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Neural mechanism for critical period of the auditory cortex

Research Project

Project/Area Number 14370542
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HIRAUMI Harukazu (2004)  KYOTO UNIVERSITY, Graduate School of medicine, Assistant Professor, 医学研究科, 助手 (10374167)

内藤 泰 (2002-2003)  京都大学, 医学研究科, 講師 (70217628)

Co-Investigator(Kenkyū-buntansha) ITO Juichi  KYOTO UNIVERSITY, Graduate School of medicine, Professor, 医学研究科, 教授 (90176339)
NAKAGAWA Takayuki  KYOTO UNIVERSITY, Graduate School of medicine, Assistant Professor, 医学研究科, 助手 (50335270)
TSUJI Jun  KYOTO UNIVERSITY, Graduate School of medicine, Lecturer, 医学研究科, 講師 (30252448)
FUJINO Kiyohiro  KYOTO UNIVERSITY, Graduate School of medicine, Assistant Professor, 医学研究科, 助手 (50359832)
平海 晴一  京都大学, 医学研究科, 助手
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2004: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2002: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsstem cell / bone marrow stromal cell / ES cell / cell transplantation / FDG / PET / 移植 / 聴覚路 / 分化 / 臨界期 / 脳磁図 / 聴皮質 / 先天性難聴 / 言語習得 / 難聴 / 聴神経 / SPM / 脳機能画像 / 再生
Research Abstract

We studied on stem cell implantation in the auditory tract of experimental animals in search for possibilities of manipulating the critical period of the auditory cortex. We injected autologous bone marrow stromal cells (MSC) into the modiolus of the cochlea damaged by aminoglycoside, and observed massive survival of MSCs, some of which differentiated into neuronal cells. Mouse embryonic stem cells (ES cells) cultured on skull bone marrow cell layer were co-cultured with cochlear sensory epithelium, which resulted in massive elongation of neurites from ES cells and attachment of the neurites to hair cells. Expression of synaptophysin was observed in the neurites of ES cell-derived neurons adjacent to the basal or basolateral portion of hair cells. These findings indicate a high potential of ES cells to differentiate into auditory tract neurons. We also used mouse ES cells after treatment with the SDIA as transplants. Hartley guinea pigs deafened by kanamycin and ethacrynic acid were us … More ed as recipient animals. ES cells were introduced into the cochlear modiolus. Transplanted cochleae exhibited significantly lower eABR thresholds in comparison with those of non-operated ones, which suggests possible contribution of SDIA-treated ES cell implantation to retrieval of auditory function. These results suggest future potential of using stem cell implantation to overcome critical period of the auditory nervous system. As for studies by functional brain imaging, we used 18F-FDG in normal hearing volunteers and let them watch silent video of a speaker's face. Positron emission tomography (PET) scan of their brain revealed significant activation of visual cortex, parietal lobe and the posterior portion of the superior temporal gyrus(STG) in the left hemisphere. If this lip reading activation of the left STG become dominant in congenitally deafened subjects, processing of visual aspects of language may be prevailing in the temporal cortex, which is expected to become one of the indicators for critical period of spoken language acquisition. Less

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (101 results)

All 2005 2004 2003 2002 Other

All Journal Article (63 results) Book (4 results) Publications (34 results)

  • [Journal Article] Aging effects on vestibulo-ocular responses in C57BL/6 mice : comparison with alteration in auditory function2005

    • Author(s)
      Shiga A, Nakagawa T, Nakayama M, et al.
    • Journal Title

      Audiol Neurootol 10

      Pages: 97-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aging effects on vestibulo-ocular responses in C57BL/6 mice : comparison with alteration in auditory function.2005

    • Author(s)
      Shiga A, Nakagawa T, Nakayama M, Endo T, Iguchi F, Kim TS, Naito Y, Ito J
    • Journal Title

      Audiol Neurootol 10

      Pages: 97-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Elevation of superoxide dismutase increases acoustic trauma from noise exposure.2005

    • Author(s)
      Endo T, Nakagawa T, Iguchi F, Kita T, Okano T, Sha SH, Schacht J, Shiga A, Kim TS, Ito J.
    • Journal Title

      Free Radic Biol Med. 38(4)

      Pages: 492-498

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aging effects on vestibulo-ocular responses in C57BL/6 mice : comparison with alteration in auditory function.2005

    • Author(s)
      Shiga A, Nakagawa T, Nakayama M, Endo T, Iguchi F, Kim TS, Naito Y, Ito J.
    • Journal Title

