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Construction of therapeutic gene library for pancreatic cancer and development of specific therapeutic vector

Research Project

Project/Area Number 14370345
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KATOH Hiroyuki  Hokkaido University, Graduate School of Medicine, Prof, 大学院・医学研究科, 教授 (80002369)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Masaaki  Hokkaido University, Hospital, Asit, 医学部・歯学部附属病院, 助手 (40333611)
OKUSHIBA Shunichi  Hokkaido University, Graduate School of Medicine, Asso.Prof, 大学院・医学研究科, 助教授 (70185536)
KONDO Satoshi  Hokkaido University, Graduate School of Medicine, Asso.Prof, 大学院・医学研究科, 助教授 (30215454)
TADA Mitsuhiro  Hokkaido University, Institute For Genetic Medicine, Asso, Prof, 遺伝子病制御研究所, 助教授 (10241316)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥11,900,000 (Direct Cost: ¥11,900,000)
Keywordspancreatic cancer diagnosis / gene therapy / cDNA library / RCAS1 / caveolin-A / PEDF / PEDF / 膵臓 / 遺伝子ライブラリー / アデノウイルスベクター
Research Abstract

We constructed a frozen tissue library containing cancer tissues obtained from 5,000 patients who agreed with informed consent and underwent surgical treatment at Hokkaido University Hospital and its 33 affiliated hospitals. We had performed gene expression assay of 31 patients with pancreatic adenocarcinoma till December in 2003, and made the expression profile of 1289 genes correlated with cancer progression. On the other hand, we reported that several gene expression such as caveolin-1, RCAS1, and PEDF correlate with prognosis of patients with pancreatic cancer. We thought that PEDF gene therapy is potentially useful for the treatment of pancreatic cancer patients with liver metastasis.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Uehara H: "Expression of Pigment Epithelium-derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma"Cancer Res. (In Press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura T: "Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection"Oncogene. 23. 2385-2400 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukunaga A: "CD8+ Tumor-infiltrating Lymphocytes Together with CD4+ Tumor-infiltrating Lymphocytes and Dendritic cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma"Pancreas. s. e26-e38 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashida H: "Fusion of HIV-1 Tat protein transduction domain to poly-lysine as a new DNA delivery tool"Br J Cancer. 90. 1252-1258 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi Y: "Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system"Experimental Cell Res. 293. 144-153 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toru Nakamura: "Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection."Oncogene. 23. 2385-2400 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Akira Fukunaga: "CD8+ Tumor-infiltrating Lymphocytes Together with CD4+ Tumor-infiltrating Lymphocytes and Dendritic cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma."Pancreas. 28. e26-e31 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hideaki Hashida: "Fusion of Tat protein transduction domain to poly-lysine as a new DNA delivery tool."British Journal of Cancer. 90. 1252-1258 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoko Takahashi: "Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system."Cell Research. 293. 144-153 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirofumi Uehara: "Expression of Pigment Epithelium-derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma."Cancer Research. (In Press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uehara H: "Expression of Pigment Epithelium-derived Factor Decreases Liver Metastasis and Correlates with Favorable Prognosis for Patients with Ductal Pancreatic Adenocarcinoma"Cancer Res. (In Press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiraoka K: "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker"Int J Cancer. 99. 418-423 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuoki M: "Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma"Br J Cancer. 87. 1140-1144 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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