| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Masatoshi Tohoku Gakuin University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (40128955)
AZUMA Yoshiaki Teijin Pharma Limited, Bio-Medical Evaluation Research Department, Group Leader, 創薬研究所, 課長(研究職)
松本 不二夫 東北大学, 大学病院, 助手 (00312588)
日向野 修一 東北大学, 大学病院, 助手 (20173148)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Research Abstract |
Bone strength depends on not only volume but also quality. The basis of bone quality is the trabecular architecture. We first introduced the Voronoi diagram to the analysis for the architecture and developed trabecular domain factor (TDF) of a parameter of the deteriorated bone quality. However, histological specimens used for the analysis were produced by destructing the bone. This study were aimed 1)to develop a new non-destructive system of analysis for the trabecular architecture using micro-CT, 2)to develop a new program for the histomorphometric analysis, 3)to evaluate the reliability of TDF calculated using the new system, by way of comparison with the TDF measured by the histomorphometry, 4)to evaluate the TDFs of the different fields of a same vertebral body and the TDFs of the defferent vertebral body levels. Materials were 124 vertebral bodies of T12 through L3 removed from the 31 postmortem cases (male, 21 ; female 10,19 through 92 years old, average, 72 years old)., The following results were obtained : 1)a new system using micro-CT was developed, which enables an analysis for trabecular architecture with less consuming of time and labor compared to the conventional method, 2)TDFs calculated with the new system well correlated with TDFs measured through the new program of histomorphometry (r=0.979, r^2 = 0.96), 3)the central part of vertebral bodies showed the lower TDF values which mean less bone strength, compared to the peripheral part of vertebral bodies, 4)TDF, that is, bone strength, varied depending on the vertebral body levels even of a same postmortem case. The new system will contribute to the development of an in vivo analysis of a human vertebral body and, further, to the development of the accurate method for the prediction of the strength of a vertebral body.
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