      Audiol Neurootol. 10(2)

      Pages: 97-104

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 内耳への新しい薬物投与方法 徐放性ドラッグデリバリーシステム2005

    • Author(s)
      伊藤壽一
    • Journal Title

      耳鼻咽喉科臨床 98巻1号

      Pages: 1-4

    • NAID

      10014088860

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 内耳障害の病態2005

    • Author(s)
      岩井浩治, 内藤 泰
    • Journal Title

      JHONS 1

      Pages: 122-124

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transplantation of bone marrow stromal cells into the cochlea of chinchillas2004

    • Author(s)
      Naito Y, Nakamura T, Nakagawa T, et al.
    • Journal Title

      Neuroreport 15

      Pages: 1-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of β-catenin in developing auditory epithelia of mice2004

    • Author(s)
      Takebayashi S, Nakagawa T, Kojima K, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 18-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of cell proliferation and β-catenin expression in rat utricles in vitro2004

    • Author(s)
      Kim TS, Nakagawa T, Lee JE, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 22-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transplantation of neural stem cells into explants of rat inner ear2004

    • Author(s)
      Fujino K, Kim TS Nishida A, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 31-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants2004

    • Author(s)
      Kim TS, Kojima K, Nishida A, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 34-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surgical techniques for cell transplantation into the mouse cochlea2004

    • Author(s)
      Iguchi F, Nakagawa T, Tateya I, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 43-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fates of mouse ES cells transplanted into inner ears of adult mice and embryonic chickens2004

    • Author(s)
      Sakamoto T, Nakagawa T, Endo T, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 48-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Relationship between cochlear implant outcome and a diameter of cochlear nerve depicted in MRI2004

    • Author(s)
      Morita T, Naito Y, Tsuji J, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 56-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chronological changes of stimulation levels in prelingually deafened children with cochlear implant2004

    • Author(s)
      Morita T, Naito Y, Nakamura T, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 60-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin2004

    • Author(s)
      Tamura T, Nakagawa T, Iguchi F, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 65-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides2004

    • Author(s)
      Lee JE, Nakagawa T, Kim TS, et al.
    • Journal Title

      Acta Otolaryngol (Stockh) Suppl 551

      Pages: 69-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transplantation of bone marrow stromal cells into the cochlea of chinchillas.2004

    • Author(s)
      Naito Y, Nakamura T, Nakagawa T, Iguchi F, Endo T, Fujino K, Kim TS, Hiratsuka H, Tamura T, Kanemaru S, Shimizu S, Ito J
    • Journal Title

      Neuroreport 15

      Pages: 1-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of β-catenin in developing auditory epithelia of mice.2004

    • Author(s)
      Takebayashi S, Nakagawa T, Kojima K, Kim TS, Kita T, Dong Y, Endo T, Iguchi F, Naito Y, Omori K, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 18-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of cell proliferation and β-catenin expression in rat utricles in vitro.2004

    • Author(s)
      Kim TS, Nakagawa T, Lee JE, Fujino K, Iguchi F, Endo T, Naito Y, Omori K, Lefebvre PP, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 22-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transplantation of neural stem cells into explants of rat inner ear.2004

    • Author(s)
      Fujino K, Kim TS, Nishida A, Nakagawa T, Omori K, Naito Y, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 31-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants.2004

    • Author(s)
      Kim TS, Kojima K, Nishida A, Tashiro K, Lee JE, Fujino K, Nakagawa T, Iguchi F, Endo T, Naito Y, Omori K, Lefebvre PP, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 34-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surgical techniques for cell transplantation into the mouse cochlea.2004

    • Author(s)
      Iguchi F, Nakagawa T, Tateya I, Endo T, Kim TS, Dong Y, Kita T, Kojima K, Naito Y, Omori K, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 43-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fates of mouse ES cells transplanted into inner ears of adult mice and embryonic chickens.2004

    • Author(s)
      Sakamoto T, Nakagawa T, Endo T, Kim TS, Iguchi F, Naito Y, Sasai Y, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 48-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Relationship between cochlear implant outcome and a diameter of cochlear nerve depicted in MRI.2004

    • Author(s)
      Morita T, Naito Y, Tsuji J, Nakamura T, Yamaguchi S, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 56-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chronological changes of stimulation levels in prelingually deafened children with cochlear implant.2004

