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The development of 3-D computer simulation system for hyperthermic treatment of malignant brain tumor

Research Project

Project/Area Number 14370427
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

TAKAHASHI Hideaki  NIIGATA UNIVERSITY, Medical & Dental Hospital, Lecturer, 医歯学総合病院, 講師 (70236305)

Co-Investigator(Kenkyū-buntansha) YAMANAKA Ryuya  NIIGATA UNIVERSITY, Brain Research Institute, Lecturer, 脳研究所, 講師 (20323991)
TANAKA Ryuichi  NIIGATA UNIVERSITY, Brain Research Institute, Professor, 脳研究所, 教授 (30018816)
森 宏  新潟大学, 脳研究所, 講師 (70291359)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥11,100,000 (Direct Cost: ¥11,100,000)
Keywordsmalignant brain tumor / hyperthermia / computer simulation / RF / three-dimensional / interstisial / 組織内加温
Research Abstract

Using thermal simulation software that we independently based on the 2-dimensional finite element method, we have previously described a treatment protocol for interstitial hyperthermia and understanding of thermal distributions in two dimensions. The present investigation examined 3-dimensional simulation of thermal distributions.
Since 2002, we have conducted basic research on electromagnetic field analysis using RF waves. This involved using the previous 2-dimensional finite element method to solve Maxwell equations and differentiate in space and time regions, and the algorithm for this method was applied to three dimensions. Although analysis using a model of the human brain was not possible in the 2002 investigation, a 3-dimensional simulation using a phantom model was performed. Specifically, a 3-dimensional simulation of re-entrant heating, a centrifugal heating method similar to interstitial hyperthermia, was achieved.
Next, using Vitrea 2 imaging software (Vital Images), a 3-dim … More ensional model was constructed through computer reconstruction of 2-dimensional cranial CT or MRI images from patients with brain tumors. Application of this method provided surgically useful images.
In 2003, using JMAG electromagnetic field analysis software, a thermal simulation was performed for a phantom model heating with a re-entrant-type applicator. When the phantom was heated and temperature measured using an optical fiber, thermal distribution was found to very closely approximate predicted temperatures.
Based on the 3-dimensional model tumor was attempted using JMAG software. Due to the complexity of the tumor shape, however, analysis of the distribution was not achieved.
Although phantom studies showed accuracy of the predicted 3-dimensional distributions to be suitable for clinical application, the complexity of the method poses an obstacle to use in clinical apply. Efficacy of hyperthermia treatment depends on accurate heating, and predicting 3-dimensional thermal distribution will therefore become an essential aspect of the treatment protocol. The present investigation completed the first step toward system that applies simulation of 2-dimensional thermal distributions to three dimensions. We will continue to expand on this work, and we anticipate that the reliable hyperthermia that will result from safe treatment protocols will contribute to improvements in the efficacy of treatment for malignant brain tumors. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 田中 隆一: "脳腫瘍の温熱療法:悪性グリオーマのRF組織内加温法"集学的癌治療の研究と臨床. 305-313 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Takahashi: "Successful Treatments of Malignant Glioma in the Elderly by Radio frequency Interstitial Hyperthermia : A Report of Two Cases"Jpn J Hyperthermic Oncol. 18・3. 157-164 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 宇塚 岳夫: "悪性神経膠腫に対する温熱治療-コンピュータシュミレーションによる治療計画法を用いて-"ポストシークエンス時代における脳腫瘍の研究と治療. 497-501 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Morita: "Combination therapy of rat brain tumors using localized interstitial hyperthermia and intra-arterial chemotherapy"Int J Hyperthermia. 19・2. 204-212 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田中 隆一: "脳腫瘍の温熱療法-最近の進歩"Annual Review 神経 2003. 163-168 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Kato: "Improvement of the resonant cavity applicator for brain tumor hyperthermia"EMBC 2003,Proceedings of the 25th annual international conference of the EEEE. 3271-3274 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryuichi Tanaka: "Hyperthermia for brain tumor : RF interstitial hyperthermia of malignant glioma"Syugakuteki Ganchiryo no Kenkyuu to Rinsyo. 305-313 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hideaki Takahashi: "Successful Treatments of Malignant Glioma in the Elderly by Radiofrequency Interstitial Hyperthermia : A Report of Two cases"Jpn J Hyperthermic Oncol. 18・3. 157-164 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeo Uzuka: "Interstitial Hyperthemia for Malignant Glioma -Treatment Planning with Computer Simulation -"Postsequence Jidai ni okeru Nousyuyou no Kenkyuu to Chiryo. 497-501 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kotaro Morita: "Combination therapy of rat brain tumors using localized interstitial hyperthermia and intra--arterial chemotherapy"Int J Hyperthermia. 19・2. 204-212 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryuichi Tanaka: "Hypertermia for brain tumor -Recent progression"Annual Review Nerves 2003. 163-168 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kazuo Kato: "Improvement of the resonant cavity applicator for brain tumor hyperthermia"EMBC 2003, Proceedings of the 25th annual international conference of the IEEE. 3271-3274 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田中 隆一: "脳腫瘍の温熱療法-最近の進"Annual Review 神経 2003. 163-168 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 田中 隆一: "VII.温熱療法 悪性グリオーマの温熱療法"脳神経外科Advanced Practice 5,神経膠腫. 136-141 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 田中 隆一: "脳腫瘍の温熱療法:悪性グリオーマのRF組織内加温法"集学的癌治療の研究と臨床. 305-313 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Tankahashi: "Successful Treatments of Malignant Glioma in the Elderly by Radiofrequency Interstitial Hyperthermia : A Report of Two Cases"Jpn J Hyperthermic Oncol. 18・3. 157-164 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宇塚 岳夫: "悪性神経膠腫に対する温熱治療-コンピュータシュミレーションによる治療計画法を用いて-"ポストシークエンス時代における脳腫瘍の研究と治療. 497-501 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Morita: "Combination therapy of rat brain tumors using localized interstitial hyperthermia and intra-arterial chemotherapy"Int J Hyperthermia. (in press). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋 英明: "第7章.温熱療法 RF組織内温熱療法"先端医療シリーズ18、脳腫瘍の最新医療. 232-238 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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