| Project/Area Number |
14370531
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
FUJIWARA Hiroshi KYOTO UNIVERSITY Graduate school of Medicine, Lecturer, 医学研究科, 講師 (30252456)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Jun KYOTO UNIVERSITY Graduate school of Medicine, Prof., 医学研究科, 教授 (50173430)
HIGUCHI Toshihiro KYOTO UNIVERSITY Graduate school of Medicine, Assistant, 医学研究科, 助手 (00283614)
YOSHIOKA Shinya KYOTO UNIVERSITY Graduate school of Medicine, Assistant, 医学研究科, 助手 (90333575)
NAKATSUJI Norio Institute for Frontier Medical Science, Prof., 再生医科学研究所, 教授 (80237312)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2003: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2002: ¥7,900,000 (Direct Cost: ¥7,900,000)
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| Keywords | embryo / hCG / Corpus luteum of pregnancy / implantation / immune cells / crosstalk |
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| Research Abstract |
It has been generally accepted that human chorionic gonadotropin (hCG), which is secreted from embryo, plays an important role in establishment of embryo implantation by stimulating progesterone production from corpus luteum of pregnancy and maintaining subsequent endometrial differentiation. These facts indicate that the interaction between embryo and mother reproductive organs through blood circulation system is essential phenomenon for successful pregnancy. On the other hand, it has been pointed out that it is difficult to explain the whole regulation of crosstalk mechanism only by hCG. However, no other soluble factors have been proposed to mediate this systemic crosstalk between embryo and mother especially during early pregnancy.
Based on these backgrounds, we further found that peripheral blood mononuclear cells (PBMC) could participate in the crosstalk mechanisms. PBMC in the pregnant women enhanced progesterone production by luteal cells and influence on differentiation of endometrial cells to facilitate embryo implantation. Furthermore, PBMC have been demonstrated to induce extravillous trophoblasts in the maternal deciduas.
These findings provided a novel concept that human embryo implantation is co-operatively regulated by not only endocrine but also immune systems, contributing to reproductive medicine.
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