    • Author(s)
      Morita T, Naito Y, Nakamura T, Yamaguchi S, Tsuji J, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 60-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin.2004

    • Author(s)
      Tamura T, Nakagawa T, Iguchi F, Tateya I, Endo T, Kim TS, Dong Y, Kita T, Kojima K, Naito Y, Omori K, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 65-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides.2004

    • Author(s)
      Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Kita T, Murai N, Naito Y, Lee SH, Ito J
    • Journal Title

      Acta Otolaryngol (Stockh) 551(Suppl)

      Pages: 69-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.2004

    • Author(s)
      Kitajiri S, Fukumoto K, Hata M, Sasaki H, Katsuno T, Nakagawa T, Ito J, Tsukita S, Tsukita S.
    • Journal Title

      J Cell Biol. 166(4)

      Pages: 559-570

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis2004

    • Author(s)
      Lee JE, Nakagawa T, Kita T, Kim TS, Iguchi F, Endo T, Shiga A, Lee SH, Ito J.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 66(3)

      Pages: 111-118

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential.2004

    • Author(s)
      Kitajiri S, Miyamoto T, Mineharu A, Sonoda N, Furuse K, Hata M, sasaki H, Mori Y, Kubota T, Ito J, Furuse M, Tsukita S.
    • Journal Title

      J Cell Sci. 117(Pt 21)

      Pages: 5087-5096

    • Related Report
      2004 Annual Research Report
  • [Journal Article] OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst2004

    • Author(s)
      Nishida AT, Kobuke K, Kojima K, Ito J, Honjo T, Tashiro K
    • Journal Title

      Dev Dyn.2004 231(4)

      Pages: 766-774

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 空間識研究の進歩 空間識に関する脳機能画像の知見2004

    • Author(s)
      内藤 泰
    • Journal Title

      Equilibrium Research 63巻3号

      Pages: 262-266

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 若年者に生じた中枢性頭位眩暈の3例2004

    • Author(s)
      平海晴一, 三浦 誠, 廣瀬知子
    • Journal Title

      耳鼻咽喉科臨床 97巻12号

      Pages: 1053-1058

    • NAID

      10014203925

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 【画像・動画の保存とプレゼンテーション】ポスターの効果的作成法2004

    • Author(s)
      平海晴一, 内藤 泰
    • Journal Title

      耳鼻咽喉科・頭頸部外科 76巻4号

      Pages: 257-262

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 内耳への神経道細胞移植2004

    • Author(s)
      中川隆之, 井口福一郎, 伊藤壽一
    • Journal Title

      炎症・再生 24巻5号

      Pages: 562-566

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 聴力のバイオロジー 老化による聴力低下のメカニズムと聴力再生への取り組み2004

    • Author(s)
      中川隆之
    • Journal Title

      日本老年医学会雑誌 41巻6号

      Pages: 607-609

    • NAID

      10014285559

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Relationship between intraoperative ECAP threshold and postoperative behavioral levels : Difference between postlingually deafened adults and prelingually deafened pediatric cochlear implant users2003

    • Author(s)
      Morita R, Naito Y, Hirai T, et al.
    • Journal Title

      Eur Arch Otorhinolaryngol 260

      Pages: 67-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel technique for inducing local inner ear damage2003

    • Author(s)
      Nakagawa T, Kim TS, Murai N, et al.
    • Journal Title

      Hear Res 176

      Pages: 122-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Trophic support of mouse inner ear by neural stem cell transplantation2003

    • Author(s)
      Iguchi F, Nakagawa T, Tateya I, et al.
    • Journal Title

      Neuroreport 14

      Pages: 77-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced activation of the auditory cortex in patients with inner-ear hearing impairment : An MEG study2003

    • Author(s)
      Morita T, Naito Y, Nagamine T, et al.
    • Journal Title

      Clin Neurophysiol 114

      Pages: 851-859

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice2003

    • Author(s)
      Dong Y, Nakagawa T, Endo T, et al.
    • Journal Title

      Neuroreport 14

      Pages: 759-761

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inner ear hearing loss modulates ipsi-lateral temporal lobe activation by monaural speech stimuli2003

    • Author(s)
      Tateya I, Naito Y, Hirano S, et al.
    • Journal Title

      Neuroreport 14

      Pages: 763-767

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel model for rapid induction of apoptosis in spiral ganglions of mice2003

