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Instrument for measuring intrauterine oxygen metabolism using optical technique.

Research Project

Project/Area Number 14370529
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KANAYAMA Naohiro  Hamamatsu University School of Medicine, Department of Obstetrics and gynecology, Professor, 医学部, 教授 (70204550)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Motoi  Hamamatsu University School of Medicine, Associate professor, 医学部附属病院, 助教授 (30273189)
NISHIGUCHI Tomizou  Hamamatsu University School of Medicine, lecturer, 医学部附属病院, 講師 (30198452)
SUMIMOTO Kazuhiro  Kawasaki City Nursing University, professor, 看護学科, 教授 (30126817)
茂庭 將彦  浜松医科大学, 医学部附属病院, 講師 (00230053)
竹内 欽哉  浜松医科大学, 医学部, 助手 (80362193)
須床 和恵  浜松医科大学, 医学部付属病院, 助手 (40343199)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥6,500,000 (Direct Cost: ¥6,500,000)
Keywordsnear-infrared spectroscopy (NIRS) / oxygenation / placenta / uterus / transabdominal monitaring / 酸素動態 / 胎児情報 / 筋赤外線 / 胎盤
Research Abstract

The oxygenation status of uterus could be closely related to uterine contraction. However, there have been no methods to detect its changes through maternal abdominal wall. Near-infrared(NIR) spectroscopy has shown immense potential as a non-invasive method for monitoring real-time oxygenation status. We have investigated the trans-abdominal monitoring of oxygenation status of uterus continuously by NIR spectroscopy. We improved the sensor of NIRO 500 (Hamamatsu Photonics KK, Hamamatsu, Japan) to obtain convincing data of oxygenation changes of uterus. Using the sensor, we could succeed in obtaining the data for oxyhemoglobin(HbO_2) and deoxyhemoglobin(Hb) through maternal abdomen. This method could be a viable technique for intrapartum monitoring.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (15 results)

All 2005 2004 2003 2002 Other

All Journal Article (13 results) Publications (2 results)

  • [Journal Article] Transabdominal measurement of oxygenation of the placenta by near-infrared spectroscopy.2005

    • Author(s)
      Kakogawa J, Kanayama N
    • Journal Title

      Semi Tromb Hemat (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transabdominal measurement of oxygenation of the placenta by near-infrared spectroscopy.2005

    • Author(s)
      Kakogawa J, Sumimoto K, Ho E, Kaanyama N.
    • Journal Title

      Semi Tromb Hemat (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Golf in the rat placenta : Possible implication in olfactory receptor transduction.2005

    • Author(s)
      Itakura S, Ohno K, Ueki T, Sato K, Kanayama N.
    • Journal Title

      Placenta (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transabdominal measurement of oxygenation of the placenta by near-infrared spectroscopy.2005

    • Author(s)
      Kakogaw J, Kaanyama N
    • Journal Title

      Semi Tromb Hemat (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocacinoma cell line BeWo.2004

    • Author(s)
      Iwaki T, Kanayama N
    • Journal Title

      Gynecol Obstet Invest 57

      Pages: 196-203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo.2004

    • Author(s)
      Iwaki T, Matsuura T, Sugimura M, Kobayashi T, Kanayama N.
    • Journal Title

      Gynecol Obstet Invest 57

      Pages: 196-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo.2004

    • Author(s)
      Iwaki T, Kanayama N
    • Journal Title

      Gynecol Obstet Invest 57

      Pages: 196-203

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Trophoblastic injury : New etiological and pathological concept of preeclampsia.2003

    • Author(s)
      Kanayama N.
    • Journal Title

      Croat Med J 44

      Pages: 148-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of mature plasma cells in early rat yolk sac. A possible origin from the endodermal cell layer : Immunohisochemistry and immunoelectron microscopic study.2003

    • Author(s)
      El-Neffiawy N, Abdel-Hakim K, Kanayama N, Suganuma N, Terao T.
    • Journal Title

      Immunol Cell Bio 81

      Pages: 335-342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ontogeny of plasma cells in the early yolk sac.2003

    • Author(s)
      El-Neffiawy N, Abdel-Hakim K, Kanayama N, Suganuma N, Terao T.
    • Journal Title

      Arch Histol Cytol 66

      Pages: 327-335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Deficiency in p57^<Kip2> expression induces preeclampsia-like symptoms in mice.2002

    • Author(s)
      Kanayama N, Takahashi K, Matsuura T, Sugimura M, Kobayashi T, Moniwa N, Tomita M, Nakayama K
    • Journal Title

      Mol Hum Reprod 8

      Pages: 1129-1135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Embryonic macrophages of early rat yolk sac : Immunohistochemistry and ultrastructure with reference to endodemal cell layer.2002

    • Author(s)
      El-Nefiawy N, Abdel-Hakim K, Yamashita A, Kanayama N.
    • Journal Title

      Immunol Cell Biol. 80

      Pages: 441-447

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased expression of vascular endothelial growth factor in placentas of p57^<Kip2> null embryos.2002

    • Author(s)
      Matsuura T, Takahashi K, Nakayama K, Kobayashi T, Choi-Miura N, Tomita M, Kanayama N.
    • Journal Title

      FEBS Lett. 532

      Pages: 283-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] 水主川純, 住本和博, 金山尚裕: "近赤外線分光法による非侵襲的子宮酸素動態モニタリング"産婦人科の世界. 55巻12号. 1363-1369 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naohiro Kanayama: "Deficiency in P57^<kip2> expression induces preeclampsia-like symptoms in mice"Molecular Human Reproduction. 8(11). 1129-1135 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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