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Factors affecting human placental transfer of anesthesia-related drugs.

Research Project

Project/Area Number 14370498
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHyogo College of Medicine

Principal Investigator

TASHIRO Chikara  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (20107048)

Co-Investigator(Kenkyū-buntansha) KAMINOH Yoshiroh  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30289061)
YANAMOTO Fujio  Hyogo College of Medicine, Faculty of Medicine, Instructor, 医学部, 助手 (40368543)
UEKI Ryusuke  Hyogo College of Medicine, Faculty of Medicine, Instructor, 医学部, 助手 (10340986)
TATARA Tsuneo  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 講師 (30207039)
辻本 三郎  兵庫医科大学, 医学部, 講師 (00144254)
奥谷 龍  兵庫医科大学, 医学部, 助教授 (90204122)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥11,100,000 (Direct Cost: ¥11,100,000)
Keywordsplacental perfusion model / human placenta / anesthetic agents / pharmacokinetics / placental transfer / local anesthetics / propofol / 胎盤潅流 / 産科麻酔
Research Abstract

Placental transfer of porpofol and local anesthetics in human dually perfused cotyledon in vitro.
We investigated the effects of uterine and umbilical blood flow and albumin concentration (protein binding) on the placental transfer of propofol and local anesthetics by using the dually perfused human placental cotyledon (single pass mode). For propofol, placental transfer was incresed (1)with increasing albumin concentrations of the fetal perfusate, (2)with increasing maternal blood flow, and (3)with increasing fetal blood flow. The transfer was decreased with increasing albumin concentrations of maternal perfusate. Propofol significantly partitioned to placental tissues and the placenta would act as a condenser.
For local anesthetics, fetal (F)/maternal (M) concentration ratio was increased (1)with increased uncharged form, namely lower pKa (mepivacaine) at pH 7.4 (F & M), (2)with lower pH in fetal perfusate. When pH in both sides became 6.9, F/M ratio was decreased. The F/M ratio was small in ropivacaine and bupivacaine which possess high clinical potency. In summary, our model could exactly denote the placental transfer of drug using the parameter of clearance while traditional determination of maternal and fetal blood concentration (F/M ratio) was extremely influenced with uterine blood flow, umbilical blood flow, and protein binding in maternal and umbilical blood).

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report

Research Products

(12 results)

All 2006 2005 2003 2002

All Journal Article (12 results)

  • [Journal Article] プロポフォール血管痛の軽減 -メトクロプラミドとフェンタニル前処置の比較2006

    • Author(s)
      木下雅晴, 谷本賢明, 植木隆介, 平島佳奈, 吉田史絵, 太城力良
    • Journal Title

      臨床麻酔 30(1)

      Pages: 27-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] プロポフォール血管痛の軽減-メトクロプラミドとフェンタニル前処置の比較.2006

    • Author(s)
      木下雅晴, 谷本賢明, 植木隆介, 平島佳奈, 吉田史絵, 太城力良
    • Journal Title

      臨床麻酔 30(1)

      Pages: 27-31

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 胎児麻酔の反省2005

    • Author(s)
      太城力良, 柳本富士雄, 植木隆介, 宮川慈子, 和田麻子, 矢田幸子
    • Journal Title

      分娩と麻酔 87

      Pages: 17-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 胎児手術と麻酔2005

    • Author(s)
      柳本富士雄, 長尾嘉晃, 恒遠剛示, 太城力良
    • Journal Title

      周産期医学 35(5)

      Pages: 615-619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 気管挿管後に娩出した頸部腫瘤出生前診断症例の帝王切開の麻酔経験2003

    • Author(s)
      柳本富士雄, 和泉良平, 玉石一正, 平島佳奈, 太城力良
    • Journal Title

      麻酔 52(8)

      Pages: 886-889

    • NAID

      80016057472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Report of a case : the anesthetic management for fetal tracheal intubation with intact uteroplacental circulation during cesarean section2003

    • Author(s)
      Yanamoto F, Izumi R, Tamaishi K, Hirashima K, Tashiro C.
    • Journal Title

      Masui. (Japanese) 52(8)

      Pages: 886-889

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.2002

    • Author(s)
      He YL, Seno H, Sasaki K, Tashiro C
    • Journal Title

      Anesth Analg 94(4)

      Pages: 1312-1314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various rat tissues.2002

    • Author(s)
      Seno H, He YL, Tashiro C, Ueyama H, Mashimo T
    • Journal Title

      J Anesthesia 16(1)

      Pages: 87-89

    • NAID

      50001067950

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.2002

    • Author(s)
      He YL, Seno H, Sasaki K, Tashiro C
    • Journal Title

      Anesth Analg 2002 94(4)

      Pages: 1312-1314

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various rat tissues.2002

    • Author(s)
      Seno H, He YL, Tashiro C, Ueyama H, Mashimo T
    • Journal Title

      J Anesthesia 2002 16(1)

      Pages: 87-89

    • NAID

      50001067950

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The influences of maternal albumin concentration on the placental transfer of propofol in human dually perfused cotyledon in vitro2002

    • Author(s)
      Yan-Ling He
    • Journal Title

      Anesthesia & Analgesia 94

      Pages: 1312-1314

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various tissues2002

    • Author(s)
      Seno H.
    • Journal Title

      J Anesthesia 16

      Pages: 87-89

    • Related Report
      2004 Annual Research Report

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Published: 2002-03-31   Modified: 2016-04-21  

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