    • Author(s)
      Lee JE, Nakagawa T, Kim TS, et al.
    • Journal Title

      Laryngoscope 113

      Pages: 994-999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cortical correlates of vestibulo-ocular reflex modulation : a PET study2003

    • Author(s)
      Naito Y, Tateya I, Hirano S, et al.
    • Journal Title

      Brain 126

      Pages: 1562-1578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fate of neural stem cells grafted into injured inner ears of mice2003

    • Author(s)
      Tateya I, Nakagawa T, Iguchi F, et al.
    • Journal Title

      Neuroreport 14

      Pages: 1677-1681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relationship between intraoperative ECAP threshold and postoperative behavioral levels : Difference between postlingually deafened adults and prelingually deafened pediatric cochlear implant users.2003

    • Author(s)
      Morita T, Naito Y, Hirai T, Yamaguchi S, Ito J
    • Journal Title

      Eur Arch Otorhinolaryngol 260

      Pages: 67-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel technique for inducing local inner ear damage.2003

    • Author(s)
      Nakagawa T, Kim TS, Murai N, Endo T, Iguchi F, Tateya I, Yamamoto N, Naito Y, Ito J
    • Journal Title

      Hear Res 176

      Pages: 122-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Trophic support of mouse inner ear by neural stem cell transplantation.2003

    • Author(s)
      Iguchi F, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, Naito Y, Ito J
    • Journal Title

      Neuroreport 14

      Pages: 77-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Enhanced activation of the auditory cortex in patients with inner-ear hearing impairment : An MEG study.2003

    • Author(s)
      Morita T, Naito Y, Nagamine T, Fujiki N, Shibasaki H, Ito J
    • Journal Title

      Clin Neurophysiol 114

      Pages: 851-859

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice.2003

    • Author(s)
      Dong Y, Nakagawa T, Endo T, Kim TS, Iguchi F, Yamanmoto N, Naito Y, Ito J
    • Journal Title

      Neuroreport 14

      Pages: 759-761

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inner ear hearing loss modulates ipsi-lateral temporal lobe activation by monaural speech stimuli.2003

    • Author(s)
      Tateya I, Naito Y, Hirano S, Kojima H, Inoue M, Kaneko K, Toyoda H, Ueno M, Ishizu K, Ito J
    • Journal Title

      Neuroreport 14

      Pages: 763-767

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel model for rapid induction of apoptosis in spiral ganglions of mice.2003

    • Author(s)
      Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Dong Y, Yuki K, Naito Y, Lee SH, Ito J
    • Journal Title

      Laryngoscope 113

      Pages: 994-999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cortical correlates of vestibulo-ocular reflex modulation : a PET study.2003

    • Author(s)
      Naito Y, Tateya I, Hirano S, Inoue M, Funabiki K, Toyoda H, Ueno M, Ishizu K, Nagahama Y, Fukuyama H, Ito J
    • Journal Title

      Brain 216

      Pages: 1562-1578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fate of neural stem cells grafted into injured inner ears of mice.2003

    • Author(s)
      Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, Kageyama R, Naito Y, Ito J
    • Journal Title

      Neuroreport 14

      Pages: 1677-1681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration of E-cadherin and b-catenin in mouse vestibular epithelia during induction of apoptosis2002

    • Author(s)
      Kim TS, Nakagawa T, Endo T, et al.
    • Journal Title

      Neurosci lett 329

      Pages: 173-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration in expression of p27 in auditory epithelia and neurons of mice during degeneration2002

    • Author(s)
      Endo T, Nakagawa T, Lee JE, et al.
    • Journal Title

      Neurosci lett 334

      Pages: 173-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration of E-cadherin and b-catenin in mouse vestibular epithelia during induction of apoptosis.2002

    • Author(s)
      Kim TS, Nakagawa T, Endo T, Iguchi F, Murai N, Naito Y, Ito J
    • Journal Title

      Neurosci Lett 334

      Pages: 173-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alteration in expression of p27 in auditory epithelia and neurons of mice during degeneration.2002

    • Author(s)
      Endo T, Nakagawa T, Lee JE, Dong Y, Kim TS, Iguchi F, Taniguchi Z, Naito Y, Ito J
    • Journal Title

      Neurosci lett 334

      Pages: 173-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Capillary hemangioma of the tympanic membrane

    • Author(s)
      Hiraumi H, Miura M, Hirose T
    • Journal Title

      Am J Otolaryngol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 前庭情報と空間識の皮質処理機構-PETとfMRIによる知見-

