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Analysis on the genes producing the diversity of the cancers, resulting the difficulties of their treatment.

Research Project

Project/Area Number 14370358
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

INOUE Hiroshi  Kyushu Unlv., Medical Institute of Bioregulation, Associate Professor, 生体防御医学研究所, 助教授 (90203249)

Co-Investigator(Kenkyū-buntansha) MORI Masaki  Kyushu Unlv., Medical Institute of Bioregulation, Professor, 生体防御医学研究所, 教授 (70190999)
MIMORI Koshi  Kyushu Unlv., Medical Institute of Bioregulation, Research Assoctate, 生体防御医学研究所, 助手 (50322748)
UTSUNOMIYA Tohru  Kyushu Unfv.Hospital, lecturer, 大学病院, 講師 (30304801)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 2003: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2002: ¥6,200,000 (Direct Cost: ¥6,200,000)
Keywordslaser mierodissection / cDNA microarray / T7 amplificationinase / matrix metalloproteinase / lymph node metastasis
Research Abstract

Purpose : To estimate gastric cancer patients' prognosis more comprehensively, we tried to develop a prognostic scoring system using cDNA microarray.
Experimental Design : RNA was extracted from tumor/normal paired samples of 43 patients with gastric cancer, and cDNA microarray hybridization was performed.
Results : We selected 78 genes that were differentially expressed between aggressive and non-aggressive groups with respect to five conventional pathologic factors. Next, we determined a coefficient for each gene. Thereafter a prognostic score was calculated by summing-up the value for each gene. It ranged from-47 to 201 with a median of 114. There were two peaks in its distribution. Ten of 11 patients who were alive with no evidence of recurrence more than 5 years after the operation showed a score of less than 100 point, while all 19 patients who died of disease showed more than 100 point. In 13 patients who were alive but the follow-uptime was less than 5 years, two of the3 patients with more than 100 point revealed recurrent disease during the follow up.
Conclusions : These findings demonstrate that such a system with cDNA microarray can contribute to the comprehensive analysis of malignant behavior of the tumor and may provide accurate information on prognosis.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Masuda TA, Inoue H, et al.: "Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma."Clin Cancer Res. 15. 5693-5698 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuyama A, Shiraishi T, et al.: "Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2 : Evolutionarily conserved but highly recombinogenic"Proc Natl Acad Sci U S A. 100. 14988-14993 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita K, Mimori K, et al.: "A tumor-suppressive role for trypsin in human cancer progression."Cancer Res. 63. 6575-6578 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mimori K, Shiraishi T, et al.: "MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway"Oncogene. 22. 3463-3471 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mimori K, Inoue H, et al.: "INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia"Oncology Rep. 10. 551-553 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inoue H, Matsuyama A et al.: "Prognostic score of gastric cancer determined by cDNA microarray"Clin Cancer Res. 8. 3475-9 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 黒木 保, 井上 裕, 森 正樹: "消化器外科 レビュー:発癌機構(分担執筆)"総合医学社. 268 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuda TA, Inoue H, et al.: "Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma."Clin Cancer Res. 15. 5693-5698 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuyama A, Shiraishi T, et al.: "Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2 : Evolutionary conserved but highly recombinogenic"Proc Natl Acad Sci USA. 100. 14988-14993 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita K, Mimori K, et al.: "A tumor-suppressive role for trypsin in human cancer Progression"Cancer Res. 63. 6575-6578 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mimori K, Shiraishi T, et al.: "MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway"Oncogen. 22. 3463-6471 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mimori K, Inoue H, et al.: "INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia"Oncology Rep. 10. 551-553 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inoue H.Matsuyama A et al.: "Prognostic score of gastric cancer determined by cDNA microarray"Clin Cancer Res. 8. 2475-2479 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroki T, et al.: "SHOKAKIGEKA REVIEW : Carcinogenesis(Japanese)"SHOKAKIGEKA. 268 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuda TA, Inoue H, et al.: "Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma"Clin Cancer Res. 15. 5693-5698 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuyama A, Shiraishi T, et al.: "Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2 : Evolutionarily conserved but highly recombinogenic"Proc Natl Acad Sci USA. 100. 14988-14993 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashita K, Mimori K, et al.: "A tumor-suppressive role for trypsin in human cancer progression"Cancer Res. 63. 6575-6578 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashita K, Sunil, et al.: "MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway"Oncogene. 22. 3463-3471 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mimori K, Inoue H, et al.: "INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia"Oncology Rep. 10. 551-553 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue H, Matsuyama A et al.: "Prognostic score of gastric cancer determined by cDNA microarray"Clin Cancer Res. 8. 3475-3479 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 黒木 保, 井上 裕, 森 正樹: "消火器外科 レビュー:発癌機構(分担執筆)"総合医学社. 268 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue H: "Prognostic score of gastric cancer determined by cDNA microarray"Clin Cancer Res. 8. 3475-3479 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masuda T, Inoue H, et al.: "Clinical and Biological Significance of S-Phase Kinase-associated Protein 2 (Skp2) Gene Expression in Gastric Carcinoma : Modulation of Malignant Phenotyp by Skp2 Overexpression, Possibly via p27 Proteolysis"Cancer Res. 62. 3819-3825 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue H: "Heparanase expression in clinical digestive malignancies"Oncol Rep. 8. 539-542 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mashino K, Inoue H, et al.: "Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma"Cancer Res. 62. 2937-2941 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mori M: "Expression profile of metastasis related genes in gastro-intestinal tract carcinomas by a combination study of cDNA microarray and Laser Capture Microdissection"Surgery. 131. S39-S47 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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