part1

      Pages: 604-608

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue Elasticity Estimation from Ultrasonic Wave form Using Fuzzy Inference2002

    • Author(s)
      T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, K.Taniguchi
    • Journal Title

      Proc.of the Joint 1st Int.Conf.on Soft Computing and Intelligent Systems (CDROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An Automated Ultrasound Discrimination System of Tissue under an Obstacle by Fuzzy Reasoning2002

    • Author(s)
      T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.of the Joint 1st Int.Conf.on Soft Computing and Intelligent Systems (CDROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Fuzzy Logic Approach to Transcranial Sonography System with Placement Free2002

    • Author(s)
      Y.Hata, T.Shimizu, S.Kobashi, K.Kondo, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Proc.1st Int.Conf.on Information Technology & Applications (CDROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 超音波を用いた障害物下の材質のファジィ推論による自動推定2002

    • Author(s)
      清水孝, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄
    • Journal Title

      第18回ファジィシステムシンポジウム講演論文集

      Pages: 245-248

    • NAID

      10015751367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Challenge to the Development of a Transcranial Sonography System2002

    • Author(s)
      K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Knowledge-Based Intelligent Information Engineering Systems & Allied Technologies (IOS Press) KES2002

      Pages: 604-608

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue Elasticity Estimation from Ultrasonic Waveform Using Fuzzy Inference2002

    • Author(s)
      T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, K.Taniguchi
    • Journal Title

      Proc.of the Joint 1st Int.Conf.on Soft Computing and Intelligent Systems (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An Automated Fuzzy Rule-Based Discrimination System of Tissue under an Obstacle Using Ultrasound2002

    • Author(s)
      T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida
    • Journal Title

      Fuzzy System Symposium (in Japanese)

      Pages: 245-248

    • NAID

      10015751367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida: "Three-Dimensional Bone Shape Sonography System Aided by Fuzzy Logic"Proc.of The 8th Australian and New Zealand Conference on Intelligent Information Systems. 63-68 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida: "Skull and Brain Visualization by Transcranial Sonography System"Proc.of The 8th Australian and New Zealand Conference on Intelligent Information Systems. 427-432 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 畑 豊, 清水孝, 長宗高樹, 小橋昌司, 近藤克哉, 大和一晴, 喜多村祐里, 柳田敏雄: "ファジィ論理を用いた超音波脳診断支援システムの開発"多値論理とその応用研究会技術研究報告. 47-55 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 清水孝, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄: "超音波を用いた脳構造の知識に基づく脳表可視化"第2回 情報科学技術フォーラム. 423-424 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 木村是, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄: "ファジィ論理を用いた超音波骨計上画像化システムの開発"第2回 情報科学技術フォーラム. 421-422 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida: "Challenge to the Development of a Transcranial Sonography System"Knowledge-Based Intelligent Information Engineering Systems & Allied Technologies, KES2002, IOS Press. Part 1. 604-608 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Kimura, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, K.Taniguchi: "Tissue Elasticity Estimation from Ultrasonic Waveform Using Fuzzy Inference"Proc. of the Joint 1st Int. Conf. on Soft Computing and Intelligent Systems. (CDROM). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Shimizu, K.Nagamune, S.Kobashi, K.Kondo, Y.Hata, Y.T.Kitamura, T.Yanagida: "An Automated Ultrasound Discrimination System of Tissue under an Obstacle by Fuzzy Reasoning"Proc. of the Joint 1st Int. Conf. on Soft Computing and Intelligent Systems. (CDROM). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hata, T.Shimizu, S.Kobashi, K.Kondo, Y.T.Kitamura, T.Yanagida: "A Fuzzy Logic Approach to Transcranial Sonography System with Placement Free"Proc. 1st Int. Conf. on Information Technology & Applications. (CDROM). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 清水孝, 長宗高樹, 小橋昌司, 近藤克哉, 畑 豊, 喜多村祐里, 柳田敏雄: "超音波を用いた障害物下の材質のファジィ推論による自動推定"第18回フアジィシステムシンポジウム講演論文集. 245-248 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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