    • Author(s)
      内藤 泰
    • Journal Title

      神経進歩 (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 人工内耳の聴覚機能

    • Author(s)
      内藤 泰
    • Journal Title

      Cognition and Dementia (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 人工内耳手術による難聴の克服-現況と将来展望-

    • Author(s)
      内藤 泰
    • Journal Title

      耳喉頭頸 (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] Subjective audiometry(ed by Suzuki J, Kobayashi T, Koga K)2004

    • Author(s)
      Naito Y
    • Publisher
      Springer-Verlag, Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Sound-induced activation of auditory cortices in patients with inner-ear hearing loss(ed by Hakagawa M, Hirata K, Koga Y, Nagata K)2004

    • Author(s)
      Naito Y
    • Publisher
      Elsevier, Amsterdam
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Subjective audiometry. Hearing Impairment - An Invisible Disability (ed by Suzuki J, Kobayashi T, Koga K)2004

    • Author(s)
      Naito Y
    • Publisher
      Springer-Verlag, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Sound-induced activation of auditory cortices in patients with inner-ear hearing loss. Frontiers in Human Brain Topography (ed by Hakagawa M, Hirata K, Koga Y, Nagata K)ICS 12702004

    • Author(s)
      Naito Y
    • Publisher
      Elsevier, Amsterdam
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Morita T, Naito Y, Hirai T, Yamaguchi S, Ito J: "Relationship between intraoperative ECAP threshold and postoperative behavioral levels : Difference between postlingually deafened adults and prelingually deafened pediatric cochlear implant users"Eur Arch Otorhinolaryngol. 260. 67-72 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakagawa T, Kim TS, Murai N, Endo T, Iguchi F, Tateya I, Yamamoto N, Naito Y, Ito J: "A novel technique for inducing local inner ear damage"Hear Res. 176. 122-127 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iguchi f, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, Naito Y, Ito J: "Trophic support of mouse inner ear by neural stem cell transplantation"NeuroReport. 14. 77-80 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morita T, Naito Y, Nagamine T, Fujiki N, Shibasaki H, Ito J: "Enhanced activation of the auditory cortex in patients with inner-ear hearing impairment : An MEG study"Clin Neurophysiol. 114. 851-859 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Dong Y, Nakagawa T, Endo T, Kim TS, Iguchi F, Yamanmoto N, Naito Y, Ito J: "Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice"NeuroReport. 14. 759-761 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tateya I, Naito Y, Hirano S, Kojima H, Inoue M, Kaneko K, Toyoda H, Ueno M, Ishizu K, Ito J: "Inner ear hearing loss modulates ipsi-lateral temporal lobe activation by monaural speech stimuli"NeuroReport. 14. 763-767 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Dong Y, Yuki K, Naito Y, Lee SH, Ito J: "A novel model for rapid induction of apoptosis in spiral ganglions of mice"Laryngoscope. 113. 994-999 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naito Y, Tateya I, Hirano S, Inoue M, Funabiki K, Toyoda H, Ueno M, Ishizu K, Nagahama Y, Fukuyama H, Ito J: "Cortical correlates of vestibulo-ocular reflex modulation : a PET study"Brain. 126. 1562-1578 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, Kageyama R, Naito Y, Ito J: "Fate of neural stem cells grafted into injured inner ears of mice"Neuroreport. 14. 1677-1681 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naito Y, Nakamura T, Nakagawa T, Iguchi f, Endo T, Fujino K, Kim TS, Hiratsuka H, Tamura T, Kanemaru S, Shimizu S, Ito J: "Transplantation of bone marrow stromal cells into the cochlea of chinchillas"Neuroreport. 15. 1-4 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kim TS, Nakagawa T, Lee JE, Fujino K, Iguchi F, Endo T, Naito Y, Omori K, Lefebvre PP, Ito: "Induction of cell proliferation and β-catenin expression in rat utricles in vitro"Acta Otolaryngol (Stockh) Suppl. 551. 22-25 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujino K, Kim TS, Nishida A, Nakatawa T, Omori K, Naito Y, Ito J: "Transplantation of neural stem cells into explants of rat inner ear"Acta Otolaryngol (Stockh) Suppl. 551. 31-33 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kim TS, Kojima K, Nishida A, Tashiro K, Lee JE, Fujino K, Nakagawa T, Iguchi F, Endo T, Naito Y, Omori K, Lefebvre PP, Ito: "Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants"Acta Otolaryngol (Stockh) Suppl. 551. 34-38 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iguchi F, Nakagawa T, Tateya I, Endo T, Kim TS, Dong Y, Kita T, Kojima K, Naito Y, Omori K, Ito J: "Surgical techniques for cell transplantaion into the mouse cochlea"Acta Otolaryngol (Stockh) Suppl. 551. 43-47 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakamoto T, Nakagawa T, Endo T, Kim TS, Iguchi F, Naito Y, sasai Y, Ito J: "Fates of mouse ES cells Transplanted into inner ears of adult mice and embryonic chickens"Acta Otolaryngol (Stockh) Suppl. 551. 48-52 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morita T, Naito Y, Tsuji J, Nakamura T, Yamaguchi S, Ito J: "The Relationship between cochlear implant outcome and a diameter of cochlear nerve depicted in MRI"Acta Otolaryngol (Stockh) Suppl. 551. 56-59 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morita T, Naito Y, Nakamura T, Yamaguchi S, Tsuji J, Ito J: "Chronological changes of stimulation levels in prelingually deafened children with cochlear implant"Acta Otolaryngol (Stockh) Suppl. 551. 60-64 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamura T, Nakagawa T, Iguchi F, Tateya I, Endo T, Kim TS, Dong Y, Kita T, KOjima K, Naito Y, Omori K, Ito J: "Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin"Acta Otolaryngol (Stockh) Suppl. 551. 65-68 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Kita T, Murai N, Naito Y, Lee SH, Ito J: "Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides"Acta Otolaryngol (Stockh) Suppl. 551. 69-74 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 内藤 泰, 金丸眞一, 伊藤壽一: "経中頭蓋窩聴神経手術におけるナビゲーションの使用経験"耳展. 45. 397-398 (2003)

