| Project/Area Number |
14370503
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
ITO Kazuto (2004) Gunma University, Graduate School of Medicine, Assistant professor, 大学院・医学系研究科, 講師 (00302472)
山中 英壽 (2002-2003) 群馬大学, 医学部, 教授 (70110393)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kazuhiro Gunma University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80312891)
伊藤 一人 群馬大学, 医学部, 助手 (00302472)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥10,900,000 (Direct Cost: ¥10,900,000)
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| Keywords | familial prostate cancer / genetic analysis / linkage analysis / RNASEL / HPC2 / ELAC2 |
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| Research Abstract |
Involvement of genetic factors to prostate cancer development has long been proposed. Genetic analysis using large scale hereditary prostate cancer pedigrees has been reported from Western countries. In Japan, no reports have been published on genetic analysis of familial prostate cancer. In this study, we performed genetic analysis of high penetrance and low penetrance genes involved in prostate cancer. First, we determined the genotypes of RNASEL gene and ELAC2/HPC2 genes those have been reported as candidate genes to prostate cancer susceptibility. In HPC2 gene, A1a 541Thr genotype was exclusively found in prostate cancer. In RNASEL gene, Asp541Glu genotype was associated with prostate cancer development and progression.
Linkage analysis showed that 1p36, D1S2667 and 8p23 D8S550 were significantly associated with suggestive linkage. 1p36 locus is coincident to CAPB locus and 8p23 locus is coincident to MRS1 and FDFT1 genes. We are now trying to find the association of these regions to prostate cancer risk.
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