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      2003 Annual Research Report
  • [Publications] 野中信之, 村尾卓也, 酒井俊一, 中嶋 誠, 馬場朱美, 西岡奈美江, 山口 忍, 国吉京子, 川野通夫, 内藤 泰, 伊藤壽一: "人工内耳によって発達する聴覚性情動的認知"音声言語医学. 44. 15-22 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 金 賢熙, 山口 忍, 李 相欣, 内藤 泰, 川野通夫: "韓国と日本の人工内耳装用幼児の発達"音声言語医学. 44. 30-35 (2003)

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      2003 Annual Research Report
  • [Publications] 中川隆之, 金 泰秀, 藤野清大, 井口福一郎, 遠藤 剛, 内藤 泰, 伊藤壽一: "ラット卵形嚢器官培養による増殖期細胞の誘導"Equilibrium Res. 62. 83-87 (2003)

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      2003 Annual Research Report
  • [Publications] 内藤 泰: "脳機能画像からみた空間識"Equilibrium Res. 62. 157-167 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 平海晴一, 内藤 泰: "人工内耳と聴覚認知"JHONS. 20. 43-47 (2004)

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      2003 Annual Research Report
  • [Publications] 内藤 泰: "実地医科のための検査法 画像診断-聴器"JHONS. 20. 433-436 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 金丸眞一, 中村達雄, Magrufov Akhmar, 大森孝一, 山下 勝, 平海晴一, 藤野清大, 内藤 泰, 伊藤壽一: "乳突蜂巣構造の再生-In situ tissue engineering の臨床応用-"耳鼻臨床. 97. 205-210 (2004)

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      2003 Annual Research Report
  • [Publications] 楯谷一郎, 内藤 泰: "小児人工内耳例の脳機能"ENTONI(EB ENT). 27. 81-87 (2004)

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      2003 Annual Research Report
  • [Publications] 内藤 泰: "人工内耳の仕組みと聴覚認知"神経進歩. 46. 128-140 (2002)

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      2002 Annual Research Report
  • [Publications] 内藤 泰: "5歳の難聴児に人工内耳手術適応はあるか"JHONS. 18. 318-319 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中野信之: "人工内耳によって発達する聴覚性情動的認知"音声言語医学. 44. 15-22 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakagawa T: "A novel technique for inducing local inner ear damage"Hearing Research. 176. 122-127 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morita T: "Enhanced activation of the auditory cortex in patients with inner-ear hearing impairment : An MEG study"Clinical Neurophysiology. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Tateya I: "Inner ear hearing loss modulates ipsi-lateral temporal lobe activation by monaural speech stimuli"Neuroreport. (in press).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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